Prevalence of psychiatric disorders in 4 to 16‐year‐olds with Williams syndrome
Open accessAbstract
The prevalence of a range of DSM‐IV psychiatric disorders in a sample of 119 4–16‐year‐old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM‐IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4–6 years) to Inattentive for the oldest group (ages 11–16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS. © 2006 Wiley‐Liss, Inc.
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Attentional issues are widely reported in WS.
“which is unsurprising given the attentional issues widely reported in WS (Breckenridge et al., 2013; Greer et al., 2017; Leyfer et al., 2006).”
From NIH Toolbox Cognition Battery Feasibility in Individuals With Williams Syndrome (2022) · cites this paper as Leyfer et al., 2006
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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- Authors
- Leyfer, O. T., Woodruff‐Borden, J., Klein‐Tasman, B. P., Fricke, J. S., & Mervis, C. B.
- Affiliations
- University of Louisville (US)
- University of Nevada, Las Vegas (US)
- Corresponding author
- Leyfer, Ovsanna T.
- ORCID
- Leyfer, Ovsanna T.
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2006-07-05
- Volume
- 141B
- Issue
- 6
- Pages
- 615-622
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- PMC
- PMC2561212
- OpenAlex
- W2140224103
- Cited by
- 306
- References
- 75
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 7 · 2021: 16 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 15 · 2015: 20 · 2014: 21 · 2013: 22 · 2012: 20
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01/NS35102, R01NS035102)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD029957, R37 HD29957)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- Williams syndrome, mental illness, children, attention deficit hyperactivity disorder, specific phobia, generalized anxiety disorder, age differences, behavioral phenotypes, prevalence
- MeSH terms
- Adolescent, Mental Disorders, Child, Child, Preschool, Female, Humans, Male, Prevalence, Williams Syndrome
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