Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination
Open accessAbstract
Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.
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CDCA can inhibit C. difficile germination and growth.
“chenodeoxycholic acid (CDCA) can inhibit germination and growth”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [27]
C. difficile is exquisitely sensitive to different BAs.
“Since C. difficile is exquisitely sensitive to different BAs27,28, we employed sets of glycine and taurine-preferring BSHs to inhibit C. difficile (Figs. 3d, 4a and 5a).”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [27]
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- Authors
- Sorg, J. A., & Sonenshein, A. L.
- Affiliations
- Tufts University (US)
- Corresponding author
- Sonenshein, Abraham L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2009-02
- Volume
- 191
- Issue
- 3
- Pages
- 1115-1117
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC2632082
- OpenAlex
- W2155378208
- Cited by
- 199
- References
- 18
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 12 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 18 · 2019: 12 · 2018: 21 · 2017: 12 · 2016: 23 · 2015: 11 · 2014: 13 · 2013: 8 · 2012: 7
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ai30050-20-0-3, N01-AI-30050)
- National Institute of General Medical Sciences (K12GM074869)
- National Institute of Allergy and Infectious Diseases (N01 AI030050)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- chenodeoxycholic acid, Clostridium difficile, spore germination, bile acids, cholate, taurocholate, glycine, bile components, germination inhibition
- MeSH terms
- Chenodeoxycholic Acid, Spores, Bacterial, Taurocholic Acid, Clostridioides difficile, Cholates
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