Cited by 671Extracellular vesicles in diseaseAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue

Zhao, Hui, Shang, Qianwen, Pan, Zhenzhen, Bai, Yang, Li, Zequn, Zhang, Huiying, Zhang, Qiu, Guo, Chun +2 more·2018·Diabetes

Abstract

Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in several diseases, but their roles in obesity and related pathological conditions remain unclear. In this study, we showed that treatment of obese mice with ADSC-derived exosomes facilitated their metabolic homeostasis, including improved insulin sensitivity (27.8% improvement), reduced obesity, and alleviated hepatic steatosis. ADSC-derived exosomes drove alternatively activated M2 macrophage polarization, inflammation reduction, and beiging in white adipose tissue (WAT) of diet-induced obese mice. Mechanistically, exosomes from ADSCs transferred into macrophages to induce anti-inflammatory M2 phenotypes through the transactivation of arginase-1 by exosome-carried active STAT3. Moreover, M2 macrophages induced by ADSC-derived exosomes not only expressed high levels of tyrosine hydroxylase responsible for catecholamine release, but also promoted ADSC proliferation and lactate production, thereby favoring WAT beiging and homeostasis in response to high-fat challenge. These findings delineate a novel exosome-mediated mechanism for ADSC–macrophage cross talk that facilitates immune and metabolic homeostasis in WAT, thus providing potential therapy for obesity and diabetes.

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Crossref · 10.2337/db17-0356

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  • Zhao et al. engineered exosomes using ADSC to treat obesity; smart exosomes reduced WAT inflammation, improved energy expenditure and resilience to obesity progression.

    “The smart exosomes reduced WAT inflammation, improved energy expenditure and resilience to obesity progression [136].”

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Authors
Zhao, H., Shang, Q., Pan, Z., Bai, Y., Li, Z., Zhang, H., Zhang, Q., Guo, C., Zhang, L., & Wang, Q.
Affiliations
Shandong University (CN)
Corresponding author
Wang, Qun
Venue
Diabetes
Published
2017-11-13
Volume
67
Issue
2
Pages
235-247
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2769957434
Cited by
657
References
50
Citations by year
2026: 53 · 2025: 74 · 2024: 98 · 2023: 83 · 2022: 108 · 2021: 94 · 2020: 77 · 2019: 50 · 2018: 19
FWCI
16.30
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81770838, 81471065, 81270923)
  • Shandong Major Research Program (2016GSF201005)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipose-derived stem cells, exosomes, obesity, adipose tissue inflammation, M2 macrophage polarization, insulin sensitivity, hepatic steatosis, arginase-1, STAT3, tyrosine hydroxylase, catecholamine release, metabolic homeostasis
MeSH terms
Adipocytes, Beige, Animals, Cell Communication, Cells, Cultured, Insulin Resistance, Macrophage Activation, Male, Mice, Inbred C57BL, Microscopy, Fluorescence, Obesity, Phagocytosis, Biomarkers, Cell Polarity, Macrophages, Peritoneal, Microscopy, Electron, Transmission, Cell Proliferation, Adipogenesis, Adipocytes, White, Adult Stem Cells, Exosomes, Diet, High-Fat, Non-alcoholic Fatty Liver Disease

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