Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
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NMDA receptor blockade increases glutamate transmission in rodents and humans via blockade of NMDA receptors on GABAergic interneurons.
“There is evidence that NMDA receptor blockade increases glutamate transmission in rodents and humans via blockade of NMDA receptors on GABAergic interneurons27,161,162.”
From Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants (2016) · cites this paper as [162]
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- Authors
- Stone, J. M., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D., & Barker, G. J.
- Affiliations
- Imperial College London (GB)
- Kennedy Krieger Institute (US)
- King's College London (GB)
- Yale University (US)
- Corresponding author
- Stone, J M
- Venue
- Molecular Psychiatry
- Published
- 2012-01-03
- Volume
- 17
- Issue
- 7
- Pages
- 664-665
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3883303
- OpenAlex
- W1995221679
- Cited by
- 295
- References
- 29
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 9 · 2023: 12 · 2022: 29 · 2021: 13 · 2020: 22 · 2019: 29 · 2018: 32 · 2017: 20 · 2016: 27 · 2015: 29 · 2014: 19 · 2013: 22 · 2012: 7
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (P41EB015909)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- ketamine, GABA, glutamate, brain metabolites, 1H NMR, schizophrenia, glutamatergic dysfunction, D-cycloserine, resting-state EEG
- MeSH terms
- Brain, gamma-Aminobutyric Acid, Humans, Ketamine, Male, Magnetic Resonance Spectroscopy, Protons, Psychiatric Status Rating Scales, Psychopathology, Excitatory Amino Acid Antagonists, Glutamic Acid
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