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Cited by 72Vaccine Coverage and HesitancyAutism Spectrum Disorder ResearchVirology and Viral Diseases

Lack of Association Between Measles-Mumps-Rubella Vaccination and Autism in Children: A Case-Control Study

Mrożek-Budzyn, Dorota, Kiełtyka, Agnieszka, Majewska, Renata·2010·Pediatric Infectious Disease Journal
DOI 10.1097/inf.0b013e3181c40a8a
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Abstract

OBJECTIVE: The first objective of the study was to determine whether there is a relationship between the measles-mumps-rubella (MMR) vaccination and autism in children. The second objective was to examine whether the risk of autism differs between use of MMR and the single measles vaccine. DESIGN: Case-control study. STUDY POPULATION: The 96 cases with childhood or atypical autism, aged 2 to 15, were included into the study group. Controls consisted of 192 children individually matched to cases by year of birth, sex, and general practitioners. METHODS: Data on autism diagnosis and vaccination history were from physicians. Data on the other probable autism risk factors were collected from mothers. Logistic conditional regression was used to assess the risk of autism resulting from vaccination. Assessment was made for children vaccinated (1) Before diagnosis of autism, and (2) Before first symptoms of autism onset. Odds ratios were adjusted to mother's age, medication during pregnancy, gestation time, perinatal injury and Apgar score. RESULTS: For children vaccinated before diagnosis, autism risk was lower in children vaccinated with MMR than in the nonvaccinated (OR: 0.17, 95% CI: 0.06-0.52) as well as to vaccinated with single measles vaccine (OR: 0.44, 95% CI: 0.22-0.91). The risk for vaccinated versus nonvaccinated (independent of vaccine type) was 0.28 (95% CI: 0.10-0.76). The risk connected with being vaccinated before onset of first symptoms was significantly lower only for MMR versus single vaccine (OR: 0.47, 95% CI: 0.22-0.99). CONCLUSIONS: The study provides evidence against the association of autism with either MMR or a single measles vaccine.

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Crossref · 10.1097/inf.0b013e3181c40a8a

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  • In multivariate analysis, MMR vaccination before autism diagnosis was associated with a reduced risk of autism (OR 0.17; 95% CI 0.06 to 0.52; P = 0.002), but this association was not confirmed when exposure before symptom onset was considered (OR 0.42; 95% CI 0.15 to 1.16).

    “In multivariate analysis, administration of MMR vaccine before the diagnosis was associated with a relevant reduced risk of autism (OR 0.17; 95% CI 0.06 to 0.52; P = 0.002); this association was not confirmed when exposure before symptom onset was considered (OR 0.42; 95% CI 0.15 to 1.16).”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Mrozek-Budzyn 2010

  • Risk of autism was significantly lower for MMR-vaccinated children than for children immunised with single-component measles vaccine, both before diagnosis (OR 0.47; 95% CI 0.22 to 0.99) and before symptom onset.

    “Risk of autism was significantly lower for MMR vaccinated children when compared with children immunised with single component measles vaccine, both before diagnosis (OR 0.47; 95% CI 0.22 to 0.99)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Mrozek-Budzyn 2010

  • Compared with children immunised with single component measles vaccine, MMR vaccination was associated with lower odds of autism at symptom onset (OR 0.44; 95% CI 0.22 to 0.91).

    “and symptom onset (OR 0.44; 95% CI 0.22 to 0.91).”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Mrozek-Budzyn 2010

  • Compared with children immunised with single component measles vaccine, MMR vaccination was associated with lower odds of autism before diagnosis (OR 0.47; 95% CI 0.22 to 0.99).

    “when compared with children immunised with single component measles vaccine, both before diagnosis (OR 0.47; 95% CI 0.22 to 0.99)”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Mrozek-Budzyn 2010

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Authors
Mrożek-Budzyn, D., Kiełtyka, A., & Majewska, R.
Affiliations
Jagiellonian University (PL)
ORCID
Majewska, Renata
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-05
Volume
29
Issue
5
Pages
397-400
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/inf.0b013e3181c40a8a
OpenAlex
W2011584144
Cited by
72
References
20
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 14
FWCI
10.39
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
MMR vaccine, autism spectrum disorder, autism risk factors, measles vaccine, childhood immunization, vaccine safety
MeSH terms
Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Female, Humans, Infant, Male, Measles, Mumps, Pregnancy, Rubella, Vaccination, Case-Control Studies, Measles-Mumps-Rubella Vaccine

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