The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Mechanisms for fiber-type specificity of skeletal muscle atrophy
Open accessAbstract
PURPOSE OF REVIEW: There are a variety of pathophysiologic conditions that are known to induce skeletal muscle atrophy. However, muscle wasting can occur through multiple distinct signaling pathways with differential sensitivity between selective skeletal muscle fiber subtypes. This review summarizes some of the underlying molecular mechanisms responsible for fiber-specific muscle mass regulation. RECENT FINDINGS: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha protects slow-twitch oxidative fibers from denervation/immobilization (disuse)-induced muscle atrophies. Nutrient-related muscle atrophies, such as those induced by cancer cachexia, sepsis, chronic heart failure, or diabetes, are largely restricted to fast-twitch glycolytic fibers, of which the underlying mechanism is usually related to abnormality of protein degradation, including proteasomal and lysosomal pathways. In contrast, nuclear factor kappaB activation apparently serves a dual function by inducing both fast-twitch fiber atrophy and slow-twitch fiber degeneration. SUMMARY: Fast-twitch glycolytic fibers are more vulnerable than slow-twitch oxidative fibers under a variety of atrophic conditions related to signaling transduction of Forkhead box O family, autophagy inhibition, transforming growth factor beta family, and nuclear factor-kappaB. The resistance of oxidative fibers may result from the protection of peroxisome proliferator-activated receptor gamma coactivator 1-alpha.
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Cites
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Cited by
Aging of skeletal muscle fibers
Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R. (2015) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2015.39.2.155 · Cited by 309
“pha (PGC1a) protects type I fibers from atrophy while the transforming growth factor beta (TGFb) family and the nuclear factor kappaB (NF-kB) predominantly affect type IIx fibers [39].”
BackgroundMuscle metabolism and atrophy: let’s talk about sex
Rosa-Caldwell, M. E., & Greene, N. P. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0257-3 · Cited by 202
Skeletal muscle autophagy: a new metabolic regulator
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Myricanol rescues dexamethasone-induced muscle dysfunction Via a sirtuin 1-dependent mechanism
Shen, S., Liao, Q., Liu, J., Pan, R., Lee, S. M., & Lin, L. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12393 · Cited by 142
Metadata
- Authors
- Wang, Y., & Pessin, J. E.
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2013-05
- Volume
- 16
- Issue
- 3
- Pages
- 243-250
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2012329777
- Cited by
- 414
- References
- 51
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
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