The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Androgen deficiency, diabetes, and the metabolic syndrome in men
Abstract
PURPOSE OF REVIEW: The burden of androgen deficiency in men with diabetes and the metabolic syndrome has become increasingly apparent in population-based studies. This article focuses on the mechanisms underlying the interdependent relationship between these conditions. RECENT FINDINGS: Various definitions of hypogonadism, the metabolic syndrome and diabetes have been proposed and are used in the literature. Cross-sectional studies have found that between 20 and 64% of men with diabetes have hypogonadism, with higher prevalence rates found in the elderly. Hypogonadism can be a risk factor for the development of diabetes and the metabolic syndrome through various mechanisms including changes in body composition; androgen receptor polymorphisms; glucose transport; and reduced antioxidant effect. Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or Leydig cell testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess. SUMMARY: The relationship between diabetes, the metabolic syndrome and androgen deficiency is complex. Testosterone supplementation, by either oral or intramuscular routes and through exogenous or endogenous delivery, has a promising role in this population although further clinical trials are needed.
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Cites
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
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Prevalence of hypogonadism in males aged at least 45 years: the HIM study
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Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes
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Association of Specific Symptoms and Metabolic Risks with Serum Testosterone in Older Men
Zitzmann, M., Faber, S., & Nieschlag, E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0401 · Cited by 552
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Cited by
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867
Golden, S. H., Robinson, K. A., Saldanha, I., Anton, B., & Ladenson, P. W. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2291 · Cited by 542
Heufelder, A. E., Saad, F., Bunck, M. C., & Gooren, L. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.007005 · Cited by 349
Meacham, L. R., Sklar, C. A., Li, S., Liu, Q., Gimpel, N., Yasui, Y., Whitton, J. A., Stovall, M., Robison, L. L., & Oeffinger, K. C. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.209 · Cited by 339
Metadata
- Authors
- Kalyani, R. R., & Dobs, A. S.
- Venue
- Current Opinion in Endocrinology, Diabetes & Obesity
- Published
- 2007-06
- Volume
- 14
- Issue
- 3
- Pages
- 226-234
- ISSN
- 1752-296X (ISSN-L)
- OpenAlex
- W1990183405
- Cited by
- 177
- References
- 26
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kalyani, R. R., & Dobs, A. S. (2007). Androgen deficiency, diabetes, and the metabolic syndrome in men. Current Opinion in Endocrinology, Diabetes & Obesity. https://doi.org/10.1097/med.0b013e32814db856
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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