The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Biologic Effects of Nitrous Oxide: A Mechanistic and Toxicologic Review
Abstract
Nitrous oxide is the longest serving member of the anesthesiologist's pharmacologic armamentarium but remains a source of controversy because of fears over its adverse effects. Recently, the Evaluation of Nitrous oxide In a Gas Mixture for Anaesthesia (ENIGMA) trial reported that nitrous oxide use increases postoperative complications; further preclinical reports have suggested that nitrous oxide may contribute to neurocognitive dysfunction in the young and elderly. Therefore, nitrous oxide's longevity in anesthetic practice is under threat. In this article, the authors discuss the evidence for the putative toxicity of nitrous oxide, from either patient or occupational exposure, within the context of the mechanism of nitrous oxide's action. Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread prescription from clinical practice is unconvincing.
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Cited by
Fenech, M., & Bonassi, S. (2011) · Mutagenesis · doi:10.1093/mutage/geq050 · Cited by 371
Garakani, A., Jaffe, R. J., Savla, D., Welch, A. K., Protin, C. A., Bryson, E. O., & McDowell, D. M. (2016) · The American Journal on Addictions · doi:10.1111/ajad.12372 · Cited by 279
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
Nagele, P., Duma, A., Kopec, M., Gebara, M. A., Parsoei, A., Walker, M., Janski, A., Panagopoulos, V. N., Cristancho, P., Miller, J. P., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.016 · Cited by 230
Zorumski, C. F., Nagele, P., Mennerick, S., & Conway, C. R. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00172 · Cited by 57
Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts
Nagele, P., Zorumski, C. F., & Conway, C. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000837 · Cited by 43
Metadata
- Authors
- Sanders, R. D., Weimann, J., Maze, M., Warner, D. S., & Warner, M. A.
- Venue
- Anesthesiology
- Published
- 2008-10-01
- Volume
- 109
- Issue
- 4
- Pages
- 707-722
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2036377942
- Cited by
- 366
- References
- 88
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sanders, R. D., Weimann, J., Maze, M., Warner, D. S., & Warner, M. A. (2008). Biologic Effects of Nitrous Oxide: A Mechanistic and Toxicologic Review. Anesthesiology. https://doi.org/10.1097/aln.0b013e3181870a17
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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