Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease

Monaghan, Tanya M.; Cockayne, Alan; Mahida, Yashwant R.

doi:10.1097/mib.0000000000000461

Cited by 38Clostridium difficile and Clostridium perfringens researchGut microbiota and healthInflammatory Bowel Disease

Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease

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Monaghan, Tanya M., Cockayne, Alan, Mahida, Yashwant R.·2015·Inflammatory Bowel Diseases

DOI 10.1097/mib.0000000000000461

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Abstract

Colonization with toxigenic Clostridium difficile may be associated with a wide spectrum of clinical presentation ranging from asymptomatic carriage to mild diarrhea to life-threatening colitis. Over the last 15 years, there has been a marked increase in the incidence of C. difficile infection, which predominantly affects elderly patients on antibiotics. More recently, there has been significant interest in the association between inflammatory bowel disease (IBD) and C. difficile infection. This review article discusses in some detail current knowledge of the mechanisms by which C. difficile toxins may mediate mucosal inflammation, together with the role of cell wall components of the microorganism in disease pathogenesis. Innate and adaptive host responses to C. difficile toxins and other components are described and include consideration of the potential role of known mucosal changes in IBD that may lead to an enhanced inflammatory response in the presence of C. difficile infection. Recent studies, which have characterized resident microbiota that may mediate protection against colonization by C. difficile, including their mechanisms of action, are also discussed. This includes the role of bile acids and 7α-dehydroxylase-expressing bacteria, such as Clostridium scindens. Recent studies suggest a higher carriage rate of C. difficile in patients with IBD. It is anticipated that future studies will determine the role of dysbiosis in IBD in predisposing to colonization with C. difficile.

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Increased abundance of Clostridium has been linked to IBD.
“increased abundance of Clostridium has been linked to IBD”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [45]
Clostridium difficile infection is a common complication of IBD.
“C difficile infection is a common complication of IBD45.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [45]

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Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice
Cabrera-Rubio, R., Patterson, A. M., Cotter, P. D., & Beraza, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-48784-z · Cited by 61 · see citing works

Authors: Monaghan, T. M., Cockayne, A., & Mahida, Y. R.
Affiliations: University of Nottingham (GB)
NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
ORCID: Monaghan, Tanya M.
Mahida, Yashwant R.
Venue: Inflammatory Bowel Diseases
Publisher: Oxford University Press (OUP)
Published: 2015-08
Volume: 21
Issue: 8
Pages: 1957-1966
ISSN: 1078-0998 (ISSN-L)
DOI: 10.1097/mib.0000000000000461
OpenAlex: W1023016907
Cited by: 38
References: 151
Citations by year: 2025: 2 · 2024: 1 · 2022: 6 · 2021: 3 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 8
FWCI: 0.94
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Inflammatory Bowel Diseases (publishedVersion)
PubMed (publishedVersion)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion)
Funders: National Institute for Health and Care Research (CL-2012-12-001)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: Clostridium difficile infection, inflammatory bowel disease
MeSH terms: Clostridium Infections, Humans, Prognosis, Inflammatory Bowel Diseases, Clostridioides difficile

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Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease

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