Aging of skeletal muscle fibers
Open accessAbstract
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
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Sarcopenia is accompanied by diminished regenerative capacity due to loss in number and activity of satellite cells in type II fast fibers.
“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [17]
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · cited 1× · see citing works
“More recently, the European Working Group on Sarcopenia in Older People has expanded the definition and suggested criteria for diagnosis [12] including the presence of muscle weakness (for example handgrip strength), a lower muscle mass (determined by bioelec1960 40”
BackgroundSkeletal muscle mass and distribution in 468 men and women aged 18–88 yr
Janssen, I., Heymsfield, S. B., Wang, Z., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.81 · Cited by 3,087 · cited 1× · see citing works
“In contrast, type I muscle fiber size is largely unaffected [22,28,29].”
BackgroundStudenski, S. A., Peters, K. W., Alley, D. E., Cawthon, P. M., McLean, R. R., Harris, T. B., Ferrucci, L., Guralnik, J. M., Fragala, M. S., Kenny, A. M., et al. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu010 · Cited by 2,545 · cited 2× · see citing works
“The FNIH Sarcopenia Project Group [13] recently recommended normative values for muscle strength and lean body mass as follows: 1) grip strength in men <26 kg and in women <16 kg, or alternate grip strength adjusted for BMI <1.0 for men and <0.56 for women; and 2) appendicular lean body mass in men <19.75 kg and <15.0…”
MethodInfluentialSarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399 · cited 1× · see citing works
“The term sarcopenia was used for the first time by Rosenberg [10,11] to refer to the loss of lean body mass with aging.”
MethodSatellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · cited 1× · see citing works
“Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19-21].”
BackgroundLongitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446 · cited 1× · see citing works
“However, a direct relationship between increased intermuscular fat and age-related muscle weakness has not been established [51].”
BackgroundAging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443 · cited 3× · see citing works
“The loss of muscle mass and strength in older people is of greater magnitude in longitudinal compared to cross-sectional studies [15].”
BackgroundResultHuman aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308 · cited 1× · see citing works
“The decline in muscle mass, most prominent in the lower limbs, is accompanied by a 30% to 40% decrease in muscle fiber number between the second and eight decade [25].”
BackgroundAttenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,201 · see citing works
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148 · cited 1× · see citing works
“Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19-21].”
BackgroundGoodpaster, B. H., Kelley, D. E., Thaete, F. L., He, J., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.104 · Cited by 956 · cited 1× · see citing works
“Adipocyte infiltration Aging is associated with increases in both intra- and inter-muscular adipose tissue and it has been showed that increased muscle fat content is associated with reduced muscle strength [49,50].”
BackgroundHUGHES, V. A., Frontera, W. R., Wood, M., Evans, W. J., Dallal, G. E., Roubenoff, R., & Singh, M. A. F. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b209 · Cited by 924 · cited 1× · see citing works
“It must be noted that the loss of strength with advancing age is not a universal phenomenon and some individuals maintain muscle strength after 10 years of follow-up [17].”
BackgroundDynapenia and aging: an update
Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875 · cited 1× · see citing works
“Disruption or uncoupling at any step of this process may result in reduced muscle fiber activation, force generation, and lower whole muscle strength [41].”
BackgroundMuscle type and fiber type specificity in muscle wasting
Ciciliot, S., Rossi, C. A., Dyar, K. A., Blaauw, B., & Schiaffino, S. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.016 · Cited by 626 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · Cited by 589 · see citing works
Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle
Shefer, G., de Mark, D. P. V., Richardson, J. B., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.022 · Cited by 506 · cited 1× · see citing works
“Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19-21].”
BackgroundSatellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2006 · Cited by 489 · cited 2× · see citing works
“At the level of the individual muscle fiber, sarcopenia may be associated with a reduced number of satellite cells; especially those associated with fibers expressing type II (fast) myosin heavy chain [22].”
BackgroundThe effect of ageing and immobilization on structure and function of human skeletal muscle fibres
D’Antona, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046276 · Cited by 477 · cited 3× · see citing works
“Many molecular mechanisms have been proposed to explain such dysfunction including a reduction in myosin protein content; this may be particularly true in immobilized muscle [32].”
BackgroundSkeletal muscle fiber quality in older men and women
Frontera, W. R., Suh, D., Krivickas, L. S., HUGHES, V. A., Goldstein, R., & Roubenoff, R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c611 · Cited by 424 · cited 2× · see citing works
“The reduction in muscle fiber size is fiber type specific, with 10%–40% smaller type II fibers observed in muscle tissue collected from elderly compared with young controls [27].”
BackgroundMechanisms for fiber-type specificity of skeletal muscle atrophy
Wang, Y., & Pessin, J. E. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328360272d · Cited by 416 · cited 2× · see citing works
“pha (PGC1a) protects type I fibers from atrophy while the transforming growth factor beta (TGFb) family and the nuclear factor kappaB (NF-kB) predominantly affect type IIx fibers [39].”
BackgroundPress, J. M., & Young, J. L. (2003) · Elsevier eBooks · doi:10.1016/b978-1-56053-493-8.50021-0 · Cited by 389 · see citing works
Apoptosis in skeletal muscle with aging
Dirks, A., & Leeuwenburgh, C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00458.2001 · Cited by 377 · cited 1× · see citing works
“Further evidence has suggested that apoptosis may play a considerable role in mediating the progression of muscle fiber loss in aging [26].”
BackgroundRecovery From Disability Among Community-Dwelling Older Persons
Hardy, S. E. (2004) · JAMA · doi:10.1001/jama.291.13.1596 · Cited by 365 · see citing works
Reid, M. B., Lännergren, J., & Westerblad, H. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2202005 · Cited by 322 · see citing works
Muscle fiber size and function in elderly humans: a longitudinal study
Frontera, W. R., Reid, K. F., Phillips, E. M., Krivickas, L. S., HUGHES, V. A., Roubenoff, R., & Fielding, R. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90332.2008 · Cited by 285 · see citing works
Knee Extension Strength Cutpoints for Maintaining Mobility
Manini, T. M., Visser, M., Won‐Park, S., Patel, K. V., Strotmeyer, E. S., Chen, H., Goodpaster, B., De Rekeneire, N., Newman, A. B., Simonsick, E. M., et al. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01087.x · Cited by 249 · cited 1× · see citing works
“1-fold greater risk of mortality compared to older adults with high muscle strength [8].”
BackgroundTransitions between States of Disability and Independence among Older Persons
Hardy, S. E., Dubin, J. A., Holford, T. R., & Gill, T. M. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi083 · Cited by 249 · cited 1× · see citing works
“These findings suggest the road to disability in elderly is a dynamic process and offers several opportunities to restore function and recover independence [4-7].”
BackgroundHIONA, A. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.001 · Cited by 247 · cited 1× · see citing works
“There are two possible mechanisms underlying these intrinsic mitochondrial changes: 1) mitochondrial genome damage that accumulates over the years and leads to impaired synthesis of mitochondria or synthesis of mitochondria with impaired function [55] and 2) disruption of mitochondrial turnover—mitochondrial removal a…”
BackgroundReid, K. F., Pasha, E., Doros, G., Clark, D. J., Patten, C., Phillips, E. M., Frontera, W. R., & Fielding, R. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2728-2 · Cited by 246 · cited 2× · see citing works
“It is interesting that longitudinal studies suggest that clusters of fibers that are not lost during aging try to compensate for these agerelated differences in fiber size and quality [18,46,47] and although whole muscle performance is reduced, single muscle fiber properties may be relatively well preserved.”
BackgroundThe Dynamic Nature of Mobility Disability in Older Persons
Gill, T. M., Allore, H. G., Hardy, S. E., & Guo, Z. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00586.x · Cited by 215 · cited 2× · see citing works
“Several studies [4,5] have shown that older men and women transition more frequently from intermittent to continuous mobility limitation, than from no mobility limitation to intermittent mobility limitation.”
BackgroundAge-Related Changes in Motor Cortical Properties and Voluntary Activation of Skeletal Muscle
Clark, B. C., & Taylor, J. L. (2011) · Current Aging Science · doi:10.2174/1874609811104030192 · Cited by 201 · cited 1× · see citing works
“In contrast, type I muscle fiber size is largely unaffected [22,28,29].”
BackgroundRyu, M., Jo, J., Lee, Y., Chung, Y.-S., Kim, K.-M., & Baek, W.-C. (2013) · Age and Ageing · doi:10.1093/ageing/aft063 · Cited by 168 · see citing works
Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · cited 1× · see citing works
“There are two possible mechanisms underlying these intrinsic mitochondrial changes: 1) mitochondrial genome damage that accumulates over the years and leads to impaired synthesis of mitochondria or synthesis of mitochondria with impaired function [55] and 2) disruption of mitochondrial turnover—mitochondrial removal a…”
BackgroundSkeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training
Broskey, N. T., Greggio, C., Boss, A., Boutant, M., Dwyer, A., Schlueter, L., Hans, D., Gremion, G., Kreis, R., Boesch, C., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3983 · Cited by 157 · see citing works
Dihydropyridine Receptor-Ryanodine Receptor Uncoupling in Aged Skeletal Muscle
Renganathan, M., Messi, M. L., & Delbono, O. (1997) · The Journal of Membrane Biology · doi:10.1007/s002329900233 · Cited by 155 · cited 3× · see citing works
“The mechanism underlying this reduction includes agerelated alterations in cellular and molecular processes such as changes in the satellite cell population, excitation-contraction coupling, myofilament interaction, mitochondrial function, and adipocyte infiltration [37,38] (see below).”
BackgroundMitochondrial Involvement and Impact in Aging Skeletal Muscle
Hepple, R. T. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00211 · Cited by 155 · cited 2× · see citing works
“Apart from this intrinsic alteration in mitochondrial function, extrinsic factors known as ‘aging milieu’ including oxidative stress and muscle fiber denervation may play a very important role in mitochondrial dysfunction [54].”
BackgroundGill, T. M., & Kurland, B. F. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.1.m70 · Cited by 148 · cited 2× · see citing works
“Several studies [4,5] have shown that older men and women transition more frequently from intermittent to continuous mobility limitation, than from no mobility limitation to intermittent mobility limitation.”
BackgroundSingle Skeletal Muscle Fiber Elastic and Contractile Characteristics in Young and Older Men
Ochala, J., Frontera, W. R., Dorer, D. J., Hoecke, J. V., & Krivickas, L. S. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.375 · Cited by 145 · cited 2× · see citing works
“An increased in instantaneous stiffness (reduction in elasticity) has been reported in whole muscle as well as in single fibers [33].”
BackgroundBrady, A. O., Straight, C. R., & Evans, E. M. (2014) · Journal of Aging and Physical Activity · doi:10.1123/japa.2013-0009 · Cited by 143 · cited 1× · see citing works
“Functional changes in elderly Aging is associated with changes in body composition (increase in body fat and decreases in muscle and bone mass) which together with a decline in cognitive, visual, and hearing function, sleeping disorders, depression, and increased fatigue lead to a decline in physical function and sign…”
BackgroundEffects of ageing and gender on contractile properties in human skeletal muscle and single fibres
Yu, F., Hedström, M., Cristea, A., Dalén, N., & Larsson, L. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01699.x · Cited by 119 · see citing works
Yamada, M., Moriguch, Y., Mitani, T., Aoyama, T., & Arai, H. (2014) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12209 · Cited by 117 · see citing works
New records in aerobic power among octogenarian lifelong endurance athletes
Trappe, S. W., Hayes, E., Galpin, A. J., Kaminsky, L. A., Jemioło, B., Fink, W., Trappe, T. A., Jansson, A., Gustafsson, T. P., & Tesch, P. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01107.2012 · Cited by 111 · cited 1× · see citing works
“It is interesting to note that the loss in mitochondrial function can be partially reversed by exercise training [57].”
BackgroundElectrodiagnostic medicine, 2nd edition
Engstrom, J. W. (2003) · Muscle & Nerve · doi:10.1002/mus.10399 · Cited by 110 · see citing works
Development of Physical Disability in Older Adults
Manini, T. M. (2011) · Current Aging Science · doi:10.2174/1874609811104030184 · Cited by 107 · cited 1× · see citing works
“Several recent research studies show that other factors such as changes in central nervous system drive, peripheral nerve dysfunction, alterations in the neuromuscular junction structure and function, fat infiltration, and a number of complex cellular and molecular changes at the level of single muscle fibers impair m…”
BackgroundReid, K. F., Doros, G., Clark, D. J., Patten, C., Carabello, R. J., Cloutier, G. J., Phillips, E. M., Krivickas, L. S., Frontera, W. R., & Fielding, R. A. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2200-0 · Cited by 100 · cited 1× · see citing works
“It is interesting that longitudinal studies suggest that clusters of fibers that are not lost during aging try to compensate for these agerelated differences in fiber size and quality [18,46,47] and although whole muscle performance is reduced, single muscle fiber properties may be relatively well preserved.”
BackgroundD’Antona, G., Pellegrino, M. A., Carlizzi, C. N., & Bottinelli, R. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0402-2 · Cited by 98 · cited 1× · see citing works
“In other words, loss of muscle strength and power with aging can in part be explained by reductions in intrinsic force-generating capacity of skeletal muscle fibers [32-36].”
BackgroundExpression and Regulation of Excitation-Contraction Coupling Proteins in Aging Skeletal Muscle
Delbono, O. (2011) · Current Aging Science · doi:10.2174/1874609811104030248 · Cited by 90 · cited 2× · see citing works
“Changes in muscle fiber quality (force corrected for size) have been reported by several investigators [15,27,30,31].”
BackgroundMcKay, B. R., Ogborn, D. I., Baker, J. M., Toth, K., Tarnopolsky, M. A., & Parise, G. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2012 · Cited by 83 · cited 1× · see citing works
“org after acute exercise-induced trauma [23].”
Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers
Lowe, D. A., Thomas, D. D., & Thompson, L. V. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00008.2002 · Cited by 83 · cited 1× · see citing works
“Other than receptor changes, structural alterations of myosin causing a change in the kinetics of the crossbridge cycle, has been suggested to contribute to ageassociated muscle weakness [45].”
BackgroundRuss, D. W., Grandy, J. S., Toma, K., & Ward, C. W. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02191.x · Cited by 61 · cited 3× · see citing works
“[34] showed that older skeletal muscle exhibits a 34% reduction in its intrinsic force-generating capacity.”
BackgroundWhat Is the Role of Titin in Active Muscle?
Monroy, J. A., Powers, K. L., Gilmore, L. A., Uyeno, T. A., Lindstedt, S. L., & Nishikawa, K. C. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31824580c6 · Cited by 55 · cited 1× · see citing works
“As previously noted, the role of this important protein in muscle actions has been recently reviewed [48].”
BackgroundMyofilament Protein Alterations Promote Physical Disability in Aging and Disease
Miller, M. S., & Toth, M. J. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31828bbcd8 · Cited by 42 · cited 1× · see citing works
“Myofilament aging The importance of age-related changes at the level of the myofilaments has been recently discussed [43].”
BackgroundAnderson, A. A., Altafaj, X., Zheng, Z., Wang, Z., Delbono, O., Ronjat, M., Treves, S., & Zorzato, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.02935 · Cited by 36 · cited 3× · see citing works
“One mechanism to explain this sequence of events is the reduction in the expression of the sarcoplasmic reticulum junctional-face membrane (JP-45) [42] that alters the levels of specific dihydropyridine receptor 159www.e-arm.org subunits [38,42] interfering with the protein-protein interactions involved in excitation-…”
BackgroundDelbono, O. (2000) · PubMed · Cited by 32 · see citing works
Electron Paramagnetic Resonance Resolves Effects of Oxidative Stress on Muscle Proteins
Moen, R. J., Klein, J. C., & Thomas, D. D. (2013) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000004 · Cited by 19 · cited 1× · see citing works
“Oxidative modification of myosin may disrupt the binding of the myosin head to the actin filament and, thus, reduce the number of actin-myosin cross-bridges in the strongbinding state [44].”
BackgroundAge-Related Changes in Adult Muscle Morphology
Kostek, M. C., & Delmonico, M. J. (2011) · Current Aging Science · doi:10.2174/1874609811104030221 · Cited by 19 · cited 2× · see citing works
“Changes in muscle fiber quality (force corrected for size) have been reported by several investigators [15,27,30,31].”
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Nishikawa, H., Shiraki, M., Hiramatsu, A., Moriya, K., Hino, K., & Nishiguchi, S. (2016) · Hepatology Research · doi:10.1111/hepr.12774 · Cited by 656 · see citing works
The bystander effect contributes to the accumulation of senescent cells in vivo
da Silva, P. F. L., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja‐Grellscheid, S., Nelson, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12848 · Cited by 247 · see citing works
Roman, M. A., Rossiter, H. B., & Casaburi, R. H. (2016) · European Respiratory Journal · doi:10.1183/13993003.00347-2016 · Cited by 195 · see citing works
“Muscle size, architecture and metabolism are altered with advancing adult age.[23] Limb muscles, particularly large locomotor muscles, are 25335% smaller in older age and have more fat and connective tissue than those of younger individuals.”
BackgroundDiagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM
Kara, M., Kaymak, B., Frontera, W. R., Ata, A. M., Ricci, V., Ekiz, T., Chang, K. C., Han, D., Michail, X., Quittan, M., et al. (2021) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-2851 · Cited by 183 · see citing works
“Although it is assumed that type I fibres are protected from atrophy by the peroxisome proliferator-activated receptor-gamma coactivator 1-α (52), it has been reported that the number of type I fibres in pectoralis minor muscle decreased after 60 years of age.”
BackgroundAngulo, J., Assar, M. E., & Rodríguez‐Mañas, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.06.001 · Cited by 185 · see citing works
Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166 · see citing works
Calf circumference: clinical validation for evaluation of muscle mass in the elderly
Pagotto, V., dos Santos, K. F., Malaquias, S. G., Bachion, M. M., & Silveira, É. A. (2018) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2017-0121 · Cited by 159 · see citing works
“Human aging is accompanied by changes in body composition that include progressive decrease in muscle mass(1), termed sarcopenia in 1989 by Rosenberg(2).”
BackgroundSarcopenia and Its Implications for Metabolic Health
Hunter, G. R., Singh, H., Carter, S. J., Bryan, D. R., & Fisher, G. (2019) · Journal of Obesity · doi:10.1155/2019/8031705 · Cited by 153 · see citing works
“Interestingly, a preferential denervation of fast motor units could lead to a greater loss in number and area of Type II versus Type I motor units with aging [36].”
BackgroundMuscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment
Colón, C. J. P., Molina-Vicenty, I. L., Frontera-Rodríguez, M., García-Ferré, A., Rivera, B. P., Cintrón-Vélez, G., & Frontera-Rodríguez, S. (2018) · Journal of Biomedicine · doi:10.7150/jbm.23390 · Cited by 150 · see citing works
“Of those, approximately 400 million will be 80 years or older [5, 6].”
BackgroundIntrinsic muscle clock is necessary for musculoskeletal health
Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145 · see citing works
“A well-known feature of ageing in skeletal muscle is a shift in fibre type characterized by a decrease in the type IIB fibres with increases in the more oxidative type IIA fibres (Ciciliot et al. 2013; Miller et al. 2014; Purves-Smith et al. 2014; Miljkovic et al. 2015).”
BackgroundOsteosarcopenic Obesity: Current Knowledge, Revised Identification Criteria and Treatment Principles
Kelly, O. J., Gilman, J. C., Boschiero, D., & Ilich, J. Z. (2019) · Nutrients · doi:10.3390/nu11040747 · Cited by 127 · see citing works
Van Ancum, J. M., Scheerman, K., Jonkman, N. H., Smeenk, H. E., Kruizinga, R. C., Meskers, C. G. M., & Maier, A. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.03.006 · Cited by 118 · see citing works
The Role of Ultrasound as a Diagnostic Tool for Sarcopenia
Stringer, H. J., & Wilson, D. V. (2018) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.24 · Cited by 113 · see citing works
“Whilst a direct relationship between adipose infiltration and muscle weakness is not yet fully understood, there are several potential mechanisms explaining the phenomenon (38–41).”
Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis
Moran, J., Ramírez‐Campillo, R., & Granacher, U. (2018) · Sports Medicine · doi:10.1007/s40279-018-1002-5 · Cited by 113 · see citing works
Handgrip Strength: An Irreplaceable Indicator of Muscle Function
Lee, S. Y. (2021) · Annals of Rehabilitation Medicine · doi:10.5535/arm.21106 · Cited by 111 · see citing works
“It is an important tool for diagnosing sarcopenia and is widely used as a single indicator to represent overall muscle strength [1-4].”
MethodPotential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration
Tachtsis, B., Camera, D., & Lacham-Kaplan, O. (2018) · Nutrients · doi:10.3390/nu10030309 · Cited by 104 · see citing works
“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
BackgroundPérez, K., Ciotlos, S., McGirr, J., Limbad, C., Doi, R., Nederveen, J. P., Nilsson, M. I., Winer, D. A., Evans, W. J., Tarnopolsky, M. A., et al. (2022) · Aging · doi:10.18632/aging.204435 · Cited by 105 · see citing works
Impact of Melatonin on Skeletal Muscle and Exercise
Stacchiotti, A., Favero, G., & Rodella, L. F. (2020) · Cells · doi:10.3390/cells9020288 · Cited by 115 · see citing works
“Satellite cells Present Reduced/Absent [6,42,47]”
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature
González‐Freire, M., Semba, R. D., Ubaida‐Mohien, C., Fabbri, E., Scalzo, P., Højlund, K., Dufresne, C. P., Lyashkov, A. E., & Ferrucci, L. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12121 · Cited by 97 · see citing works
Ali, A. M., & Kunugi, H. (2020) · Foods · doi:10.3390/foods9101362 · Cited by 99 · see citing works
“Loss of lean body mass is a direct effect of the inflammatory and oxidative conditions that develop with aging [1,2]—described as inflammaging.”
BackgroundDowling, P., Gargan, S., Swandulla, D., & Ohlendieck, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032415 · Cited by 95 · see citing works
“Skeletal muscle aging can be considered a fundamental biological process that occurs in all humans of advanced age [334].”
BackgroundMitochondrial Dysfunction in Skeletal Muscle Pathologies
Abrigo, J., Simon, F., Cabrera, D., Vilos, C., & Cabello-Verrugio, C. (2019) · Current Protein & Peptide Science · doi:10.2174/1389203720666190402100902 · Cited by 88 · see citing works
Zampieri, S., Mammucari, C., Romanello, V., Barberi, L., Pietrangelo, L., Fusella, A., Mosole, S., Gherardi, G., Höfer, C., Löfler, S., et al. (2016) · Physiological Reports · doi:10.14814/phy2.13005 · Cited by 88 · see citing works
“Age-related sarcopenia is a syndrome characterized by a progressive loss of muscle mass and strength that greatly impacts on mobility and mortality in elderly persons (Hughes et al. 2001; Aagaard et al. 2010; Cruz-Jentoft et al. 2010; Mitchell et al. 2012; Bijlsma et al. 2013; Miljkovic et al. 2015).”
BackgroundKim, H.-K., & Kim, C.-H. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1348 · Cited by 85 · see citing works
“A major factor that affects muscle strength is myosteatosis because increased myosteatosis leads to changes in muscle fiber orientation and significantly impairs the force generation of muscle fibers [61].”
BackgroundMoro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110723 · Cited by 85 · see citing works
Improved efficacy of a next-generation ERT in murine Pompe disease
Xu, S., Lun, Y., Frascella, M., Garcia, A., Soska, R., Nair, A., Ponery, A. S., Schilling, A. E., Feng, J., Tuske, S. J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125358 · Cited by 88 · see citing works
“Muscle atrophy is a prominent feature in Pompe disease (45, 55, 56) as well as in other myopathies and muscular dystrophies (57), and in aging (58).”
BackgroundAli, A. M., & Kunugi, H. (2020) · Antioxidants · doi:10.3390/antiox9100937 · Cited by 82 · see citing works
Potential roles of vitamin E in age-related changes in skeletal muscle health
Chung, E., Mo, H., Wang, S. F., Zu, Y., Elfakhani, M., Rios, S. R., Chyu, M.-C., Yang, R., & Shen, C. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.09.005 · Cited by 75 · see citing works
Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte
Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 73 · see citing works
“Myosteatosis can contribute to type 2 diabetes (T2D) development and is associatedwith cardiovascularmortality (29, 30).”
BackgroundPhua, W. W. T., Wong, M. X. Y., Liao, Z., & Tan, N. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051425 · Cited by 72 · see citing works
“In aged muscles, type II glycolytic fibers, particularly type IIx, are susceptible to both atrophy and fiber type switching [180].”
BackgroundIncreased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy
Miller, S. G., Hafen, P. S., & Brault, J. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010088 · Cited by 65 · see citing works
“These decreases are mainly attributed to reductions in the average size of type II (fast) fibers, while type I (slow) fibers change to a lesser extent [127,128].”
BackgroundZullo, A., Fleckenstein, J., Schleip, R., Hoppe, K., Wearing, S. C., & Klingler, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00592 · Cited by 70 · see citing works
Advanced Glycation End-Products in Skeletal Muscle Aging
Olson, L. C., Redden, J. T., Schwartz, Z., Cohen, D. J., & McClure, M. J. (2021) · Bioengineering · doi:10.3390/bioengineering8110168 · Cited by 63 · see citing works
Evaluation of effects of aging on skeletal muscle elasticity using shear wave elastography
Şendur, H. N., Cindil, E., Cerit, M. N., Kılıç, P., Gültekin, I. İ., & Oktar, S. Ö. (2020) · European Journal of Radiology · doi:10.1016/j.ejrad.2020.109038 · Cited by 60 · see citing works
Apigenin Enhances Skeletal Muscle Hypertrophy and Myoblast Differentiation by Regulating Prmt7
Jang, Y. J., Son, H. J., Choi, Y. M., Ahn, J., Jung, C. H., & Ha, T. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20962 · Cited by 59 · see citing works
“Type 1 is an oxidative muscle fiber that contains MHC1, and type 2 is a fast oxidative/glycolytic fiber that contains MHC2A and the fast-glycolytic fiber MHC2B [39].”
BackgroundImpacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition
Luk, H., Appell, C. R., Chyu, M., Chen, C., Wang, C., Yang, R., & Shen, C. (2020) · Antioxidants · doi:10.3390/antiox9111050 · Cited by 58 · see citing works
“According to the World Health Organization, by 2050, about two billion people worldwide will be 60 years or older and approximately 400 million will be 80 years or older [9], making SC a potentially serious health issue.”
D’Souza, R. F., Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., Lee, C., Cohen, P., Cameron-Smith, D., Mitchell, C. J., et al. (2020) · Aging · doi:10.18632/aging.102944 · Cited by 55 · see citing works
“In addition to loss of muscle mass, aging is associated with a fast-to-slow fiber type shift [31].”
BackgroundLee, J. H., Jeon, J. H., & Lee, M. J. (2020) · Nutrients · doi:10.3390/nu12092597 · Cited by 56 · see citing works
“During the aging process, while slow-twitch muscle fibers (type I, which relies on aerobic respiration for muscle endurance) remain largely unchanged, the mass of fast-twitch fibers (type II, which determines muscle power) is significantly reduced via the progressive denervation and reinnervation processes [1].”
BackgroundScreening for Sarcopenia (Physical Frailty) in the COVID-19 Era
Ali, A. M., & Kunugi, H. (2021) · International Journal of Endocrinology · doi:10.1155/2021/5563960 · Cited by 55 · see citing works
“Beyond these measures, current guidelines recommend interventional studies addressing sarcopenia to assess a number of outcome indicators that take into account the progressive nature of sarcopenia [16, 76].”
BackgroundInfluentialThe biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function
Clemens, Z. J., Sivakumar, S., Pius, A., Sahu, A., Shinde, S. S., Mamiya, H., Luketich, N., Cui, J., Dixit, P. D., Hoeck, J. D., et al. (2021) · eLife · doi:10.7554/elife.61138 · Cited by 51 · see citing works
“Tissue-level features of sarcopenia have been described extensively, and include a decreased myofiber size, increased intramuscular fat accumulation, a preferential atrophy of type II (fast-twitch) muscle fibers, and compromised function (Doherty, 2003; Morley et al., 2014; Miljkovic et al., 2015).”
BackgroundMitochondrial function in skeletal myofibers is controlled by a TRF2‐SIRT3 axis over lifetime
Robin, J. D., Burbano, M. S. J., Peng, H., Croce, O., Thomas, J. L., Laberthonnìère, C., Renault, V. M., Lototska, L., Pousse, M., Tessier, F., et al. (2020) · Aging Cell · doi:10.1111/acel.13097 · Cited by 51 · see citing works
“…NADH-TR staining in downregulated TERF2 myotubes (Figure S5b), suggesting a switch from glycolytic (fast, type II) toward oxidative (slow, type I) fibers, the latter being associated with development, aging, and stronger resistance to oxidative stress (Lexell, 1995; Miljkovic et al., 2015).”
BackgroundMethodInfluentialSukari, A. W., Muqbil, I., Mohammad, R. M., Philip, P. A., & Azmi, A. S. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.01.002 · Cited by 50 · see citing works
“The number of fibers in a muscle and the size of fibers remain relatively stable from puberty until the fifth decade of life, at which point a noticeable decline in muscle fiber number and size begins [15].”
BackgroundMelatonin as a Potential Agent in the Treatment of Sarcopenia
Coto‐Montes, A. M., Boga, J. A., Tan, D., & Reiter, R. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101771 · Cited by 51 · see citing works
“Eventually, sarcopenia is related to adipocyte infiltration with increases in both intra- and inter-muscular adipose tissue which significantly contributes to the decline in muscle quality [21].”
BackgroundAChRs Degeneration at NMJ in Aging-Associated Sarcopenia–A Systematic Review
Bao, Z., Cui, C., Chow, S. K., Qin, L., Wong, R. M. Y., & Cheung, W. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.597811 · Cited by 49 · see citing works
“Notably, sarcopenia is also accompanied with obviously smaller type II fibers and commonly unaffected type I fibers (Miljkovic et al., 2015).”
BackgroundNeuromuscular junction transmission failure is a late phenotype in aging mice
Chugh, D., Iyer, C. C., Wang, X., Bobbili, P. J., Rich, M. M., & Arnold, W. D. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.022 · Cited by 48 · see citing works
Morphological and Functional Aspects of Human Skeletal Muscle
Trovato, F., Imbesi, R., Conway, N., & Castrogiovanni, P. (2016) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk1030289 · Cited by 41 · see citing works
“In age-related sarcopenia, a reduced number of satellite cells have been highlighted [66,67].”
BackgroundHart, C. R., Layec, G., Trinity, J. D., Kwon, O. S., Zhao, J., Reese, V. R., Gifford, J. R., & Richardson, R. S. (2018) · Experimental Physiology · doi:10.1113/ep086905 · Cited by 44 · see citing works
Lee, M. J., Kim, H., Kim, E. H., Bae, S. J., Kim, K. W., Kim, M.-J., & Choe, J. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315054 · Cited by 44 · see citing works
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Zhang, F., Wu, H.-F., Wang, K., Yu, D., Zhang, X.-Z., Ren, Q., Chen, W., Lin, F., Yu, Z., & Zhuang, C.-L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06851-y · Cited by 42 · see citing works
Sinclair, A. J., Pennells, D., & Abdelhafiz, A. H. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02142-8 · Cited by 44 · see citing works
“With increasing age, there is increased atrophy of type II muscle fibres that accounts for the majority of body muscle loss [49, 50].”
BackgroundAge-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Li, D., Rudloff, S., Langer, H., Norman, K., & Herpich, C. (2024) · Cells · doi:10.3390/cells13030255 · Cited by 39 · see citing works
“…trained middle-age, then young trained males [17] Here, the results hint that training status may benefit older athletes in recovery, but the impacts of external Similarly, in another subset of trained young and old men, the therapeutic applications (i.e., nutrition and exercise) are out of the”
Dankel, S. J., Kang, M., Abe, T., & Loenneke, J. P. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-4022-9 · Cited by 41 · see citing works
Lee, C., Woods, P. C., Paluch, A. E., & Miller, M. S. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00347.2024 · Cited by 40 · see citing works
YALVAÇ, M. E., Amornvit, J., Chen, L., Shontz, K. M., Lewis, S., & Sahenk, Z. (2018) · Gene Therapy · doi:10.1038/s41434-018-0009-8 · Cited by 40 · see citing works
Vitamin D 3 supplementation does not enhance the effects of resistance training in older adults
Mølmen, K. S., Hammarström, D., Pedersen, K. K., Lie, A. C. L., Steile, R. B., Nygaard, H., Khan, Y., Hamarsland, H., Koll, L., Hanestadhaugen, M., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12688 · Cited by 40 · see citing works
“older adults, for whom larger spatial heterogeneity are present in muscle fibre characteristics compared with young adults,(110) possibly relating to the age-related remodeling of motor units.(111) Despite these issues, the data provided sufficient resolution to disclose marked increases in muscle fibre CSA and change…”
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
Lim, J., & Frontera, W. R. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04924-4 · Cited by 40 · see citing works
“Chemical alterations of the myofilaments include posttranslational modifications such as protein methylation, glycosylation, phosphorylation, carbonylation, and oxidation (Miljkovic et al. 2015).”
BackgroundInfluentialNeural and musculotendinous mechanisms underpinning age-related force reductions
Orssatto, L. B. R., Wiest, M. J., & Diefenthaeler, F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.06.005 · Cited by 52 · see citing works
Metabolic Impact of Frailty Changes Diabetes Trajectory
Sinclair, A. J., & Abdelhafiz, A. H. (2023) · Metabolites · doi:10.3390/metabo13020295 · Cited by 42 · see citing works
“Increasing age is also associated with significant type II muscle fibres atrophy, which accounts for most of the muscle loss in old age [61,62].”
BackgroundThe Prospect of the Fourth Industrial Revolution and Home Healthcare in Super-Aged Society
Lee, J.-Y., & Lim, J. (2017) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.2017.21.3.95 · Cited by 37 · see citing works
Relationship Between Low Handgrip Strength and Chronic Kidney Disease: KNHANES 2014-2017
Lee, Y. L., Jin, H., Lim, J., & Lee, S. Y. (2020) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.03.002 · Cited by 37 · see citing works
Serrano, N., Hyatt, J. K., Houmard, J. A., Murgia, M., & Katsanos, C. S. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2023 · Cited by 36 · see citing works
Relationship between serum vitamin D level and sarcopenia in chronic liver disease
Okubo, T., Atsukawa, M., Tsubota, A., Yoshida, Y., Arai, T., Iwashita, A., Itokawa, N., Kondo, C., & Iwakiri, K. (2020) · Hepatology Research · doi:10.1111/hepr.13485 · Cited by 36 · see citing works
Prdx6 Plays a Main Role in the Crosstalk between Aging and Metabolic Sarcopenia
Pacifici, F., Della‐Morte, D., Piermarini, F., Arriga, R., Scioli, M. G., Capuani, B., Pastore, D., Coppola, A., Rea, S., Donadel, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9040329 · Cited by 36 · see citing works
“In particular, Prdx4 may protect from diabetes and its chronic complications, by reducing oxidative stress levels [45].”
Assessing the Effects of Aging on Muscle Stiffness Using Shear Wave Elastography and Myotonometer
Do, Y., Lall, P. S., & Lee, H. (2021) · Healthcare · doi:10.3390/healthcare9121733 · Cited by 36 · see citing works
“In the present study, the relationship was stronger in young adults than in older adults in the MG and TA at rest and under contraction, which is evident from the contractility of muscle fibers, the muscle mass, and the total amount that force generation decreases with aging due to structural changes in the skeletal m…”
BackgroundMüller, D. C., Izquierdo, M., Boeno, F. P., Aagaard, P., Teodoro, J. L., Grazioli, R., Radaelli, R., Bayer, H., Neske, R., Pinto, R. S., et al. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04355-z · Cited by 35 · see citing works
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats
Das, M. M., Avalos, P., Suezaki, P., Godoy, M. I., Garcia, L., Chang, C. D., Vit, J., Shelley, B., Gowing, G., & Svendsen, C. N. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.023 · Cited by 34 · see citing works
Toyoda, H., Hoshino, M., Ohyama, S., Terai, H., Suzuki, A., Yamada, K., Takahashi, S., Hayashi, K., Tamai, K., Hori, Y., et al. (2018) · European Spine Journal · doi:10.1007/s00586-018-5858-8 · Cited by 33 · see citing works
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values
Lee, Y. L., Lee, B. H., & Lee, S. Y. (2019) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.19.0042 · Cited by 33 · see citing works
“Ann Geriatr Med Res 2019;23(4):183-189 185 Handgrip Strength in Korean”
BackgroundInfluentialHerbst, A. J., Prior, S. J., Lee, C. C., Aiken, J. M., McKenzie, D. I., Hoang, A. N., Liu, N., Chen, X., Xun, P., Allison, D. B., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00351-z · Cited by 33 · see citing works
Diet and exercise in frailty and sarcopenia. Molecular aspects
Millan-Domingo, F., Garcia-Dominguez, E., Gambini, J., Olaso-Gonzalez, G., Viña, J., & Gomez-Cabrera, M. C. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101322 · Cited by 31 · see citing works
Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration
Rajabian, N., Shahini, A., Asmani, M., Vydiam, K., Choudhury, D., Nguyen, T. M., Ikhapoh, I. A., Zhao, R., Lei, P., & Andreadis, S. T. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0005 · Cited by 32 · see citing works
“With aging, these cells lose their proliferation and differentiation potential, and SkM tissues exhibit decreased fiber number, volume, and contractile protein content, and dysregulated calcium flux, leading to significantly impaired contractile force generation.(7) Consequently, senescent SkM develops sarcopenia and…”
BackgroundWhy Fast Velocity Resistance Training Should Be Prioritized for Elderly People
Orssatto, L. B. R., Cadore, E. L., Andersen, L. L., & Diefenthaeler, F. (2018) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000407 · Cited by 31 · see citing works
“(36,37) including muscle atrophy and loss of maxima l strength, muscle power output, and explosive force (33,35,52).”
Exercise capacity, physical activity, and morbidity
Brunjes, D. L., Kennel, P. J., & Schulze, P. C. (2017) · Heart Failure Reviews · doi:10.1007/s10741-016-9592-1 · Cited by 31 · see citing works
Gargallo, P., Tamayo-Torres, E., Jiménez‐Martínez, P., Juesas, Á., Casaña, J., Benítez-Martínez, J. C., Gené‐Morales, J., Garrido, J. F., Sáez, G. T., & Colado, J. C. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112340 · Cited by 30 · see citing works
“Considering its significance in diagnosing sarcopenia and predicting mortality (Miljkovic et al., 2015), the improvement in manual dynamometry is crucial for older adults.”
Yamada, S., Tsuruya, K., Yoshida, H., Tokumoto, M., Ueki, K., Ooboshi, H., & Kitazono, T. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0118-6 · Cited by 30 · see citing works
Chen, Z.-T., Jin, F.-S., Guo, L.-H., Li, X.-L., Wang, Q., Zhao, H., Sun, L.-P., & Xu, H.-X. (2023) · European Radiology · doi:10.1007/s00330-022-09382-2 · Cited by 29 · see citing works
“It is considered one of the main causes of depression, social isolation, frailty, and invalidity, which places an increasing burden on public health and social services [2, 3].”
BackgroundLean, fast and strong: Determinants of functional performance in the elderly
Orssatto, L. B. R., Bezerra, E. S., Schoenfeld, B. J., & Diefenthaeler, F. (2020) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2020.105073 · Cited by 28 · see citing works
Microstructural analysis of skeletal muscle force generation during aging
Zhang, Y., Chen, J., He, Q., He, X., Basava, R. R., Hodgson, J. A., Sinha, U. S., & Sinha, S. (2019) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.3295 · Cited by 28 · see citing works
“Apart from the microstructural changes in the passive components, the loss of muscle's force generation capacity can result from other age-associated factors, such as the decreased force generation capacity of muscle fibers.(62) It was reported that the specific force generated by muscle fiber decreases by around 30%…”
BackgroundAli, A. M., & Kunugi, H. (2021) · BioMed · doi:10.3390/biomed1010002 · Cited by 28 · see citing works
“Evidence denotes that biological aging of human skeletal muscle is not necessarily related to chronological aging—loss of muscle mass can start as early as the second decade of life, and it is exacerbated by muscle inactivity associated with a sedentary lifestyle [2,3,15].”
BackgroundLim, J., & Frontera, W. R. (2023) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2023.111559 · Cited by 27 · see citing works
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
Malhan, D., Yalçın, M., Schoenrock, B., Blottner, D., & Relógio, A. (2023) · npj Microgravity · doi:10.1038/s41526-023-00273-4 · Cited by 27 · see citing works
From molecular to physical function: The aging trajectory
Janssen, T. A. H., Lowisz, C. V., & Phillips, S. M. (2024) · Current Research in Physiology · doi:10.1016/j.crphys.2024.100138 · Cited by 28 · see citing works
“A reduction in myosin protein content and post-translational modifications may disrupt the mechanism of contraction at the cross-bridge level (Miljkovic et al., 2015).”
Responsiveness to muscle mass gain following 12 and 24 weeks of resistance training in older women
Nunes, J. P., Pina, F. L. C., Ribeiro, A. S., Cunha, P. M., Kassiano, W., Costa, B. D. V., Kunevaliki, G., do Nascimento, M. A., Carneiro, N. H., Venturini, D., et al. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01587-z · Cited by 26 · see citing works
“This seems to be plausible in older women since the aging process leads to a reduction in the innervation of high-threshold fibers and decrease in the proportion of type II fibers [24], which might explain the small improvements or absence of gains in SMM in N-RP individuals.”
BackgroundCamerino, G. M., Bellis, M. D., Conte, E., Liantonio, A., Musaraj, K., Cannone, M., Fonzino, A., Giustino, A., Luca, A. D., Romano, R., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.032 · Cited by 26 · see citing works
Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women
Park, H. M. (2018) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.2018.22.2.52 · Cited by 25 · see citing works
Association between echo intensity of the tongue and its thickness and function in elderly subjects
Ariya, C., Tohara, H., Nakagawa, K., Hara, K., Nakane, A., Yamaguchi, K., Yoshimi, K., Furuya, J., & Minakuchi, S. (2019) · Journal of Oral Rehabilitation · doi:10.1111/joor.12788 · Cited by 25 · see citing works
Fritzen, A. M., Thøgersen, F. B., Qadri, K. A. N., Krag, T. O. B., Sveen, M., Vissing, J., & Jeppesen, T. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072188 · Cited by 25 · see citing works
Long, D. E., Peck, B. D., Tuggle, S. C., Villasante Tezanos, A. G., Windham, S. T., Bamman, M. M., Kern, P. A., Peterson, C. A., & Walton, R. G. (2021) · GeroScience · doi:10.1007/s11357-020-00315-9 · Cited by 25 · see citing works
Mobley, C. B., Mumford, P. W., Kephart, W. C., Haun, C. T., Holland, A. M., Beck, D. T., Martin, J. S., Young, K. C., Anderson, R. G., Patel, R. K., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00518 · Cited by 24 · see citing works
“Hence, these data collectively suggest a potential fiber type shift in the plantaris muscle whereby older rats may lose type IIa fibers thereby increasing the proportion of type I fibers, and this phenomena has been reported in past human (Miljkovic et al., 2015) and rodent literature (Putman et al.”
BackgroundKrumpolec, P., Klepochová, R., Just, I., Jelenc, M. T., Frollo, I., Ukropec, J., Ukropcová, B., Trattnig, S., Krššák, M., & Valkovič, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00644 · Cited by 24 · see citing works
“With the average age of the earth’s population increasing steadily, incidence of chronic diseases, and prevalence of impairments and disabilities increases as well (Miljkovic et al., 2015).”
BackgroundAbdelhafiz, A. H., Emmerton, D., & Sinclair, A. J. (2021) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14214 · Cited by 24 · see citing works
Markotegi, M., Irazusta, J., Sanz, B., & Rodriguez‐Larrad, A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111580 · Cited by 24 · see citing works
Sawaya, Y., Ishizaka, M., Akira, K. U. B. O., Sadakiyo, K., Yakabi, A., Sato, T., Shiba, T., Onoda, K., & Maruyama, H. (2018) · Journal of Physical Therapy Science · doi:10.1589/jpts.30.1424 · Cited by 23 · see citing works
Castillo-Mariqueo, L., Pérez‐García, M. J., & Giménez‐Llort, L. (2021) · Biomedicines · doi:10.3390/biomedicines9101365 · Cited by 23 · see citing works
Abdelhafiz, A. H., & SINCLAIR, A. J. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108144 · Cited by 22 · see citing works
Essex, A. L., Huot, J. R., Deosthale, P. J., Wagner, A., Figueras, J. H., Davis, A., Damrath, J. G., Pin, F., Wallace, J. M., Bonetto, A., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4572 · Cited by 21 · see citing works
“Aging skeletal muscle is known to undergo fiber-type–specific changes, primarily affecting glycolytic, Type II fibers which are the predominant fiber type found in the EDL.((74,75)) These Type II fibers that make up the majority of the EDL have been shown to express more Activin receptor type-2B (ACVRIIB) receptors fo…”
BackgroundOh, H., Jin, H., & Lee, B.-Y. (2023) · Cells · doi:10.3390/cells12152015 · Cited by 23 · see citing works
Wen, D., Zheng, L., Ni, L., Wang, H., Feng, Y., & Zhang, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.006 · Cited by 23 · see citing works
“…decline in locomotor ability including the ability to walk because aging profoundly affects skeletal muscle, including loss ofmusclemass and strength and increasing the levels of fat and connective tissue (Miljkovic et al., 2015; Flachsbart et al., 2009; Suh et al., 2008; Willcox et al., 2008).”
Nishiguchi, S., Hino, K., Moriya, K., Shiraki, M., Hiramatsu, A., & Nishikawa, H. (2016) · Kanzo · doi:10.2957/kanzo.57.353 · Cited by 22 · see citing works
Olson, L. C., Nguyen, T., Heise, R. L., Boyan, B. D., Schwartz, Z., & McClure, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168832 · Cited by 22 · see citing works
“Slow‐twitch mus‐ cle fibers are known to increase relative to fast‐twitch muscle fibers with age, especially in sarcopenia [85,86].”
Background
- Authors
- Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R.
- Affiliations
- Vanderbilt University (US)
- Seoul National University (KR)
- University of Pittsburgh (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Frontera, Walter R.
- Venue
- Annals of Rehabilitation Medicine
- Published
- 2015
- Volume
- 39
- Issue
- 2
- Pages
- 155
- ISSN
- 2234-0645 (ISSN-L)
- 2234-0653
- PMC
- PMC4414960
- OpenAlex
- W2049942632
- Cited by
- 309
- References
- 58
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 32 · 2023: 30 · 2022: 24 · 2021: 42 · 2020: 44 · 2019: 28 · 2018: 30 · 2017: 14 · 2016: 23 · 2015: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Annals of Rehabilitation Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle fiber atrophy, muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridges, muscle energy metabolism, muscle regeneration, muscle architecture, functional capacity decline, exercise training intervention
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