Cited by 158Fatty Acid Research and HealthCardiovascular and exercise physiologyMuscle metabolism and nutrition

Fish oil reduces heart rate and oxygen consumption during exercise

Peoples, Gregory E, McLennan, Peter L, Howe, Peter R C, Groeller, Herbert·2008·Journal of Cardiovascular Pharmacology

Abstract

Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumption during exercise were evaluated. Sixteen well-trained men (cyclists), randomly assigned to receive 8 x 1 g capsules per day of olive oil (control) or FO for 8 weeks in a double-blind, parallel design, completed the study (control: n = 7, age 27.1 +/- 2.7 years; FO: n = 9, age 23.2 +/- 1.2 years). Subjects used an electronically braked cycle ergometer to complete peak O2 consumption tests (VO 2peak) and sustained submaximal exercise tests at 55% of peak workload (from the VO 2peak test) before and after supplementation. Whole-body O2 consumption and indirect measurements of myocardial O2 consumption [heart rate and rate pressure product (RPP)] were assessed. FO supplementation increased omega-3 PUFA content of erythrocyte cell membranes. There were no differences in VO 2peak (mL kg(-1) min(-1)) (control: pre 66.8 +/- 2.4, post 67.2 +/- 2.3; FO: pre 68.3 +/- 1.4, post 67.2 +/- 1.2) or peak workload after supplementation. The FO supplementation lowered heart rate (including peak heart rate) during incremental workloads to exhaustion (P < 0.05). In addition, the FO supplementation lowered steady-state submaximal exercise heart rate, whole-body O2 consumption, and RPP (P < 0.01). Time to voluntary fatigue was not altered by FO supplementation. This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance.

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Crossref · 10.1097/fjc.0b013e3181911913

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  • Regarding endurance-based sports, n-3 supplementation has been reported to positively affect parameters of oxidative capacity and oxygen efficiency but has not translated to any meaningful improvements in endurance exercise performance.

    “Regarding endurance based sports, n-3 supplementation has been reported to positively affect parameters of oxidative capacity [146,147] and oxygen efficiency [148,149] but this also has not translated to any meaningful improvements in endurance exercise performance [150].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [148]

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Authors
Peoples, G. E., McLennan, P. L., Howe, P. R. C., & Groeller, H.
Affiliations
University of Wollongong (AU)
Corresponding author
  • Peoples, Gregory E
  • McLennan, Peter L
  • Howe, Peter R C
Venue
Journal of Cardiovascular Pharmacology
Published
2008-12
Volume
52
Issue
6
Pages
540-547
ISSN
0160-2446 (ISSN-L)
OpenAlex
W1979240894
Cited by
158
References
59
Citations by year
2026: 3 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 14 · 2013: 14 · 2012: 14
FWCI
7.90
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Figshare (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
fish oil supplementation, omega-3 polyunsaturated fatty acids, exercise oxygen consumption, heart rate, myocardial oxygen consumption, rate-pressure product, erythrocyte membrane fatty acid composition, submaximal exercise, peak oxygen uptake, endurance performance
MeSH terms
Administration, Oral, Adult, Capsules, Docosahexaenoic Acids, Double-Blind Method, Erythrocyte Membrane, Fish Oils, Heart Rate, Humans, Male, Membrane Lipids, Myocardium, Oxygen Consumption, Time Factors, Eicosapentaenoic Acid, Exercise, Muscle, Skeletal, Muscle Fatigue, Dietary Supplements, Young Adult

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