A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder
Open accessAbstract
The N-methyl-D-aspartate receptor antagonist ketamine can improve major depressive disorder (MDD) within hours. To evaluate the putative role of glutamatergic and GABAergic systems in ketamine's antidepressant action, medial prefrontal cortical (mPFC) levels of glutamate+glutamine (Glx) and γ-aminobutyric acid (GABA) were measured before, during, and after ketamine administration using proton magnetic resonance spectroscopy. Ketamine (0.5 mg kg(-1) intravenously) was administered to 11 depressed patients with MDD. Glx and GABA mPFC responses were measured as ratios relative to unsuppressed voxel tissue water (W) successfully in 8/11 patients. Ten of 11 patients remitted (50% reduction in 24-item Hamilton Depression Rating Scale and total score ⩽10) within 230 min of commencing ketamine. mPFC Glx/W and GABA/W peaked at 37.8%±7.5% and 38.0%±9.1% above baseline in ~26 min. Mean areas under the curve for Glx/W (P=0.025) and GABA/W (P=0.005) increased and correlated (r=0.796; P=0.018). Clinical improvement correlated with 90-min norketamine concentration (df=6, r=-0.78, P=0.023), but no other measures.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
1H MRS shows changes in tissue content of glutamate and/or glutamine during ketamine infusion.
“1 H MRS, a method capable of estimating total-but not dynamic cycling of-prefrontal glutamate and glutamine levels show changes in tissue content of glutamate and/or glutamine during ketamine infusion [32,[41][42][43], but also see [44].”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Murrough, J. W., Perez, A. M., Pillemer, S., Stern, J., Parides, M. K., aan het Rot, M., Collins, K. A., Mathew, S. J., Charney, D. S., & Iosifescu, D. V. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.022 · Cited by 786 · see citing works
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627 · see citing works
Auer, D. P., Pütz, B., Kraft, E., Lipinski, B., Schill, J., & Holsboer, F. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00159-6 · Cited by 562 · see citing works
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553 · see citing works
Hou, L., & Klann, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0995-04.2004 · Cited by 527 · see citing works
Meyer, J. H., Wilson, A. A., Sagrati, S., Hussey, D., Carella, A., Potter, W. Z., Ginovart, N., Spencer, E. P., Cheok, A., & Houle, S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.826 · Cited by 517 · see citing works
Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT
Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R., & Krystal, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.577 · Cited by 512 · see citing works
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman, D. L., Petroff, O. A. C., Behar, K. L., & Mattson, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5662 · Cited by 510 · see citing works
Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 495 · see citing works
Awad, H., Hubert, G. W., Smith, Y., Levey, A. I., & Conn, P. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07871.2000 · Cited by 423 · see citing works
Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression
Cryan, J. F., & Kaupmann, K. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.11.004 · Cited by 421 · see citing works
Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works
The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Jernigan, C. S., Goswami, D. B., Austin, M. C., Iyo, A. H., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.05.010 · Cited by 386 · see citing works
GABA and mood disorders: a brief review and hypothesis
Petty, F. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00025-i · Cited by 378 · see citing works
McGirr, A., Berlim, M. T., Bond, D. J., Fleck, M. P., Yatham, L. N., & Lam, R. W. (2015) · Psychological Medicine · doi:10.1017/s0033291714001603 · Cited by 373 · see citing works
Antidepressants for the new millennium.
Skolnick, P. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00330-1 · Cited by 372 · see citing works
Boldrini, M., Santiago, A. N., Hen, R., Dwork, A. J., Rosoklija, G. B., Tamir, H., Arango, V., & John Mann, J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.5 · Cited by 361 · see citing works
Self-citationKoike, H., Iijima, M., & Chaki, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.035 · Cited by 346 · see citing works
Ketamine administration in depressive disorders: a systematic review and meta-analysis
Fond, G., Loundou, A., Rabu, C., Macgregor, A., Lançon, C., Brittner, M., Micoulaud-Franchi, J.-A., Richieri, R., Courtet, P., Abbar, M., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3664-5 · Cited by 339 · see citing works
Cammalleri, M., Lütjens, R., Berton, F., King, A. R., Simpson, C., Francesconi, W., & Sanna, P. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2336098100 · Cited by 314 · see citing works
Rowland, L. M., Bustillo, J. R., Mullins, P. G., Jung, R. E., Lenroot, R., Landgraf, E., Barrow, R., Yeo, R., Lauriello, J., & Brooks, W. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.394 · Cited by 304 · see citing works
Stone, J. M., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D., & Barker, G. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.171 · Cited by 295 · see citing works
Lauterborn, J. C., LYNCH, G. S., Vanderklish, P. W., Arai, A., & Gall, C. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00008.2000 · Cited by 291 · see citing works
Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272 · see citing works
Price, R. B., Shungu, D. C., Mao, X., Nestadt, P., Kelly, C., Collins, K. A., Murrough, J. W., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.025 · Cited by 270 · see citing works
Self-citationGABA levels in CSF of patients with psychiatric disorders
Gold, B. I., Bowers, M. B., Roth, R. H., & Sweeney, D. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.3.362 · Cited by 270 · see citing works
Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder
Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261 · see citing works
Sex differences in the antidepressant-like effects of ketamine
Carrier, N., & Kabbaj, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.12.009 · Cited by 251 · see citing works
Proc. Intl. Soc. Magn. Reson. Med
Beqiri, A., Padormo, F., Hand, J. W., Hajnal, J. V., & Malik, S. (2014) · Cited by 238 · see citing works
Bhagwagar, Z., Wylezinska, M., Taylor, M. J., Jezzard, P., Matthews, P. M., & Cowen, P. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.368 · Cited by 227 · see citing works
Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
Li, X., Tizzano, J. P., Griffey, K., Clay, M., Lindstrom, T., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00194-5 · Cited by 225 · see citing works
Shiroma, P. R., Johns, B., Kuskowski, M. A., Wels, J., THURAS, P. D., Albott, C. S., & Lim, K. O. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.036 · Cited by 222 · see citing works
Pharmacological validation of the chronic mild stress model of depression
Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205 · see citing works
Valentine, G. W., Mason, G. F., Gomez, R., Fasula, M. K., Watzl, J., Pittman, B. P., Krystal, J. H., & Sanacora, G. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.009 · Cited by 205 · see citing works
Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001845 · Cited by 175 · see citing works
Basic neurochemistry : principles of molecular, cellular and medical neurobiology
Brady, S. T., Siegel, G. J., Albers, R. W., & Price, D. L. (2012) · Cited by 171 · see citing works
Maciąg, D., Hughes, J., O'Dwyer, G., Pride, Y., Stockmeier, C. A., Sanacora, G., & Rajkowska, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.027 · Cited by 170 · see citing works
Antidepressant-like properties of zinc in rodent forced swim test
Kroczka, B., Brański, P., Pałucha-Poniewiera, A., Pilc, A., & Nowak, G. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00473-7 · Cited by 161 · see citing works
Bai, F., Bergeron, M., & Nelson, D. L. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00104-7 · Cited by 144 · see citing works
Alcaro, A., Panksepp, J., Witczak, J., Hayes, D. J., & Northoff, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.023 · Cited by 144 · see citing works
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats
Maj, J., Rogóż, Z., Skuza, G., & Sowińska, H. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90034-6 · Cited by 141 · see citing works
Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons*
Lenz, G., & Avruch, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500363200 · Cited by 140 · see citing works
Increased Vertical Axon Numbers in Cingulate Cortex of Schizophrenics
Benes, F. M. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800230097015 · Cited by 140 · see citing works
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)
Layer, R. T., Popik, P., Olds, T., & Skolnick, P. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00155-p · Cited by 137 · see citing works
Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X.-X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001858 · Cited by 137 · see citing works
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
Pałucha-Poniewiera, A., Brański, P., Szewczyk, B., Wierońska, J. M., Kłak, K., & Pilc, A. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.015 · Cited by 135 · see citing works
Brandoli, C., Sanna, A., Bernardi, M. A. D., Follesa, P., Brooker, G., & Mocchetti, I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07953.1998 · Cited by 131 · see citing works
Sanacora, G., & Sarıçiçek, A. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363294 · Cited by 131 · see citing works
Chowdhury, G. M. I., Behar, K. L., Cho, W., Thomas, M. A., Rothman, D. L., & Sanacora, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.006 · Cited by 125 · see citing works
An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study
Maćkowiak, M., O’Neill, M. J., Hicks, C. A., Bleakman, D., & Skolnick, P. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00066-7 · Cited by 125 · see citing works
Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory
Tischmeyer, W., Schicknick, H., Kraus, M., Seidenbecher, C., Staak, S., Scheich, H., & Gundelfinger, E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02820.x · Cited by 124 · see citing works
Hasler, G., Neumeister, A., van der Veen, J. W. C., Tumonis, T., Bain, E., Shen, J., Drevets, W. C., & Charney, D. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.017 · Cited by 122 · see citing works
Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury
Smith, D. H., Okiyama, K., Gennarelli, T. A., & McIntosh, T. K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90739-8 · Cited by 114 · see citing works
Przegaliński, E., Tatarczynska, E., Dereń-Wesołek, A., & Chojnacka-Wójcik, E. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(96)00157-8 · Cited by 111 · see citing works
Magnesium and depression: A systematic review
Derom, M.-L., Sayón-Orea, C., Martínez-Ortega, J. M., & Martínez-González, M. A. (2013) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000044 · Cited by 108 · see citing works
Legutko, B., Li, X., & Skolnick, P. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00006-5 · Cited by 106 · see citing works
Zarate, C. A., Quiroz, J. A., Quiroz, J. A., Manji, H. K., Payne, J. L., Kornstein, S. G., Manji, A. H. K., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4204 · Cited by 104 · see citing works
Protein synthesis‐dependent LTP in isolated dendrites of CA1 pyramidal cells
Cracco, J., Serrano, P., Moskowitz, S. I., Bergold, P., & Sacktor, T. (2005) · Hippocampus · doi:10.1002/hipo.20078 · Cited by 101 · see citing works
Neuron density and serotonin receptor binding in prefrontal cortex in suicide
Underwood, M. D., Kassir, S. A., Bakalian, M. J., Galfalvy, H., Mann, J. J., & Arango, V. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000691 · Cited by 100 · see citing works
Self-citationPohl, C., Block, W., Karitzky, J., Träber, F., Schmidt, S., Grothe, C., Lamerichs, R. M. J. N., Schild, H. H., & Klockgether, T. (2001) · Archives of Neurology · doi:10.1001/archneur.58.5.729 · Cited by 99 · see citing works
Baker, E. H., Basso, G., Barker, P. B., Smith, M. A., Bonekamp, D., & Horská, A. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21285 · Cited by 90 · see citing works
GABA-ergic hypotheses of anxiety and depression: Focus on GABA-B receptor
Pilc, A., & Nowak, G. (2005) · Drugs of today · doi:10.1358/dot.2005.41.11.904728 · Cited by 86 · see citing works
Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
Nugent, A. C., Diazgranados, N., Carlson, P. J., Ibrahim, L. A., Luckenbaugh, D. A., Brutsché, N. E., Herscovitch, P., Drevets, W. C., & Zarate, C. A. (2013) · Bipolar Disorders · doi:10.1111/bdi.12118 · Cited by 85 · see citing works
Papp, M., & Moryl, E. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00675-9 · Cited by 80 · see citing works
Labak, M., Foniok, T., Kirk, D., Rushforth, D., Tomanek, B., Jasiński, A., & Grieb, P. (2010) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-211-98811-4_32 · Cited by 79 · see citing works
Maj, J., Rogóż, Z., Skuza, G., & Sowińska, H. (1992) · PubMed · Cited by 78 · see citing works
Ketamine, magnesium and major depression – From pharmacology to pathophysiology and back
Murck, H. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.015 · Cited by 72 · see citing works
Nery, F. G., Stanley, J. A., Chen, H.-H., Hatch, J. P., Nicoletti, M., Monkul, E. S., Matsuo, K., Caetano, S. C., Peluso, M. A. M., Najt, P., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.05.003 · Cited by 71 · see citing works
Taylor, M. J., Tiangga, E. R., Mhuircheartaigh, R. N., & Cowen, P. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111405359 · Cited by 66 · see citing works
Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide.
Nair, N. P. V., Ahmed, S. K., & Kin, N. M. K. N. Y. (1993) · PubMed · Cited by 65 · see citing works
Nowak, G., Legutko, B., Skolnick, P., & Popik, P. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01589-6 · Cited by 61 · see citing works
Selective Inhibition of Calcium Entry Induced by Benzylisoquinolines in Rat Smooth Muscle
Anselmi, E., Fayos, G., Blasco, R., Candenas, L., Cortés, D., & D’Ocón, P. (1992) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1992.tb03617.x · Cited by 56 · see citing works
MK-801 and enantiomers: Potential antidepressants or false positives in classical screening models?
Panconi, E., Roux, J., Altenbaumer, M., Hampe, S., & Porsolt, R. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90310-p · Cited by 56 · see citing works
Magnesium Intake Is Not Related to Depression Risk in Spanish University Graduates
Derom, M.-L., Martínez‐González, M. Á., Sayón-Orea, M. D. C., Bes‐Rastrollo, M., Beunza, J. J., & Sánchez‐Villegas, A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.155572 · Cited by 50 · see citing works
Unschuld, P. G., Ising, M., Specht, M., Erhardt, A., Ripke, S., Heck, A., Kloiber, S., Straub, V., Brueckl, T., Müller‐Myhsok, B., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30938 · Cited by 40 · see citing works
Pilc, A., Brański, P., Pałucha-Poniewiera, A., Tokarski, K., & Bijak, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00169-1 · Cited by 40 · see citing works
Sanacora, G. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.003 · Cited by 39 · see citing works
The effect of NMDA antagonists on footshock-induced fighting behavior in chronically stressed rats.
Ossowska, G., Klenk-Majewska, B., & Szymczyk, G. (1997) · PubMed · Cited by 38 · see citing works
Kg, L., Pl, M., & Bartholini, G. (1987) · PubMed · Cited by 38 · see citing works
Streeter, C. C., Hennen, J. A., Ke, Y., Jensen, J. E., Sarid‐Segal, O., Nassar, L. E., Knapp, C. M., Meyer, A. A., Kwak, T., Renshaw, P. F., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0121-5 · Cited by 37 · see citing works
Proton MRS and MRSI of the brain without water suppression
Dong, Z. (2014) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2014.12.001 · Cited by 34 · see citing works
The added value of quantitative multi-voxel MR spectroscopy in breast magnetic resonance imaging
Dorrius, M. D., Pijnappel, R. M., der Weide, M. C. J., Jansen, L., Kappert, P., Oudkerk, M., & Sijens, P. E. (2011) · European Radiology · doi:10.1007/s00330-011-2322-0 · Cited by 32 · see citing works
THE EFFECTS OF MAGNESIUM DEFICIENCY ON KETAMINE SLEEPING TIMES IN THE RAT
Douglas, B., & Dagirmanjian, R. (1975) · British Journal of Anaesthesia · doi:10.1093/bja/47.3.336 · Cited by 29 · see citing works
Zahorodna, A., & Bijak, M. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00757-8 · Cited by 27 · see citing works
Clinical Handbook for the Management of Mood Disorders
Mann, J., McGrath, P. J., & Roose, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139175869 · Cited by 21 · see citing works
Self-citationLin, J., Tsai, S., Liu, H., Chung, H., Mulkern, R. V., Cheng, C., Yeh, T., & Chen, N. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22119 · Cited by 17 · see citing works
Silva, S. S. D., Payne, G. S., Morgan, V. A., Ind, T. E. J., Shepherd, J. H., Barton, D. P. J., & deSouza, N. M. (2009) · European Radiology · doi:10.1007/s00330-009-1363-0 · Cited by 16 · see citing works
Zhang, Y., Marenco, S., & Shen, J. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21265 · Cited by 15 · see citing works
Modulation of the AMPA receptor by phospholipase A2: Effect of the antidepressant trimipramine
Bernard, J., Ohayon, M. M., & Massicotte, G. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90030-2 · Cited by 11 · see citing works
[Proton magnetic resonance spectroscopy of the autistic brain].
Mori, K., Hashimoto, T., Harada, M., Yoneda, Y., Shimakawa, S., Fujii, E., Yamaue, T., Miyazaki, M., Saijo, T., & Kuroda, Y. (2001) · PubMed · Cited by 9 · see citing works
Magnesium intake and depression.
Wilson, K., & Brakoulias, V. (2009) · PubMed · Cited by 8 · see citing works
Ketamine in treatment-resistant depression
Lapidus, K. A. B., & Mathew, S. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139175869.027 · Cited by 4 · see citing works
Lin, J., Chuang, T., Chung, H., & Tsai, S. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2877 · Cited by 3 · see citing works
Flagged first, then by citations
3 of the 106 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [29]Sanacora G Gueorguieva R Epperson CN Wu YT Appel M Rothman DL Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression Archives of general psychiatry 2004 61 7 705 713 15237082
- [32]Biersack HJ Letter to the Editor Journal of nuclear medicine: official publication, Society of Nuclear Medicine 2012
- [33]Graham MM Menda Y Letter to the Editor Journal of nuclear medicine: official publication, Society of Nuclear Medicine 2012
Cited by
Sorted by citations
Duman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026 · see citing works
Targeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482 · see citing works
Lener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468 · see citing works
Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions
Fogaça, M. V., & Duman, R. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00087 · Cited by 396 · see citing works
The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects
Abdallah, C. G., De Feyter, H. M., Averill, L. A., Jiang, L., Averill, C. L., Chowdhury, G. M. I., Purohit, P., de Graaf, R. A., Esterlis, I., Juchem, C., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0136-3 · Cited by 229 · see citing works
Pan, J.-X., Xia, J.-J., Deng, F.-L., Liang, W., Wu, J., Yin, B., Dong, M.-X., Chen, J., Ye, F., Wang, H., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0183-x · Cited by 232 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.010 · Cited by 219 · see citing works
Godfrey, K. E. M., Gardner, A. C., Kwon, S., Chea, W., & Muthukumaraswamy, S. D. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.015 · Cited by 207 · see citing works
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206 · see citing works
Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder
Sarawagi, A., Soni, N. D., & Patel, A. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.637863 · Cited by 172 · see citing works
Dubin, M. J., Mao, X., Banerjee, S., Goodman, Z. T., Lapidus, K. A. B., Kang, G., Liston, C. M., & Shungu, D. C. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150223 · Cited by 156 · see citing works
Self-citationRole of GABAB receptors in learning and memory and neurological disorders
Heaney, C. F., & Kinney, J. W. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.007 · Cited by 154 · see citing works
Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial
Taylor, J. H., Landeros-Weisenberger, A., Coughlin, C., Mulqueen, J., Johnson, J. A., Gabriel, D., Reed, M. O., Jakubovski, E., & Bloch, M. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.194 · Cited by 142 · see citing works
Astrocyte, a Promising Target for Mood Disorder Interventions
Zhou, X., Xiao, Q., Xie, L., Yang, F., Wang, L., & Tu, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00136 · Cited by 120 · see citing works
Abdallah, C. G., Averill, C. L., Salas, R., Averill, L. A., Baldwin, P. R., Krystal, J. H., Mathew, S. J., & Mathalon, D. H. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.006 · Cited by 111 · see citing works
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works
Jelen, L. A., & Stone, J. M. (2021) · International Review of Psychiatry · doi:10.1080/09540261.2020.1854194 · Cited by 102 · see citing works
Kantrowitz, J. T., Dong, Z., Milak, M. S., Rashid, R., Kegeles, L. S., Javitt, D. C., Lieberman, J. A., & John Mann, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01541-1 · Cited by 100 · see citing works
Self-citationYin, H., Pantazatos, S. P., Galfalvy, H., Huang, Y., Rosoklija, G. B., Dwork, A. J., Burke, A., Arango, V., Oquendo, M. A., & Mann, J. J. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32423 · Cited by 91 · see citing works
Self-citationKetamine-Associated Brain Changes: A Review of the Neuroimaging Literature
Ionescu, D. F., Felicione, J. M., Gosai, A., Cusin, C., Shin, P., Shapero, B. G., & Deckersbach, T. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000179 · Cited by 91 · see citing works
Hashimoto, K., Bruno, D., Nierenberg, J., Marmar, C. R., Zetterberg, H., Blennow, K., & Pomara, N. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.8 · Cited by 90 · see citing works
de la Fuente‐Sandoval, C., Reyes-Madrigal, F., Mao, X., León-Ortíz, P., Rodríguez-Mayoral, O., Solís‐Vivanco, R., Favila, R., Graff‐Guerrero, A., & Shungu, D. C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv105 · Cited by 88 · see citing works
Self-citationThe anterior cingulate cortex as a key locus of ketamine’s antidepressant action
Alexander, L., Jelen, L. A., Mehta, M. A., & Young, A. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.003 · Cited by 83 · see citing works
Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77 · see citing works
Cao, G., Edden, R. A. E., Gao, F., Li, H., Gong, T., Chen, W., Liu, X., Wang, G., & Zhao, B. (2017) · European Radiology · doi:10.1007/s00330-017-5064-9 · Cited by 76 · see citing works
Krystal, J., Kaye, A. P., Jefferson, S., Girgenti, M., Wilkinson, S. T., Sanacora, G., & Esterlis, I. (2023) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2305772120 · Cited by 69 · see citing works
da Rosa, P. B., Neis, V. B., Ribeiro, C. M., Moretti, M., & Rodrigues, A. L. S. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.05.010 · Cited by 73 · see citing works
Novel Pharmacological Approaches to the Treatment of Depression
Elias, E., Zhang, A. Y., & Manners, M. T. (2022) · Life · doi:10.3390/life12020196 · Cited by 74 · see citing works
Abdallah, C. G., Dutta, A., Averill, C. L., McKie, S., Akiki, T. J., Averill, L. A., & William Deakin, J. F. (2018) · Chronic Stress · doi:10.1177/2470547018796102 · Cited by 70 · see citing works
Shungu, D. C., Mao, X., Gonzales, R., Soones, T. N., Dyke, J. P., van der Veen, J. W. C., & Kegeles, L. S. (2016) · NMR in Biomedicine · doi:10.1002/nbm.3539 · Cited by 70 · see citing works
Self-citationLeschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 70 · see citing works
Li, M., Demenescu, L. R., Čolić, L., Metzger, C. D., Heinze, H., Steiner, J. H., Speck, O., Fejtová, A., Salvadore, G., & Walter, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.184 · Cited by 66 · see citing works
Woelfer, M., Li, M., Colic, L., Liebe, T., Di, X., Biswal, B., Murrough, J., Lessmann, V., Brigadski, T., & Walter, M. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1679391 · Cited by 64 · see citing works
Milak, M. S., Rashid, R., Dong, Z., Kegeles, L. S., Grunebaum, M. F., Ogden, R. T., Lin, X., Mulhern, S. T., Suckow, R. F., Cooper, T. B., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.13211 · Cited by 63 · see citing works
Self-citationRodríguez, C. I., Kegeles, L. S., Levinson, A. R., Ogden, R. T., Mao, X., Milak, M. S., Vermes, D., Xie, S., Hunter, L. E., Flood, P. D., et al. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.06.001 · Cited by 61 · see citing works
Self-citationMcGirr, A., LeDue, J. M., Chan, A. W., Xie, Y., & Murphy, T. H. (2017) · Brain · doi:10.1093/brain/awx142 · Cited by 58 · see citing works
Levitt, J. G., Kalender, G., O’Neill, J., Diaz‐Fong, J. P., Cook, I. A., Ginder, N. D., Krantz, D. E., Minzenberg, M., Vince-Cruz, N., Nguyen, L. D., et al. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180230 · Cited by 59 · see citing works
Lv, S., Yao, K., Zhang, Y., & Zhu, S. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109378 · Cited by 57 · see citing works
Zhu, X., Nedelcovych, M. T., Thomas, A. G., Hasegawa, Y., Moreno-Megui, A., Coomer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0177-7 · Cited by 53 · see citing works
Default mode network connectivity change corresponds to ketamine’s delayed glutamatergic effects
Li, M., Woelfer, M., Čolić, L., Safron, A., Chang, C. E., Heinze, H., Speck, O., Mayberg, H. S., Biswal, B. B., Salvadore, G., et al. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0942-y · Cited by 57 · see citing works
7T 1H-MRS in major depressive disorder: a Ketamine Treatment Study
Evans, J. W., Lally, N., An, L., Li, N., Nugent, A. C., Banerjee, D., Snider, S. L., Shen, J., Roiser, J. P., & Zarate, C. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0057-1 · Cited by 53 · see citing works
The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression
Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49 · see citing works
Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance
van Veenendaal, T. M., Backes, W. H., van Bussel, F. C. G., Edden, R. A. E., Puts, N. A. J., Aldenkamp, A. P., & Jansen, J. F. A. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2017.12.029 · Cited by 50 · see citing works
The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants
Yin, Y., Wang, Y., Liu, W., Yao, J.-Q., Yuan, J., Li, Z.-H., Ran, Y., Zhang, L., & Li, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108573 · Cited by 48 · see citing works
Brennan, B. P., Admon, R., Perriello, C., LaFlamme, E. M., Athey, A. J., Pizzagalli, D. A., Hudson, J. I., Pope, H. G., & Jensen, J. E. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.08.009 · Cited by 47 · see citing works
Medeiros, G. C., Matheson, M., Demo, I., Reid, M. J., Matheson, S., Twose, C., Smith, G. S., Gould, T. D., Zarate, C. A., Barrett, F. S., et al. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00183-9 · Cited by 49 · see citing works
Managing Negative Symptoms of Schizophrenia: How Far Have We Come?
Kantrowitz, J. T. (2017) · CNS Drugs · doi:10.1007/s40263-017-0428-x · Cited by 43 · see citing works
Silberbauer, L., Spurny‐Dworak, B., Handschuh, P. A., Klöbl, M., Bednařík, P., Reiter, B., Ritter, V., Trost, P., Konadu, M. E., Windpassinger, M., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.549903 · Cited by 42 · see citing works
Ketamine metabolite pilot study in a suicidal depression trial
Grunebaum, M. F., Galfalvy, H. C., Choo, T.-H., Parris, M. S., Burke, A. K., Suckow, R. F., Cooper, T. B., & Mann, J. J. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.08.005 · Cited by 41 · see citing works
Self-citationMaddock, R. J., Caton, M., & Ragland, J. D. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.07.003 · Cited by 41 · see citing works
Jelen, L. A., Lythgoe, D. J., Stone, J. M., Young, A. H., & Mehta, M. A. (2025) · Nature Medicine · doi:10.1038/s41591-025-03800-w · Cited by 41 · see citing works
Sala, N., Paoli, C., Bonifacino, T., Mingardi, J., Schiavon, E., Via, L. L., Milanese, M., Tornese, P., Datusalia, A. K., Rosa, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.759626 · Cited by 38 · see citing works
Pałucha-Poniewiera, A. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.02.011 · Cited by 36 · see citing works
Neurobiological biomarkers of response to ketamine
Kadriu, B., Ballard, E. D., Henter, I. D., Murata, S., Gerlus, N., & Zarate, C. A. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.05.003 · Cited by 36 · see citing works
Fogaça, M. V., Daher, F., & Picciotto, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02002-1 · Cited by 34 · see citing works
Mobed, A., Hasanzadeh, M., Ahmadalipour, A., & Fakhari, A. (2019) · Analytical Methods · doi:10.1039/c9ay02390a · Cited by 35 · see citing works
Xie, J., Wang, Y., Zhong, Q., Bai, S., Zhou, C., Tian, T., & Chen, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.906303 · Cited by 33 · see citing works
Bojesen, K. B., Andersen, K. A., Rasmussen, S. N., Baandrup, L., Madsen, L. M., Glenthoj, B. Y., Rostrup, E., & Broberg, B. V. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00022 · Cited by 31 · see citing works
Zhang, N., Zhang, Y., Wang, Z., & Chen, N. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00861-2 · Cited by 31 · see citing works
The potential of 1H-MRS in CNS drug development
Egerton, A. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05344-7 · Cited by 30 · see citing works
Gonsalves, M. A., White, T. L., Barredo, J., Fukuda, A. M., Joyce, H. E., Harris, A. D., & Carpenter, L. L. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103049 · Cited by 29 · see citing works
Li, C., Juan, C.-H., Lin, H., Cheng, C., Wu, H.-T., Yang, B., Tsai, S., Su, T., & Fitzgerald, P. B. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.107 · Cited by 30 · see citing works
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review
Demchenko, I., Tassone, V. K., Kennedy, S. H., Dunlop, K., & Bhat, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864902 · Cited by 29 · see citing works
“Evidence pooled from 1H-MRS studies agrees that ketamine transiently increases GLX levels in the mPFC of MDD individuals (222), which is a central hub within the midline core subnetwork.”
BackgroundNeuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine
Zavaliangos‐Petropulu, A., Al‐Sharif, N., Taraku, B., Leaver, A. M., Sahib, A. K., Espinoza, R. T., & Narr, K. L. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.11.005 · Cited by 28 · see citing works
Imaging the neuroplastic effects of ketamine with VBM and the necessity of placebo control
Höflich, A. S., Ganger, S., Tik, M., Hahn, A., Kranz, G. S., Vanicek, T., Spies, M., Kraus, C., Windischberger, C., Kasper, S. F., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.12.032 · Cited by 26 · see citing works
Ketamine vs midazolam: Mood improvement reduces suicidal ideation in depression
Hochschild, A., Keilp, J. G., Madden, S. P., Burke, A. K., Mann, J. J., & Grunebaum, M. F. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.055 · Cited by 25 · see citing works
Self-citationAstrocytic GABAergic Regulation in Alcohol Use and Major Depressive Disorders
Ali, D. N., Ali, H. M., Lopez, M. R., Kang, S., & Choi, D. (2024) · Cells · doi:10.3390/cells13040318 · Cited by 26 · see citing works
A Systematic Review on the Efficacy of Intravenous Racemic Ketamine for Bipolar Depression
Joseph, B., Parsaik, A. K., Ahmed, A. T., Erwin, P. J., & Singh, B. (2020) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001317 · Cited by 26 · see citing works
Network-Guided Transcranial Magnetic Stimulation for Depression
Dubin, M. J., Liston, C. M., Avissar, M., Ilieva, I. P., & Gunning, F. M. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0108-7 · Cited by 25 · see citing works
Astroglial Mechanisms of Ketamine Action Include Reduced Mobility of Kir4.1-Carrying Vesicles
Stenovec, M., Božić, M., Pirnat, S., & Zorec, R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02744-1 · Cited by 25 · see citing works
Weigand, A., Gärtner, M., Scheidegger, M., Wyss, P. O., Henning, A., Seifritz, E., Stippl, A., Herrera-Meléndez, A. L., Bajbouj, M., Aust, S., et al. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac049 · Cited by 22 · see citing works
Imaging TMS: antidepressant mechanisms and treatment optimization
Dubin, M. J. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1283297 · Cited by 22 · see citing works
Veldić, M., Millischer, V., Port, J. D., Ho, A. M., Jia, Y., Geske, J. R., Biernacka, J. M., Backlund, L., McElroy, S. L., Bond, D. J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0483-9 · Cited by 23 · see citing works
Kantrowitz, J. T., Milak, M. S., Mao, X., Shungu, D. C., & Mann, J. J. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16060735 · Cited by 21 · see citing works
Self-citationInflammation Effects on Glutamate as a Pathway to Neuroprogression in Mood Disorders
Haroon, E., & Miller, A. H. (2017) · Modern trends in psychiatry · doi:10.1159/000470805 · Cited by 21 · see citing works
Huang, L.-C., Lin, S.-H., Tseng, H.-H., Chen, K. C., Abdullah, M., & Yang, Y. K. (2022) · Psychological Medicine · doi:10.1017/s003329172100533x · Cited by 20 · see citing works
Boucherie, D. E., Reneman, L., Ruhé, H. G., & Schrantee, A. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103517 · Cited by 20 · see citing works
Ketamine and ECT: better alone than together?
Kellner, C. H., & Iosifescu, D. V. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30099-8 · Cited by 19 · see citing works
Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression
Fagerholm, E. D., Leech, R., Williams, S., Zarate, C. A., Moran, R., & Gilbert, J. R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01442-3 · Cited by 18 · see citing works
Sorel, M., Zrek, N., Locko, B., Armessen, C., Ayache, S. S., & Lefaucheur, J. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2018.02.124 · Cited by 18 · see citing works
Singh, B., Port, J. D., Voort, J. L. V., Coombes, B. J., Geske, J. R., Lanza, I. R., Morgan, R. J., & Frye, M. A. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113953 · Cited by 18 · see citing works
Tang, X.-H., Diao, Y.-G., Ren, Z.-Y., Zang, Y., Zhang, G.-F., Wang, X., Duan, G., Shen, J.-C., Hashimoto, K., Zhou, Z., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109383 · Cited by 18 · see citing works
Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect
Stenovec, M. (2021) · Life · doi:10.3390/life11060573 · Cited by 17 · see citing works
Functional MRI markers for treatment-resistant depression: Insights and challenges
Kotoula, V., Evans, J. W., Punturieri, C., Johnson, S. C., & Zarate, C. A. (2023) · Progress in brain research · doi:10.1016/bs.pbr.2023.04.001 · Cited by 17 · see citing works
Ketamine and Esketamine for Depression in Daily Practice
Singh, B. (2024) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001898 · Cited by 17 · see citing works
Bhattacharyya, P. K., Anand, A., Lin, J. Y., & Altinay, M. I. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.665347 · Cited by 16 · see citing works
Funayama, Y., Li, H., Ishimori, E., Kawatake-Kuno, A., Inaba, H., Yamagata, H., Seki, T., Nakagawa, S., Watanabe, Y., Murai, T., et al. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.009 · Cited by 16 · see citing works
Liu, H., Wang, C., Lan, X., Li, W., Zhang, F., Fu, L., Ye, Y., Ning, Y., & Zhou, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1123797 · Cited by 15 · see citing works
Čolić, L., McDonnell, C., Li, M., Woelfer, M., Liebe, T., Kretzschmar, M., Speck, O., Schott, B. H., Bianchi, M., & Walter, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.10.021 · Cited by 15 · see citing works
Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms
Piao, J., Wang, Y., Zhang, T., Zhao, J., Lv, Q., Ruan, M., Yu, Q., & Li, B. (2023) · Molecules · doi:10.3390/molecules28196992 · Cited by 15 · see citing works
Frizzo, M. E. (2019) · Current Therapeutic Research · doi:10.1016/j.curtheres.2019.100566 · Cited by 16 · see citing works
Glutamate-Based Drug Discovery for Novel Antidepressants
Pałucha-Poniewiera, A., & Pilc, A. (2016) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2016.1213234 · Cited by 14 · see citing works
Neurochemical correlates of behavioral treatment of pediatric trichotillomania
Peris, T. S., Piacentini, J. C., Vreeland, A., Salgari, G. C., Levitt, J. G., Alger, J., Posse, S., McCracken, J. T., & O’Neill, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.04.061 · Cited by 13 · see citing works
Gärtner, M., Weigand, A., Scheidegger, M., Lehmann, M., Wyss, P. O., Wunder, A., Henning, A., & Grimm, S. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01377-2 · Cited by 13 · see citing works
NMDA Antagonists for Treatment-Resistant Depression
Farber, N. B. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_165 · Cited by 13 · see citing works
Dong, Z., Grunebaum, M. F., Lan, M. J., Wagner, V., Choo, T.-H. J., Milak, M. S., Sobeih, T. M., Mann, J. J., & Kantrowitz, J. T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.653026 · Cited by 12 · see citing works
Self-citationJiang, Y., Dong, Y., & Hu, H. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0225 · Cited by 11 · see citing works
Gärtner, M., de Rover, M., Václavů, L., Scheidegger, M., van Osch, M. J. P., & Grimm, S. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.2020900 · Cited by 11 · see citing works
- Authors
- Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., Cooper, T. B., Keilp, J. G., Shungu, D. C., & Mann, J. J.
- Affiliations
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Cornell University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Venue
- Molecular Psychiatry
- Published
- 2015-08-18
- Volume
- 21
- Issue
- 3
- Pages
- 320-327
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4758914
- OpenAlex
- W1846441878
- Cited by
- 144
- References
- 106
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 20 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 17 · 2017: 15 · 2016: 18 · 2015: 2
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01mh093637-04)
- National Institute of Mental Health (R01 MH-093637, R01MH075895, K23MH092434)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ketamine, major depressive disorder, NMDA receptor antagonists, antidepressant mechanism, glutamate, glutamine, GABA, medial prefrontal cortex, glutamatergic system, GABAergic system, norketamine, rapid-acting antidepressants, 1H NMR
- MeSH terms
- Adult, Amino Acids, Antidepressive Agents, Brain, Major Depressive Disorder, Female, gamma-Aminobutyric Acid, Glutamine, Humans, Ketamine, Magnetic Resonance Imaging, Male, Middle Aged, Pilot Projects, Psychiatric Status Rating Scales, Tritium, Neurotransmitter Agents, Glutamic Acid, Proton Magnetic Resonance Spectroscopy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review