Cited by 187Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesCognitive Functions and Memory

Neuropsychiatric Disorders in Persons With Severe Traumatic Brain Injury: Prevalence, Phenomenology, and Relationship With Demographic, Clinical, and Functional Features

Ciurli, Paola, Formisano, Rita, Bivona, Umberto, Cantagallo, Anna, Angelelli, Paola·2011·Journal of Head Trauma Rehabilitation

Abstract

Objective To characterize neuropsychiatric symptoms in a large group of individuals with severe traumatic brain injury (TBI) and to correlate these symptoms with demographic, clinical, and functional features. Methods The Neuropsychiatric Inventory (NPI), a frequently used scale to assess behavioral, emotional, and motivational disorders in persons with neurological diseases, was administered to a sample of 120 persons with severe TBI. Controls were 77 healthy subjects. Results A wide range of neuropsychiatric symptoms was found in the population with severe TBI: apathy (42%), irritability (37%), dysphoria/depressed mood (29%), disinhibition (28%), eating disturbances (27%), and agitation (24%). A clear relationship was also found with other demographic and clinical variables. Conclusion Neuropsychiatric disorders constitute an important part of the comorbidity in populations with severe TBI. Our study emphasizes the importance of integrating an overall assessment of cognitive disturbances with a specific neuropsychiatric evaluation to improve clinical understanding and treatment of persons with TBI.

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Crossref · 10.1097/htr.0b013e3181dedd0e

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  • There are some reports that TBI can induce eating disruptions which can include both lack of interest in eating as well as hyperphagia.

    “There are some reports that TBI can induce eating disruptions which can include both lack of interest in eating as well as hyperphagia.119,124–126”

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Authors
Ciurli, P., Formisano, R., Bivona, U., Cantagallo, A., & Angelelli, P.
Affiliations
  • Fondazione Santa Lucia (IT)
  • University of Ferrara (IT)
Venue
Journal of Head Trauma Rehabilitation
Published
2011-03
Volume
26
Issue
2
Pages
116-126
ISSN
0885-9701 (ISSN-L)
OpenAlex
W2094738658
Cited by
187
References
66
Citations by year
2026: 2 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 17 · 2020: 19 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 10 · 2013: 13 · 2012: 12
FWCI
7.21
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Head Trauma Rehabilitation (publishedVersion)
  • PubMed (publishedVersion)
  • AIRUS (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
severe traumatic brain injury, neuropsychiatric symptoms, Neuropsychiatric Inventory, apathy, irritability, dysphoria, disinhibition, disordered eating, agitation, behavioral and emotional disorders, comorbidities
MeSH terms
Adolescent, Adult, Affective Symptoms, Mental Disorders, Brain Injuries, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Cohort Studies, Glasgow Coma Scale, Prevalence, Case-Control Studies, Young Adult

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