Cited by 226Nutrition and Health in AgingMuscle Physiology and DisordersClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features

Jeejeebhoy, Khursheed N.·2012·Current Opinion in Clinical Nutrition and Metabolic Care

Open this paper in CoChat — free account

Abstract

Purpose of review Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia all phenotypically present with the same features because they are subject to the operation of similar mechanistic factors. However, the conditions referred to above differ by which mechanism dominates the cause of the clinical condition. This review discusses the overlap and differences, which distinguish as well as unite these different conditions and allow a rationale for treatment. Recent findings In the continuum of malnutrition, cachexia, sarcopenia and frailty the recent activities focus on two areas. The first is a better understanding of the mechanisms of cachexia and sarcopenia and frailty. In particular, the differential effects of cytokines on muscle and on the hypothalamic system. The effects of inactivity promoting the loss of body mass in cachexia and sarcopenia as well as the positive effects of exercise. The second is the development of a synthesis of available literature to develop consensus documents about the definition, causes, diagnosis and treatment of cachexia, sarcopenia and frailty. Summary Loss of body tissues resulting in wasting is a common phenotype for several different conditions which can be caused by a combination of reduced food intake, excessive requirements, altered metabolism, sepsis, trauma, ageing and inactivity. They have been referred to loosely as malnutrition but in not all will respond to simply providing nutrients. In this review the common fe…

Integrity signals

Registry

Crossref · 10.1097/mco.0b013e328352694f

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Predictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809
Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice
Appel, L. J., Clark, J. M., Yeh, H.-C., Wang, N.-Y., Coughlin, J. W., Daumit, G., Miller, E. R., Dalcin, A., Jerome, G. J., Geller, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1108660 · Cited by 783
Low-Load High Volume Resistance Exercise Stimulates Muscle Protein Synthesis More Than High-Load Low Volume Resistance Exercise in Young Men
Burd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531

Show all 0 references

Research works printed but not linked: 21

William, 2008, Clin Nutr, 27, 793, 10.1016/j.clnu.2008.06.013 · DOI
Fearon, 2011, Lancet Oncol, 12, 489, 10.1016/S1470-2045(10)70218-7 · DOI
Papersack, 2011, Lancet Oncol, 12, 423, 10.1016/S1470-2045(11)70113-9 · DOI
Alfonso, 2010, Age and Ageing, 39, 412, 10.1093/ageing/afq034 · DOI · Paper page
Rosenberg, 1997, J Nutr, 127, 990S, 10.1093/jn/127.5.990S · DOI · Paper page
Rosenberg, 2011, Clin Geriatr Med, 27, 337, 10.1016/j.cger.2011.03.003 · DOI · Paper page
Buehring, 2011, J Appl Physiol, 111, 87, 10.1152/japplphysiol.01294.2010 · DOI
Glover, 2008, J Physiol, 586, 6049, 10.1113/jphysiol.2008.160333 · DOI · Paper page
Leiter, 1982, JAMA, 248, 2306, 10.1001/jama.1982.03330180066037 · DOI
Blum, 2011, Crit Rev Oncol Hematol, 80, 114, 10.1016/j.critrevonc.2010.10.004 · DOI
Mitch, 2001, ancet, 337, 734
Zoico, 2002, Nutr Rev, 60, 39, 10.1301/00296640260085949 · DOI
Grossberg, 2010, Physiol Behav, 100, 478, 10.1016/j.physbeh.2010.03.011 · DOI
Hughes, 2002, Am J Clin Nutr, 76, 473, 10.1093/ajcn/76.2.473 · DOI · Paper page
Fielding, 2011, J Am Med Dir Assoc, 12, 249, 10.1016/j.jamda.2011.01.003 · DOI · Paper page
Heuberger, 2011, J Nutr Gerontol Geriatr, 30, 315, 10.1080/21551197.2011.623931 · DOI
Hart, 2002, Ann Surg, 235, 152, 10.1097/00000658-200201000-00020 · DOI
Lynch, 2007, Med Sci Sports Exerc, 39, 1124, 10.1249/01.mss.0b013e3180557466 · DOI
Vogiatzis, 2010, Eur Respir J, 36, 301, 10.1183/09031936.00112909 · DOI
Temel, 2009, J Thorac Oncol, 4, 595, 10.1097/JTO.0b013e31819d18e5 · DOI
Sillen, 2009, Chest, 136, 44, 10.1378/chest.08-2481 · DOI

Sorted by citations

Sarcopenia
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905
ESPEN guidelines on definitions and terminology of clinical nutrition
Cederholm, T., Barazzoni, R., Austin, P., Ballmer, P., Biolo, G., Bischoff, S. C., Compher, C., Correia, I., Higashiguchi, T., Holst, M., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.004 · Cited by 2,560
“major infections, burns, closed head injury) or those after major surgical procedures display specific nutritional challenges with high risk of consequent malnutrition due to their often highly pronounced stress metabolism [14].”
Frailty measurement in research and clinical practice: A review
Dent, E., Kowal, P. R., & Hoogendijk, E. O. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.03.007 · Cited by 1,356
Clinical definition of sarcopenia
Santilli, V. (2014) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2014.11.3.177 · Cited by 747
“increased inflammatory status, increased muscle proteolysis, impaired carbohydrate, protein and lipid metabolism (15).”
Background
Malnutrition in Older Adults—Recent Advances and Remaining Challenges
Norman, K., Haß, U., & Pirlich, M. (2021) · Nutrients · doi:10.3390/nu13082764 · Cited by 905
“As such, there is a close relationship between malnutrition and frailty which has been well documented [38], although they are considered conceptually distinct conditions.”
Background
Nutritional status in older persons according to healthcare setting: A systematic review and meta-analysis of prevalence data using MNA®
Cereda, E., Pedrolli, C., Klersy, C., Bonardi, C., Quarleri, L., Cappello, S., Turri, A., Rondanelli, M., & Caccialanza, R. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.008 · Cited by 499
Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients
Moisey, L. L., Mourtzakis, M., Cotton, B. A., Premji, T., Heyland, D. K., Wade, C. E., Bulger, E. M., & Kozar, R. A. (2013) · Critical Care · doi:10.1186/cc12901 · Cited by 494
“Though the injured elderly admitted to the ICU receive inadequate nutrition [13], we do not know the extent to which optimizing nutrition after injury will have on muscle mass, as malnutrition is only one factor contributing to sarcopenia [34].”
Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia
Ticinesi, A., Nouvenne, A., Cerundolo, N., Catania, P., Prati, B., Tana, C., & Meschi, T. (2019) · Nutrients · doi:10.3390/nu11071633 · Cited by 418
Frailty, Sarcopenia, and Malnutrition Frequently (Co-)occur in Hospitalized Older Adults: A Systematic Review and Meta-analysis.
Ligthart-Melis, G., Luiking, Y., Kakourou, A., Cederholm, T., Maier, A., & de van der Schueren, M. D. V. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.03.006 · Cited by 313
“40 Furthermore, in spite of applied strati ﬁ cation, heterogeneity remained high, possibly because of the difference in type of patients inherent to the variety of reasons for admission.”
Background
Exercise as a remedy for sarcopenia
Landi, F., Marzetti, E., Martone, A. M., Bernabei, R., & Onder, G. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000018 · Cited by 255
Cachexia in patients with oesophageal cancer
Anandavadivelan, P., & Lagergren, P. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.200 · Cited by 265
The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia
Sasegbon, A., & Hamdy, S. (2017) · Neurogastroenterology and Motility · doi:10.1111/nmo.13100 · Cited by 238
Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer
Nipp, R. D., Fuchs, G., El-Jawahri, A. R., Mario, J., Troschel, F. M., Greer, J. A., Gallagher, E. R., Jackson, V. A., Kambadakone, A. R., Hong, T. S., et al. (2017) · The Oncologist · doi:10.1634/theoncologist.2017-0255 · Cited by 273
Exercise and physical activity for patients with end-stage liver disease: improving functional status and sarcopenia while on the transplant waiting list
Duarte‐Rojo, A., Ruiz‐Margáin, A., Montaño‐Loza, A. J., Macías‐Rodríguez, R. U., Ferrando, A., & Kim, W. R. (2018) · Liver Transplantation · doi:10.1002/lt.24958 · Cited by 221
“( 7 2 ) (2 0 1 6 ) R C T 2 9 pa tie nt s w ith”
Background
The essence of frailty: A systematic review and qualitative synthesis on frailty concepts and definitions
Junius‐Walker, U., Onder, G., Soleymani, D., Wiese, B., Albaina, O., Bernabei, R., & Marzetti, E. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.04.023 · Cited by 231
Prevalence and overlap of sarcopenia, frailty, cachexia and malnutrition in older medical inpatients
Gingrich, A., Volkert, D., Kiesswetter, E., Thomanek, M., Bach, S., Sieber, C., & Zopf, Y. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1115-1 · Cited by 189
“One central aspect of all syndromes is the loss of body tissue [9], which however affects different tissues to a varying extent.”
Background
Differentiating Sarcopenia and Cachexia Among Patients With Cancer
Peterson, S. J., & Mozer, M. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616680354 · Cited by 200
Frailty and Malnutrition: Related and Distinct Syndrome Prevalence and Association among Community-Dwelling Older Adults: Singapore Longitudinal Ageing Studies
Wei, K., Nyunt, M. S. Z., Gao, Q., Wee, S. L., & Ng, T. P. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.06.017 · Cited by 186
Association of Frailty and Malnutrition With Long-term Functional and Mortality Outcomes Among Community-Dwelling Older Adults
Wei, K., Nyunt, M., Gao, Q., Wee, S., Yap, K., & Ng, T. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.0650 · Cited by 157
Malnutrition in Older Adults - Urgent Need for Action: A Plea for Improving the Nutritional Situation of Older Adults
Volkert, D. (2013) · Gerontology · doi:10.1159/000346142 · Cited by 144
Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
Hu, X., Zhang, L., Wang, H., Hao, Q., Dong, B., & Yang, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-03388-3 · Cited by 141
Malnutrition or frailty? Overlap and evidence gaps in the diagnosis and treatment of frailty and malnutrition
Laur, C. V., McNicholl, T., Valaitis, R. F., & Keller, H. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0652 · Cited by 158
“Exclusion of those with cachexia, and potentially sarcopenia, is also needed as these individuals may respond differentially to refeeding (Jeejeebhoy 2012).”
Influential
Delirium in adult cancer patients: ESMO Clinical Practice Guidelines
Bush, S. H., Lawlor, P. G., Ryan, K., Centeno, C., Lucchesi, M., Kanji, S., Siddiqi, N., Morandi, A., Davis, D. H. J., Laurent, M., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy147 · Cited by 197
What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials
Kidd, T., Mold, F., Jones, C., Ream, E., Grosvenor, W., Sund‐Levander, M., Tingström, P., & Carey, N. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1196-x · Cited by 156
Delirium in patients with cancer: assessment, impact, mechanisms and management
Lawlor, P. G., & Bush, S. H. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.147 · Cited by 122
Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis
Shen, Y., Chen, J., Chen, X., Hou, L., Lin, X., & Yang, M. J. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.09.012 · Cited by 124
Association of vitamin D deficiency and frailty: A systematic review and meta-analysis.
Zhou, J.-H., Huang, P., Liu, P., Hao, Q., Chen, S.-P., Dong, B., & Wang, J. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.09.003 · Cited by 95
Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen
Ali, A. M., & Kunugi, H. (2020) · Foods · doi:10.3390/foods9101362 · Cited by 103
Nutrition Screening vs Nutrition Assessment: What’s the Difference?
Correia, M. I. T. D. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617719669 · Cited by 120
Prevalence of Undernutrition, Frailty and Sarcopenia in Community-Dwelling People Aged 50 Years and Above: Systematic Review and Meta-Analysis
AlMohaisen, N., Gittins, M., Todd, C. J., Sremanakova, J., Sowerbutts, A. M., Aldossari, A., Almutairi, A. S., Jones, D. J., & Burden, S. T. (2022) · Nutrients · doi:10.3390/nu14081537 · Cited by 105
“There are many similarities between the three conditions, and these conditions have wide-reaching implications for functionality, independence, cognitive function, and overall wellbeing [10].”
Background
Masticatory function and nutrition in old age.
Schimmel, M., Katsoulis, J., Genton, L., & Müller, F. (2015) · Swiss dental journal · doi:10.7892/boris.78401 · Cited by 85
Exercise training as treatment in cancer cachexia
Lira, F. S., Neto, J. C. R., & Seelaender, M. C. L. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0554 · Cited by 79
“Strength protocols may also be a concern, since muscle frailty is a common symptom in patients with advanced cachexia (Jeejeebhoy 2012).”
Background
ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease
Singal, A. K., Wong, R. J., Dasarathy, S., Abdelmalek, M. F., Neuschwander‐Tetri, B. A., Limketkai, B. N., Petrey, J., & McClain, C. J. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003379 · Cited by 93
“Tumor necrosis factor (TNF) can mediate muscle wasting and serum testosterone levels are often decreased in subjects with liver disease (31,32).”
Sarcopenia: A useful paradigm for physical frailty
Cruz-Jentoft, A., & Michel, J. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2013.02.009 · Cited by 76
“There is an urgent need to obtain an operational definition of musculoskeletal health that can be used for prevention and therapy [37] and there is much confusion between these terms [38].”
Background
The association between nutritional status and frailty characteristics among geriatric outpatients
Kurkcu, M., Meijer, R. I., Lonterman, S., Muller, M., & de van der Schueren, M. A. E. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.11.006 · Cited by 75
Prognostic Impact of Sarcopenia on Clinical Outcomes in Malignancies Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
Li, S., Wang, T., Tong, G., Li, X., You, D., & Cong, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.726257 · Cited by 71
Relationships between muscle mass, strength and regional bone mineral density in young men
Sutter, T., Toumi, H., Valéry, A., Hage, R. E., Pinti, A., & Lespessailles, É. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213681 · Cited by 58
Frailty, sarcopenia, cachexia and malnutrition as comorbid conditions and their associations with mortality: a prospective study from UK Biobank.
Petermann-Rocha, F., Pell, J., Celis-Morales, C., & Ho, F. (2021) · Journal of public health · doi:10.1093/pubmed/fdaa226 · Cited by 52
Prevalence and factors associated with malnutrition in older patients with cancer.
Zhang, X., Pang, L., Sharma, S. V., Li, R.-S., Nyitray, A., & Edwards, B. (2019) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2019.01.021 · Cited by 52
Nutritional intervention as part of functional rehabilitation in older people with reduced functional ability: a systematic review and meta‐analysis of randomised controlled studies
Beck, A. M., Dent, E., & Baldwin, C. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12382 · Cited by 49
Malnutrition as Key Predictor of Physical Frailty among Malaysian Older Adults
Norazman, C. W., Adznam, S., & Jamaluddin, R. (2020) · Nutrients · doi:10.3390/nu12061713 · Cited by 51
“The pathophysiology of malnutrition and physical frailty is known to share common pathways and has been described as un-interchangeable [12].”
Background
Nutritional Status and Frailty in Community-Dwelling Older Korean Adults: The Korean Frailty and Aging Cohort Study
Kim, J., Lee, Y., Won, C., Lee, K., & Chon, D. (2018) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-018-1005-9 · Cited by 51
“Wasting is a common phenotype of malnutrition and frailty, but the etiology may differ (14).”
Lower skeletal muscle index and early complications in patients undergoing radical cystectomy for bladder cancer
Wan, F., Zhu, Y., Gu, C., Yao, X., Shen, Y., Dai, B., Zhang, S., Zhang, H., Cheng, J., & Ye, D. (2014) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-12-14 · Cited by 49
“Cancer cells are highly metabolic, leading to diminished homeostatic reserves from release of endogenous transmitters and changes in inflammatory markers and other mediators [33,34].”
Background
Multifactorial immunodeficiency in frail elderly patients: Contributing factors and management
Tannou, T., Koeberle, S., Manckoundia, P., & Aubry, R. (2019) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2019.01.012 · Cited by 54
Nutritional assessment in cirrhotic patients with hepatic encephalopathy
Romeiro, F. G. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i30.2940 · Cited by 47
A position paper on how cost and quality reforms are changing healthcare in America: focus on nutrition.
Rosen, B., Maddox, P., & Ray, N. (2013) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113492337 · Cited by 42
Evaluating the concurrent validity of body mass index (BMI) in the identification of malnutrition in older hospital inpatients.
Ng, W., Collins, P., Hickling, D., & Bell, J. J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.10.025 · Cited by 41
Frailty Assessment in Hospitalized Older Adults Using the Electronic Health Record
Lekan, D. A., Wallace, D. C., McCoy, T. P., Hu, J., Silva, S. G., & Whitson, H. E. (2016) · Biological Research For Nursing · doi:10.1177/1099800416679730 · Cited by 42
“1007/BF03324664 Jeejeebhoy, K. N. (2012). Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: Overlap of clinical features.”
Morphological and Functional Aspects of Human Skeletal Muscle
Trovato, F. M., Imbesi, R., Conway, N., & Castrogiovanni, P. (2016) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk1030289 · Cited by 51
“Cachexia is clinically relevant since it increases patients’ morbidity and mortality [65].”
Background
Bee Pollen Improves Muscle Protein and Energy Metabolism in Malnourished Old Rats through Interfering with the Mtor Signaling Pathway and Mitochondrial Activity
Salles, J., Cardinault, N., Patrac, V., Berry, A., Giraudet, C., Collin, M.-L., Chanet, A., Tagliaferri, C., Denis, P., Pouyet, C., et al. (2014) · Nutrients · doi:10.3390/nu6125500 · Cited by 41
“In this situation, muscle is one of the prime targets of malnutrition [41].”
Background
Impact of frailty on 30-day and 1-year mortality in hospitalised elderly patients with community-acquired pneumonia: a prospective observational study
Luo, J., Tang, W., Sun, Y., & Jiang, C.-Y. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038370 · Cited by 40
Malnutrition in Hospitalized Older Patients: Management Strategies to Improve Patient Care and Clinical Outcomes
Avelino‐Silva, T. J., & Jaluul, O. (2017) · International journal of gerontology · doi:10.1016/j.ijge.2016.11.002 · Cited by 45
A review of nutrition screening tools used to assess the malnutrition-sarcopenia syndrome (MSS) in the older adult
Juby, A. G., & Mager, D. R. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.04.003 · Cited by 40
The accuracy of the Geriatric Nutritional Risk Index in detecting frailty and sarcopenia in hospitalized older adults
Rasheedy, D., & El-Kawaly, W. H. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01492-5 · Cited by 46
Malnutrition and Physical Frailty among Nursing Home Residents: A Cross-Sectional Study in China
Liu, W.-W., Chen, S., Jiang, F., Zhou, C., & Tang, S.-Y. (2020) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-020-1348-x · Cited by 34
The clinical relevance and mechanism of skeletal muscle wasting
Duan, K., Gao, X., & Zhu, D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.07.029 · Cited by 44
Coexistence of malnutrition, frailty, physical frailty and disability in patients with COPD starting a pulmonary rehabilitation program.
ter Beek, L., van der Vaart, H., Wempe, J., Krijnen, W., Roodenburg, J., van der Schans, C. P., & Jager-Wittenaar, H. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.016 · Cited by 33
“Furthermore, these conditions share social, demographic, and cognitive risk factors.(15,16) However, the underlying mechanisms differ, as malnutrition is primarily caused by an imbalance between nutritional intake and nutritional requirements, and frailty is predominantly caused by immobility, ageing and psychosocial…”
Background
Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?
Nomellini, V., Kaplan, L. J., Sims, C. A., & Caldwell, C. C. (2017) · Shock · doi:10.1097/shk.0000000000000939 · Cited by 34
Malnutrition and Frailty Are Associated with a Higher Risk of Prolonged Hospitalization and Mortality in Hospitalized Older Adults
Tseng, H.-K., Cheng, Y.-J., Yu, H.-K., Chou, K.-T., Pang, C., & Hu, G.-C. (2025) · Nutrients · doi:10.3390/nu17020221 · Cited by 32
“Although they are distinct conditions, malnutrition and frailty share many pathophysiological pathways, including the loss of body tissue and a low inflammatory state [5,6].”
Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure
Goldfarb, M., Sheppard, R. J., & Afilalo, J. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0651-3 · Cited by 32
Exercise, nutrition and managing hip fracture in older persons.
Singh, M. F. F. (2013) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000015 · Cited by 31
“Sarcopenia is particularly relevant to discussions of the role of exercise and nutrition in this cohort, as it is more prevalent in patients presenting with hip fracture [19], is associated with lower bone mass [20,21] and mobility limitations [22 && ], and is responsive to anabolic interventions [23].”
Background
Physical Frailty among Urban-Living Community-Dwelling Older Adults in Malaysia
Norazman, C. W., Adznam, S., & Jamaluddin, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186549 · Cited by 31
“Although still not fully understood, the overlapping pathway is apparent as they present similar phenotypes of weight loss and shrinking but may respond distinctively to treatments due to different etiologies [43].”
Background
Predictive Effect of Malnutrition on Long-Term Clinical Outcomes among Older Men: A Prospectively Observational Cohort Study
Hsu, Y.-H., Chou, M.-Y., Chu, C.-S., Liao, M., Wang, Y.-C., Lin, Y.-T., Chen, L.-K., & Liang, C.-K. (2019) · The Journal of Nutrition, Health & Aging · doi:10.1007/s12603-019-1246-2 · Cited by 31
“…causes of malnutrition in older adults include old age, frailty, general health decline, loss of interest in life, impaired efficacy of swallowing, and institutionalization (10, 11); potential results include reduced body mass, poor wound healing, risk of infection, and organ failure (12, 13).”
A Clinically Relevant Diagnosis Code for “Malnutrition in Adults” Is Needed in ICD-11
Cederholm, T., Rothenberg, E., & Barazzoni, R. (2022) · The Journal of nutrition, health and aging · doi:10.1007/s12603-022-1774-z · Cited by 31
Lower values of handgrip strength and adductor pollicis muscle thickness are associated with hepatic encephalopathy manifestations in cirrhotic patients
Augusti, L., Franzoni, L. C., Santos, L., Lima, T., Ietsugu, M., Koga, K., Moriguchi, S., Betting, L., Caramori, C. A., Silva, G. F., et al. (2016) · Metabolic brain disease · doi:10.1007/s11011-016-9828-8 · Cited by 29
Physiological and functional failure in chronic obstructive pulmonary disease, congestive heart failure and cancer: a debilitating intersection of sarcopenia, cachexia and breathlessness
Dudgeon, D., & Baracos, V. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000222 · Cited by 28
“conditions, and those which may be distinctively associated with specific diseases [2].”
Background
Brazilian Academy of Neurology practice guidelines for stroke rehabilitation: part I
Minelli, C., Bazán, R., Pedatella, M. T. A., Neves, L. D. O., Cacho, R. D. O., Magalhães, S. C. S. A., Luvizutto, G. J., Moro, C. H. C., Lange, M. C., Módolo, G. P., et al. (2022) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2021-0354 · Cited by 56
Pulmonary function and functional capacity cut-off point to establish sarcopenia and dynapenia in patients with COPD
Mansour, K., Goulart, C. D. L., de Carvalho-Junior, L. C. S., Trimer, R., Borghi-Silva, A., & da Silva, A. L. G. (2019) · Jornal Brasileiro de Pneumologia · doi:10.1590/1806-3713/e20180252 · Cited by 27
“other disorders,(15) but the presence and prevalence of the overlapping between dynapenia and sarcopenia is still unknown.”
Anthropometric measures associated with sarcopenia in outpatients with liver cirrhosis.
Santos, L. A. A., Lima, T., Ietsugu, M., Nunes, H. R. D. C., Qi, X., & Romeiro, F. (2019) · Nutrition & Dietetics · doi:10.1111/1747-0080.12523 · Cited by 27
Frailty in end-stage liver disease: Understanding pathophysiology, tools for assessment, and strategies for management
Elsheikh, M., Sabagh, A. E., Mohamed, I. B., Bhongade, M., Hassan, M. M., & Jalal, P. K. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i46.6028 · Cited by 28
Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial
Delrieu, L., Martin, A., Touillaud, M. S., Pérol, O., Morelle, M., Febvey‐Combes, O., Freyssenet, D. G., Friedenreich, C. M., Dufresne, A., Bachelot, T., et al. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06238-z · Cited by 28
Impact of Elderly Masticatory Performance on Nutritional Status: An Observational Study
Aquilanti, L., Alia, S., Pugnaloni, S., Coccia, E., Mascitti, M., Santarelli, A., Limongelli, L., Favia, G., Mancini, M., Vignini, A., et al. (2020) · Medicina · doi:10.3390/medicina56030130 · Cited by 25
“Nevertheless, it is important to consider that the reduction of lean mass is frequent in elderly patients and is linked to PEM [26].”
Background
Frailty Assessment in Heart Failure: an Overview of the Multi-domain Approach
Mcdonagh, J., Ferguson, C., & Newton, P. (2018) · Current Heart Failure Reports · doi:10.1007/s11897-018-0373-0 · Cited by 25
The Effect of Sarcopenia on Outcomes in Geriatric Blunt Trauma
Malekpour, M., Bridgham, K., Jaap, K., Erwin, R., Widom, K., Rapp, M., Leonard, D., Baro, S., Dove, J., Hunsinger, M., et al. (2017) · The American surgeon · doi:10.1177/000313481708301120 · Cited by 25
Associations of Inflammatory, Metabolic, Malnutrition, and Frailty Indexes with Multimorbidity Incidence and Progression, and Mortality Impact: Singapore Longitudinal Aging Study
Cheong, C., Yap, P., Yap, K., & Ng, T. (2023) · Gerontology · doi:10.1159/000527428 · Cited by 24
Exercise as a therapy for cancer-induced muscle wasting
Halle, J. L., Counts, B. R., & Carson, J. A. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.11.004 · Cited by 28
Physical Frailty/Sarcopenia as a Key Predisposing Factor to Coronavirus Disease 2019 (COVID-19) and Its Complications in Older Adults
Ali, A. M., & Kunugi, H. (2021) · BioMed · doi:10.3390/biomed1010002 · Cited by 28
“Most patients with cachexia and malnutrition are sarcopenic—disease-related and nutrition-related secondary sarcopenia [15,48].”
BackgroundInfluential
Eating less the logical thing to do? Vulnerability to malnutrition with advancing age: A qualitative study
Chatindiara, I., Sheridan, N., Kruger, M. C., & Wham, C. A. (2019) · Appetite · doi:10.1016/j.appet.2019.104502 · Cited by 28
Perspective: Protein and exercise for frailty and sarcopenia: still learning.
Cruz-Jentoft, A. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.09.024 · Cited by 23
Dietary Supplements in People with Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, and Frailty: A Scoping Review
Johal, J., Han, C. Y., Joseph, R., Munn, Z., Agbejule, O. A., Crawford-Williams, F. M., Wallen, M. P., Chan, R. J., & Hart, N. H. (2022) · Nutrients · doi:10.3390/nu14132642 · Cited by 28
“Malnutrition, cachexia, sarcopenia, and frailty exhibit phenotypically similar features that are interrelated [20].”
Background
Nutrition and Lifestyle Interventions for Managing Parkinson’s Disease: A Narrative Review
Lister, T. (2020) · Journal of Movement Disorders · doi:10.14802/jmd.20006 · Cited by 33
Handgrip Strength, but Not 5-Meter Walk, Adds Value to a Clinical Nutrition Assessment.
McNicholl, T., Dubin, J., Curtis, L. J., Mourtzakis, M., Nasser, R., Laporte, M., & Keller, H. (2018) · Nutrition in clinical practice · doi:10.1002/ncp.10198 · Cited by 22
Frailty Assessment Predicts Acute Outcomes in Patients Undergoing Screening Colonoscopy
Taleban, S., Toosizadeh, N., Junna, S., Golden, T., Ghazala, S., Wadeea, R., Tirambulo, C., & Mohler, J. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5129-x · Cited by 22
Prognostic impact of nutritional risk assessment in patients with chronic schizophrenia.
Tsai, M.-T., Chang, T.-H., & Wu, B.-J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.011 · Cited by 21
“(2016), http://dx.doi.org/10.1016/j.schres.2017.04.011 to have a poor quality of life, reduced physical performance, and an increased risk of mortality (Jeejeebhoy, 2012).”
BackgroundInfluential
Porcine placenta mitigates protein–energy malnutrition-induced fatigue
Han, N., Kim, K.-Y., Kim, M. J., Kim, M.-H., Kim, H., & Jeong, H. (2013) · Nutrition · doi:10.1016/j.nut.2013.04.016 · Cited by 18
Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives
Kottorou, A. E., Dimitrakopoulos, F.-I. D., & Tsezou, A. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101101 · Cited by 21
High prevalence of malnutrition and frailty among older adults at admission to residential aged care.
Chatindiara, I., Allen, J., Hettige, D., Senior, S., Richter, M., Kruger, M., & Wham, C. (2020) · Journal of Primary Health Care · doi:10.1071/hc20042 · Cited by 20
Synergistic effect of low handgrip strength and malnutrition on 4-year all-cause mortality in older males: A prospective longitudinal cohort study.
Wang, Y.-C., Liang, C.-K., Hsu, Y.-H., Peng, L.-N., Chu, C.-S., Liao, M., Shen, H.-C., Chou, M.-Y., & Lin, Y.-T. (2019) · Archives of gerontology and geriatrics (Print) · doi:10.1016/j.archger.2019.05.007 · Cited by 20
Nutrition Support for Critically Ill Patients With Cancer
Lach, K., & Peterson, S. J. (2017) · Nutrition in Clinical Practice · doi:10.1177/0884533617712488 · Cited by 27
Prevalence of 'being at risk of malnutrition' and associated factors in adult patients receiving nursing care at home in Belgium.
Geurden, B., MPsych, E. F., Hartmann, M. L., Weyler, J., & Ysebaert, D. (2015) · International Journal of Nursing Practice · doi:10.1111/ijn.12341 · Cited by 20
Relationship between preoperative malnutrition, frailty, sarcopenia, body composition, and anthropometry in elderly patients undergoing major pancreatic and biliary surgery
Wang, L.-J., Li, P., Hu, Y.-F., Cheng, B., Ding, L.-L., Li, L., Song, J.-H., Wei, J.-M., & Xu, J.-Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1135854 · Cited by 19
Prognostic Value of Isolated Sarcopenia or Malnutrition–Sarcopenia Syndrome for Clinical Outcomes in Hospitalized Patients
Sousa, I. M., Burgel, C. F., Silva, F. M., & Fayh, A. P. T. (2022) · Nutrients · doi:10.3390/nu14112207 · Cited by 19
“As a result, there is a complex relationship between them, and each condition is increased by the other [17,18].”
Background
Effects of Resistance Training Intervention along with Leucine-Enriched Whey Protein Supplementation on Sarcopenia and Frailty in Post-Hospitalized Older Adults: Preliminary Findings of a Randomized Controlled Trial
Amasene, M., Cadenas‐Sánchez, C., Echeverria, I., Sanz, B., Alonso, C., Tobalina, I., Irazusta, J., Labayen, I., & Besga, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010097 · Cited by 23
Protein-Energy Malnutrition Causes Deficits in Motor Function in Adult Male Rats
Alaverdashvili, M., Li, X., & Paterson, P. G. (2015) · Journal of Nutrition · doi:10.3945/jn.115.216382 · Cited by 19
“Forelimb and hindlimb use was rated by using a 7-movement category scale (23), as follows: 1) total miss (0), 2) deep slip (1), 3) slight slip (2), 4) replacement (3), 5) correction (4), 6) partial placement (5), and 7) correct placement (6).”
Method
Prognostic impact of pretreatment skeletal muscle index and CONUT score in diffuse large B-cell Lymphoma
Go, S., Choi, B.-H., Park, M., Park, S., Kang, M., Kim, H.-G., Kang, J. H., Jeong, E., & Lee, G.-W. (2023) · BMC Cancer · doi:10.1186/s12885-023-11590-y · Cited by 18
“While malnutrition and sarcopenia have common features in terms of etiology and pathogenesis, including systemic inflammation and anorexia [37, 38], there are differences in their clinical manifestation and the dominant contributing factors for each condition.”
Background
Combined Depression and Malnutrition As an Effective Predictor of First Fall Onset in a Chinese Community-Dwelling Population: A 2-Year Prospective Cohort Study
Wang, L., Wang, X., Song, P., Han, P., Fu, L., Chen, X., Yu, H., Hou, L., Yu, X., Zhang, Y., et al. (2020) · Rejuvenation Research · doi:10.1089/rej.2019.2188 · Cited by 18
“39 Our data reached a similar conclusion that older adults malnourished at baseline showed a significant decrease in body weight, BMI, muscle mass, muscle strength, and TUGT performance compared with individuals without malnutrition.”
Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia
Yedigaryan, L., Gatti, M., Marini, V., Maraldi, T., & Sampaolesi, M. (2022) · Cells · doi:10.3390/cells11152293 · Cited by 19
“Digestive factors inducing poor intake of food including nausea, dysphagia, mucositis, dysgeusia, and constipation, inflammatory mediators such as cytokines, and reductions in hormonal mediators such as IGF-1, testosterone, and ghrelin all contribute greatly to cachexia [14].”
Background
Fast digestive, leucine‐rich, soluble milk proteins improve muscle protein anabolism, and mitochondrial function in undernourished old rats
Salles, J., Chanet, A., Berry, A., Giraudet, C., Patrac, V., Domingues-Faria, C., Rocher, C., Guillet, C., Denis, P., Pouyet, C., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700287 · Cited by 22
“Muscle is therefore one the prime targets of malnutrition [7].”
Background
Making the Case for Nutrition Screening in Older Adults in Primary Care
Laur, C. V., & Keller, H. (2017) · Nutrition Today · doi:10.1097/nt.0000000000000218 · Cited by 20
“gradual and general loss of skeletal muscle mass and strength, accompanied by risk of adverse outcomes(6) and other conditions.(7) Older adults who have the reduced”
Background
Independent and joint association of sarcopenia and frailty with mortality in older patients with gastrointestinal cancer: a cohort study with prospective data collection
de Sousa, I. M., Silva, F. M., das Virgens, I. P. A., Costa, E. C., & Fayh, A. P. T. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-08173-9 · Cited by 14
“Both sarcopenia and frailty have central aspects and etiological factors in common, including the loss of body tissue and reduced strength and physical function, low food intake, and inflammation [16].”

Authors: Jeejeebhoy, K. N.
Affiliations: St. Michael's Hospital (CA)
Corresponding author: Jeejeebhoy, Khursheed N.
Venue: Current Opinion in Clinical Nutrition and Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-05
Volume: 15
Issue: 3
Pages: 213-219
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/mco.0b013e328352694f
OpenAlex: W2332422741
Cited by: 226
References: 0
Citations by year: 2026: 2 · 2025: 15 · 2024: 27 · 2023: 17 · 2022: 15 · 2021: 18 · 2020: 23 · 2019: 17 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 16 · 2013: 11 · 2012: 7
FWCI: 10.08
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords: malnutrition, fatigue, frailty, vulnerability, sarcopenia, cachexia, muscle atrophy, cytokines, hypothalamic-pituitary-adrenal axis, physical inactivity, physical activity, weight loss, sepsis, aging, consensus definition
MeSH terms: Cachexia, Energy Intake, Clinical Trials as Topic, Fatigue, Hormones, Humans, Phenotype, Protein-Energy Malnutrition, Exercise, Cytokines, Nutritional Support, Sarcopenia, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks