Cited by 112Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactSexual Differentiation and Disorders

The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.

Endocrine-disrupting chemicals and child health

Ghassabian, Akhgar, Vandenberg, Laura, Kannan, Kurunthachalam, Trasande, Leonardo·2022·Annual Review of Pharmacology and Toxicology

Abstract

While definitions vary, endocrine-disrupting chemicals (EDCs) have two fundamental features: their disruption of hormone function and their contribution to disease and disability. The unique vulnerability of children to low-level EDC exposures has eroded the notion that only the dose makes the thing a poison, requiring a paradigm shift in scientific and policy practice. In this review, we discuss the unique vulnerability of children as early as fetal life and provide an overview of epidemiological studies on programming effects of EDCs on neuronal, metabolic, and immune pathways as well as on endocrine, reproductive, and renal systems. Building on this accumulating evidence, we dispel and address existing myths about the health effects of EDCs with examples from child health research. Finally, we provide a list of effective actions to reduce exposure and subsequent harm that are applicable to individuals, communities, and policy-makers.

Overview

Integrity signals

Registry

Crossref · 10.1146/annurev-pharmtox-021921-093352

Cites

146 of 146 references verified0 citation errors · 0 not checkable

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Verification

Claims the paper makes

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Claims other papers make about this one

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  • Fetal development is a time particularly sensitive to chemical perturbations.

    “The consequences of endocrine disruption can be particularly dire when exposure takes place prenatally, as fetal development is a time particularly sensitive to chemical perturbations (Ghassabian et al., 2022).”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Ghassabian et al., 2022

  • Prenatal life is a susceptible window of development during which chemical exposures can permanently alter fetal development, leading to an increased likelihood of disease later in life.

    “Prenatal life represents a susceptible window of development during which chemical exposures can permanently alter fetal development, leading to an increased likelihood of disease later in life.”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Ghassabian et al., 2022

Citations

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Research works printed but not linked: 4

  1. Surveill. Epidemiol. End Results Program, 2018, Cancer stat facts: testicular cancer
  2. Bradford Hill A, 1965, Proc. R. Soc. Med., 58, 295
  3. IPCS (Int. Programme Chem. Saf.), 2004, IPCS risk assessment terminology
  4. US FDA (US Food Drug Admin.), 2019, Fed. Regist., 84, 244

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Metadata

Authors
Ghassabian, A., Vandenberg, L., Kannan, K., & Trasande, L.
Affiliations
  • New York University (US)
  • University of Massachusetts Amherst (US)
Corresponding author
Trasande, Leonardo
Venue
Annual Review of Pharmacology and Toxicology
Published
2022-01-06
Volume
62
Issue
1
Pages
573-594
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W3200808253
Cited by
112
References
146
Citations by year
2026: 21 · 2025: 28 · 2024: 27 · 2023: 19 · 2022: 15 · 2021: 2
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (ES000260, UH3OD023305)
  • National Institute of Environmental Health Sciences (ES-000260, U2CES026542, P30ES000260, R01ES022972, R01ES029779)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
endocrine disruptors, child health, developmental programming, low-dose exposure, prenatal exposure, brain development, metabolic pathways, immune pathways, reproductive health, kidney health, exposure reduction, environmental policy
MeSH terms
Child Health, Child, Humans, Endocrine Disruptors

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