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The efficacy of mindfulness-based interventions in acute pain: a systematic review and meta-analysis
Abstract
Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reported on randomized controlled trials of MBIs for people with acute pain and one of the following outcomes: pain severity, pain threshold, pain tolerance, or pain-related distress. Two authors independently extracted the data, assessed risk of bias, and provided GRADE ratings. Twenty-two studies were included. There was no evidence of an effect of MBIs on the primary outcome of pain severity in clinical {Hedges' g = 0.52; (95% confidence interval [CI] −0.241 to 1.280)} or experimental settings (Hedges' g = 0.04; 95% CI [−0.161 to 0.247]). There was a beneficial effect of MBIs on pain tolerance (Hedges' g = 0.68; 95% CI [0.157-1.282]) and pain threshold (Hedges' g = 0.72; 95% CI [0.210-1.154]) in experimental studies. There was no evidence of an effect of MBIs compared to control for pain-related distress in clinical (Hedges' g = 0.16; 95% CI [−0.018 to 0.419]) or experimental settings (Hedges' g = 0.44; 95% CI [−0.164 to 0.419]). GRADE assessment indicated that except for pain tolerance, the data were of low or very low quality. There is moderate evidence that MBIs are efficacious in increasing pain tolerance and weak evidence for pain threshold. However, there is an absence of good-quality evidence for the efficacy of MBIs for reducing the pain severity or pain-related distress in either clinical or experimental settings.
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“Three reviews evaluated mindfulness interventions following injury, and all reviews reported no evidence for improvements in distress-related outcomes.4547”
From Impact of healthcare interventions on distress following acute musculoskeletal/orthopaedic injury: A scoping review of systematic reviews (2024) · cites this paper as [47]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
GRADE guidelines: 5. Rating the quality of evidence—publication bias
Guyatt, G. H., Oxman, A. D., Montori, V., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Djulbegovic, B., Atkins, D., Falck-Ytter, Y., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.011 · Cited by 1,819
The clinical use of mindfulness meditation for the self-regulation of chronic pain
Kabat-Zinn, J., Lipworth, L., & Burney, R. (1985) · Journal of Behavioral Medicine · doi:10.1007/bf00845519 · Cited by 1,745
Mindfulness-based stress reduction for healthy individuals: A meta-analysis
Khoury, B., Sharma, M., Rush, S. E., & Fournier, C. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.03.009 · Cited by 1,617 · cited 1×
“Mindfulness is an effective intervention for a range of indications.(3,23,24) Meta-analyses confirm that mindfulness-based interventions (MBIs) are efficacious for managing stress,(3,24) depression,(16,22) and physical health problems.”
BackgroundVan Dam, N. T., van Vugt, M. K., Vago, D. R., Schmalzl, L., Saron, C. D., Olendzki, A., Meissner, T., Lazar, S. W., Kerr, C. E., Gorchov, J., et al. (2018) · Perspectives on Psychological Science · doi:10.1177/1745691617709589 · Cited by 1,506 · cited 2×
“The absence of an effect on pain severity may not be surprising in a chronic pain setting because most psychosocial interventions for chronic pain do not focus on changing pain severity but rather on accepting the pain and changing behaviours, which lead to improvements in functional outcomes.(10,40,41) However, this…”
BackgroundMethodMindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis
Goldberg, S. B., Tucker, R. P., Greene, P. A., Davidson, R. J., Wampold, B. E., Kearney, D. J., & Simpson, T. L. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.10.011 · Cited by 1,145
Mindfulness-Based Interventions for Anxiety and Depression
Hofmann, S. G., & Gómez, A. F. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.08.008 · Cited by 756
Veehof, M. M., Trompetter, H. R., Bohlmeijer, E. T., & Schreurs, K. M. G. (2016) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2015.1098724 · Cited by 737 · cited 1×
“The absence of an effect on pain severity may not be surprising in a chronic pain setting because most psychosocial interventions for chronic pain do not focus on changing pain severity but rather on accepting the pain and changing behaviours, which lead to improvements in functional outcomes.(10,40,41) However, this…”
BackgroundThe Role of Science in Addressing the Opioid Crisis
Volkow, N. D., & Collins, F. S. (2017) · New England Journal of Medicine · doi:10.1056/nejmsr1706626 · Cited by 566
Grossman, P., Tiefenthaler-Gilmer, U., Raysz, A., & Kesper, U. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000101501 · Cited by 505
Chapman, C. R., & Vierck, C. J. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2016.11.004 · Cited by 423
Burton, A., Burgess, C., Dean, S., Koutsopoulou, G. Z., & Hugh‐Jones, S. (2017) · Stress and Health · doi:10.1002/smi.2673 · Cited by 412
Cortical thickness and pain sensitivity in zen meditators.
Grant, J. A., Courtemanche, J., Duerden, E. G., Duncan, G. H., & Rainville, P. (2010) · Emotion · doi:10.1037/a0018334 · Cited by 395
Mindfulness-based interventions for chronic pain: a systematic review of the evidence
Chiesa, A., & Serretti, A. (2011) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0546 · Cited by 374
Zeidan, F., Emerson, N. M., Farris, S. R., Ray, J. N., Jung, Y., McHaffie, J. G., & Coghill, R. C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2542-15.2015 · Cited by 369
Wachholtz, A. B., & Pargament, K. I. (2005) · Journal of Behavioral Medicine · doi:10.1007/s10865-005-9008-5 · Cited by 350
Gard, T., Holzel, B. K., Sack, A. T., Hempel, H., Lazar, S. W., Vaitl, D., & Ott, U. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr352 · Cited by 276
Lutz, A., McFarlin, D. R., Perlman, D. M., Salomons, T. V., & Davidson, R. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.030 · Cited by 233
Duncan, L. G., Cohn, M. A., Chao, M. T., Cook, J. G., Riccobono, J., & Bardacke, N. (2017) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-017-1319-3 · Cited by 224
Kingston, J., Chadwick, P., Meron, D., & Skinner, T. C. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.10.007 · Cited by 218
Pain Sensitivity and Analgesic Effects of Mindful States in Zen Meditators: A Cross-Sectional Study
Grant, J. A., & Rainville, P. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818f52ee · Cited by 209
Do mindfulness-based interventions reduce pain intensity? A critical review of the literature
Reiner, K., Tibi, L., & Lipsitz, J. D. (2013) · Pain Medicine · doi:10.1111/pme.12006 · Cited by 208
Vowles, K. E., Witkiewitz, K., Sowden, G., & Ashworth, J. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2013.10.002 · Cited by 201
Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis
Garland, E. L., Brintz, C. E., Hanley, A. W., Roseen, E. J., Atchley, R. M., Gaylord, S. A., Faurot, K. R., Yaffe, J., Fiander, M., & Keefe, F. J. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.4917 · Cited by 190
Mindfulness-meditation-based pain relief is not mediated by endogenous opioids
Zeidan, F., Adler-Neal, A. L., Wells, R. E., Stagnaro, E., May, L. M., Eisenach, J. C., McHaffie, J. G., & Coghill, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4328-15.2016 · Cited by 132
Brief Mindfulness-Based Interventions for Acute and Chronic Pain: A Systematic Review
McClintock, A. S., McCarrick, S. M., Garland, E. L., Zeidan, F., & Zgierska, A. E. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0351 · Cited by 107
Soo, M. S., Jarosz, J. A., Wren, A. A., Soo, A. E., Mowery, Y. M., Johnson, K. S., Yoon, S. C., Kim, C., Hwang, E. S., Keefe, F. J., et al. (2016) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2015.12.004 · Cited by 105
Liu, X., Wang, S., Chang, S., Chen, W., & Si, M. (2013) · Stress and Health · doi:10.1002/smi.2446 · Cited by 100
Darnall, B. D., Ziadni, M. S., Krishnamurthy, P., Flood, P., Heathcote, L. C., Mackey, I. G., Taub, C. J., & Wheeler, A. (2019) · Pain Medicine · doi:10.1093/pm/pnz094 · Cited by 83
Advancing psychological therapies for chronic pain
Eccleston, C., & Crombez, G. (2017) · F1000Research · doi:10.12688/f1000research.10612.1 · Cited by 67
Prins, B., Decuypere, A., & Van Damme, S. (2014) · European Journal of Pain · doi:10.1002/j.1532-2149.2014.491.x · Cited by 61
Wren, A. A., Shelby, R., Soo, M., Huysmans, Z., Jarosz, J., & Keefe, F. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-4657-z · Cited by 55
Westenberg, R. F., Zale, E. L., Heinhuis, T. J., Özkan, S., Nazzal, A., Lee, S.-G., Chen, N. C., & Vranceanu, A.-M. (2018) · Clinical Orthopaedics & Related Research · doi:10.1007/s11999.0000000000000086 · Cited by 52 · cited 1×
“The 7 studies examining the effects of mindfulness on acute pain in clinical settings included 4 studies involving breast biopsy,(6,32,36,47) one examining pain during childbirth,(8) one acute care surgery patients,(29) and one acute upper-limb injury.(46) Seven of the 22 studies had an active control group: one hypno…”
BackgroundEffect of Acceptance Versus Attention on Pain Tolerance: Dissecting Two Components of Mindfulness
Wang, Y., Qi, Z., Hofmann, S. G., Si, M., Liu, X., & Xu, W. (2019) · Mindfulness · doi:10.1007/s12671-019-1091-8 · Cited by 51
Ratcliff, C. G., Prinsloo, S., Chaoul, A., Zepeda, S. G., Cannon, R., Spelman, A., Yang, W. T., & Cohen, L. (2019) · Journal of the American College of Radiology · doi:10.1016/j.jacr.2018.09.009 · Cited by 35
Forsyth, L., & Hayes, L. L. (2014) · The Psychological Record · doi:10.1007/s40732-014-0010-6 · Cited by 30
A comparison of the effect of mindfulness and relaxation on responses to acute experimental pain.
Sharpe, L., Nicholson Perry, K., Rogers, P., Refshauge, K., & Nicholas, M. K. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00241.x · Cited by 30
Self-citationEsch, T., Winkler, J., Auwärter, V., Gnann, H., Huber, R., & Schmidt, S. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00674 · Cited by 29
The relative efficacy of mindfulness versus distraction: The moderating role of attentional bias
Shires, A. G., Sharpe, L., & John, T. R. O. N. (2018) · European Journal of Pain · doi:10.1002/ejp.1340 · Cited by 29
Self-citationCoelho, B. A., Paiva, S. D. P. C., & Filho, A. L. D. S. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4869-9 · Cited by 20
Miller-Matero, L. R., Coleman, J. P., Smith-Mason, C. E., Moore, D. A., Marszalek, D., & Ahmedani, B. K. (2019) · Pain Medicine · doi:10.1093/pm/pnz082 · Cited by 20
Swain, N., & Trevena, J. A. (2014) · New Zealand journal of psychology · Cited by 15
The Effect of Brief Mindfulness Meditation on Cold-Pressor Induced Pain Responses in Healthy Adults
Burnett, D., Phillips, G., & Tashani, O. A. (2017) · Pain Studies and Treatment · doi:10.4236/pst.2017.52002 · Cited by 10
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Self-citationDavies, J. N., Sharpe, L., Day, M. A., & Colagiuri, B. (2022) · Pain · doi:10.1097/j.pain.0000000000002593 · Cited by 18
Mascaro, J. S., Singh, V., Wehrmeyer, K., Scott, B., Juan, J., McKenzie-Brown, A. M., Lane, O. P., & Haack, C. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000924 · Cited by 14
Sim, A., McNeilage, A. G., Gholamrezaei, A., Rebbeck, T., & Ashton-James, C. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085778 · Cited by 8
“The total duration of interventions ranged from 1 week to 12 months.”
Background
Metadata
- Authors
- Shires, A., Sharpe, L., Davies, J. N., & Newton-John, T. R. O.
- Affiliations
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- Corresponding author
- Sharpe, Louise
- Venue
- Pain
- Published
- 2020-06-18
- Volume
- 161
- Issue
- 8
- Pages
- 1698-1707
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- OpenAlex
- W3035847997
- Cited by
- 43
- References
- 48
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- mindfulness-based interventions, acute pain, pain intensity, pain tolerance, pain threshold, pain-related distress, mindfulness meditation, pain management
- MeSH terms
- Humans, Pain Threshold, Acute Pain, Mindfulness
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