The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Macrophage polarization in metabolic disorders: functions and regulation
Abstract
Purpose of review To discuss recent findings on the role and regulation of macrophage polarization in obesity and atherosclerosis. Recent findings Macrophages infiltrate the vascular wall during atherosclerosis and adipose tissue during obesity. At least two distinct subpopulations with different functions, the classically (M1) and the alternatively (M2) activated macrophages, have been found in these tissues. Reciprocal skewing of macrophage polarization between the M1 and M2 states is a process modulated by diet, humoral and transcription factors, such as the nuclear receptor peroxisome proliferator-activated receptor gamma. Summary Recent literature highlights the importance not only of the number of infiltrated macrophages, but also their activation in the maintenance of the inflammation state. Identifying mechanisms and molecules able to modify the balance between M1 and M2 represents a promising field of research.
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“The M1 versus M2 model has been very helpful in describing immune responses during acute infections, allergies, asthma, and obesity”
From Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014) · cites this paper as Chinetti-Gbaguidi and Staels, 2011
Citations
Cites
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Cited by
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210
Zhao, H., Shang, Q., Pan, Z., Bai, Y., Li, Z., Zhang, H., Zhang, Q., Guo, C., Zhang, L., & Wang, Q. (2018) · Diabetes · doi:10.2337/db17-0356 · Cited by 657
Vinchi, F., Costa da Silva, M., Ingoglia, G., Petrillo, S., Brinkman, N., Zuercher, A., Cerwenka, A., Tolosano, E., & Muckenthaler, M. U. (2016) · Blood · doi:10.1182/blood-2015-08-663245 · Cited by 269
Zhong, X., & Liu, H. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13853 · Cited by 60
Bermudez, B., Dahl, T. B., Medina, I., Groeneweg, M., Holm, S., Montserrat-de la Paz, S., Rousch, M., Otten, J., Herias, V., Varela, L. M., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.308187 · Cited by 47
Metadata
- Authors
- Chinetti-Gbaguidi, G., & Staels, B.
- Venue
- Current Opinion in Lipidology
- Published
- 2011-10
- Volume
- 22
- Issue
- 5
- Pages
- 365-372
- ISSN
- 0957-9672
- Cited by
- 175
- References
- 65
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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