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Cited by 191Schizophrenia research and treatmentMental Health and PsychiatryAdvanced MRI Techniques and Applications

Increased Hippocampal Glutamate and Volumetric Deficits in Unmedicated Patients With Schizophrenia

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Kraguljac, Nina V., White, David M., Reid, Meredith A., Lahti, Adrienne C.·2013·JAMA Psychiatry
DOI 10.1001/jamapsychiatry.2013.2437PMC PMC7891898
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Abstract

IMPORTANCE: Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. OBJECTIVE: To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers. Our a priori hypothesis was that glutamate levels would negatively correlate with hippocampal volume in schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Combined 3-T structural magnetic resonance imaging and single-voxel proton magnetic resonance spectroscopy study at the Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, of 27 unmedicated patients with schizophrenia and 27 healthy controls. MAIN OUTCOMES AND MEASURES: Hippocampal volumetric measures and neurometabolites, and the correlations between volumetric measurements and neurometabolites. RESULTS: Hippocampal volumetric deficits, increased ratios of hippocampal glutamate and glutamine to creatine (Glx/Cr), and a loss of correlation between hippocampal N-acetylaspartate (NAA)/Cr and Glx/Cr in patients with schizophrenia were found. Significant correlations between hippocampal volumetric measures and Glx/Cr were also found in patients with schizophrenia but not healthy controls. CONCLUSIONS AND RELEVANCE: Our findings support the theory that alterations in hippocampal glutamate levels potentially account for structural deficits in the hippocampus observed in schizophrenia neuroimaging studies.

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  • Evidence suggests adolescent alcohol exposure alters glutamatergic function, and increases in hippocampal glutamate have been linked to schizophrenia and psychosis.

    “This finding is particularly relevant given the evidence suggesting AAE alters glutamatergic function [73, 74], and increases in hippocampal glutamate have been linked to schizophrenia [75] and psychosis [76].”

    From Consequences of adolescent drug use (2023) · cites this paper as [75]

  • Psychosis has also been associated with increased hippocampal glutamate levels in humans.

    “In humans, psychosis has also been associated with increased hippocampal glutamate levels 65,66 ,”

    From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [65]

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Cited by

Sorted by citations

Authors
Kraguljac, N. V., White, D. M., Reid, M. A., & Lahti, A. C.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Lahti, Adrienne C.
ORCID
Venue
JAMA Psychiatry
Publisher
American Medical Association (AMA)
Published
2013-12-01
Volume
70
Issue
12
Pages
1294
ISSN
2168-622X (ISSN-L)
DOI
10.1001/jamapsychiatry.2013.2437
PMC
PMC7891898
OpenAlex
W2153185503
Cited by
191
References
3
Citations by year
2026: 5 · 2025: 14 · 2024: 7 · 2023: 14 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 21 · 2017: 15 · 2016: 14 · 2015: 19 · 2014: 22
FWCI
13.04
Type
journal article
Language
en
Open access
Locations
  • JAMA Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH081014)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
schizophrenia, hippocampus, glutamate, glutamatergic neurotransmission, hippocampal volume, unmedicated patients, 1H NMR, N-acetylaspartate, brain structure
MeSH terms
Adult, Aspartic Acid, Creatine, Female, Glutamine, Hippocampus, Humans, Hydrogen, Magnetic Resonance Imaging, Male, Middle Aged, Magnetic Resonance Spectroscopy, Schizophrenia, Biomarkers, Glutamic Acid, Young Adult, Multimodal Imaging

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