Cited by 53Preterm Birth and ChorioamnionitisPregnancy and preeclampsia studiesBlood Coagulation and Thrombosis Mechanisms

Novel insights into molecular mechanisms of abruption-induced preterm birth

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Buhimschi, Catalin S., Schatz, Frederik, Krikun, Graciela, Buhimschi, Irina A., Lockwood, Charles J.·2010·Expert Reviews in Molecular Medicine

Abstract

Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.

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  1. [82]Buhimschi CS Buhimschi IA 2007 Proteomic biomarkers of adverse pregnancy outcome in preterm birth – a theranostics opportunity. Future drugs – expert review Obstetrics and Gynecology 2 743 753

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Authors
Buhimschi, C. S., Schatz, F., Krikun, G., Buhimschi, I. A., & Lockwood, C. J.
Affiliations
Yale University (US)
Corresponding author
Buhimschi, Catalin S.
Venue
Expert Reviews in Molecular Medicine
Published
2010-11
Volume
12
Pages
e35-e35
ISSN
1462-3994 (ISSN-L)
OpenAlex
W2016250971
Cited by
53
References
140
Citations by year
2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 2 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 7
FWCI
0.36
Type
journal article
Language
en
Open access
Locations
  • Expert Reviews in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1r01hl033937-01a1)
  • National Heart, Lung, and Blood Institute (HL 33937)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD047321, HD 047321, R01HD033937, R01 HD29540)
Topics
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords
preterm birth, placental abruption, chorioamnionitis, tissue factor, thrombin, cytokines, matrix metalloproteinases, chemokines, neutrophils, decidual cells
MeSH terms
Abruptio Placentae, Female, Hemorrhage, Humans, Immunohistochemistry, Pregnancy, Signal Transduction, Premature Birth

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