Novel insights into molecular mechanisms of abruption-induced preterm birth
Open accessAbstract
Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.
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Decidual bleeding leads to release of excess thrombin, which is generated by tissue factor expressed on decidual cells to promote hemostasis.
“Decidual bleeding leads to release of excess thrombin, which is generated by tissue factor expressed on decidual cells to promote hemostasis (17, 18).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [18]
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Thromboembolic Diseases in Families of Women With Placental Abruption
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- [82]Buhimschi CS Buhimschi IA 2007 Proteomic biomarkers of adverse pregnancy outcome in preterm birth – a theranostics opportunity. Future drugs – expert review Obstetrics and Gynecology 2 743 753
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Multiple Placental Abruptions With Fetal Loss: A Case Report and Review of the Literature
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- Authors
- Buhimschi, C. S., Schatz, F., Krikun, G., Buhimschi, I. A., & Lockwood, C. J.
- Affiliations
- Yale University (US)
- Corresponding author
- Buhimschi, Catalin S.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-11
- Volume
- 12
- Pages
- e35-e35
- ISSN
- 1462-3994 (ISSN-L)
- PMC
- PMC4792258
- OpenAlex
- W2016250971
- Cited by
- 53
- References
- 140
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 2 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 7
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Expert Reviews in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1r01hl033937-01a1)
- National Heart, Lung, and Blood Institute (HL 33937)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD047321, HD 047321, R01HD033937, R01 HD29540)
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- preterm birth, placental abruption, chorioamnionitis, tissue factor, thrombin, cytokines, matrix metalloproteinases, chemokines, neutrophils, decidual cells
- MeSH terms
- Abruptio Placentae, Female, Hemorrhage, Humans, Immunohistochemistry, Pregnancy, Signal Transduction, Premature Birth
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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