Morphometric Analysis of Neuronal and Glial Cell Pathology in the Caudate Nucleus in Late-Life Depression
Open accessAbstract
Objective To assess glial and neuronal density and neuronal volume in two areas of the caudate nucleus in late-life major depression.Design A postmortem study using the disector and nucleator methods to estimate neuronal density and volume and glial density of cells from human brain tissue from the anterior portion (dorsolateral and ventromedial aspects) of the caudate nucleus.Setting Brain tissues were obtained from the Newcastle Brain Tissue Resource at Newcastle University, UK.Participants The study group consisted of 13 subjects with late-life major depression and nine comparison subjects of similar age.Results Evidence of moderate reductions in neuronal density was found in the depressed group in both the dorsolateral and ventromedial areas of the caudate nucleus. There were no significant changes in glial density or neuronal volume in either area nor was there any evidence of differences in depression in early and late-onset subgroups.Conclusions Neuroimaging abnormalities in frontal and subcortical areas including ischemic hyperintensities and a reduction in volume and metabolism in the caudate nucleus have been reported in late-life depression, and previous morphometric studies have reported neuronal changes in prefrontal cortical areas. The findings in this study extend these morphometric investigations in late-life depression to the caudate nucleus, suggesting that neuronal abnormalities are present in this subcortical nucleus as well as in these related prefrontal areas.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Quantifying the whole medial prefrontal cortex volume from its demarcated brain regions accurately was not possible, so neuronal density measurements were used instead.
“We would have ideally estimated total neuronal numbers, but quantifying the whole mPFC volume from its demarcated brain regions accurately was not possible, so neuronal density measurements were used instead. 70”
From High vulnerability of medial prefrontal pyramidal neurons in post-stroke, vascular, Alzheimer's disease, and aging-related dementias (2026) · cites this paper as [70]
Cites
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541 · see citing works
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533 · see citing works
The efficiency of systematic sampling in stereology and its prediction *
Gundersen, H., & Jensen, E. B. V. (1987) · Journal of Microscopy · doi:10.1111/j.1365-2818.1987.tb02837.x · Cited by 3,586 · see citing works
The unbiased estimation of number and sizes of arbitrary particles using the disector
Sterio, D. C. (1984) · Journal of Microscopy · doi:10.1111/j.1365-2818.1984.tb02501.x · Cited by 2,533 · see citing works
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403 · see citing works
Frontal–subcortical neuronal circuits and clinical neuropsychiatry
Tekin, S., & Cummings, J. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00428-2 · Cited by 1,240 · see citing works
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Unbiased Stereology: Three-Dimensional Measurement in Microscopy
Howard, C. V., & Reed, M. (1998) · Cited by 1,149 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
Review of community prevalence of depression in later life
Beekman, A. T. F., Copeland, J. R. M., & Prince, M. J. (1999) · The British Journal of Psychiatry · doi:10.1192/bjp.174.4.307 · Cited by 1,139 · see citing works
Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07564.x · Cited by 897 · see citing works
Unbiased Stereology. Three‐Dimensional Measurement in Microscopy.
Sandau, K. (1999) · Journal of Microscopy · doi:10.1046/j.1365-2818.1999.0429a.x · Cited by 890 · see citing works
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766 · see citing works
Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies
Middleton, F. A., & Strick, P. L. (2000) · Brain and Cognition · doi:10.1006/brcg.1999.1099 · Cited by 657 · see citing works
Frontal-subcortical circuitry and behavior
Bonelli, R. M., & Cummings, J. L. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.2/rbonelli · Cited by 613 · see citing works
Cerebral Metabolic Rates for Glucose in Mood Disorders
Baxter, L. R. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790280019002 · Cited by 602 · see citing works
Clinically defined vascular depression
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.562 · Cited by 557 · see citing works
Tissue shrinkage and unbiased stereological estimation of particle number and size*
Dorph‐Petersen, K., Nyengaard, J. R., & Gundersen, H. J. G. (2001) · Journal of Microscopy · doi:10.1046/j.1365-2818.2001.00958.x · Cited by 539 · see citing works
Antidepressants and neuroplasticity
D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 516 · see citing works
Gundersen, H. J. G. (1988) · Journal of Microscopy · doi:10.1111/j.1365-2818.1988.tb04609.x · Cited by 452 · see citing works
Buchsbaum, M. S., Wu, J. C., DeLisi, L. E., Holcomb, H. H., KESSLER, R. M., Johnson, J., King, A. C., Hazlett, E., Langston, K. C., & Post, R. M. (1986) · Journal of Affective Disorders · doi:10.1016/0165-0327(86)90036-4 · Cited by 368 · see citing works
Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations
Krishnan, K. R. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070047007 · Cited by 365 · see citing works
Ischemic Basis for Deep White Matter Hyperintensities in Major Depression
Thomas, A. J., O'Brien, J. T., Davis, S., Ballard, C. G., Barber, R., Kalaria, R. N., & Perry, R. H. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.785 · Cited by 364 · see citing works
Self-citationMiguel-Hidalgo, J. J., Baucom, C. C., Dilley, G. E., Overholser, J. C., Meltzer, H. Y., Stockmeier, C. A., & Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00999-9 · Cited by 337 · see citing works
Levy, R., Friedman, H. R., Davachi, L., & Goldman-Rakic, P. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03870.1997 · Cited by 279 · see citing works
MRI and neuropsychological differences in early- and late-life-onset geriatric depression
Salloway, S., Malloy, P., Kohn, R., Gillard, E., Duffy, J., Rogg, J., Tung, G., Richardson, E., Thomas, C., & Westlake, R. (1996) · Neurology · doi:10.1212/wnl.46.6.1567 · Cited by 278 · see citing works
Cerebrovascular Disease and Depression Symptoms in the Cardiovascular Health Study
Steffens, D. C., Helms, M. J., Krishnan, K., & Burke, G. L. (1999) · Stroke · doi:10.1161/01.str.30.10.2159 · Cited by 259 · see citing works
Cotter, D., Landau, S., Beasley, C. L., Stevenson, R. N., Chana, G., MacMillan, L., & Everall, I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01243-4 · Cited by 211 · see citing works
Incidence and Recurrence of Late-Life Depression
Luijendijk, H. J., van den Berg, J. F., Dekker, M. J. H. J., van Tuijl, H. R., Otte, W., Smit, F., Albert Hofman, D., Stricker, B. H. C., & Tiemeier, H. W. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1394 · Cited by 192 · see citing works
Reduced caudate gray matter volume in women with major depressive disorder
Kim, M. J., Hamilton, J. P., & Gotlib, I. H. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.12.020 · Cited by 173 · see citing works
O'Brien, J. T., Ames, D. J., Schweitzer, I., Colman, P. G., Desmond, P. M., & Tress, B. M. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.6.679 · Cited by 172 · see citing works
Vascular basis of late-onset depressive disorder
Baldwin, R., & O'Brien, J. T. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.2.157 · Cited by 168 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Dubey, P., Stockmeier, C. A., & Krishnan, K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.013 · Cited by 146 · see citing works
Nair, A. R., & Vaidya, V. A. (2006) · Journal of Biosciences · doi:10.1007/bf02704114 · Cited by 139 · see citing works
Cotter, D., Hudson, L., & Landau, S. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00230.x · Cited by 133 · see citing works
Magnetic-resonance morphometry in patients with major depression
Parashos, I. A., Tupler, L. A., Blitchington, T. F., & Krishnan, K. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00042-0 · Cited by 130 · see citing works
Volume deficits of subcortical nuclei in mood disorders
Bielau, H., Trübner, K., Krell, D., Agelink, M. W., Bernstein, H., Stauch, R., Mawrin, C., Dános, P., Gerhard, L., Bogerts, B., et al. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0581-y · Cited by 129 · see citing works
Hickie, I. B., Naismith, S. L., Ward, P. B., Scott, E. M., Mitchell, P. B., Schofield, P. R., Scimone, A., Wilhelm, K. A., & Parker, G. B. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.010 · Cited by 126 · see citing works
Neuronal Correlates of Obsessions in the Caudate Nucleus
Guehl, D., Benazzouz, A., Aouizerate, B., Cuny, E., Rotgé, J., Rougier, A., Tignol, J., Bioulac, B. H., & Burbaud, P. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.023 · Cited by 124 · see citing works
Circumscribed numerical deficit of dorsal raphe neurons in mood disorders
Baumann, B., Bielau, H., Krell, D., Agelink, M. W., Diekmann, S., Wurthmann, C., Trübner, K., Bernstein, H., Dános, P., & Bogerts, B. (2002) · Psychological Medicine · doi:10.1017/s0033291701004822 · Cited by 102 · see citing works
Thomas, A. J., Ferrier, I. N., Kalaria, R. N., Woodward, S. A., Ballard, C. G., Oakley, A. E., Perry, R. H., & O'Brien, J. T. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1682 · Cited by 102 · see citing works
Self-citationA neuropathological study of vascular factors in late-life depression
Thomas, A. J. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.1.83 · Cited by 93 · see citing works
Self-citationMatsumoto, T., Numakawa, T., Yokomaku, D., Adachi, N., Yamagishi, S., Numakawa, Y., Kunugi, H., & Taguchi, T. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.09.002 · Cited by 88 · see citing works
Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study
Davis, S. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.5.556 · Cited by 77 · see citing works
Thomas, A. J., Ferrier, I. N., Kalaria, R. N., Davis, S., & O'Brien, J. T. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.2.129 · Cited by 72 · see citing works
Self-citationKhundakar, A., Morris, C., Oakley, A., McMeekin, W., & Thomas, A. J. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.052688 · Cited by 71 · see citing works
Self-citationKhundakar, A. A., & Zetterström, T. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.063 · Cited by 67 · see citing works
Self-citationWhite matter lesion volumes and caudate volumes in late‐life depression
Hannestad, J. O., Taylor, W. D., McQuoid, D. R., Payne, M. E., Krishnan, K., Steffens, D. C., & MacFall, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1640 · Cited by 66 · see citing works
Three-Dimensional Surface Mapping of the Caudate Nucleus in Late-Life Depression
Butters, M. A., Aizenstein, H. J., Hayashi, K. M., MELTZER, C. C., Seaman, J., Reynolds, C. F., Toga, A. W., Thompson, P. M., & Becker, J. T. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31816ff72b · Cited by 61 · see citing works
Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophrenia
Dorph‐Petersen, K., Delevich, K. M., Marcsisin, M. J., Zhang, W., Sampson, A. R., Gundersen, H. J. G., Lewis, D. A., & Sweet, R. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.019 · Cited by 57 · see citing works
Best Linear Unbiased Estimators for Stereology
Cruz-Orive, L. M. (1980) · Biometrics · doi:10.2307/2556113 · Cited by 49 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 269 · see citing works
Meta-analysis of molecular imaging of serotonin transporters in major depression
Gryglewski, G., Lanzenberger, R., Kranz, G. S., & Cumming, P. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.82 · Cited by 227 · see citing works
A Systematic Review and Meta-Analysis of Magnetic Resonance Imaging Studies in Late-Life Depression
Sexton, C. E., Mackay, C. E., & Ebmeier, K. P. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.019 · Cited by 210 · see citing works
O’Leary, L. A., & Mechawar, N. (2021) · Glia · doi:10.1002/glia.23994 · Cited by 122 · see citing works
Bouckaert, F., De Winter, F.-L., Emsell, L., Dols, A., Rhebergen, D., Wampers, M., Sunaert, S., Stek, M., Sienaert, P., & Vandenbulcke, M. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140322 · Cited by 115 · see citing works
The Vascular Depression Hypothesis: An Update
Sneed, J. R., & Culang‐Reinlieb, M. E. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318202fc8a · Cited by 115 · see citing works
Brain Network Dysfunction in Late-Life Depression
Tadayonnejad, R., & Ajilore, O. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713516539 · Cited by 114 · see citing works
Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression
Dwivedi, Y. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.026 · Cited by 86 · see citing works
Foster, V., Oakley, A. E., Slade, J. Y., Hall, R., Polvikoski, T. M., Burke, M., Thomas, A. J., Khundakar, A., Allan, L. M., & Kalaria, R. N. (2014) · Brain · doi:10.1093/brain/awu172 · Cited by 62 · see citing works
Self-citationKhan, A. R., Geiger, L., Wiborg, O., & Czéh, B. (2020) · Cells · doi:10.3390/cells9041026 · Cited by 62 · see citing works
Cortical thickness and VBM-DARTEL in late-life depression
Colloby, S. J., Firbank, M., Vasudev, A., Parry, S. W., Thomas, A. J., & O'Brien, J. T. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.010 · Cited by 58 · see citing works
Self-citationLiu, S., Du, Y., Chen, L., & Cheng, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02672-8 · Cited by 55 · see citing works
Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
Alcaide, J., Guirado, R., Crespo, C., Blasco-Ibáñez, J. M., Varea, E., Sanjuan, J., & Nacher, J. (2019) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0161-0 · Cited by 51 · see citing works
The role of glia in late-life depression
Paradise, M., Naismith, S. L., Norrie, L. M., Graeber, M. B., & Hickie, I. B. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212000828 · Cited by 47 · see citing works
Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
Damborská, A., Honzírková, E., Barteček, R., Hořínková, J., Fedorová, S., Ondruš, Š., Michel, C. M., & Rubega, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61264-z · Cited by 45 · see citing works
Liu, X., Li, L., Li, M., Ren, Z., & Ma, P. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111239 · Cited by 39 · see citing works
Khundakar, A. A., Morris, C. M., & Thomas, A. J. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210001444 · Cited by 32 · see citing works
Self-citationKhundakar, A. A., Morris, C. M., Oakley, A. E., & Thomas, A. J. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.04.008 · Cited by 29 · see citing works
Self-citationNeurochemical Characterization of the Tree Shrew Dorsal Striatum
Rice, M. W., Roberts, R. C., Meléndez‐Ferro, M., & Pérez‐Costas, E. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00053 · Cited by 26 · see citing works
Bobb, D. S., Adinoff, B. H., Laken, S. J., McClintock, S. M., Rubia, K., Huang, H.-W., Husain, M. M., Mapes, K. S., Tamminga, C. A., Cullum, C. M., et al. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318235b728 · Cited by 24 · see citing works
Organic bases of late-life depression: a critical update
Jellinger, K. A. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-012-0945-1 · Cited by 24 · see citing works
Subcortical biophysical abnormalities in patients with mood disorders
Kumar, A., Yang, S., Ajilore, O., Wu, M., Charlton, R. A., & Lamar, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.84 · Cited by 21 · see citing works
Zhang, J., Wu, X., Si, Y., Liu, Y., Wang, X., Geng, Y., Chang, Q., Jiang, X., & Zhang, H. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111769 · Cited by 16 · see citing works
Cellular Morphometry in Late-Life Depression: A Review of Postmortem Studies
Khundakar, A. A., & Thomas, A. J. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.06.003 · Cited by 16 · see citing works
Self-citationAssessment of neuroplasticity in late-life depression with transcranial magnetic stimulation
Bhandari, A., Lissemore, J. I., Rajji, T. K., Mulsant, B. H., Cash, R. F. H., Noda, Y., Zomorrodi, R., Karp, J. F., Lenze, E. J., Reynolds, C. F., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.022 · Cited by 13 · see citing works
Depression and Cerebrovascular Disease: Could Vortioxetine Represent a Valid Treatment Option?
Carta, M. G., Pala, A. N., Finco, G., Musu, M., & Moro, M. F. (2015) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/1745017901511010144 · Cited by 12 · see citing works
Pseudodementia, a Term for its Time: The Impact of Leslie Kiloh's 1961 Paper
Snowdon, J. A. (2011) · Australasian Psychiatry · doi:10.3109/10398562.2011.610105 · Cited by 12 · see citing works
Hanson, K. L., Lew, C. H., Hrvoj-Mihić, B., Groeniger, K. M., Halgren, E., Bellugi, U., & Semendeferi, K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22554 · Cited by 12 · see citing works
Robillard, R., Lagopoulos, J., Hermens, D. F., Naismith, S. L., Rogers, N. L., White, D., Carpenter, J. S., Kaur, M., Scott, E. M., & Hickie, I. B. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00336 · Cited by 10 · see citing works
Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies—A Narrative Review
Capatina, T.-F., Oatu, A., Babasan, C., & Trifu, S. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094285 · Cited by 9 · see citing works
Gunduz‐Bruce, H., Kenney, J. G., Changlani, S., Peixoto, A. J., Gueorguieva, R. V., Leone, C. A., & Stachenfeld, N. S. (2017) · Experimental Physiology · doi:10.1113/ep086212 · Cited by 6 · see citing works
Is depression really different in older people?
Thomas, A. J. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213001038 · Cited by 5 · see citing works
Self-citationOliva, V., Martone, A., Fanelli, G., Domschke, K., Minelli, A., Gennarelli, M., Martini, P. G. V., Bortolomasi, M., Maron, E., Squassina, A., et al. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.103937 · Cited by 4 · see citing works
Neurobiology and Risk Factors of Late-Life Depression
Jain, N., & Steffens, D. C. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_23 · Cited by 3 · see citing works
Jobson, D. D., Hase, Y., Walker, L., Polvikoski, T., Khundakar, A. A., Allan, L., & Kalaria, R. N. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71151 · Cited by 2 · see citing works
“70 We recognize that using densities as a measure may still have several limitations, which stem from the inherent challenges of stereological analysis upon human post mortem tissue.”
Self-citationGlial Cells as Key Orchestrators of Neural Degeneration in Basal Ganglia Disorders
Bhaduri, B., & Alladi, P. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_15 · Cited by 2 · see citing works
Post-Stroke Depression and Vascular Depression
Volk, S., & Steffens, D. C. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796816.003.0015 · Cited by 1 · see citing works
The Possible Applications (and Pitfalls!) of Stereological Analysis in Postmortem Brain Research
Khundakar, A. A., & Thomas, A. J. (2013) · doi:10.1002/9781118444177.ch10 · Cited by 1 · see citing works
Self-citationNeuropathological Markers in Late-Life Depression
Miguel-Hidalgo, J. J., & Rajkowska, G. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796816.003.0036
Kopchak, O. O. (2017) · INTERNATIONAL NEUROLOGICAL JOURNAL · doi:10.22141/2224-0713.2.88.2017.100200
Stereology of the Human Caudate Nucleus
Delgado‐González, J., & Artacho‐Pérula, E. (2024) · Neuromethods · doi:10.1007/978-1-0716-3977-1_4
- Authors
- Khundakar, A., Morris, C., Oakley, A., & Thomas, A. J.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Thomas, Alan J.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 19
- Issue
- 2
- Pages
- 132-141
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W1984408194
- Cited by
- 42
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 10 · 2012: 3
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Teesside University Research Portal (Teesside University) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- geriatric depression, caudate nucleus, neuronal density, glial density, neuronal volume, postmortem brain, major depressive disorder
- MeSH terms
- Aged, 80 and over, Caudate Nucleus, Cell Count, Major Depressive Disorder, Female, Humans, Male, Neuroglia, Neurons, Case-Control Studies, Cell Size
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
