The treatment modalities of masticatory muscle pain a network meta-analysis
Open accessAbstract
Background: Numerous treatment modalities have been attempted for masticatory muscle pain in patients with temporomandibular disorders (TMD). To compare the treatment efficacy of more than 2 competing treatments, a network meta-analysis (NMA) was conducted. Methods: This study was reported with reference to the extended Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting of systematic reviews incorporating network meta-analyses. Medline via Pubmed, Embase via OVID, and Cochrane Library Central were searched (up to February 11, 2019). Axis I protocol of Diagnostic Criteria or Research Diagnostic Criteria for Temporomandibular Disorders (DC/TMD, RDC/TMD) were chosen as diagnostic standards. The PICOS (Problem/patient, Intervention, Comparison, Outcome, Study design) method was used to screen trials under eligibility criteria. And the NMA was performed with mvmeta commands in Stata (StataCorp, Tex). Results: Of 766 studies searched, 12 randomized clinical trials (RCTs) were finally included. Nineteen different therapies were found and further categorized into 9 treatment modalities. The general heterogeneity was not found among included trials. But predictive intervals (PrIs) were conspicuously wider than confidential intervals (CIs) of all pairwise comparisons, indicating that heterogeneity may exist between studies. Complementary therapy showed the greatest probability (42.7%) to be the best intervention. It also had the highest mean rank (2.3) in the rankogram and the biggest value of surface under the cumulative ranking (SUCRA, 84.1%). Conclusions: Based on the limited evidence of available trials, complementary therapy seemed to be slightly more effective than remaining treatment modalities for pain reduction in TMD patients with masticatory muscle pain. High-quality randomized controlled trials are expected to validate the findings.
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There have been nine prior network meta-analyses of interventions for chronic temporomandibular disorder pain.
“There have been nine prior network meta-analyses (NMAs) of interventions for chronic TMD pain.[6][7][8][9][10][11][12][13][14]”
From Management of chronic pain secondary to temporomandibular disorders: a systematic review and network meta-analysis of randomised trials (2023) · cites this paper as [8]
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- Authors
- Feng, J., Luo, M., Ma, J., Tian, Y., Han, X., & Bai, D.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Bai, Ding
- Venue
- Medicine
- Published
- 2019-11
- Volume
- 98
- Issue
- 46
- Pages
- e17934
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC6867722
- OpenAlex
- W2987522976
- Cited by
- 23
- References
- 54
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
- Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
- Keywords
- masticatory muscle pain, temporomandibular disorders, treatment efficacy, complementary therapy, analgesia, treatment comparison, randomized controlled trials
- MeSH terms
- Complementary Therapies, Analgesics, Botulinum Toxins, Humans, Masticatory Muscles, Temporomandibular Joint Disorders, Randomized Controlled Trials as Topic
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