The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?
Abstract
PURPOSE OF REVIEW: High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusses the relevance of their effects on systemic inflammation, as frequently seen in obesity. RECENT FINDINGS: SCFAs have been shown to reduce chemotaxis and cell adhesion; this effect is dependent on type and concentration of SCFA. In spite of conflicting results, especially butyrate seems to have an anti-inflammatory effect, mediated by signaling pathways like nuclear factor-κB and inhibition of histone deacetylase. The discrepancies in the results could be explained by differences in cell types used and their proliferative and differentiation status. SUMMARY: SCFAs show anti-inflammatory effects and seem to have the potency to prevent infiltration of immune cells from the bloodstream in, for example, the adipose tissue. In addition, their ability to inhibit the proliferation and activation of T cells and to prevent adhesion of antigen-presenting cells could be important as it recently has been shown that obesity-associated inflammation might be antigen-dependent. More studies with concentrations in micromolar range are needed to approach more physiological concentrations.
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“Other studies have shown that SCFA, particularly acetate and butyrate, can act as anti-inflammatory agents and have been shown to be effective in inhibiting the production of pro-inflammatory cytokines and maintaining intestinal barrier immune function [255].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [255]
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Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
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Metadata
- Authors
- Meijer, K., de Vos, P., & Priebe, M. G.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Priebe, Marion G
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2010-11
- Volume
- 13
- Issue
- 6
- Pages
- 715-721
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2109832621
- Cited by
- 443
- References
- 79
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 27 · 2023: 35 · 2022: 48 · 2021: 29 · 2020: 39 · 2019: 32 · 2018: 43 · 2017: 38 · 2016: 32 · 2015: 24 · 2014: 27 · 2013: 21 · 2012: 14
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- short-chain fatty acids, butyrate, immunomodulation, anti-inflammatory activity, systemic inflammation, obesity, high-fiber diet, gut fermentation, chemotaxis, cell adhesion, NF-κB signaling, histone deacetylase inhibition, T cell proliferation, antigen-presenting cells, adipose tissue, inflammatory markers
- MeSH terms
- Anti-Inflammatory Agents, Antigen-Presenting Cells, Butyrates, Cell Adhesion, Chemotaxis, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Humans, Immune System, Immunologic Factors, Obesity, Signal Transduction, Inflammation Mediators
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