Fish oil reduces heart rate and oxygen consumption during exercise
Abstract
Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumption during exercise were evaluated. Sixteen well-trained men (cyclists), randomly assigned to receive 8 x 1 g capsules per day of olive oil (control) or FO for 8 weeks in a double-blind, parallel design, completed the study (control: n = 7, age 27.1 +/- 2.7 years; FO: n = 9, age 23.2 +/- 1.2 years). Subjects used an electronically braked cycle ergometer to complete peak O2 consumption tests (VO 2peak) and sustained submaximal exercise tests at 55% of peak workload (from the VO 2peak test) before and after supplementation. Whole-body O2 consumption and indirect measurements of myocardial O2 consumption [heart rate and rate pressure product (RPP)] were assessed. FO supplementation increased omega-3 PUFA content of erythrocyte cell membranes. There were no differences in VO 2peak (mL kg(-1) min(-1)) (control: pre 66.8 +/- 2.4, post 67.2 +/- 2.3; FO: pre 68.3 +/- 1.4, post 67.2 +/- 1.2) or peak workload after supplementation. The FO supplementation lowered heart rate (including peak heart rate) during incremental workloads to exhaustion (P < 0.05). In addition, the FO supplementation lowered steady-state submaximal exercise heart rate, whole-body O2 consumption, and RPP (P < 0.01). Time to voluntary fatigue was not altered by FO supplementation. This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance.
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Regarding endurance-based sports, n-3 supplementation has been reported to positively affect parameters of oxidative capacity and oxygen efficiency but has not translated to any meaningful improvements in endurance exercise performance.
“Regarding endurance based sports, n-3 supplementation has been reported to positively affect parameters of oxidative capacity [146,147] and oxygen efficiency [148,149] but this also has not translated to any meaningful improvements in endurance exercise performance [150].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [148]
Cites
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610 · see citing works
Direct transesterification of all classes of lipids in a one-step reaction.
Lepage, G., & ROY, C. C. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38861-1 · Cited by 2,385 · see citing works
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365 · see citing works
GISSI-HF investigators (2008) · The Lancet · doi:10.1016/s0140-6736(08)61239-8 · Cited by 1,350 · see citing works
Endurance exercise performance: the physiology of champions
Joyner, M. J., & Coyle, E. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143834 · Cited by 1,307 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
The Omega-3 Index: A new risk factor for death from coronary heart disease?
Harris, W. S., & von Schacky, C. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.02.030 · Cited by 1,111 · see citing works
Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099 · see citing works
Siscovick, D. S. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530170043030 · Cited by 920 · see citing works
Fox, K., Ford, I., Steg, P. G., Tendera, M., Robertson, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61171-x · Cited by 789 · see citing works
Hemodynamic correlates of myocardial oxygen consumption during upright exercise
Kitamura, K., Jorgensen, C. R., Gobel, F. L., Taylor, H. L., & Wang, Y. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.4.516 · Cited by 575 · see citing works
A new validated endurance performance test
Jeukendrup, A. E., Saris, W. H. M., Brouns, F. J. P. H., & Kester, A. D. M. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199602000-00017 · Cited by 560 · see citing works
Physiological Testing of the High-Performance Athlete
MacDOUGALL, J. D., Wenger, H. A., & Green, H. J. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199302000-00027 · Cited by 446 · see citing works
Determinants of endurance in well-trained cyclists
Coyle, E. F., Coggan, A. R., Hopper, M. K., & Walters, T. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.6.2622 · Cited by 440 · see citing works
: what do we know, and what do we still need to know?
Levine, B. D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147629 · Cited by 436 · see citing works
Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Trials
Mozaffarian, D., Geelen, A., Brouwer, I. A., Geleijnse, J. M., Zock, P. L., & Katan, M. B. (2005) · Circulation · doi:10.1161/circulationaha.105.556886 · Cited by 399 · see citing works
McLennan, P. L., Abeywardena, M. Y., & Charnock, J. S. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90328-6 · Cited by 329 · see citing works
Self-citationOmega-3 Fatty Acids in Cardiac Biopsies From Heart Transplantation Patients
Harris, W. S., Sands, S. A., Windsor, S. L., Ali, H. A., Stevens, T. L., Magalski, A., Porter, C., & Borkon, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000142292.10048.b2 · Cited by 325 · see citing works
Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest
Katona, P. G., McLean, M., Dighton, D. H., & Guz, A. (1982) · Journal of Applied Physiology · doi:10.1152/jappl.1982.52.6.1652 · Cited by 312 · see citing works
Skeletal muscle membrane lipid composition is related to adiposity and insulin action.
Pan, D. A., Lillioja, S., Milner, M. R., Kriketos, A. D., Baur, L. A., Bogardus, C., & Storlien, L. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118350 · Cited by 303 · see citing works
Elevated Heart Rate: A Major Risk Factor for Cardiovascular Disease
Palatini, P., & Julius, S. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031959 · Cited by 302 · see citing works
Fish Intake and Risk of Incident Heart Failure
Mozaffarian, D., Bryson, C. L., Lemaître, R. N., Burke, G. L., & Siscovick, D. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.038 · Cited by 275 · see citing works
Gissi-Prevenzione Investigators (2000) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200003000-00011 · Cited by 256 · see citing works
Fatty acid composition of skeletal muscle reflects dietary fat composition in humans
Andersson, A., Nälsén, C., Tengblad, S., & Vessby, B. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1222 · Cited by 221 · see citing works
Pepe, S., & McLennan, P. L. (2002) · Circulation · doi:10.1161/01.cir.0000015604.88808.74 · Cited by 209 · see citing works
Self-citationO’Keefe, J. H., Abuissa, H., Sastre, A., Steinhaus, D. M., & Harris, W. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.11.025 · Cited by 207 · see citing works
Energy cost and fatigue during intermittent electrical stimulation of human skeletal muscle
Bergström, M., & Hultman, E. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.4.1500 · Cited by 186 · see citing works
Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey
McLennan, P. L., Bridle, T. M., Abeywardena, M. Y., & Charnock, J. S. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90809-a · Cited by 185 · see citing works
Self-citationPUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+activation of PDH
Pepe, S., Tsuchiya, N., Lakatta, E. G., & Hansford, R. G. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.1.h149 · Cited by 161 · see citing works
Cardiac fatigue following prolonged endurance exercise of differing distances
Whyte, G. P., George, K., Sharma, S., Lumley, S. A., GATES, P., Prasad, K., & McKenna, W. J. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200006000-00005 · Cited by 161 · see citing works
Training affects muscle phospholipid fatty acid composition in humans
Helge, J. W., Wu, B. J., Willer, M., Daugaard, J. R., Storlien, L. H., & Kiens, B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.670 · Cited by 150 · see citing works
Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men
Andersson, A., Sjödin, A. M., Hedman, A., Olsson, R., & Vessby, B. O. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e744 · Cited by 139 · see citing works
Fish Consumption Is Associated With Lower Heart Rates
Dallongeville, J., Yarnell, J., Ducimetière, P., Arveiler, D., Ferrières, J., Montaye, M., Luc, G., Evans, A., Bingham, A., Hass, B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000084542.64687.97 · Cited by 138 · see citing works
Dietary Fish Oil Confers Direct Antiarrhythmic Properties on the Myocardium of Rats
Pepe, S., & McLennan, P. L. (1996) · Journal of Nutrition · doi:10.1093/jn/126.1.34 · Cited by 137 · see citing works
Self-citationEffects of fat adaptation and carbohydrate restoration on prolonged endurance exercise
Carey, A. L., Staudacher, H. M., Cummings, N. K., Stepto, N. K., Nikolopoulos, V., Burke, L. M., & Hawley, J. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.1.115 · Cited by 135 · see citing works
Oostenbrug, G. S., Mensink, R. P., Hardeman, M. R., Vries, T. D., Brouns, F. J. P. H., & Hornstra, G. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.3.746 · Cited by 132 · see citing works
BURKE, L. M., HAWLEY, J. A., ANGUS, D. J., COX, G. R., CLARK, S. A., CUMMINGS, N. K., DESBROW, B., & HARGREAVES, M. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200201000-00014 · Cited by 131 · see citing works
Non‐autonomic component in bradycardia of endurance trained men at rest and during exercise
Lewis, S. F., Nylander, E., Gad, P., & Areskog, N. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06600.x · Cited by 121 · see citing works
N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise
Toft, A. D., Thorn, M., Ostrowski, K., Asp, S., Møller, K., Iversen, S. A., Hermann, C., Søndergaard, S. R., & Pedersen, B. K. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2401 · Cited by 106 · see citing works
Dietary fish oil dose‐ and time‐response effects on cardiac phospholipid fatty acid composition
Owen, A. J., Peter‐Przyborowska, B. A., Hoy, A. J., & McLennan, P. L. (2004) · Lipids · doi:10.1007/s11745-004-1317-0 · Cited by 106 · see citing works
Self-citationEffects of n–3 fatty acids from fish on premature ventricular complexes and heart rate in humans
Geelen, A., Brouwer, I. A., Schouten, E. G., Maan, A. C., Katan, M., & Zock, P. L. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.416 · Cited by 106 · see citing works
Dietary Fatty Acid Profile Influences the Composition of Skeletal Muscle Phospholipids in Rats
Ayre, K. J., & Hulbert, A. J. (1996) · Journal of Nutrition · doi:10.1093/jn/126.3.653 · Cited by 91 · see citing works
Rustan, A. C., Hustvedt, B. E., & Drevon, C. A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36960-1 · Cited by 89 · see citing works
Raastad, T., Hastmark, A. T., & Strømme, S. B. (1997) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1997.tb00113.x · Cited by 81 · see citing works
The effect of dietary fish oil supplementation on exercising horses
O'Connor, C. I., LAWRENCE, L. M., Lawrence, A. C. S., Janicki, K. M., Warren, L. K., & Hayes, S. H. (2004) · Journal of Animal Science · doi:10.2527/2004.82102978x · Cited by 78 · see citing works
Dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling
McLennan, P. L., Barnden, L. R., Bridle, T. M., Abeywardena, M. Y., & Charnock, J. S. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.9.871 · Cited by 75 · see citing works
Self-citationCharnock, J. S., Abeywardena, M. Y., Poletti, V. E., & McLennan, P. L. (1992) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(92)90551-z · Cited by 73 · see citing works
Self-citationHarris, W. S., Gonzales, M., Laney, N., Sastre, A., & Borkon, A. M. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.06.033 · Cited by 68 · see citing works
McLennan, P. L., & Abeywardena, M. Y. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0787-y · Cited by 61 · see citing works
Self-citationCardiovascular and Endothelial Effects of Fish Oil Supplementation in Healthy Volunteers
Shah, A. P., Ichiuji, A., Han, J. K., Traina, M., El-Bialy, A., Meymandi, S., & Wachsner, R. Y. (2007) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248407304749 · Cited by 54 · see citing works
Kudo, Y., Liu, K.-Y., Kawado, S., Xiaowei, Z., & Hirano, K. (2001) · Journal of Applied Physics · doi:10.1063/1.1380406 · Cited by 51 · see citing works
Pepe, S., & McLennan, P. L. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2377 · Cited by 43 · see citing works
Self-citationPlasma plasmalogens of the phosphoethanolamine type and angiopathy in diabetic patients
Goto, I., Antoku, Y., & Hayakawa, T. (1990) · Journal of Molecular Medicine · doi:10.1007/bf01648892 · Cited by 17 · see citing works
The relationship between linoleic acid level in serum, adipose tissue and myocardium in humans.
Sexton, P. T., Aj, S., O’Dea, K., Sanigorski, A., & Walsh, J. (1995) · PubMed · Cited by 16 · see citing works
Alteration of Cardiovascular Function in Trained Rats Fed With Fish Oil
Lortet, S., & Verger, P. (1995) · International Journal of Sports Medicine · doi:10.1055/s-2007-973047 · Cited by 14 · see citing works
EFFECT OF ADAPTATION TO A HIGH-FAT DIET ON SUBSTRATE UTILIZATION AT DIFFERENT EXERCISE INTENSITIES
Burke, L. M., Cox, G. R., Anderson, M., Brakkhuis, A., Hargreaves, M., & Hawley, J. A. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200205001-01454 · Cited by 9 · see citing works
Acides gras omega-3 et prévention cardiovasculaire
Grynberg, A., Oudot, F., McLennan, P. L., & Athias, P. (1997) · HAL · Cited by 4 · see citing works
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Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771 · see citing works
Omega-3 Polyunsaturated Fatty Acids: Benefits and Endpoints in Sport
Gammone, M. A., Riccioni, G., Parrinello, G., & D’Orazio, N. (2018) · Nutrients · doi:10.3390/nu11010046 · Cited by 326 · see citing works
Dietary sources of omega 3 fatty acids: public health risks and benefits
Tur, J. A., Bibiloni, M. M., Sureda, A., & Pons, A. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512001456 · Cited by 283 · see citing works
How does high DHA fish oil affect health? A systematic review of evidence
Fard, S. G., Wang, F., Sinclair, A. J., Elliott, G., & Turchini, G. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425978 · Cited by 259 · see citing works
McGlory, C., Calder, P. C., & Nunes, E. A. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00144 · Cited by 228 · see citing works
Mozaffarian, D., Lemaître, R. N., King, I. B., Song, X., Spiegelman, D. L., Sacks, F. M., Rimm, E. B., & Siscovick, D. S. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-3-201108020-00006 · Cited by 182 · see citing works
Herbst, E. A. F., Paglialunga, S., Gerling, C., Whitfield, J., Mukai, K., Chabowski, A., Heigenhauser, G. J. F., Spriet, L. L., & Holloway, G. P. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267336 · Cited by 179 · see citing works
Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
Wu, J. H. Y., Micha, R., & Mozaffarian, D. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0206-1 · Cited by 167 · see citing works
Wu, J. H. Y., Lemaître, R. N., King, I. B., Song, X., Sacks, F. M., Rimm, E. B., Heckbert, S. R., Siscovick, D. S., & Mozaffarian, D. (2012) · Circulation · doi:10.1161/circulationaha.111.062653 · Cited by 143 · see citing works
Update on lipids and mitochondrial function
Stanley, W. C., Khairallah, R. J., & Dabkowski, E. R. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834fdaf7 · Cited by 126 · see citing works
Role of fish oil in human health and possible mechanism to reduce the inflammation
Ellulu, M. S., Khaza’ai, H., Abed, Y. A., Rahmat, A. B., Ismail, P., & Ranneh, Y. (2015) · Inflammopharmacology · doi:10.1007/s10787-015-0228-1 · Cited by 122 · see citing works
The Role of Essential Fatty Acids in Human Health
Glick, N. R., & Fischer, M. H. (2013) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587213488788 · Cited by 121 · see citing works
Omega-3 Polyunsaturated Fatty Acids in Physical Performance Optimization
Mickleborough, T. D. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.1.83 · Cited by 116 · see citing works
Applications of omega-3 polyunsaturated fatty acid supplementation for sport performance
Philpott, J. D., Witard, O. C., & Galloway, S. D. R. (2018) · Research in Sports Medicine · doi:10.1080/15438627.2018.1550401 · Cited by 103 · see citing works
Colombo, J. A., Carlson, S. E., Cheatham, C. L., Gustafson, K. M., Kepler, A., & Doty, T. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e31822a59f5 · Cited by 97 · see citing works
Nutritional Considerations for Performance in Young Athletes
Smith, J. W., Holmes, M. E., & McAllister, M. J. (2015) · Journal of Sports Medicine · doi:10.1155/2015/734649 · Cited by 94 · see citing works
Thielecke, F., & Blannin, A. (2020) · Nutrients · doi:10.3390/nu12123712 · Cited by 72 · see citing works
Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults
Yoshino, J., Smith, G. I., Kelly, S. C., Julliand, S., Reeds, D. N., & Mittendorfer, B. (2016) · Physiological Reports · doi:10.14814/phy2.12785 · Cited by 76 · see citing works
Lewis, E. J. H., Radonic, P. W., Wolever, T. M. S., & Wells, G. D. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0089-4 · Cited by 73 · see citing works
Fit with good fat? The role of n-3 polyunsaturated fatty acids on exercise performance
Boit, M. D., Hunter, A. M., & Gray, S. R. (2016) · Metabolism · doi:10.1016/j.metabol.2016.10.007 · Cited by 72 · see citing works
McLennan, P. L. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2876-z · Cited by 68 · see citing works
Self-citationThe effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment
Billman, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.011 · Cited by 69 · see citing works
Elevated heart rate in cardiovascular diseases: a target for treatment?
Palatini, P. (2009) · Progress in cardiovascular diseases · doi:10.1016/j.pcad.2009.05.005 · Cited by 68 · see citing works
Calder, P. C., Dangour, A. D., Diekman, C. B., Eilander, A., Koletzko, B. V., Meijer, G. W., Mozaffarian, D., Niinikoski, H., Osendarp, S. J. M., Pietinen, P., et al. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.242 · Cited by 64 · see citing works
Macartney, M. J., Hingley, L., Brown, M. A., Peoples, G. E., & McLennan, P. L. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514003146 · Cited by 60 · see citing works
Self-citationLuo, X., Feng, J., Yang, Z., Huang, Q., Lin, J., Yang, B., Su, K., & Pan, J. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02656-3 · Cited by 57 · see citing works
Advances in sports food: Sports nutrition, food manufacture, opportunities and challenges
Cui, P., Li, M., Yu, M., Liu, Y., Ding, Y., Liu, W., & Liu, J. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111258 · Cited by 55 · see citing works
Peoples, G. E., & McLennan, P. L. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002928 · Cited by 54 · see citing works
Self-citationOmega-3 Polyunsaturated Fatty Acids in the Optimization of Physical Performance
Shei, R., Lindley, M. R., & Mickleborough, T. D. (2014) · Military Medicine · doi:10.7205/milmed-d-14-00160 · Cited by 50 · see citing works
Hara, M., Sakata, Y., Nakatani, D., Suna, S., Usami, M., Matsumoto, S., Hamasaki, T., Doi, Y., Nishino, M., Sato, H., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-0875 · Cited by 48 · see citing works
Wu, J. H. Y., & Mozaffarian, D. (2014) · Heart · doi:10.1136/heartjnl-2013-305257 · Cited by 47 · see citing works
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Kang, J. X. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00416 · Cited by 44 · see citing works
Body mass index contributes to sympathovagal imbalance in prehypertensives
Pal, G. K., Chandrasekaran, A., Hariharan, A. P., Dutta, T. K., Pal, P., Nanda, N., & Venugopal, L. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-54 · Cited by 44 · see citing works
Jäger, R., Heileson, J. L., Sawan, S. A., Dickerson, B. L., Leonard, M., Kreider, R. B., Kerksick, C. M., Cornish, S. M., Candow, D. G., Cordingley, D. M., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2441775 · Cited by 47 · see citing works
Are There Benefits from the Use of Fish Oil Supplements in Athletes? A Systematic Review
Lewis, N. A., Daniels, D., Calder, P. C., Castell, L. M., & Pedlar, C. R. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa050 · Cited by 43 · see citing works
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West, S., Monteyne, A. J., van der Heijden, I., Stephens, F. B., & Wall, B. T. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.012 · Cited by 42 · see citing works
“Regarding endurance based sports, n-3 supplementation has been reported to positively affect parameters of oxidative capacity [146,147] and oxygen efficiency [148,149] but this also has not translated to any meaningful improvements in endurance exercise performance [150].”
BackgroundMarine Bioactives and Potential Application in Sports
Gammone, M. A., Gemello, E., Riccioni, G., & D’Orazio, N. (2014) · Marine Drugs · doi:10.3390/md12052357 · Cited by 41 · see citing works
Billman, G. E., & Harris, W. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00140.2011 · Cited by 39 · see citing works
Hidayat, K., Yang, J., Zhang, Z., Chen, G., Qin, L., Eggersdorfer, M. L., & Zhang, W. (2017) · European Journal of Clinical Nutrition · doi:10.1038/s41430-017-0052-3 · Cited by 39 · see citing works
Tian, Y., Zhu, S. Z., Xie, M., Wang, W., Wu, H., & Gong, D. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.024 · Cited by 38 · see citing works
Kawabata, F., Neya, M., Hamazaki, K., Watanabe, Y., Kobayashi, S., & Tsuji, T. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.946392 · Cited by 36 · see citing works
The Effect of Krill Oil Supplementation on Exercise Performance and Markers of Immune Function
Boit, M. D., Mastalurova, I., Brazaite, G., McGovern, N., Thompson, K., & Gray, S. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139174 · Cited by 36 · see citing works
Do Fat Supplements Increase Physical Performance?
Macaluso, F., Barone, R., Catanese, P., Carini, F., Rizzuto, L., Farina, F., & Felice, V. D. (2013) · Nutrients · doi:10.3390/nu5020509 · Cited by 35 · see citing works
Acute high-intensity exercise with low energy expenditure reduced LDL-c and total cholesterol in men
Lira, F. S., Zanchi, N. E., Lima‐Silva, A. E., Pires, F. O., Bertuzzi, R., dos Santos, R. V. T., Caperuto, É. C., Kiss, M. A., & Seelaender, M. C. L. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1115-5 · Cited by 33 · see citing works
Fiamoncini, J., Turner, N. A., Hirabara, S. M., Salgado, T. M., Marçal, A. C., Leslie, S. J., Silva, S. M. A., Deschamps, F. C., Luz, J., Cooney, G. J., et al. (2013) · Obesity · doi:10.1002/oby.20132 · Cited by 32 · see citing works
Long-Chain Omega-3 Fatty Acids and Optimization of Cognitive Performance
Muldoon, M. F., Ryan, C. M., Yao, J. K., Conklin, S. M., & Manuck, S. B. (2014) · Military Medicine · doi:10.7205/milmed-d-14-00168 · Cited by 32 · see citing works
Henry, R., Peoples, G. E., & McLennan, P. L. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002512 · Cited by 30 · see citing works
Self-citationOmega-3s and cardiovascular health.
DiNicolantonio, J. J., Niazi, A. K., McCarty, M. F., O’Keefe, J. H., Meier, P., & Lavie, C. J. (2014) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model
Peoples, G. E., & McLennan, P. L. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003449 · Cited by 29 · see citing works
Self-citationMoyers, B., Farzaneh‐Far, R., Harris, W. S., Garg, S. K., Na, B., & Whooley, M. A. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.040 · Cited by 27 · see citing works
Sympathovagal Imbalance in Young Prehypertensives: Importance of Male-Female Difference
Pal, G. K., Pal, P., Lalitha, V., Dutta, T. K., Adithan, C., & Nanda, N. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31824ba080 · Cited by 25 · see citing works
Macartney, M. J., Peoples, G. E., Treweek, T. M., & McLennan, P. L. (2019) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2019.08.006 · Cited by 26 · see citing works
Self-citationOmega-3 fatty acids and heart failure
Marchioli, R., Silletta, M. G., Levantesi, G., & Pioggiarella, R. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0066-y · Cited by 25 · see citing works
Membrane modulatory effects of omega-3 fatty acids: Analysis of molecular level interactions
Ayee, M. A. A., Bunker, B. C., & Groot, J. L. D. (2020) · Current topics in membranes · doi:10.1016/bs.ctm.2020.08.001 · Cited by 24 · see citing works
Boss, A., Lecoultre, V., Ruffieux, C., Tappy, L., & Schneiter, P. (2009) · British Journal Of Nutrition · doi:10.1017/s000711450999287x · Cited by 23 · see citing works
Nookaew, I., Gabrielsson, B. G., Holmäng, A. B., Sandberg, A., & Nielsen, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012361 · Cited by 23 · see citing works
Rontoyanni, V. G., Hall, W. L., Pombo-Rodrigues, S., Appleton, A., Chung, R., & Sanders, T. A. B. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511005721 · Cited by 22 · see citing works
Metabolic Health Benefits of Long-Chain Omega-3 Polyunsaturated Fatty Acids
Howe, P. R. C., & Buckley, J. D. (2014) · Military Medicine · doi:10.7205/milmed-d-14-00154 · Cited by 22 · see citing works
Self-citationAnthony, R., Macartney, M. J., Heileson, J. L., McLennan, P. L., & Peoples, G. E. (2023) · Nutrition Research Reviews · doi:10.1017/s095442242300001x · Cited by 21 · see citing works
Self-citationBillman, G. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00071 · Cited by 21 · see citing works
Ginty, A. T., & Conklin, S. M. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.09.012 · Cited by 21 · see citing works
Effects of 12 Wk of Omega-3 Fatty Acid Supplementation in Long-Distance Runners
Tomczyk, M., Jost, Z., Chroboczek, M., Urbański, R., Calder, P. C., Fisk, H. L., SPRENGEL, M., & Antosiewicz, J. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003038 · Cited by 20 · see citing works
Omega-3 Fatty Acids and Vitamin D in Cardiology
Güttler, N., Zheleva, K., Parahuleva, M. S., Chasan, R., Bilgin, M., Neuhof, C., Burgazli, K. M., Niemann, B., Erdogan, A. R., & Böning, A. (2012) · Cardiology Research and Practice · doi:10.1155/2012/729670 · Cited by 20 · see citing works
Goo, S., Han, J., Nisbet, L. A., LeGrice, I. J., Taberner, A. J., & Loiselle, D. S. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.269977 · Cited by 18 · see citing works
Omega-3 fatty acid supplementation in horses
Hess, T. M., & Ross-Jones, T. (2014) · Revista Brasileira de Zootecnia · doi:10.1590/s1516-35982014001200008 · Cited by 18 · see citing works
Medoro, A., Buonsenso, A., Centorbi, M., Calcagno, G., Scapagnini, G., Fiorilli, G., & Davinelli, S. (2024) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk9020091 · Cited by 16 · see citing works
Macartney, M. J., Peoples, G. E., & McLennan, P. L. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa256 · Cited by 16 · see citing works
Self-citationNorouziasl, R., Zeraattalab-Motlagh, S., Jayedi, A., & Shab‐Bidar, S. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523002052 · Cited by 17 · see citing works
Craddock, J. C., Probst, Y., Neale, E. P., & Peoples, G. E. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1886196 · Cited by 18 · see citing works
Self-citationHerbal and Nutritional Supplements for Painful Conditions
Zengion, A. H., & Yarnell, E. L. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3779-8.10020-x · Cited by 15 · see citing works
Crestani, D. M., Bonin, É. F. R., Barbieri, R. A., Zagatto, A. M., Higino, W. P., & Milioni, F. (2016) · Sport Sciences for Health · doi:10.1007/s11332-016-0322-9 · Cited by 14 · see citing works
Tiryaki-Sonmez, G., Schoenfeld, B., & Vatansever-Ozen, S. (2011) · Biomedical Human Kinetics · doi:10.2478/v10101-011-0007-4 · Cited by 17 · see citing works
Effect of Gender on Sympathovagal Imbalance in Prehypertensives
Pal, G. K., Pal, P., Nanda, N., Lalitha, V., Dutta, T. K., & Adithan, C. (2011) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2011.618208 · Cited by 13 · see citing works
Saputra, H. K., Nirmala, K., Supriyono, E., & Rochman, N. T. (2018) · Omni-Akuatika · doi:10.20884/1.oa.2018.14.2.539 · Cited by 13 · see citing works
Lyudinina, A. Y., Андреевна, Б. Е., Геннадьевна, В. Н., & Bojko, E. R. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00385-2 · Cited by 13 · see citing works
Hosomi, R., Fukunaga, K., Nagao, T., Tanizaki, T., Miyauchi, K., Yoshida, M., Kanda, S., Nishiyama, T., & Takahashi, K. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14416 · Cited by 13 · see citing works
Preference for salt contributes to sympathovagal imbalance in the genesis of prehypertension
Pal, G. K., Adithan, C., Dutta, T. K., Pal, P., Nanda, N., Kiran, A. N. S., Lalitha, V., & Amudharaj, D. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.64 · Cited by 12 · see citing works
Association of healthy dietary patterns and cardiorespiratory fitness in the community
Mi, M., Gajjar, P., Walker, M. E., Miller, P., Xanthakis, V., Murthy, V. L., Larson, M. G., Vasan, R. S., Shah, R. V., Lewis, G. D., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad113 · Cited by 12 · see citing works
HEALTH BENEFITS OF MARINE-DERIVED OMEGA-3 FATTY ACIDS
Harris, K. A., Hill, A. M., & Kris‐Etherton, P. M. (2010) · ACSMʼs Health & Fitness Journal · doi:10.1249/fit.0b013e3181cff40f · Cited by 12 · see citing works
Lewicka, A., Lewicki, S., Kłos, A., Dębski, B., Kurył, T., & Bertrandt, J. (2017) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1228391 · Cited by 11 · see citing works
Posnakidis, G., Giannaki, C. D., Mougios, V., Pantzaris, M., Patrikios, I. S., Calder, P. C., Sari, D. K., Bogdanis, G. C., & Aphamis, G. (2024) · Nutrients · doi:10.3390/nu16172914 · Cited by 10 · see citing works
Young, K. G., Vanderboor, C., Regnault, T. R. H., & Guglielmo, C. G. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00249.2020 · Cited by 10 · see citing works
Okut, S., Ozan, M., Buzdağlı, Y., Uçar, H., İnaç, M. R., Han, M. T., Bayram, E., & Baygutalp, N. K. (2025) · Nutrients · doi:10.3390/nu17132088 · Cited by 9 · see citing works
Marchioli, R., & Levantesi, G. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.041 · Cited by 9 · see citing works
Fish Oil for Healthy Aging: Potential Application to Master Athletes
Murphy, C. H., & McGlory, C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01509-7 · Cited by 9 · see citing works
Tajik, B., Kurl, S., Tuomainen, T., Savonen, K. P., & Virtanen, J. K. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517003191 · Cited by 9 · see citing works
Macartney, M. J., Ghodsian, M., Noel-Gough, B., McLennan, P. L., & Peoples, G. E. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1953417 · Cited by 9 · see citing works
Self-citationGoo, S., Han, J., Nisbet, L. A., LeGrice, I. J., Taberner, A. J., & Loiselle, D. S. (2014) · Physiological Reports · doi:10.1002/phy2.272 · Cited by 9 · see citing works
Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease
Marchioli, R. (2010) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s4743 · Cited by 8 · see citing works
Peoples, G. E., & McLennan, P. L. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0501 · Cited by 8 · see citing works
Self-citationHarbaugh, M. P., Manuck, S. B., Jennings, J. R., Conklin, S. M., Yao, J. K., & Muldoon, M. F. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.05.110 · Cited by 8 · see citing works
Physical response of dogs supplemented with fish oil during a treadmill training programme
Pellegrino, F. J., Risso, A., Relling, A. E., & Corrada, Y. (2018) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13033 · Cited by 7 · see citing works
Rittenhouse, M. A., Khurana, S., Scholl, S. R., & Emerson, C. (2025) · Nutrients · doi:10.3390/nu17020307 · Cited by 6 · see citing works
Nutrition and Cardiovascular Disease
Mozaffarian, D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00048-2 · Cited by 6 · see citing works
Tsuji, K., Tsuchiya, Y., Yokoi, K., Yanagimoto, K., Ueda, H., & Ochi, E. (2023) · Nutrients · doi:10.3390/nu15173692 · Cited by 6 · see citing works
Alves, J., Pérez, F. J. G., Toro-Román, V., Bartolomé, I., Maynar-Mariño, M., & Barrientos, G. (2024) · Nutrients · doi:10.3390/nu16121895 · Cited by 6 · see citing works
Holdsworth, C. T., Copp, S. W., Hirai, D. M., Ferguson, S. K., Sims, G. E., Hageman, K. S., Stebbins, C. L., Poole, D. C., & Musch, T. I. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0301 · Cited by 6 · see citing works
The association of serum long-chainn-3 PUFA and hair mercury with exercise cardiac power in men
Tajik, B., Kurl, S., Tuomainen, T., & Virtanen, J. K. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002142 · Cited by 6 · see citing works
Jost, Z., Tomczyk, M., Chroboczek, M., Calder, P. C., & Laskowski, R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114043 · Cited by 6 · see citing works
Concurrent EPA and DHA Supplementation Impairs Brown Adipogenesis of C2C12 Cells
Ghnaimawi, S., Baum, J., Liyanage, R., & Huang, Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00531 · Cited by 6 · see citing works
- Authors
- Peoples, G. E., McLennan, P. L., Howe, P. R. C., & Groeller, H.
- Affiliations
- University of Wollongong (AU)
- Corresponding author
- Peoples, Gregory E
- McLennan, Peter L
- Howe, Peter R C
- Venue
- Journal of Cardiovascular Pharmacology
- Published
- 2008-12
- Volume
- 52
- Issue
- 6
- Pages
- 540-547
- ISSN
- 0160-2446 (ISSN-L)
- OpenAlex
- W1979240894
- Cited by
- 158
- References
- 59
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 14 · 2013: 14 · 2012: 14
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- fish oil supplementation, omega-3 polyunsaturated fatty acids, exercise oxygen consumption, heart rate, myocardial oxygen consumption, rate-pressure product, erythrocyte membrane fatty acid composition, submaximal exercise, peak oxygen uptake, endurance performance
- MeSH terms
- Administration, Oral, Adult, Capsules, Docosahexaenoic Acids, Double-Blind Method, Erythrocyte Membrane, Fish Oils, Heart Rate, Humans, Male, Membrane Lipids, Myocardium, Oxygen Consumption, Time Factors, Eicosapentaenoic Acid, Exercise, Muscle, Skeletal, Muscle Fatigue, Dietary Supplements, Young Adult
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