Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
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Background: Alterations in the structure and physiology of interneurons in the prefrontal cortex (PFC) are important factors in the etiopathology of different psychiatric disorders. Among the interneuronal subpopulations, parvalbumin (PV) expressing cells appear to be specially affected. Interestingly, during development and adulthood the connectivity of these interneurons is regulated by the presence of perineuronal nets (PNNs), specialized regions of the extracellular matrix, which are frequently surrounding PV expressing neurons. Previous reports have found anomalies in the density of PNNs in the PFC of schizophrenic patients. However, although some studies have described alterations in PNNs in some extracortical regions of bipolar disorder patients, there are no studies focusing on the prefrontocortical PNNs of bipolar or major depression patients. For this reason, we have analyzed the density of PNNs in post-mortem sections of the dorsolateral PFC (DLPFC) from the Stanley Neuropathology Consortium, which includes controls, schizophrenia, bipolar and major depression patients. Results: We have not observed differences in the distribution of PV+ cells or PNNs, or in the percentage of PV+ interneurons surrounded by PNNs. The density of PV+ interneurons was similar in all the experimental groups, but there was a significantly lower density of PNNs in the DLPFC of bipolar disorder patients and a tendency towards a decrease in schizophrenic patients. No differences were found when evaluating the density of PV+ cells surrounded by PNNs. Interestingly, when assessing the influence of demographic data, we found an inverse correlation between the density of PNNs and the presence of psychosis. Conclusions: The present results point to prefrontocortical PNNs and their role in the regulation of neuronal plasticity as putative players in the etiopathology of bipolar disorder and schizophrenia. Our findings also suggest a link between these specialized regions of the extracellular matrix and the presence of psychosis.
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A deficit in the number of PNNs has been described in the PFC of schizophrenic and bipolar patients.
“a deficit in the number of PNNs has been described in the PFC of schizophrenic (Mauney et al., 2013) and bipolar patients (Alcaide et al., 2019)”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Alcaide et al., 2019
Alterations of prefrontocortical PV1 interneurons and PNNs have been described in schizophrenia or bipolar disorder.
“in which alterations of prefrontocortical PV1 interneurons and PNNs have been described (Mauney et al., 2013;Enwright et al., 2016;Alcaide et al., 2019).”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Alcaide et al., 2019
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The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435 · see citing works
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Self-citation
- Authors
- Alcaide, J., Guirado, R., Crespo, C., Blasco-Ibáñez, J. M., Varea, E., Sanjuan, J., & Nacher, J.
- Affiliations
- Universitat de València (ES)
- Venue
- International Journal of Bipolar Disorders
- Published
- 2019-11-15
- Volume
- 7
- Issue
- 1
- Pages
- 24-24
- ISSN
- 2194-7511 (ISSN-L)
- PMC
- PMC6856240
- OpenAlex
- W2987185267
- Cited by
- 51
- References
- 16
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 1
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Bipolar Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- Funders
- Ministerio de Ciencia, Innovación y Universidades (SAF2015-68436-R, IJCI-2016-27758)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- perineuronal nets, dorsolateral prefrontal cortex, parvalbumin interneurons, bipolar disorder, schizophrenia, major depressive disorder, psychosis, extracellular matrix, neuroplasticity, postmortem brain
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