Anabolic and catabolic pathways regulating skeletal muscle mass
Open accessAbstract
PURPOSE OF REVIEW: The purpose of this review is to discuss recent findings as they pertain to anabolic and catabolic-signaling pathways involved in the regulation of adult skeletal muscle mass. RECENT FINDINGS: Research conducted over the past few years has continued to refine our understanding of the pathways that govern skeletal muscle mass, in particular the mTOR, FoxO and NF-kappaB pathways. Alternative signaling pathways have also emerged as important regulators of muscle mass such as the beta-catenin pathway. SUMMARY: A better understanding of the anabolic and catabolic processes which regulate skeletal muscle mass is critical for the development of more effective therapeutics to prevent the loss of muscle with disuse, aging and disease.
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Overall loss of skeletal mass results from an imbalance between muscle protein anabolic and catabolic pathways, where protein synthesis is hindered and protein breakdown is excessive.
“Overall loss of skeletal mass results from an imbalance between muscle protein anabolic and catabolic pathways, where protein synthesis is hindered and protein breakdown is excessive [113].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [113]
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- Authors
- McCarthy, J. J., & Esser, K. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Esser, Karyn A
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2010-05
- Volume
- 13
- Issue
- 3
- Pages
- 230-235
- ISSN
- 1363-1950 (ISSN-L)
- PMC
- PMC2877703
- OpenAlex
- W2073720580
- Cited by
- 148
- References
- 46
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 12 · 2023: 18 · 2022: 19 · 2021: 15 · 2020: 10 · 2019: 6 · 2018: 12 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 10
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045617)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- skeletal muscle mass, muscle anabolism, muscle catabolism, mTOR signaling, FoxO signaling, NF-κB signaling, β-catenin signaling, muscle atrophy, sarcopenia, aging, myopathy
- MeSH terms
- Forkhead Box Protein O1, Organ Size, Signal Transduction, NF-kappa B, Protein Serine-Threonine Kinases, Muscle, Skeletal, Intracellular Signaling Peptides and Proteins, beta Catenin, Forkhead Transcription Factors, TOR Serine-Threonine Kinases
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