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Macrophage polarization in metabolic disorders: functions and regulation

Chinetti-Gbaguidi, Giulia, Staels, Bart·2011·Current Opinion in Lipidology

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Abstract

Purpose of review To discuss recent findings on the role and regulation of macrophage polarization in obesity and atherosclerosis. Recent findings Macrophages infiltrate the vascular wall during atherosclerosis and adipose tissue during obesity. At least two distinct subpopulations with different functions, the classically (M1) and the alternatively (M2) activated macrophages, have been found in these tissues. Reciprocal skewing of macrophage polarization between the M1 and M2 states is a process modulated by diet, humoral and transcription factors, such as the nuclear receptor peroxisome proliferator-activated receptor gamma. Summary Recent literature highlights the importance not only of the number of infiltrated macrophages, but also their activation in the maintenance of the inflammation state. Identifying mechanisms and molecules able to modify the balance between M1 and M2 represents a promising field of research.

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See all 175

Authors: Chinetti-Gbaguidi, G., & Staels, B.
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-10
Volume: 22
Issue: 5
Pages: 365-372
ISSN: 0957-9672
DOI: 10.1097/mol.0b013e32834a77b4
Cited by: 175
References: 65
Language: en

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Macrophage polarization in metabolic disorders: functions and regulation

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