The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
How do placebo effects contribute to mindfulness-based analgesia? Probing acute pain effects and interactions using a randomized balanced placebo design
Abstract
ABSTRACT: Recent sham-controlled studies suggest placebo effects contribute to acute pain relief after mindfulness interventions. However, the specific effects of mindfulness processes and their interaction with placebo effects remain unclear. This study aimed to characterize the role of mindfulness and placebo processes underlying mindfulness-based pain attenuation. Both treatment (focused attention mindfulness vs sham) and instruction (told mindfulness vs told sham) were manipulated in a balanced placebo design. Changes in acute heat pain were evaluated in 153 healthy adults randomized to receive 6 × 20 minutes of 1 of 4 treatment by instruction interventions or no treatment. Participants receiving any intervention demonstrated improved pain outcomes (unpleasantness, intensity, and tolerance) relative to those receiving no treatment. The instruction manipulation increased expectation for pain relief in those told mindfulness relative to those told sham, but there were no main effects or interactions of treatment or instruction on pain outcomes. However, irrespective of actual intervention received, the belief of receiving mindfulness predicted increased pain threshold and tolerance, with expectancy fully mediating the effect on pain tolerance. These findings suggest a lack of specific effects of mindfulness and instruction on acute pain. Nonetheless, participants' expectancies and beliefs about the treatment they received did predict pain relief. Together with the overall improvement after any intervention, these findings suggest that expectancy and belief may play a stronger role in attenuating acute pain in novices following brief mindfulness interventions than the actual mindfulness-specific processes or instructions delivered.
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In the citing paper
“Results showed that, while any active treatment resulted in better outcomes compared to no treatment, no significant interaction as well as no main effect of either focused-attention mindfulness or expectation induction on pain was found.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“They did find a significant main effect of mindfulness on anxiety.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“To date, one other study has used a balanced placebo design to examine the effects of six 20-minute sessions of mindfulness (i.e., focused-attention mindfulness vs sham) and induced expectations (i.e., told mindfulness vs told sham) on pain and as well as anxiety as a secondary outcome measure (Davies et al., 2022).”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“This may explain why Davies et al. (2022) also found that, while there were no main effects of mindfulness or expectation induction on pain, receiving any treatment was always better than no treatment at all.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“Results showed that, while any active treatment resulted in better outcomes compared to no treatment, no significant interaction as well as no main effect of either focused-attention mindfulness or expectation induction on pain was found.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“They also included a no treatment control group.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
In the citing paper
“Similarly, Davies et al. (2022) found that a participant's a-priori conviction that the intervention was mindfulness predicted the effectiveness of the intervention, independently of what intervention was actually used.”
From Mindfulness Effects on Anxiety: Disentangling the Role of Decentering and Treatment Expectations (2024) · cites this paper as Davies et al., 2022
Citations
Cites
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227
How important are the common factors in psychotherapy? An update
Wampold, B. E. (2015) · World Psychiatry · doi:10.1002/wps.20238 · Cited by 1,728
Mindfulness meditation improves cognition: evidence of brief mental training
Zeidan, F., Johnson, S. K., Diamond, B. J., David, Z., & Goolkasian, P. (2010) · Consciousness and Cognition · doi:10.1016/j.concog.2010.03.014 · Cited by 1,363
Response expectancy as a determinant of experience and behavior.
Kirsch, I. (1985) · American Psychologist · doi:10.1037/0003-066x.40.11.1189 · Cited by 1,014
Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis
Hilton, L., Hempel, S., Ewing, B. A., Apaydin, E., Xenakis, L., Newberry, S., Colaiaco, B., Maher, A. R., Shanman, R. M., Sorbero, M. E., et al. (2017) · Annals of Behavioral Medicine · doi:10.1007/s12160-016-9844-2 · Cited by 977
The Pain Catastrophizing Scale: further psychometric evaluation with adult samples
Osman, A., Barrios, F. X., Gutierrez, P. M., Kopper, B. A., Merrifield, T., & Grittmann, L. (2000) · Journal of Behavioral Medicine · doi:10.1023/a:1005548801037 · Cited by 944
Factor structure, reliability, and validity of the Pain Catastrophizing Scale
Osman, A., Barrios, F. X., Kopper, B. A., Hauptmann, W., Jones, J., & O'Neill, E. (1997) · Journal of Behavioral Medicine · doi:10.1023/a:1025570508954 · Cited by 881
Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice
Dahl, C. J., Lutz, A., & Davidson, R. J. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.07.001 · Cited by 809
Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
Zeidan, F., Martucci, K. T., Kraft, R. A., Gordon, N. S., McHaffie, J. G., & Coghill, R. C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5791-10.2011 · Cited by 640
Weekly change in mindfulness and perceived stress in a mindfulness-based stress reduction program
Baer, R. A., Carmody, J., & Hunsinger, M. (2012) · Journal of Clinical Psychology · doi:10.1002/jclp.21865 · Cited by 546
Desbordes, G., Gard, T., Hoge, E. A., Hölzel, B. K., Kerr, C., Lazar, S. W., Olendzki, A., & Vago, D. R. (2015) · Mindfulness · doi:10.1007/s12671-013-0269-8 · Cited by 505
Response expectancies in placebo analgesia and their clinical relevance
Pollo, A., Amanzio, M., Arslanian, A., Casadio, C., Maggi, G., & Benedetti, F. (2001) · Pain · doi:10.1016/s0304-3959(01)00296-2 · Cited by 442
Gu, J., Strauss, C., Crane, C., Barnhofer, T., Karl, A., Cavanagh, K., & Kuyken, W. (2016) · Psychological Assessment · doi:10.1037/pas0000263 · Cited by 431
Zeidan, F., Emerson, N. M., Farris, S. R., Ray, J. N., Jung, Y., McHaffie, J. G., & Coghill, R. C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2542-15.2015 · Cited by 369
Moore, A., Gruber, T., Derose, J., & Malinowski, P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00018 · Cited by 351
The validation of an active control intervention for Mindfulness Based Stress Reduction (MBSR)
MacCoon, D. G., Imel, Z. E., Rosenkranz, M. A., Sheftel, J. G., Weng, H. Y., Sullivan, J. C., Bonus, K. A., Stoney, C. M., Salomons, T. V., Davidson, R. J., et al. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.10.011 · Cited by 335
Grant, J. A., Courtemanche, J., & Rainville, P. (2011) · Pain · doi:10.1016/j.pain.2010.10.006 · Cited by 297
The placebo effect: From concepts to genes
Colagiuri, B., Schenk, L. A., Keßler, M., Dorsey, S. G., & Colloca, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.017 · Cited by 278
Lutz, A., McFarlin, D. R., Perlman, D. M., Salomons, T. V., & Davidson, R. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.030 · Cited by 233
Differential effects on pain intensity and unpleasantness of two meditation practices.
Perlman, D. M., Salomons, T. V., Davidson, R. J., & Lutz, A. (2010) · Emotion · doi:10.1037/a0018440 · Cited by 202
Locher, C., Nascimento, A. F., Kirsch, I., Kossowsky, J., Meyer, A. H., & Gaab, J. (2017) · Pain · doi:10.1097/j.pain.0000000000001012 · Cited by 190
Dissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 177
Goldberg, S. B., Wielgosz, J., Dahl, C., Schuyler, B., MacCoon, D. S., Rosenkranz, M., Lutz, A., Sebranek, C. A., & Davidson, R. J. (2016) · Psychological Assessment · doi:10.1037/pas0000233 · Cited by 172
What Is Meditation? Proposing an Empirically Derived Classification System
Matko, K., & Sedlmeier, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02276 · Cited by 145
Mindfulness-meditation-based pain relief is not mediated by endogenous opioids
Zeidan, F., Adler-Neal, A. L., Wells, R. E., Stagnaro, E., May, L. M., Eisenach, J. C., McHaffie, J. G., & Coghill, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4328-15.2016 · Cited by 132
Is mindfulness research methodology improving over time? A systematic review
Goldberg, S. B., Tucker, R. P., Greene, P. A., Simpson, T. L., Kearney, D. J., & Davidson, R. J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0187298 · Cited by 125
Placebo effects in psychotherapy: a framework
Enck, P., & Zipfel, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00456 · Cited by 115
Placebo 2.0: the impact of expectations on analgesic treatment outcome
Bingel, U. (2020) · Pain · doi:10.1097/j.pain.0000000000001981 · Cited by 113
Brief Mindfulness-Based Interventions for Acute and Chronic Pain: A Systematic Review
McClintock, A. S., McCarrick, S. M., Garland, E. L., Zeidan, F., & Zgierska, A. E. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0351 · Cited by 107
Liu, X., Wang, S., Chang, S., Chen, W., & Si, M. (2013) · Stress and Health · doi:10.1002/smi.2446 · Cited by 100
Schafer, S. M., Geuter, S., & Wager, T. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.008 · Cited by 79
The Role of Heart Rate Variability in Mindfulness-Based Pain Relief
Adler-Neal, A. L., Waugh, C. E., Garland, E. L., Shaltout, H. A., Diz, D. I., & Zeidan, F. Z. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.07.003 · Cited by 73
Perceived treatment, feedback, and placebo effects in double-blind RCTs: an experimental analysis
Colagiuri, B., & Boakes, R. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1743-9 · Cited by 50
Mindfulness, selfcompassion, and depressive symptoms in chronic pain: the role of pain acceptance
Carvalho, S. A., Gillanders, D., Palmeira, L., Pinto‐Gouveia, J., & Castilho, P. (2018) · Journal of Clinical Psychology · doi:10.1002/jclp.22689 · Cited by 49
Impact of short-term meditation and expectation on executive brain functions
Prätzlich, M., Kossowsky, J., Gaab, J., & Krummenacher, P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.012 · Cited by 43
The efficacy of mindfulness-based interventions in acute pain: a systematic review and meta-analysis
Shires, A., Sharpe, L., Davies, J. N., & Newton-John, T. R. O. (2020) · Pain · doi:10.1097/j.pain.0000000000001877 · Cited by 43
Kotsis, V., Benson, S., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01968.x · Cited by 33
Placebo and Active Treatment Additivity in Placebo Analgesia: Research to Date and Future Directions
Coleshill, M. J., Sharpe, L., Colloca, L., Zachariae, R. H., & Colagiuri, B. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.021 · Cited by 27
Laferton, J. A. C., Vijapura, S., Baer, L., Clain, A. J., Cooper, A. R., Papakostas, G. I., Price, L. H., Carpenter, L. L., Tyrka, A. R., D, M. F. M., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00424 · Cited by 23
Psychotherapy and Placebos: Manifesto for Conceptual Clarity
Blease, C. R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00379 · Cited by 20
Davies, J. N., Sharpe, L., Day, M. A., & Colagiuri, B. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000886 · Cited by 20
Tondorf, T., Kaufmann, L., Degel, A., Locher, C., Birkhäuer, J., Gerger, H., Ehlert, U., & Gaab, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187400 · Cited by 18
Grover, M. P., Jensen, M. P., Ward, L. C., Ehde, D. M., Mattingley, J. B., Thorn, B. E., Ferreira-Valente, A., & Day, M. A. (2020) · Mindfulness · doi:10.1007/s12671-020-01556-7 · Cited by 11
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Research in Mindfulness Interventions for Patients With Fibromyalgia: A Critical Review
Leça, S., & Tavares, I. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.920271 · Cited by 29
Sharpe, L., Jones, E. B., Pradhan, P., Todd, J., & Colagiuri, B. (2022) · Pain · doi:10.1097/j.pain.0000000000002784 · Cited by 23
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Sharpe, L., Richmond, B., Menzies, R. E., Forrest, D., Crombez, G., & Colagiuri, B. (2023) · Pain · doi:10.1097/j.pain.0000000000002997 · Cited by 20
Davies, J. N., Colagiuri, B., Sharpe, L., & Day, M. A. (2023) · Pain · doi:10.1097/j.pain.0000000000002928 · Cited by 16
Metadata
- Authors
- Davies, J. N., Sharpe, L., Day, M. A., & Colagiuri, B.
- Affiliations
- The University of Sydney (AU)
- The University of Queensland (AU)
- Corresponding author
- Davies, Jonathan N.
- Venue
- Pain
- Published
- 2022-01-25
- Volume
- 163
- Issue
- 10
- Pages
- 1967-1977
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- OpenAlex
- W4210571365
- Cited by
- 18
- References
- 44
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- placebo effect, acute pain, sham treatment, pain anticipation, pain tolerance, pain threshold, pain unpleasantness, treatment beliefs, brief mindfulness intervention
- MeSH terms
- Adult, Analgesia, Humans, Pain Measurement, Placebo Effect, Acute Pain, Mindfulness
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