The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features
Abstract
Purpose of review Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia all phenotypically present with the same features because they are subject to the operation of similar mechanistic factors. However, the conditions referred to above differ by which mechanism dominates the cause of the clinical condition. This review discusses the overlap and differences, which distinguish as well as unite these different conditions and allow a rationale for treatment. Recent findings In the continuum of malnutrition, cachexia, sarcopenia and frailty the recent activities focus on two areas. The first is a better understanding of the mechanisms of cachexia and sarcopenia and frailty. In particular, the differential effects of cytokines on muscle and on the hypothalamic system. The effects of inactivity promoting the loss of body mass in cachexia and sarcopenia as well as the positive effects of exercise. The second is the development of a synthesis of available literature to develop consensus documents about the definition, causes, diagnosis and treatment of cachexia, sarcopenia and frailty. Summary Loss of body tissues resulting in wasting is a common phenotype for several different conditions which can be caused by a combination of reduced food intake, excessive requirements, altered metabolism, sepsis, trauma, ageing and inactivity. They have been referred to loosely as malnutrition but in not all will respond to simply providing nutrients. In this review the common fe…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Malnutrition, cachexia, sarcopenia, and frailty are phenotypically distinct but interconnected conditions with interrelated pathophysiological processes that lead to different magnitudes of wasting and susceptibility to adverse outcomes.81–83”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [81]
Citations
Cites
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Predictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809
Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice
Appel, L. J., Clark, J. M., Yeh, H.-C., Wang, N.-Y., Coughlin, J. W., Daumit, G., Miller, E. R., Dalcin, A., Jerome, G. J., Geller, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1108660 · Cited by 783
Burd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531
Research works printed but not linked: 21
- William, 2008, Clin Nutr, 27, 793, 10.1016/j.clnu.2008.06.013 · DOI
- Fearon, 2011, Lancet Oncol, 12, 489, 10.1016/S1470-2045(10)70218-7 · DOI
- Papersack, 2011, Lancet Oncol, 12, 423, 10.1016/S1470-2045(11)70113-9 · DOI
- Alfonso, 2010, Age and Ageing, 39, 412, 10.1093/ageing/afq034 · DOI · Paper page
- Rosenberg, 1997, J Nutr, 127, 990S, 10.1093/jn/127.5.990S · DOI · Paper page
- Rosenberg, 2011, Clin Geriatr Med, 27, 337, 10.1016/j.cger.2011.03.003 · DOI · Paper page
- Buehring, 2011, J Appl Physiol, 111, 87, 10.1152/japplphysiol.01294.2010 · DOI
- Glover, 2008, J Physiol, 586, 6049, 10.1113/jphysiol.2008.160333 · DOI · Paper page
- Leiter, 1982, JAMA, 248, 2306, 10.1001/jama.1982.03330180066037 · DOI
- Blum, 2011, Crit Rev Oncol Hematol, 80, 114, 10.1016/j.critrevonc.2010.10.004 · DOI
- Mitch, 2001, ancet, 337, 734
- Zoico, 2002, Nutr Rev, 60, 39, 10.1301/00296640260085949 · DOI
- Grossberg, 2010, Physiol Behav, 100, 478, 10.1016/j.physbeh.2010.03.011 · DOI
- Hughes, 2002, Am J Clin Nutr, 76, 473, 10.1093/ajcn/76.2.473 · DOI · Paper page
- Fielding, 2011, J Am Med Dir Assoc, 12, 249, 10.1016/j.jamda.2011.01.003 · DOI · Paper page
- Heuberger, 2011, J Nutr Gerontol Geriatr, 30, 315, 10.1080/21551197.2011.623931 · DOI
- Hart, 2002, Ann Surg, 235, 152, 10.1097/00000658-200201000-00020 · DOI
- Lynch, 2007, Med Sci Sports Exerc, 39, 1124, 10.1249/01.mss.0b013e3180557466 · DOI
- Vogiatzis, 2010, Eur Respir J, 36, 301, 10.1183/09031936.00112909 · DOI
- Temel, 2009, J Thorac Oncol, 4, 595, 10.1097/JTO.0b013e31819d18e5 · DOI
- Sillen, 2009, Chest, 136, 44, 10.1378/chest.08-2481 · DOI
Cited by
Sorted by citations
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905
ESPEN guidelines on definitions and terminology of clinical nutrition
Cederholm, T., Barazzoni, R., Austin, P., Ballmer, P., Biolo, G., Bischoff, S. C., Compher, C., Correia, I., Higashiguchi, T., Holst, M., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.004 · Cited by 2,560
“major infections, burns, closed head injury) or those after major surgical procedures display specific nutritional challenges with high risk of consequent malnutrition due to their often highly pronounced stress metabolism [14].”
Frailty measurement in research and clinical practice: A review
Dent, E., Kowal, P. R., & Hoogendijk, E. O. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.03.007 · Cited by 1,356
Clinical definition of sarcopenia
Santilli, V. (2014) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2014.11.3.177 · Cited by 747
“increased inflammatory status, increased muscle proteolysis, impaired carbohydrate, protein and lipid metabolism (15).”
BackgroundMalnutrition in Older Adults—Recent Advances and Remaining Challenges
Norman, K., Haß, U., & Pirlich, M. (2021) · Nutrients · doi:10.3390/nu13082764 · Cited by 905
“As such, there is a close relationship between malnutrition and frailty which has been well documented [38], although they are considered conceptually distinct conditions.”
Background
Metadata
- Authors
- Jeejeebhoy, K. N.
- Affiliations
- St. Michael's Hospital (CA)
- Corresponding author
- Jeejeebhoy, Khursheed N.
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2012-05
- Volume
- 15
- Issue
- 3
- Pages
- 213-219
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2332422741
- Cited by
- 226
- References
- 0
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 27 · 2023: 17 · 2022: 15 · 2021: 18 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 16 · 2013: 11 · 2012: 7
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- malnutrition, fatigue, frailty, vulnerability, sarcopenia, cachexia, muscle atrophy, cytokines, hypothalamic-pituitary-adrenal axis, physical inactivity, physical activity, weight loss, sepsis, aging, consensus definition
- MeSH terms
- Cachexia, Energy Intake, Clinical Trials as Topic, Fatigue, Hormones, Humans, Phenotype, Protein-Energy Malnutrition, Exercise, Cytokines, Nutritional Support, Sarcopenia, Sedentary Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
