Cited by 443Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesMicrobial Metabolites in Food Biotechnology

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Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

Meijer, Kees, de Vos, Paul, Priebe, Marion G·2010·Current Opinion in Clinical Nutrition and Metabolic Care

DOI 10.1097/mco.0b013e32833eebe5

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Abstract

PURPOSE OF REVIEW: High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusses the relevance of their effects on systemic inflammation, as frequently seen in obesity. RECENT FINDINGS: SCFAs have been shown to reduce chemotaxis and cell adhesion; this effect is dependent on type and concentration of SCFA. In spite of conflicting results, especially butyrate seems to have an anti-inflammatory effect, mediated by signaling pathways like nuclear factor-κB and inhibition of histone deacetylase. The discrepancies in the results could be explained by differences in cell types used and their proliferative and differentiation status. SUMMARY: SCFAs show anti-inflammatory effects and seem to have the potency to prevent infiltration of immune cells from the bloodstream in, for example, the adipose tissue. In addition, their ability to inhibit the proliferation and activation of T cells and to prevent adhesion of antigen-presenting cells could be important as it recently has been shown that obesity-associated inflammation might be antigen-dependent. More studies with concentrations in micromolar range are needed to approach more physiological concentrations.

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Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515

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Schley, 2002, Br J Nutr, 87, S221, 10.1079/BJN/2002541 · DOI
Zapolska-Downar, 2009, J Physiol Pharmacol, 60, 123
Kouraklis, 2006, Oncol Rep, 15, 489
Chung, 1985, Cancer Res, 45, 2976
Kruh, 1982, Mol Cell Biochem, 42, 65

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Authors: Meijer, K., de Vos, P., & Priebe, M. G.
Affiliations: University Medical Center Groningen (NL)
Corresponding author: Priebe, Marion G
ORCID: Meijer, Kees
Priebe, Marion G
Venue: Current Opinion in Clinical Nutrition and Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-11
Volume: 13
Issue: 6
Pages: 715-721
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/mco.0b013e32833eebe5
OpenAlex: W2109832621
Cited by: 443
References: 79
Citations by year: 2026: 9 · 2025: 11 · 2024: 27 · 2023: 35 · 2022: 48 · 2021: 29 · 2020: 39 · 2019: 32 · 2018: 43 · 2017: 38 · 2016: 32 · 2015: 24 · 2014: 27 · 2013: 21 · 2012: 14
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: short-chain fatty acids, butyrate, immunomodulation, anti-inflammatory activity, systemic inflammation, obesity, high-fiber diet, gut fermentation, chemotaxis, cell adhesion, NF-κB signaling, histone deacetylase inhibition, T cell proliferation, antigen-presenting cells, adipose tissue, inflammatory markers
MeSH terms: Anti-Inflammatory Agents, Antigen-Presenting Cells, Butyrates, Cell Adhesion, Chemotaxis, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Humans, Immune System, Immunologic Factors, Obesity, Signal Transduction, Inflammation Mediators

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Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

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