The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*
Open accessAbstract
OBJECTIVE: To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Six tertiary care medical centers in the US. PATIENTS: One hundred one mechanically ventilated medical and surgical intensive care unit patients. INTERVENTION: Patients were randomly assigned to receive haloperidol or ziprasidone or placebo every 6 hrs for up to 14 days. Twice each day, frequency of study drug administration was adjusted according to delirium status, level of sedation, and side effects. MEASUREMENTS AND MAIN OUTCOMES: The primary end point was the number of days patients were alive without delirium or coma. During the 21-day study period, patients in the haloperidol group spent a similar number days alive without delirium or coma (median [interquartile range], 14.0 [6.0-18.0] days) as did patients in the ziprasidone (15.0 [9.1-18.0] days) and placebo groups (12.5 [1.2-17.2] days; p = 0.66). No differences were found in secondary clinical outcomes, including ventilator-free days (p = .25), hospital length of stay (p = .68), and mortality (p = .81). Ten (29%) patients in the haloperidol group reported symptoms consistent with akathisia, compared with six (20%) patients in the ziprasidone group and seven (19%) patients in the placebo group (p = .60), and a global measure of extrapyramidal symptoms was similar between treatment groups (p = .46). CONCLUSIONS: A randomized, placebo-controlled trial of antipsychotics for delirium in mechanically ventilated intensive care unit patients is feasible. Treatment with antipsychotics in this limited pilot trial did not improve the number of days alive without delirium or coma, nor did it increase adverse outcomes. Thus, a large trial is needed to determine whether use of antipsychotics for intensive care unit delirium is appropriate.
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Cites
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A RATING SCALE FOR EXTRAPYRAMIDAL SIDE EFFECTS
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Self-citationDelirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
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Self-citationA Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
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Nelson, J. E., Cox, C. E., Hope, A. A., & Carson, S. S. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0210ci · Cited by 616
Self-citationPostoperative Delirium: Acute Change with Long-Term Implications
Rudolph, J. L., & Marcantonio, E. R. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182147f6d · Cited by 608
Neufeld, K. J., Yue, J., Robinson, T. N., Inouye, S. K., & Needham, D. M. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14076 · Cited by 505
“68, I(2) = 77%).(13,14,17,18) Severity of delirium was not associated with administration of antipsychotics in 464 participants in eight studies (SMD = 0.”
BackgroundHerridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., & Azoulay, E. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4321-8 · Cited by 442
Delirium and Mortality in Critically Ill Children: Epidemiology and Outcomes of Pediatric Delirium
Traube, C., Silver, G., Gerber, L. M., Kaur, S., Mauer, E. A., Kerson, A., Joyce, C., & Greenwald, B. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002324 · Cited by 379
Metadata
- Authors
- Girard, T. D., Pandharipande, P. P., Carson, S. S., Schmidt, G. A., Wright, P. E., Canonico, A. E., Pun, B. T., Thompson, J. L., Shintani, A. K., Meltzer, H. Y., Bernard, G. R., Dittus, R. S., & Ely, E. W.
- Venue
- Critical Care Medicine
- Published
- 2010-02
- Volume
- 38
- Issue
- 2
- Pages
- 428-437
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W186974930
- Cited by
- 451
- References
- 45
- FWCI
- 27.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Girard, T. D., Pandharipande, P. P., Carson, S. S., Schmidt, G. A., Wright, P. E., Canonico, A. E., Pun, B. T., Thompson, J. L., Shintani, A. K., Meltzer, H. Y., Bernard, G. R., Dittus, R. S., & Ely, E. W. (2010). Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*. Critical Care Medicine. https://doi.org/10.1097/ccm.0b013e3181c58715
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
