Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
Abstract
Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.
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Mouse tau may retard human tau aggregation.
“-Synuclein inhibits ␣-synuclein aggregation in mice, and mouse tau may retard human tau aggregation (Rochet et al., 2000;Hashimoto et al., 2001;Andorfer et al., 2003).”
From Aβ40 Inhibits Amyloid Deposition<i>In Vivo</i> (2007) · cites this paper as Andorfer et al., 2003
Expressing physiological levels of tau transgene is overall benign and only produces pathology very late in life.
“Since expressing physiological levels of tau transgene has been shown to be overall benign and only produces pathology very late in life (37, 38), our reasoning could be justified as this was a comparative neuropathologic study of three different variants of tau, all of which had equivalent expression levels.”
From Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation (2022) · cites this paper as [37]
WT tau is not generally amenable to form NFT.
“As shown by other groups (37, 38), WT tau is not generally amenable to form NFT.”
From Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation (2022) · cites this paper as [37]
Transgenic mice expressing human mutated tau showed NFT formation and neuronal loss, implying a causal relationship between tau over-expression and neurodegeneration.
“transgenic mice expressing human mutated tau showed NFT formation and neuronal loss, implying a causal relationship between tau over-expression and neurodegeneration (8 -11).”
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Vargas-Caballero, M., Denk, F., Wobst, H. J., Arch, E., Pegasiou, C.-M., Oliver, P. L., Shipton, O. A., Paulsen, O., & Wade-Martins, R. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00201 · Cited by 18 · see citing works
- Authors
- Andorfer, C., Kress, Y., Espinoza, M., De Silva, R., Tucker, K. L., Barde, Y., Duff, K., & Davies, P.
- Affiliations
- Albert Einstein College of Medicine (US)
- Friedrich Miescher Institute (CH)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Davies, Peter
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2003-06-27
- Volume
- 86
- Issue
- 3
- Pages
- 582-590
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2130723719
- Cited by
- 722
- References
- 2
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 27 · 2023: 39 · 2022: 40 · 2021: 47 · 2020: 41 · 2019: 37 · 2018: 49 · 2017: 51 · 2016: 37 · 2015: 36 · 2014: 32 · 2013: 28 · 2012: 26
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute on Aging (R01AG022102)
- National Institute of Mental Health (MH38623)
- National Institute of Neurological Disorders and Stroke (T32NS007098, NS 07098)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, hyperphosphorylation, tau aggregation, neurofibrillary tangles, Alzheimer's disease, transgenic mice, paired helical filaments, microtubule-associated proteins, neuronal pathology
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Brain, Brain Chemistry, Dendrites, Disease Models, Animal, Humans, Mice, Transgenic, Neurons, Phosphorylation, Neurofibrillary Tangles, tau Proteins, Alternative Splicing, Protein Isoforms, Reverse Transcriptase Polymerase Chain Reaction, Macromolecular Substances, Mice
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