Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

Bennett, Rachel E.; Esparza, Thomas J.; Lewis, Hal A.; Kim, Eddie; Mac Donald, Christine L.; Sullivan, Patrick M.; Brody, David L.

doi:10.1097/nen.0b013e31828e24ab

Cited by 40

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

Bennett, Rachel E., Esparza, Thomas J., Lewis, Hal A., Kim, Eddie, Mac Donald, Christine L., Sullivan, Patrick M., Brody, David L.·2013·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/nen.0b013e31828e24abPMC PMC7355224

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APOE4 is associated with increased innate immune reactivity and enhanced cytokine secretion in primary microglia and peripheral macrophages in various animal models as well as human subjects.
“Recently, several studies have shown that APOE4 is associated with increased innate immune reactivity and enhanced cytokine secretion in primary microglia and peripheral macrophages in various animal models as well as human subjects [31–42].”
From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [36]
The Results section reports greater post-traumatic axonal injury in APOE4-expressing mice, not innate immune reactivity or cytokine secretion. Searches for microglia, macrophages, inflammation, and cytokines found only a reference to another study of microglial activation; no passage in our copy addresses the claimed findings in primary microglia, peripheral macrophages, or human subjects. Page numbers were not available in the indexed copy. (LLM, conf=0.72)
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
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Sorted by citations

Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627
Apolipoprotein E in Alzheimer's Disease: An Update
Yu, J.-T., Tan, L., & Hardy, J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014300 · Cited by 394
The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01869-3 · Cited by 121
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Alzheimer’s Disease: Dawn of a New Era?
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“It has also been shown that ApoE ɛ4 is associated with increased tau accumulation (28).”
Background

Authors: Bennett, R. E., Esparza, T. J., Lewis, H. A., Kim, E., Mac Donald, C. L., Sullivan, P. M., & Brody, D. L.
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2013-05
Volume: 72
Issue: 5
Pages: 396-403
ISSN: 0022-3069
1554-6578
DOI: 10.1097/nen.0b013e31828e24ab
PMC: PMC7355224
Cited by: 40
References: 9
Language: en

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Human Apolipoprotein E4 Worsens Acute Axonal Pathology but Not Amyloid-β Immunoreactivity After Traumatic Brain Injury in 3×TG-AD Mice

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