Exercise overcome adverse effects among prostate cancer patients receiving androgen deprivation therapy: An update meta-analysis
Open accessAbstract
BACKGROUND: Prostate cancer (PCa) patients initiating androgen deprivation therapy (ADT) are suffering from adverse effects; exercise has been proposed as a treatment to relieve adverse effects of ADT, available meta-analysis has proved exercise improves quality of life, and therapy caused fatigue; recently, some high-quality trials have been conducted in order to get more assessment; we conduct an updated meta-analysis to evaluate feasibility that exercise relieves adverse effects in PCa patients initiating ADT. MATERIALS AND METHODS: A systematic article search was performed from Cochrane Library, MEDLINE, EMBASE, and PubMed databases up to March 10, 2017. Outcomes included changes in body composition, physical function, bone health and cardiometabolic changes. We conduct subgroup analysis to analyze the duration and type of exercise correlated with the effect and calculated using standard mean difference (SMD) and corresponding 95% confidence intervals (CI). RESULT: Fifteen studies involving 1135 patients were included in our meta-analysis, and significant positive effects were found in body strength (leg press (SMD: 0.78 (95%CI: 0.57-0.99, P <.00001, I = 0%)), chest press (SMD: 0.71 (95%CI: 0.50-0.92, P <.00001, I = 0%)), exercise tolerance (VO2 peak SMD: 0.35 (95%CI: 0.04-0.66, P = .03, I = 0%) in 6 months and SMD: 0.59 (95%CI: 0.16-1.03, P = .007, I = 0% over 6 months)), fatigue (SMD: 0.84 (95%CI: -1.43 to 3.10, P = .85, I = 51%) in 6 months and SMD: -9.3 (95%CI: -16.22 to -2.39, P = .0030, I = 49%) over 6 months)), ADT-caused obesity (body mass index SMD: -0.33 (95%CI: -0.55 to -0.12, P = .002, I = 38% in 6 months and SMD: -0.59 95%CI: -1.02 to 0.17, P = .006, I = 25% over 6 months)), and sex function (SMD: 0.66 (95%CI: 0.35-0.97, P <.00001, I = 2%). There were no evidence of benefit for cardiometabolic changes and bone health. No systematic difference was observed between resistance exercise training (RET) and aerobic exercise training (AET) in ADT-caused obesity, fatigue, and exercise tolerance CONCLUSION:: Exercise can significantly improve the upper and lower muscle strength, increase exercise tolerance, help PCa patients receiving ADT control their body fat mass, BMI, and keep the sex function. ADT-related fatigue is correlated with exercise duration time. No differences were observed in LBM, bone mineral density, and any other metabolic blood markers. Available data show that there is no difference between AET and RET.
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Cites
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · see citing works
Physical Activity and Bone Health
Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E., & Yingling, V. R. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000142662.21767.58 · Cited by 1,043 · see citing works
Adverse Effects of Androgen Deprivation Therapy and Strategies to Mitigate Them
Nguyen, P. L., Alibhai, S. M. H., Basaria, S. S., D'Amico, A. V., Kantoff, P. W., Keating, N. L., Penson, D. F., Rosario, D. J., TOMBAL, B. F., & Smith, M. R. (2014) · European Urology · doi:10.1016/j.eururo.2014.07.010 · Cited by 842 · see citing works
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695 · see citing works
Galvão, D. A., Taaffe, D. R., Spry, N., Joseph, D., & Newton, R. U. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.2488 · Cited by 657 · see citing works
Keating, N. L., O'Malley, A. J., Freedland, S. J., & Smith, M. R. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp404 · Cited by 622 · see citing works
Segal, R. J., Reid, R. D., Courneya, K. S., Sigal, R. J., Kenny, G. P., Prud'Homme, D. G., Malone, S. C., Wells, G. A., Scott, C. G., & Slovinec D'Angelo, M. E. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.4963 · Cited by 554 · see citing works
Exercise for men with prostate cancer: a systematic review and meta-analysis
Bourke, L., Smith, D., Steed, L., Hooper, R., Carter, A., Catto, J., Albertsen, P. C., Tombal, B., Payne, H. A., & Rosario, D. J. (2016) · European Urology · doi:10.1016/j.eururo.2015.10.047 · Cited by 300 · see citing works
Physical exercise and clinically depressed patients: a systematic review and meta-analysis
Silveira, H., Moraes, H., Oliveira, N., Coutinho, E. S. F., Laks, J., & Deslandes, A. (2013) · Neuropsychobiology · doi:10.1159/000345160 · Cited by 279 · see citing works
Cormie, P., Galvao, D. A., Spry, N. A., Joseph, D. J., Chee, R., Taaffe, D. R., Chambers, S. K., & Newton, R. U. (2014) · British Journal of Urology · doi:10.1111/bju.12646 · Cited by 277 · see citing works
Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer
Galvao, D. A., Spry, N. A., Taaffe, D. R., Newton, R. U., Stanley, J., Shannon, T., Rowling, C., & Prince, R. L. (2008) · British Journal of Urology · doi:10.1111/j.1464-410x.2008.07539.x · Cited by 270 · see citing works
Contemporary Role of Androgen Deprivation Therapy for Prostate Cancer
Pagliarulo, V., Sergio Bracarda, A., Eisenberger, M. A., Mottet, N., Schröder, F. H., Sternberg, C. N., & Studer, U. E. (2011) · European Urology · doi:10.1016/j.eururo.2011.08.026 · Cited by 265 · see citing works
Culos-Reed, S. N., Robinson, J. W., Lau, H., Stephenson, L., Keats, M. R., Norris, S., Kline, G. A., & Faris, P. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-009-0694-3 · Cited by 210 · see citing works
Galvao, D. A., Spry, N. A., Denham, J. W., Taaffe, D. R., Cormie, P., Joseph, D. J., Lamb, D. S., Chambers, S. K., & Newton, R. U. (2013) · European Urology · doi:10.1016/j.eururo.2013.09.041 · Cited by 198 · see citing works
Taaffe, D. R., Newton, R. U., Spry, N. A., Joseph, D. J., Chambers, S. K., Gardiner, R. A., Wall, B., Cormie, P., Bolam, K. A., & Galvao, D. A. (2017) · European Urology · doi:10.1016/j.eururo.2017.02.019 · Cited by 165 · see citing works
Bourke, L., Doll, H., Crank, H., Daley, A., Rosario, D. J., & Saxton, J. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-1143 · Cited by 163 · see citing works
Nilsen, T. S., Raastad, T., Skovlund, E., Courneya, K. S., Langberg, C. W., Lilleby, W. A., Fosså, S. D., & Thorsen, L. (2015) · Acta Oncologica · doi:10.3109/0284186x.2015.1037008 · Cited by 142 · see citing works
Survivorship and Improving Quality of Life in Men with Prostate Cancer
Bourke, L., Boorjian, S. A., Briganti, A., Klotz, L. H., Mucci, L. A., Resnick, M. J., Rosario, D. J., Skolarus, T. A., & Penson, D. F. (2015) · European Urology · doi:10.1016/j.eururo.2015.04.023 · Cited by 121 · see citing works
Wadhwa, V. K., Weston, R., Mistry, R., & Parr, N. J. (2009) · British Journal of Urology · doi:10.1111/j.1464-410x.2009.08483.x · Cited by 117 · see citing works
Skeletal Response to Resistance and Impact Training in Prostate Cancer Survivors
Winters‐Stone, K. M., DOBEK, J. C., Bennett, J. A., Maddalozzo, G. F., Ryan, C. W., & Beer, T. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000265 · Cited by 106 · see citing works
Alibhai, S. M. H., Duong-Hua, M., Cheung, A. M., Sutradhar, R., Warde, P. R., Fleshner, N. E., & Paszat, L. F. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.04.068 · Cited by 105 · see citing works
Londen, G. J. V., Levy, M. E., Perera, S., Nelson, J. B., & Greenspan, S. L. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2008.06.006 · Cited by 101 · see citing works
Bosco, C., Crawley, D., Adolfsson, J., Rudman, S. M., & Hemelrijck, M. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117344 · Cited by 83 · see citing works
A Randomized Trial of Aerobic versus Resistance Exercise in Prostate Cancer Survivors
Mina, D. S., Alibhai, S. M. H., Matthew, A., Guglietti, C. L., Pirbaglou, M., Trachtenberg, J., & Ritvo, P. (2013) · Journal of Aging and Physical Activity · doi:10.1123/japa.21.4.455 · Cited by 76 · see citing works
Storer, T. W., Miciek, R., & Travison, T. G. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.104 · Cited by 70 · see citing works
Sajid, S., Dale, W., Mustian, K. M., Kotwal, A., Heckler, C. E., Porto, M., Fung, C., & Mohile, S. G. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.02.002 · Cited by 66 · see citing works
COBELLI, O. D., Terracciano, D., Tagliabue, E., et al. (2015) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2015.02.004 · Cited by 64 · see citing works
Hvid, T., Lindegaard, B., Winding, K. M., Iversen, P., Brasso, K., Solomon, T. P. J., Pedersen, B. K., & Højman, P. (2015) · Cancer Causes & Control · doi:10.1007/s10552-015-0694-1 · Cited by 62 · see citing works
Ferro, M., Lucarelli, G. T., Bruzzese, D., Lorenzo, G. D., Perdonà, S., Riccardo Autorino, B., Cantiello, F., Rocca, R. L., Busetto, G. M., Cimmino, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12906 · Cited by 59 · see citing works
Hojan, K., Kwiatkowska-Borowczyk, E. P., Leporowska, E., et al. (2017) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.3888 · Cited by 53 · see citing works
Bagley, L., Slevin, M., Bradburn, S., Liu, D., Murgatroyd, C., Morrissey, G., Carroll, M., Piasecki, M., Gilmore, W. S., & McPhee, J. S. (2016) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2015-000056 · Cited by 52 · see citing works
Acquired Resilience: An Evolved System of Tissue Protection in Mammals
Stone, J., Mitrofanis, J., Johnstone, D. M., Falsini, B., Bisti, S., Adam, P., Bravo‐Nuevo, A., George‐Weinstein, M., Mason, R. S., & Eells, J. T. (2018) · Dose-Response · doi:10.1177/1559325818803428 · Cited by 51 · see citing works
Zopf, E. M., Bloch, W., Machtens, S. A., Zumbe, J., Rubben, H., Marschner, S., Kleinhorst, C., Schulte-Frei, B., Herich, L., Felsch, M., et al. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415583552 · Cited by 42 · see citing works
Gaskin, C. J., Fraser, S. F., Owen, P. J., Craike, M. J., Orellana, L., & Livingston, P. M. (2016) · Journal of Cancer Survivorship · doi:10.1007/s11764-016-0543-6 · Cited by 36 · see citing works
The Quality-of-Life Impact of Prostate Cancer Treatments
Singh, J. K., Trabulsi, E. J., & Gomella, L. G. (2010) · Current Urology Reports · doi:10.1007/s11934-010-0103-y · Cited by 33 · see citing works
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CAMPBELL, K. L., WINTERS-STONE, K. M., WISKEMANN, J., MAY, A. M., SCHWARTZ, A. L., COURNEYA, K. S., ZUCKER, D. S., MATTHEWS, C. E., LIGIBEL, J. A., GERBER, L. H., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002116 · Cited by 2,988 · see citing works
Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline
Ligibel, J. A., Bohlke, K., May, A. M., Clinton, S. K., Demark-Wahnefried, W., Gilchrist, S. C., Irwin, M. L., Late, M., Mansfield, S., Marshall, T. F., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.00687 · Cited by 700 · see citing works
Fuller, J. T., Hartland, M. C., Maloney, L. T., & Davison, K. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-098285 · Cited by 199 · see citing works
- Authors
- Yunfeng, G., Weiyang, H., Xueyang, H., Yilong, H., & Xin, G.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Corresponding author
- Xin, Gou
- Venue
- Medicine
- Published
- 2017-07
- Volume
- 96
- Issue
- 27
- Pages
- e7368
- ISSN
- 0025-7974 (ISSN-L)
- PMC
- PMC5502159
- OpenAlex
- W2730614541
- Cited by
- 60
- References
- 36
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 6 · 2022: 15 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 8
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nd
- Locations
- Medicine (publishedVersion, cc-by-nd)
- PubMed Central (publishedVersion, cc-by-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- prostate cancer, androgen deprivation therapy, physical activity, fatigue, body composition, muscle strength, physical function, bone health, cardiometabolic risk, exercise tolerance, quality of life, resistance training, aerobic exercise, body mass index, bone mineral density, lipid profile, blood pressure, heart rate, peak oxygen uptake, cancer cachexia
- MeSH terms
- Androgen Antagonists, Combined Modality Therapy, Exercise Therapy, Humans, Male, Prostatic Neoplasms, Antineoplastic Agents, Hormonal
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