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Cited by 207Menopause: Health Impacts and TreatmentsSexual function and dysfunction studiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Effectiveness of group and self-help cognitive behavior therapy in reducing problematic menopausal hot flushes and night sweats (MENOS 2): a randomized controlled trial

Ayers, Beverley, Smith, Melanie, Hellier, Jennifer, Mann, Eleanor, Hunter, Myra S.·2012·Menopause
DOI 10.1097/gme.0b013e31823fe835
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Abstract

OBJECTIVE: The aim of this study was to examine the effectiveness of group cognitive behavioral therapy (CBT) and guided self-help CBT in reducing hot flush and night sweat (HF/NS) problem rating at 6 and 26 weeks after randomization. METHODS: This was a randomized control trial of 140 women having 10 or more problematic HF/NS a week for at least a month. The primary outcome was HF/NS problem rating (1-10) at 6 weeks after randomization. Secondary outcomes were physiologically measured HF/NS at 6 weeks; HF/NS problem rating at 6 weeks; and frequency, mood (Women's Health Questionnaire), and health-related quality of life (General Health Survey Short Form-36) at 6 and 26 weeks. Intention-to-treat analysis was used, and between-group differences were estimated using linear mixed models. RESULTS: Baseline mean (SD) HF/NS weekly frequency was 63.15 (49.24), and problem rating was 5.87 (2.28). Group and self-help CBT both significantly reduced HF/NS problem rating at 6 weeks-group CBT versus no treatment control (NTC; adjusted mean difference, 2.12; 95% CI, 1.36-2.88; P < 0.001) and self-help CBT versus NTC (adjusted mean difference, 2.08; 95% CI, 1.29-2.86; P < 0.001)-and at 26 weeks-group CBT versus NTC (adjusted mean difference, 1.33; 95% CI, 0.54-2.13; P = 0.001) and self-help CBT versus NTC (adjusted mean difference, 1.19; 95% CI, 0.36-2.02; P = 0.005). Group and self-help CBT significantly reduced night sweat frequency at 6 and 26 weeks. There were improvements in mood and quality of life at 6 weeks and improved emotional and physical functioning for group CBT at 26 weeks. CONCLUSIONS: These results suggest that CBT delivered in group or self-help format is an effective treatment option for women during the menopause transition and postmenopause with problematic HF/NS.

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Authors
Ayers, B., Smith, M., Hellier, J., Mann, E., & Hunter, M. S.
Affiliations
King's College London (GB)
Corresponding author
Hunter, Myra S.
ORCID
Venue
Menopause
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-07
Volume
19
Issue
7
Pages
749-759
ISSN
1072-3714 (ISSN-L)
DOI
10.1097/gme.0b013e31823fe835
OpenAlex
W2036614660
Cited by
207
References
66
Citations by year
2026: 18 · 2025: 20 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 21 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 11
FWCI
12.58
Type
journal article
Language
en
Open access
closed
Locations
  • Menopause The Journal of The North American Menopause Society (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
menopausal hot flushes, night sweats, cognitive behavioral therapy, group therapy, self-help intervention, menopause, postmenopause, mood, health-related quality of life, treatment effectiveness, Women's Health Questionnaire, SF-36, women's health services, emotional functioning, physical function
MeSH terms
Affect, Female, Humans, Hyperhidrosis, Menopause, Middle Aged, Psychotherapy, Group, Quality of Life, Surveys and Questionnaires, Self Care, Cognitive Behavioral Therapy, Treatment Outcome, Hot Flashes

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