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Cited by 53Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorElectroconvulsive Therapy Studies

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Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder

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Sterpenich, Virginie, Vidal, Sonia, Hofmeister, Jeremy, Michalopoulos, Giorgio, Bancila, Victor, Warrot, Delphine, Dayer, Alexandre, Desseilles, Martin, Aubry, Jean-Michel, Kosel, Markus, Schwartz, Sophie, Vutskits, Laszlo·2019·Anesthesiology
DOI 10.1097/aln.0000000000002667
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Abstract

Editor’s Perspective: What We Already Know about This Topic: What This Article Tells Us That Is New: Background: Ketamine rapidly improves maladaptive mood states in major depressive disorder, and some of the neural substrates underlying this therapeutic effect have been identified. This study aimed to identify functional changes within neural networks that may underlie the impact of ketamine on both reward and emotional processing in patients with treatment-resistant major depression. Methods: Ten adult patients with a Montgomery–Åsberg Depression Rating Scale score above 25 were enrolled to receive a single intravenous administration of ketamine (0.5 mg/kg). Patients’ performance along with related neural network activations were analyzed in a game-like reward task and in an emotional judgment task using functional magnetic resonance imaging 1 day before and 1 and 7 days after ketamine administration. Results: A significant correlation (R 2 = 0.46, P = 0.03) between the improvement of depression scores and the enhanced reaction time for positive items was found in the game-like reward task 1 day after ketamine administration. This enhanced sensitivity for rewarded items was accompanied by increased activity of reward-related brain regions, including the orbitofrontal cortex, ventral striatum, and the ventral tegmental area, an effect that persisted up to 1 week after ketamine injection. In the emotional judgment task, it was found that ketamine rapidly modified local brain activities in response to emotionally negative, positive, or neutral stimuli in the amygdala, insula, anterior cingulate cortex, and in the ventral tegmental area. Conclusions: Single bolus ketamine administration rapidly triggers lasting changes in mesolimbic neural networks to improve pathologic reward and emotional processing in patients with major depressive disorder.

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Metadata

Authors
Sterpenich, V., Vidal, S., Hofmeister, J., Michalopoulos, G., Bancila, V., Warrot, D., Dayer, A., Desseilles, M., Aubry, J.-M., Kosel, M., Schwartz, S., & Vutskits, L.
Affiliations
University of Geneva (CH)
ORCID
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-06
Volume
130
Issue
6
Pages
923-935
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/aln.0000000000002667
OpenAlex
W2937452922
Cited by
53
References
8
Citations by year
2026: 2 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 2
FWCI
3.72
Type
journal article
Language
en
Open access
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • Repository of the University of Namur (submittedVersion, cc-by-nc-nd)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Université de Genève
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
ketamine, mesolimbic reward system, reward processing, emotional processing, orbitofrontal cortex, ventral striatum, ventral tegmental area, amygdala, emotional judgment, rapid-acting antidepressants, neuroplasticity, mood improvement, insula, anterior cingulate cortex
MeSH terms
Adult, Anesthetics, Dissociative, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Ketamine, Limbic System, Male, Middle Aged, Photic Stimulation, Pilot Projects, Reward, Depressive Disorder, Treatment-Resistant, Administration, Intravenous

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