Chronic Critical Illness

Nelson, Judith E.; Cox, Christopher E.; Hope, Aluko A.; Carson, Shannon S.

doi:10.1164/rccm.201002-0210ci

Cited by 616Respiratory Support and MechanismsIntensive Care Unit Cognitive DisordersNosocomial Infections in ICU

Chronic Critical Illness

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Nelson, Judith E., Cox, Christopher E., Hope, Aluko A., Carson, Shannon S.·2010·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201002-0210ciPMC PMC2937238

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Abstract

Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field, we suggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.

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Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476 · see citing works
Sepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,269 · see citing works
Long-term complications of critical care
Desai, S. V., Law, T. J., & Needham, D. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181fd66e5 · Cited by 870 · see citing works
Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers
Herridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., & Azoulay, E. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4321-8 · Cited by 442 · see citing works
The Epidemiology of Chronic Critical Illness in the United States*
Kahn, J. M., Le, T., Angus, D. C., Cox, C. E., Hough, C. L., White, D. B., Yende, S., & Carson, S. S. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000710 · Cited by 420 · see citing works
Self-citation
The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation
Herridge, M. S., Chu, L. M., Matte, A. L., TOMLINSON, G. A., Chan, L. S., Thomas, C., Friedrich, J. O., Mehta, S., Lamontagne, F., Levasseur, M., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2343oc · Cited by 416 · see citing works
Outcomes after Critical Illness
Herridge, M. S., & Azoulay, É. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2104669 · Cited by 378 · see citing works
Effect of Palliative Care–Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial
Carson, S. S., Cox, C. E., Wallenstein, S., Hanson, L. C., Danis, M., Tulsky, J. A., Chai, E., & Nelson, J. E. (2016) · JAMA · doi:10.1001/jama.2016.8474 · Cited by 352 · see citing works
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The Changing Role of Palliative Care in the ICU
Aslakson, R. A., Curtis, J. R., & Nelson, J. E. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000573 · Cited by 346 · see citing works
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Long-term survival of critically ill patients treated with prolonged mechanical ventilation: a systematic review and meta-analysis
Damuth, E., Mitchell, J. A., Bartock, J. L., Roberts, B. W., & Trzeciak, S. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00150-2 · Cited by 327 · see citing works
Sudden cardiac arrest survivorship: a scientific statement from the American Heart Association
Sawyer, K. N., Camp-Rogers, T. R., Kotini-Shah, P., Del Rios, M., Gossip, M. R., Moitra, V. K., Haywood, K. L., Dougherty, C. M., Lubitz, S. A., Rabinstein, A. A., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000747 · Cited by 311 · see citing works
Ventilator-associated pneumonia in critically ill patients with COVID-19
Maes, M., Higginson, E. E., Pereira-Dias, J., Curran, M. D., Parmar, S., Khokhar, F., Cuchet, D., Lux, J., Sharma-Hajela, S., Ravenhill, B., et al. (2021) · Critical Care · doi:10.1186/s13054-021-03460-5 · Cited by 310 · see citing works
Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock
Mathias, B. J., Delmas, A. L., Ozrazgat‐Baslanti, T., Vanzant, E. L., Szpila, B. E., Mohr, A. M., Moore, F. A., Brakenridge, S. C., Brumback, B., Moldawer, L. L., et al. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001783 · Cited by 286 · see citing works
Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations
Parotto, M., Gyöngyösi, M., Howe, K. L., Myatra, S. N., Ranzani, O., Shankar‐Hari, M., & Herridge, M. S. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00239-4 · Cited by 271 · see citing works
Timing of onset and burden of persistent critical illness in Australia and New Zealand: a retrospective, population-based, observational study
Iwashyna, T. J., Hodgson, C. L., Pilcher, D. V., Bailey, M., van Lint, A., Chavan, S., & Bellomo, R. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30098-4 · Cited by 244 · see citing works
Physician-related barriers to communication and patient- and family-centred decision-making towards the end of life in intensive care: a systematic review
Visser, M., Deliëns, L., & Houttekier, D. (2014) · Critical Care · doi:10.1186/s13054-014-0604-z · Cited by 226 · see citing works
Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors*
Moitra, V. K., Guerra, C., Linde-Zwirble, W. T., & Wunsch, H. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001480 · Cited by 221 · see citing works
Trends in Tracheostomy for Mechanically Ventilated Patients in the United States, 1993–2012
Mehta, A., Syeda, S. N., BAJPAYEE, L., Cooke, C. R., Walkey, A. J., & Wiener, R. S. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201502-0239oc · Cited by 189 · see citing works
The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die*
Weiss, S. L., Balamuth, F., Hensley, J., Fitzgerald, J. C., Bush, J., Nadkarni, V., Thomas, N. J., Hall, M., & Muszynski, J. A. (2017) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001222 · Cited by 184 · see citing works
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma
Vanzant, E. L., López, C. M., Ozrazgat‐Baslanti, T., Ungaro, R. F., Davis, R., Cuenca, A. G., Gentile, L. F., Nacionales, D. C., Cuenca, A. L., Bihorac, A., et al. (2013) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182ab1ab5 · Cited by 181 · see citing works
Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation
Hill, A. D., Fowler, R., Burns, K. E. A., Rose, L., Pinto, R. L., & Scales, D. C. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201610-792oc · Cited by 158 · see citing works
Effects of a Personalized Web-Based Decision Aid for Surrogate Decision Makers of Patients With Prolonged Mechanical Ventilation
Cox, C. E., White, D. B., Hough, C. L., Jones, D. M., Kahn, J. M., Olsen, M. K., Lewis, C. L., Hanson, L. C., & Carson, S. S. (2019) · Annals of Internal Medicine · doi:10.7326/m18-2335 · Cited by 152 · see citing works
“Patient inclusion criteria were age 18 years or older, no anticipation of death or liberation from mechanical ventilation within 24 hours, and ventilation for at least 10 days—a time at which tracheotomy and surgical feeding tube placement are commonly considered (18).”
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A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation*
Carson, S. S., Kahn, J. M., Hough, C. L., Seeley, E. J., White, D. B., Douglas, I. S., Cox, C. E., Caldwell, E., Bangdiwala, S. I., Garrett, J. M., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182387d43 · Cited by 144 · see citing works
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Understanding and Reducing Disability in Older Adults Following Critical Illness*
Brummel, N. E., Balas, M. C., Morandi, A., Ferrante, L. E., Gill, T. M., & Ely, E. W. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000924 · Cited by 131 · see citing works
The reality of patients requiring prolonged mechanical ventilation: a multicenter study
Loss, S. H., de Oliveira, R. P., Maccari, J. G., Savi, A., Boniatti, M. M., Hetzel, M. P., Dallegrave, D. M., Balzano, P. D. C., Oliveira, E. S., Höher, J. A., et al. (2015) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20150006 · Cited by 130 · see citing works
Hospital-Free Days: A Pragmatic and Patient-centered Outcome for Trials among Critically and Seriously Ill Patients
Auriemma, C. L., Taylor, S. P., Harhay, M. O., Courtright, K. R., & Halpern, S. D. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202104-1063pp · Cited by 130 · see citing works
Advance Care Planning in Serious Illness: A Narrative Review
Rosa, W. E., Izumi, S., Sullivan, D. R., Lakin, J. R., Rosenberg, A. R., Creutzfeldt, C. J., Lafond, D., Tjia, J., Cotter, V. T., Wallace, C. L., et al. (2022) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2022.08.012 · Cited by 129 · see citing works
ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients
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Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients
Stortz, J. A., Mira, J. C., Raymond, S. L., Loftus, T. J., Ozrazgat‐Baslanti, T., Wang, Z., Ghita, G. L., Leeuwenburgh, C., Segal, M. S., Bihorac, A., et al. (2017) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001758 · Cited by 124 · see citing works
The patient needing prolonged mechanical ventilation: a narrative review
Ambrosino, N., & Vitacca, M. (2018) · Multidisciplinary Respiratory Medicine · doi:10.1186/s40248-018-0118-7 · Cited by 116 · see citing works
Swallowing Dysfunction After Critical Illness
Macht, M., White, S. D., & Moss, M. (2014) · Chest · doi:10.1378/chest.14-1133 · Cited by 112 · see citing works
Development and pilot testing of a decision aid for surrogates of patients with prolonged mechanical ventilation*
Cox, C. E., Lewis, C. L., Hanson, L. C., Hough, C. L., Kahn, J. M., White, D. B., Song, M., Tulsky, J. A., & Carson, S. S. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182536a63 · Cited by 112 · see citing works
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The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level–One Trauma Centers*
Mira, J. C., Cuschieri, J., Ozrazgat‐Baslanti, T., Wang, Z., Ghita, G. L., Loftus, T. J., Stortz, J. A., Raymond, S. L., Lanz, J. D., Hennessy, L. V., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002697 · Cited by 111 · see citing works
Nurses’ perceptions of communication training in the ICU
Radtke, J. V., Tate, J. A., & Happ, M. B. (2011) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2011.11.005 · Cited by 110 · see citing works
Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a review of definitions, potential therapies, and research priorities
Chadda, K. R., & Puthucheary, Z. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.11.052 · Cited by 109 · see citing works
Long-Term Outcome after Prolonged Mechanical Ventilation: A Long-Term Acute-Care Hospital Study
Jubran, A., Grant, B. J. B., Duffner, L. A., Collins, E. G., Lanuza, D. M., Hoffman, L. A., & Tobin, M. J. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1131oc · Cited by 108 · see citing works
Defining Pediatric Chronic Critical Illness for Clinical Care, Research, and Policy
Shapiro, M. C., Henderson, C. M., Hutton, N., & Boss, R. D. (2017) · Hospital Pediatrics · doi:10.1542/hpeds.2016-0107 · Cited by 105 · see citing works
Timing of onset of persistent critical illness: a multi-centre retrospective cohort study
Bagshaw, S. M., Stelfox, H. T., Iwashyna, T. J., Bellomo, R., Zuege, D. J., & Wang, X. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5440-1 · Cited by 102 · see citing works
Definitions and Epidemiology of the Chronically Critically Ill
Carson, S. S. (2012) · Respiratory Care · doi:10.4187/respcare.01736 · Cited by 102 · see citing works
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Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis
Wintermann, G., Brunkhorst, F. M., Petrowski, K., Strauss, B. M., Oehmichen, F., Pohl, M., & Rosendahl, J. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000936 · Cited by 99 · see citing works
Effectiveness of Long-term Acute Care Hospitalization in Elderly Patients With Chronic Critical Illness
Kahn, J. M., Werner, R. M., David, G., Have, T. R. T., Benson, N. M., & Asch, D. A. (2012) · Medical Care · doi:10.1097/mlr.0b013e31826528a7 · Cited by 93 · see citing works
Physical and Mental Health in Patients and Spouses After Intensive Care of Severe Sepsis
Rosendahl, J., Brunkhorst, F. M., Jaenichen, D., & Strauss, B. M. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31826766b0 · Cited by 92 · see citing works
The feasibility of measuring frailty to predict disability and mortality in older medical intensive care unit survivors
Baldwin, M. R., Reid, M. C., Westlake, A. A., Rowe, J. W., Granieri, E. C., Wunsch, H., Dam, T.-T. L., Rabinowitz, D., Goldstein, N. E., Maurer, M. S., et al. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2013.12.019 · Cited by 89 · see citing works
Impact of frailty on persistent critical illness: a population-based cohort study
Darvall, J. N., Bellomo, R., Bailey, M., Young, P. J., Rockwood, K. J., & Pilcher, D. V. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06617-0 · Cited by 84 · see citing works
Predictors of posttraumatic stress and quality of life in family members of chronically critically ill patients after intensive care
Wintermann, G., Weidner, K., Strauss, B. M., Rosendahl, J., & Petrowski, K. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0174-0 · Cited by 83 · see citing works
Chronic Critical Illness
Lamas, D. J. (2014) · New England Journal of Medicine · doi:10.1056/nejmms1310675 · Cited by 83 · see citing works
Metabolic and Nutrition Support in the Chronic Critical Illness Syndrome
Schulman, R. C., & Mechanick, J. I. (2012) · Respiratory Care · doi:10.4187/respcare.01620 · Cited by 82 · see citing works
Chronic Critical Illness: The Growing Challenge to Health Care
MacIntyre, N. R. (2012) · Respiratory Care · doi:10.4187/respcare.01768 · Cited by 76 · see citing works
Prognostic Factors for Long-Term Mortality in Critically Ill Patients Treated With Prolonged Mechanical Ventilation: A Systematic Review
Dettmer, M. R., Damuth, E., Zarbiv, S., Mitchell, J. A., Bartock, J. L., & Trzeciak, S. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002022 · Cited by 75 · see citing works
Multidisciplinary Team Approach in the Management of Tracheostomy Patients
Pandian, V., Miller, C. R., Mirski, M. A., Schiavi, A. J., Morad, A. H., Vaswani, R., Kalmar, C. L., Feller-Kopman, D. J., Haut, E. R., Yarmus, L. B., et al. (2012) · Otolaryngology · doi:10.1177/0194599812449995 · Cited by 70 · see citing works
Impact of Intensive Care Unit Organ Failures on Mortality during the Five Years after a Critical Illness
Lone, N., & Walsh, T. S. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0059oc · Cited by 70 · see citing works
Chronic critical illness: are we saving patients or creating victims?
Loss, S. H., Nunes, D. S. L., Franzosi, O. S., Salazar, G. S., Teixeira, C., & Vieira, S. R. R. (2017) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20170013 · Cited by 70 · see citing works
Early Mobility in the Intensive Care Unit: Evidence, Barriers, and Future Directions
Dirkes, S. M., & Kozlowski, C. (2019) · Critical Care Nurse · doi:10.4037/ccn2019654 · Cited by 69 · see citing works
Rehabilitation, weaning and physical therapy strategies in chronic critically ill patients
Ambrosino, N., Venturelli, E., Vagheggini, G., & Clini, E. M. (2011) · European Respiratory Journal · doi:10.1183/09031936.00094411 · Cited by 68 · see citing works
Modifiable elements of ICU supportive care and communication are associated with surrogates’ PTSD symptoms
Wendlandt, B., Ceppe, A., Choudhury, S., Cox, C. E., Hanson, L. C., Danis, M., Tulsky, J. A., Nelson, J. E., & Carson, S. S. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05550-z · Cited by 68 · see citing works
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Chronic Critical Illness in Infants and Children: A Speculative Synthesis on Adapting ICU Care to Meet the Needs of Long-Stay Patients
Marcus, K. L., Henderson, C. M., & Boss, R. D. (2016) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000792 · Cited by 68 · see citing works
Mesenchymal stem cells in multiple sclerosis - translation to clinical trials.
Moradian, S. T., Nourozi, K., Ebbadi, A., & Khankeh, H. R. (2015) · Europe PMC (PubMed Central) · Cited by 67 · see citing works
Five-Year Survival of Children With Chronic Critical Illness in Australia and New Zealand*
Namachivayam, S. P., Alexander, J., Slater, A., Millar, J., Erickson, S. J., Tibballs, J., Festa, M., Ganu, S. S., Segedin, L., Schlapbach, L. J., et al. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001076 · Cited by 67 · see citing works
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) after Polytrauma: A Rare Syndrome with Major Consequences
Hesselink, L., Hoepelman, R. J., Spijkerman, R., de Groot, M., van Wessem, K. J. P., Koenderman, L., Leenen, L. P. H., & Hietbrink, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010191 · Cited by 65 · see citing works
An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis
Burke, D., Gorman, E., Stokes, D., & Lennon, O. C. (2014) · The Clinical Respiratory Journal · doi:10.1111/crj.12234 · Cited by 65 · see citing works
A few of our favorite unconfirmed ideas
Marini, J. J., Gattinoni, L., İnce, C., Kozek‐Langenecker, S. A., Mehta, R. L., Pichard, C., Westphal, M., Wischmeyer, P. E., & Vincent, J. (2015) · Critical Care · doi:10.1186/cc14719 · Cited by 65 · see citing works
Sepsis induced immunosuppression: Implications for secondary infections and complications
Sundar, K. M., & Sires, M. (2013) · Indian Journal of Critical Care Medicine · doi:10.4103/0972-5229.117054 · Cited by 62 · see citing works
The urea-creatinine ratio as a novel biomarker of critical illness-associated catabolism
Gunst, J., KASHANI, K. B., & Hermans, G. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05810-y · Cited by 62 · see citing works
Chronic Illness in Pediatric Critical Care
Salem, S. M., & Graham, R. J. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.686206 · Cited by 62 · see citing works
Patterns of depressive symptoms in caregivers of mechanically ventilated critically ill adults from intensive care unit admission to 2 months postintensive care unit discharge
Choi, J., Sherwood, P. R., Schulz, R., Ren, D., Donahoe, M. P., Given, B. A., & Hoffman, L. A. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182451c58 · Cited by 60 · see citing works
The Voice of Surrogate Decision-Makers. Family Responses to Prognostic Information in Chronic Critical Illness
Nelson, J. E., Hanson, L. C., Keller, K. L., Carson, S. S., Cox, C. E., Tulsky, J. A., White, D. B., Chai, E. J., Weiss, S. P., & Danis, M. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0201oc · Cited by 59 · see citing works
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A multicase study of prolonged critical illness in the intensive care unit: Families’ experiences
Minton, C., Batten, L. S., & Huntington, A. (2018) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2018.08.010 · Cited by 58 · see citing works
Psychological and Physical Health in Family Caregivers of Intensive Care Unit Survivors: Current Knowledge and Future Research Strategies
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Multi-Drug Resistance Bacterial Infections in Critically Ill Patients Admitted with COVID-19
Pasero, D., Cossu, A. P., & Terragni, P. (2021) · Microorganisms · doi:10.3390/microorganisms9081773 · Cited by 57 · see citing works
Chronic critical illness: the price of survival
Marchioni, A., Fantini, R., Antenora, F., Clini, E. M., & Fabbri, L. M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12547 · Cited by 58 · see citing works
Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice
Ohbe, H., Satoh, K., Totoki, T., Tanikawa, A., Shirasaki, K., Kuribayashi, Y., Tamura, M., Takatani, Y., Ishikura, H., Nakamura, K., et al. (2024) · Critical Care · doi:10.1186/s13054-024-05215-4 · Cited by 56 · see citing works
The End-of-Life Family Meeting in Intensive Care Part I: Indications, Outcomes, and Family Needs
Billings, J. A. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2011.0038 · Cited by 56 · see citing works
Persistent Systemic Inflammation in Chronic Critical Illness
Cox, C. E. (2012) · Respiratory Care · doi:10.4187/respcare.01719 · Cited by 55 · see citing works
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The difficult-to-wean patient
Ambrosino, N., & Gabbrielli, L. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.58 · Cited by 55 · see citing works
To Trach or Not to Trach: Uncertainty in the Care of the Chronically Critically Ill
Nelson, J. E., Carson, S. S., & Bice, T. J. (2015) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0035-1564872 · Cited by 55 · see citing works
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The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis
Galiatsatos, P., Follin, A., Alghanim, F., Sherry, M., Sylvester, C., Daniel, Y., Chanmugam, A. S., Townsend, J., Saria, S., Kind, A., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004307 · Cited by 55 · see citing works
Integration of Palliative Care in Chronic Critical Illness Management
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Impact of post-traumatic stress symptoms on the health-related quality of life in a cohort study with chronically critically ill patients and their partners: age matters
Wintermann, G., Petrowski, K., Weidner, K., Strauss, B. M., & Rosendahl, J. (2019) · Critical Care · doi:10.1186/s13054-019-2321-0 · Cited by 53 · see citing works
Anterior pituitary function in critical illness
Téblick, A., Langouche, L., & Van den Berghe, G. (2019) · Endocrine Connections · doi:10.1530/ec-19-0318 · Cited by 52 · see citing works
Mechanical Ventilation Antioxidant Trial
Howe, K. P., Clochesy, J. M., Goldstein, L. S., & Owen, H. (2015) · American Journal of Critical Care · doi:10.4037/ajcc2015335 · Cited by 52 · see citing works
The Effect of Aging Physiology on Critical Care
Darden, D. B., Moore, F. A., Brakenridge, S. C., Navarro, E., Anton, S. D., Leeuwenburgh, C., Moldawer, L. L., Mohr, A. M., Efron, P. A., & Mankowski, R. T. (2020) · Critical Care Clinics · doi:10.1016/j.ccc.2020.08.006 · Cited by 52 · see citing works
Critical Care Organizations: Business of Critical Care and Value/Performance Building*
Leung, S., Gregg, S., Coopersmith, C. M., Layon, A. J., Oropello, J. M., Brown, D. R., Pastores, S. M., & Kvetan, V. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002696 · Cited by 52 · see citing works
Hospital-level variation in the development of persistent critical illness
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Patient and Family Engagement During Treatment Decisions in an ICU: A Discourse Analysis of the Electronic Health Record*
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Authors: Nelson, J. E., Cox, C. E., Hope, A. A., & Carson, S. S.
Affiliations: Mount Sinai Hospital (US)
Duke University (US)
Icahn School of Medicine at Mount Sinai (US)
University of North Carolina at Chapel Hill (US)
ORCID: Nelson, Judith E.
Cox, Christopher E.
Hope, Aluko A.
Carson, Shannon S.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2010-08
Volume: 182
Issue: 4
Pages: 446-454
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201002-0210ci
PMC: PMC2937238
OpenAlex: W2110115774
Cited by: 616
References: 78
Citations by year: 2026: 33 · 2025: 36 · 2024: 37 · 2023: 40 · 2022: 43 · 2021: 48 · 2020: 52 · 2019: 51 · 2018: 35 · 2017: 49 · 2016: 45 · 2015: 43 · 2014: 27 · 2013: 26 · 2012: 27
FWCI: 4.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institute on Aging (AG034234)
National Heart, Lung, and Blood Institute
National Institute of Nursing Research (R01NR012413)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: chronic critical illness, prolonged mechanical ventilation, ventilator liberation, mortality, functional dependence, cognitive function, family burden, end-of-life decisions, health care costs, resource utilization (health care), nutritional support, rehabilitation, palliative care, research networks
MeSH terms: Chronic Disease, Critical Care, Humans, United States, Ventilator Weaning, Critical Illness, Cost of Illness, Nutritional Support

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