Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region
Open accessAbstract
Purpose Williams-Beuren syndrome is among the most well-characterized microdeletion syndromes, caused by recurrent de novo microdeletions at 7q11.23 mediated by nonallelic homologous recombination between low copy repeats flanking this critical region. However, the clinical phenotype associated with reciprocal microduplication of this genomic region is less well described. We investigated the molecular, clinical, neurodevelopmental, and behavioral features of seven patients with dup(7)(q11.23), including two children who inherited the microduplication from one of their parents, to more fully characterize this emerging microduplication syndrome.Methods Patients were identified by array-based comparative genomic hybridization. Clinical examinations were performed on seven affected probands, and detailed cognitive and behavioral evaluations were carried out on four of the affected probands.Results Our findings confirm initial reports of speech delay seen in patients with dup(7)(q11.23) and further delineate and expand the phenotypic spectrum of this condition to include communication, social interactions, and repetitive interests that are often observed in individuals diagnosed with autism spectrum disorders.Conclusions Array-based comparative genomic hybridization is a powerful means of detecting genomic imbalances and identifying molecular etiologies in the clinic setting, including genomic disorders such as Williams-Beuren syndrome and dup(7)(q11.23). We propose that dup(7)(q11.23) syndrome may be as frequent as Williams-Beuren syndrome and a previously unrecognized cause of language delay and behavioral abnormalities. Indeed, these individuals may first be referred for evaluation of autism, even if they do not ultimately meet diagnostic criteria for an autism spectrum disorder.
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Duplications of the 7q11.23 region have been reported before in developmental disorders, including autism spectrum disorder.
“Duplications in this interval have previously been described in developmental disorders, including ASD (Berg et al., 2007; Van der Aa et al., 2009)”
From Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism (2011) · cites this paper as Berg et al., 2007
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- Authors
- Berg, J. S., Brunetti-Pierri, N., Peters, S. U., Kang, S.-H. L., Fong, C.-T., Salamone, J., Freedenberg, D., Hannig, V. L., Prock, L. A., Miller, D. T., Raffalli, P., Harris, D. J., Erickson, R. P., Cunniff, C., Clark, G. D., Blazo, M. A., Peiffer, D. A., Gunderson, K. L., Sahoo, T., Patel, A., Lupski, J. R., Beaudet, A. L., & Cheung, S. W.
- Affiliations
- Baylor College of Medicine (US)
- University of Rochester Medicine (US)
- Vanderbilt University Medical Center (US)
- Boston Children's Hospital (US)
- University of Arizona (US)
- Illumina (United States) (US)
- ORCID
- Venue
- Genetics in Medicine
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 9
- Issue
- 7
- Pages
- 427-441
- ISSN
- 1098-3600 (ISSN-L)
- OpenAlex
- W2071724105
- Cited by
- 193
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 12 · 2014: 4 · 2013: 15 · 2012: 10
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Genetics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32 GM07526-29, T32GM007526)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Williams syndrome, microduplication, speech delay, language delay, autism spectrum disorder, repetitive behavior, phenotypic spectrum, non-allelic homologous recombination, segmental duplication, genomic disorders
- MeSH terms
- Adult, Autistic Disorder, Child, Child Behavior, Child, Preschool, Chromosome Aberrations, Chromosomes, Human, Pair 7, Female, Humans, Language Development Disorders, Male, Nucleic Acid Hybridization, Social Behavior, Williams Syndrome, Oligonucleotide Array Sequence Analysis, Quantitative Trait Loci
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