Cited by 623Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

Open access

Ansari, Mubeen A., Scheff, Stephen W.·2010·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/nen.0b013e3181cb5af4PMC PMC2826839

Open this paper in CoChat — free account

Abstract

We investigated oxidative stress in human postmortem frontal cortexfrom individuals characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n = 4), and late-stage Alzheimer disease (n = 9). Samples from subjects with no cognitive impairment (n = 10) that were age- and postmortem interval-matched with these cases were used as controls. The short postmortem intervalbrain samples were processed for postmitochondrial supernatant, nonsynaptic mitochondria, and synaptosome fractions. Samples were analyzed for several antioxidants (glutathione, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, superoxide dismutase, catalase) and the oxidative marker, thiobarbituric acid reactive substances. The tissue was also analyzed for possible changes in protein damage using neurochemical markers for protein carbonyls, 3-nitrotyrosine, 4-hydroxynonenal, andacrolein. All 3 neuropil fractions (postmitochondrial supernatant, mitochondrial, and synaptosomal) demonstrated significant disease-dependent increases in oxidative markers. The highest changes were observed in the synaptosomal fraction. Both mitochondrial and synaptosomal fractions had significant declines in antioxidants (glutathione, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase). Levels of oxidative markers significantly correlated with Mini-Mental Status Examination scores. Oxidative stress was more localized to the synapses, with levels increasing in a disease-dependent fashion. These correlations implicate an involvement of oxidative stress in Alzheimer disease-related synaptic loss.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/nen.0b013e3181cb5af4

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,871
Role of Free Radicals in the Neurodegenerative Diseases: Therapeutic Implications for Antioxidant Treatment
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038

Flagged first, then by citations

Show all 96 references

Sorted by citations

Items 101–200 of 623

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer’s disease pathology
Scheff, S. W., Ansari, M. A., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.030 · Cited by 100
Self-citation
Neuroprotective effects of edaravone on cognitive deficit, oxidative stress and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats
Zhou, S., Yu, G., Chi, L., Zhu, J., Zhang, W., Zhang, Y., & Zhang, L. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.07.007 · Cited by 100
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a “Bio-Oxidizable” Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation
Peauger, L., Azzouz, R., Gembus, V., Ţînţaş, M.-L., Santos, J. S. O., Bohn, P., Papamicaël, C. A., & Levacher, V. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00702 · Cited by 99
New Evidence of Mitochondria Dysfunction in the Female Alzheimer's Disease Brain: Deficiency of Estrogen Receptor-β
Long, J., He, P., Shen, Y., & Li, R. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120283 · Cited by 102
Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease
Domenico, F. D., Pupo, G., Tramutola, A., Giorgi, A., Schininà, M. E., Coccia, R., Head, E., Butterfield, D. A., & Marzia Perluigi, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.027 · Cited by 98
The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations
Jellinger, K. A. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410502-7.00002-8 · Cited by 101
Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice
Peng, Y., Hou, C., Yang, Z., Li, C., Jia, L., Liu, J., Tang, Y., Shi, L., Li, Y., Long, J., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600332 · Cited by 103
Glutathione as a Redox Biomarker in Mitochondrial Disease—Implications for Therapy
Enns, G. M., & Cowan, T. M. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6050050 · Cited by 96
Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
Thapa, A., & Carroll, N. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071583 · Cited by 97
The KEAP1-NRF2 System in Healthy Aging and Longevity
Matsumaru, D., & Motohashi, H. (2021) · Antioxidants · doi:10.3390/antiox10121929 · Cited by 103
Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
Duarte, A. I., Candeias, E., Alves, I. N., Mena, D., da Silva, D. F., Machado, N. J., Campos, E. J., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051746 · Cited by 94
Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity
Angeloni, C., Malaguti, M., Rizzo, B., Barbalace, M. C., Fabbri, D., & Hrelia, S. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00067 · Cited by 95
Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease
Ono, K., & Tsuji, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030952 · Cited by 95
New Melatonin–N,N-Dibenzyl(N-methyl)amine Hybrids: Potent Neurogenic Agents with Antioxidant, Cholinergic, and Neuroprotective Properties as Innovative Drugs for Alzheimer’s Disease
López-Iglesias, B., Pérez, C., Morales-Garcia, J. A., Alonso‐Gil, S., Pérez‐Castillo, A., Romero, A., López, M. G., Villarroya, M., Conde, S., & Rodrı́guez-Franco, M. I. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5000613 · Cited by 90
Neuroprotection by glucose‐6‐phosphate dehydrogenase and the pentose phosphate pathway
Tang, B. L. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29004 · Cited by 85
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease
Wang, Z.-M., Cai, P., Liu, Q., Xu, D., Yang, X., Wu, J., Kong, L., & Wang, X. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.07.052 · Cited by 88
Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer’s Disease
Birla, H., Minocha, T., Kumar, G., Misra, A., & Singh, S. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200122122512 · Cited by 90
Selenoproteins in Nervous System Development and Function
Pitts, M. W., Byrns, C. N., Ogawa-Wong, A. N., Kremer, P. M., & Berry, M. J. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0060-2 · Cited by 91
Rhodiola roseaL. and Alzheimer's Disease: From Farm to Pharmacy
Nabavi, S. F., Braidy, N., Orhan, İ. E., Badiee, A., Daglia, M., & Nabavi, S. M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5569 · Cited by 90
A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-10.2010 · Cited by 85
The Impact of Surgery and Anesthesia on Post-Operative Cognitive Decline and Alzheimer's Disease Development: Biomarkers and Preventive Strategies
Kapila, A. K., Watts, H. R., Wang, T., & Ma, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132258 · Cited by 88
Mitochondrial Abnormalities in Alzheimer’s Disease
Silva, D. F., Selfridge, J. E., Lu, J., E, L., Cardoso, S. M., & Swerdlow, R. H. (2012) · Advances in Pharmacology · doi:10.1016/b978-0-12-394816-8.00003-9 · Cited by 86
A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain
Howarth, C., Sutherland, B. A., Choi, H. B., Martin, C. J., Lind, B. L., Khennouf, L., LeDue, J. M., Pakan, J. M. P., Ko, R. W. Y., Ellis‐Davies, G. C. R., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0005-16.2016 · Cited by 82
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
Piemontese, L., Tomás, D., Hiremathad, A., Capriati, V., Candeias, E., Cardoso, S. M., Chaves, S., & Santos, M. A. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1491564 · Cited by 84
Oxidative Modification of Brain Proteins in Alzheimer's Disease: Perspective on Future Studies Based on Results of Redox Proteomics Studies
Rukhsana Sultana, A., & Butterfield, D. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129018 · Cited by 84
Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons
Gunn, A. P., Wong, B. X. W., Johanssen, T., Griffith, J. C., Masters, C. L., Bush, A. I., Barnham, K. J., Duce, J. A., & Cherny, R. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.655183 · Cited by 86
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents
Shaik, J. B., Palaka, B. K., Penumala, M., Kotapati, K. V., Devineni, S. R., Eadlapalli, S., Manidhar, D. M., Ampasala, D. R., Vadde, R., & Damu, A. G. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.046 · Cited by 82
Mitochondrial metabolic function assessed in vivo and in vitro
Lanza, I. R., & Nair, K. S. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cc93d · Cited by 83
Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease
Iraji, A., Firuzi, O., Khoshneviszadeh, M., Tavakkoli, M., Mahdavi, M. R., Nadri, H., Edraki, N., & Miri, R. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.057 · Cited by 83
Oxidative stress–mediated neuroinflammation in Alzheimer’s disease
Firdous, S. M., Khan, S. A., & Maity, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03188-3 · Cited by 90
Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?
Merlo, S., Spampinato, S. F., & Sortino, M. A. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13050 · Cited by 82
Redox changes and cellular senescence in Alzheimer's disease
Yu, N., Pasha, M., & Chua, J. J. E. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103048 · Cited by 80
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model
Wang, C., Wang, Z., Xie, J., Wang, T., Wang, X., Xu, Y., & Cai, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.024 · Cited by 81
Structural Context Effects in the Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine to Hydantoin Products: Electrostatics, Base Stacking, and Base Pairing
Fleming, A. M., Muller, J. G., Dlouhy, A. C., & Burrows, C. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja306077b · Cited by 82
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin
Wang, J. Q., Wang, Z., Li, X., Li, F., Wu, J., Kong, L., & Wang, X. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.07.025 · Cited by 79
Potential therapeutic agents against Alzheimer’s disease from natural sources
Park, S. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1010-y · Cited by 79
Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer’s disease
Lan, J., Hou, J., Liu, Y., Ding, Y., Zhang, Y., Li, L. J., & Zhang, T. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1256883 · Cited by 78
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease
Lan, J., Xie, S., Li, S., Pan, L.-F., Wang, X., & Kong, L. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.08.035 · Cited by 77
Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation
Yu, L., Wang, W., Pang, W., Xiao, Z.-H., Jiang, Y., & Hong, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161216 · Cited by 77
Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities
Tiwari, M. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.09.001 · Cited by 76
Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression
Song, J., Park, J., Oh, Y., & Lee, J. E. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/426069 · Cited by 77
Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss
Prell, C. G. L., Gagnon, P. M., Bennett, D. C., & Ohlemiller, K. K. (2011) · Translational research · doi:10.1016/j.trsl.2011.02.006 · Cited by 76
Cognitive Improvement with Glutathione Supplement in Alzheimer’s Disease: A Way Forward
Mandal, P. K., Shukla, D., Tripathi, M., & Ersland, L. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181054 · Cited by 76
Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?
Sutherland, G. T., Chami, B., Youssef, P., & Witting, P. K. (2013) · Redox Report · doi:10.1179/1351000213y.0000000052 · Cited by 80
Ferroptosis: A potential therapeutic target for neurodegenerative diseases
Vitalakumar, D., Sharma, A., & Flora, S. J. S. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22830 · Cited by 75
Increased levels of 4HNE-protein plasma adducts in Rett syndrome
Pecorelli, A., Ciccoli, L., Signorini, C., Leoncini, S., Giardini, A., D’Esposito, M., Filosa, S., Hayek, J., Felice, C. D., & Valacchi, G. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.01.007 · Cited by 73
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A. (1996) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.36.1.83 · Cited by 74
Astrocytes as Key Regulators of Neural Signaling in Health and Disease
Won, W., Bhalla, M., Lee, J., & Lee, C. J. (2025) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-112723-035356 · Cited by 76
Simvastatin is the Statin that Most Efficiently Protects Against Kainate-Induced Excitotoxicity and Memory Impairment
Ramirez, C., Tercero, I., Pineda, A., & Burgos, J. S. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-101653 · Cited by 67
Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease
Wang, S., Yu, L., Yang, H., Li, C., Hui, Z., Xu, Y., & Zhu, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151397 · Cited by 72
The Potential Role of Ferroptosis in Alzheimer’s Disease
Zhang, G., Zhang, Y.-R., Shen, Y., Wang, Y., Zhao, M. L., & Sun, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201369 · Cited by 71
Oxidized phospholipids as novel mediators of neurodegeneration
Dong, Y., & Yong, V. W. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.03.002 · Cited by 69
New Perspectives on Alzheimer’s Disease and Nutrition
Gustafson, D., Morris, M. C., Scarmeas, N., Shah, R. C., Sijben, J., Yaffe, K. S., & Zhu, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150084 · Cited by 71
Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS
Shukla, D., Mandal, P. K., Tripathi, M., Vishwakarma, G., Mishra, R., & Sandal, K. (2019) · Human Brain Mapping · doi:10.1002/hbm.24799 · Cited by 68
Glutathione: An Old and Small Molecule with Great Functions and New Applications in the Brain and in Alzheimer's Disease
Haddad, M., Hervé, V., Ben Khedher, M. R., Rabanel, J.-M., & Ramassamy, C. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8129 · Cited by 68
Neuroferroptosis in health and diseases
Lei, P., Walker, T. L., & Ayton, S. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00930-5 · Cited by 77
Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways
Morroni, F., Sita, G., Tarozzi, A., Rimondini, R., & Hrelia, P. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.002 · Cited by 65
Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review
Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68
Modifiable, Non-Modifiable, and Clinical Factors Associated with Progression of Alzheimer’s Disease
Loeffler, D. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201182 · Cited by 71
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
He, Y., Yao, P.-F., Chen, S.-B., Huang, Z., Huang, S., Tan, J., Li, D., Gu, L., & Huang, Z. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.02.014 · Cited by 67
Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine
Cardoso, S., Carvalho, C., Correia, S. C., Seiça, R. M. F., & Moreira, P. I. (2016) · Brain Pathology · doi:10.1111/bpa.12402 · Cited by 69
Exercise-Induced Benefits for Alzheimer’s Disease by Stimulating Mitophagy and Improving Mitochondrial Function
Liang, J., Wang, C., Zhang, H., Huang, J., Xie, J., & Chen, N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.755665 · Cited by 70
Understanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress
Quintanilla, R. A., Orellana, J. A., & Rommy von Bernhardi, M. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.016 · Cited by 67
Antioxidant Activity of Galantamine and Some of its Derivatives
Tsvetkova, D. D., Obreshkova, D. P., Zheleva‐Dimitrova, D., & Saso, L. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990148 · Cited by 65
Inhibitory Effects of Raw-Extract Centella asiatica (RECA) on Acetylcholinesterase, Inflammations, and Oxidative Stress Activities via In Vitro and In Vivo
Hafiz, Z. Z., Amin, M. ‘. M., Johari James, R. M., Teh, L. K., Salleh, M. Z., & Adenan, M. I. (2020) · Molecules · doi:10.3390/molecules25040892 · Cited by 64
Lipid metabolism and oxidative stress in patients with Alzheimer's disease and amnestic mild cognitive impairment
Nie, Y., Chu, C., Qin, Q., Shen, H., Wen, L., Tang, Y., & Qu, M. (2023) · Brain Pathology · doi:10.1111/bpa.13202 · Cited by 68
Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease
Uddin, M. S., Mamun, A. A., Hossain, M. S., Ashaduzzaman, M., Noor, M. A. A., Hossain, M. S., Uddin, M. J., Sarker, J., & Asaduzzaman, M. (2016) · Advances in Alzheimer s Disease · doi:10.4236/aad.2016.52005 · Cited by 65
Prevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise
McGurran, H., Glenn, J. M., Madero, E. N., & Bott, N. T. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180958 · Cited by 63
Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
Watanabe, K., Shibuya, S., Ozawa, Y., Nojiri, H., Izuo, N., Yokote, K., & Shimizu, T. (2014) · BioMed Research International · doi:10.1155/2014/140165 · Cited by 63
Early Detection and Prevention of Alzheimer’s Disease: Role of Oxidative Markers and Natural Antioxidants
Arslan, J., Jamshed, H., & Qureshi, H. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00231 · Cited by 62
Vitamin A metabolites inhibit ferroptosis
Jakaria, M., Belaidi, A. A., Bush, A. I., & Ayton, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114930 · Cited by 61
Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat model
Foret, M. K., Orciani, C., Welikovitch, L. A., Huang, C., Cuello, A. C., & Carmo, S. D. (2024) · Communications Biology · doi:10.1038/s42003-024-06552-4 · Cited by 63
Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements
Poddar, J., Pradhan, M., Ganguly, G., & Chakrabarti, S. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.04.002 · Cited by 63
Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice
Thingore, C., Kshirsagar, V. V., & Juvekar, A. R. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00629-9 · Cited by 61
Neuron–astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation
Rao, K. V. R., & Kielian, T. (2015) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12237 · Cited by 62
The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer’s disease
Abate, G., Frisoni, G. B., Bourdon, J., Piccirella, S., Memo, M., & Uberti, D. L. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00732-0 · Cited by 58
Protective Roles of Hydrogen Sulfide in Alzheimer’s Disease and Traumatic Brain Injury
Paul, B. D., & Pieper, A. A. (2023) · Antioxidants · doi:10.3390/antiox12051095 · Cited by 59
Targeting redox imbalance in neurodegeneration: characterizing the role of GLP-1 receptor agonists
Ghosh, P., Fontanella, R. A., Scisciola, L., Pesapane, A., Taktaz, F., Franzese, M., Puocci, A., Ceriello, A., Prattichizzo, F., Rizzo, M. R., et al. (2023) · Theranostics · doi:10.7150/thno.86831 · Cited by 63
Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms
Herring, A., Lewejohann, L., Panzer, A.-L., Donath, A., Kröll, O., Sachser, N., Paulus, W., & Keyvani, K. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.007 · Cited by 63
Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors
Makarian, M., Gonzalez, M., Salvador, S. M., Lorzadeh, S., Hudson, P. K., & Pecic, S. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.131425 · Cited by 59
Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer’s disease compared with healthy elderly participants
Mandal, P. K., Goel, A., Bush, A. I., Punjabi, K., Joon, S., Mishra, R., Tripathi, M., Garg, A., Kumar, N. K., Sharma, P., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac215 · Cited by 59
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease
Luo, X., Wang, C., Liu, Y., & Huang, Z. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.08.052 · Cited by 57
Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study
Fraguas, D., González-Pinto, A. M., Micó, J. A., Reig, S., Parellada, M., Martínez‐Cengotitabengoa, M., Castro‐Fornieles, J., Rapado‐Castro, M., Baeza, I., Janssen, J., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.01.040 · Cited by 57
Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex
Morozov, Y. M., Datta, D., Paspalas, C. D., & Arnsten, A. F. T. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.12.001 · Cited by 60
Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats.
Heidari, S., Mehri, S., & Hosseinzadeh, H. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.9541 · Cited by 57
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Estrada, M., Herrera‐Arozamena, C., de Andrés, L., Pérez, C., Morales-Garcia, J. A., Pérez‐Castillo, A., Ramos, E., Romero, A., Viña, D., Yáñez, M., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.07.026 · Cited by 56
EVALUATION OF THE NEUROPROTECTIVE POTENTIAL OF N-ACETYLCYSTEINE FOR PREVENTION AND TREATMENT OF COGNITIVE AGING AND DEMENTIA
Hara, Y., Fillit, H. M., Dacks, P. A., & McKeehan, N. (2017) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2017.22 · Cited by 57
Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements
Tadokoro, K., Ohta, Y., Inufusa, H., Loon, A. F. N., & Abe, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061974 · Cited by 58
Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer’s disease
Zalewska, A., Klimiuk, A., Zięba, S., Wnorowska, O., Rusak, M., Waszkiewicz, N., Szarmach, I. J., Dzierżanowski, K., & Maciejczyk, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-03456-9 · Cited by 56
Sporadic Alzheimer's Disease: The Starving Brain
Mamelak, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120370 · Cited by 59
Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
Xu, W., Wang, X., Wang, Z.-M., Wu, J., Li, F., Wang, J., & Kong, L. (2016) · MedChemComm · doi:10.1039/c6md00053c · Cited by 56
Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
Capatina, L., Todirașcu-Ciornea, E., Napoli, E., Ruberto, G., Hriţcu, L., & Dumitru, G. (2020) · Antioxidants · doi:10.3390/antiox9111083 · Cited by 56
Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype
Ramamoorthy, M., Sýkora, P., Scheibye‐Knudsen, M., Dunn, C., Kasmer, C., Zhang, Y., Becker, K. G., Croteau, D. L., & Bohr, V. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.018 · Cited by 55
Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice
Xu, Y. X., Zhang, Y., Zhang, J.-H., Han, K., Zhang, X., Bai, X., You, L., Yu, P., Shi, Z., Chang, Y.-Z., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.012 · Cited by 56
Exercise for Toxicity Management in Cancer—A Narrative Review
Kleckner, I. R., Dunne, R. F., Asare, M., Cole, C. L., Fleming, F. J., Fung, C., Lin, P., & Mustian, K. M. (2018) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2018.14.1.28 · Cited by 54
Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease
Murakami, K. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.940275 · Cited by 53
Oxidative Stress: Glutathione and Its Potential to Protect Methionine-35 of Aβ Peptide from Oxidation
Mandal, P. K., Roy, R. G., & Samkaria, A. (2022) · ACS Omega · doi:10.1021/acsomega.2c02760 · Cited by 55
Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before
Mancuso, C., Siciliano, R., Barone, E., Butterfield, D. A., & Preziosi, P. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.601740 · Cited by 53
Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age
Duffy, Á., Morales‐Corraliza, J., Bermudez‐Hernandez, K., Schaner, M. J., Magagna‐Poveda, A., Mathews, P. M., & Scharfman, H. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.001 · Cited by 52
Reduced expression of SIRT1 and SOD-1 and the correlation between these levels in various regions of the brains of patients with Alzheimer's disease
Cao, K., Dong, Y., Xiang, J., Xu, Y., Hong, W., Song, H., & Guan, Z.-Z. (2018) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2018-205320 · Cited by 53

Authors: Ansari, M. A., & Scheff, S. W.
Affiliations: University of Kentucky (US)
Corresponding author: Scheff, Stephen W.
ORCID: Ansari, Mubeen A.
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2010-02
Volume: 69
Issue: 2
Pages: 155-167
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/nen.0b013e3181cb5af4
PMC: PMC2826839
OpenAlex: W2031762170
Cited by: 605
References: 96
Citations by year: 2026: 29 · 2025: 38 · 2024: 44 · 2023: 40 · 2022: 51 · 2021: 56 · 2020: 44 · 2019: 38 · 2018: 30 · 2017: 31 · 2016: 41 · 2015: 29 · 2014: 31 · 2013: 24 · 2012: 31
FWCI: 21.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG-028383, AG27219, P30AG028383, P01AG014449, R01AG043375, R01AG027219)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, Alzheimer's disease, frontal cortex, synaptosomes, mitochondria, antioxidants, glutathione, superoxide dismutase, lipid peroxidation, protein carbonyls, nitrotyrosine, 4-hydroxynonenal, acrolein, synaptic loss, disease progression, mild cognitive impairment, postmortem brain
MeSH terms: Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Antioxidants, Female, Frontal Lobe, Humans, Male, Mental Status Schedule, Synapses, Tissue Distribution, Tyrosine, Biomarkers, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Disease Progression, Protein Carbonylation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks