Cited by 91Treatment of Major DepressionElectroconvulsive Therapy StudiesTryptophan and brain disorders

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Ketamine-Associated Brain Changes: A Review of the Neuroimaging Literature

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Ionescu, Dawn F., Felicione, Julia M., Gosai, Aishwarya, Cusin, Cristina, Shin, Philip, Shapero, Benjamin G., Deckersbach, Thilo·2018·Harvard Review of Psychiatry

DOI 10.1097/hrp.0000000000000179PMC PMC6102096

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Abstract

Major depressive disorder (MDD) is one of the most prevalent conditions in psychiatry. Patients who do not respond to traditional monoaminergic antidepressant treatments have an especially difficult-to-treat type of MDD termed treatment-resistant depression. Subanesthetic doses of ketamine—a glutamatergic modulator—have shown great promise for rapidly treating patients with the most severe forms of depression. As such, ketamine represents a promising probe for understanding the pathophysiology of depression and treatment response. Through neuroimaging, ketamine’s mechanism may be elucidated in humans. Here, we review 47 articles of ketamine’s effects as revealed by neuroimaging studies. Some important brain areas emerge, especially the subgenual anterior cingulate cortex. Furthermore, ketamine may decrease the ability to self-monitor, may increase emotional blunting, and may increase activity in reward processing. Further studies are needed, however, to elucidate ketamine’s mechanism of antidepressant action.

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Authors: Ionescu, D. F., Felicione, J. M., Gosai, A., Cusin, C., Shin, P., Shapero, B. G., & Deckersbach, T.
Affiliations: Harvard University (US)
Corresponding author: Cusin, Cristina
ORCID: Felicione, Julia M.
Cusin, Cristina
Shin, Philip
Shapero, Benjamin G.
Deckersbach, Thilo
Venue: Harvard Review of Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-11
Volume: 26
Issue: 6
Pages: 320-339
ISSN: 1067-3229 (ISSN-L)
1465-7309
DOI: 10.1097/hrp.0000000000000179
PMC: PMC6102096
OpenAlex: W2794329512
Cited by: 91
References: 82
Citations by year: 2026: 7 · 2025: 4 · 2024: 11 · 2023: 17 · 2022: 11 · 2021: 17 · 2020: 12 · 2019: 10 · 2018: 2
FWCI: 1.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Harvard Review of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH102279, K23MH107776)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: ketamine, treatment-resistant depression, major depressive disorder, subgenual anterior cingulate cortex, self-monitoring, emotional blunting, reward processing, antidepressant mechanism, glutamatergic modulation, neuroimaging of depression
MeSH terms: Antidepressive Agents, Cerebral Cortex, Major Depressive Disorder, Humans, Ketamine, Depressive Disorder, Treatment-Resistant

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Ketamine-Associated Brain Changes: A Review of the Neuroimaging Literature

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