Capturing Ambulatory Activity Decline in Parkinson's Disease
Open accessAbstract
BACKGROUND AND PURPOSE: Relatively little is known about the natural evolution of physical activity-related participation restrictions associated with Parkinson's disease (PD). We examined this issue prospectively, using continuous monitoring technology to capture the free-living ambulatory activity of persons with PD engaging in life situations. We specifically sought (1) to explore natural, long-term changes in daily ambulatory activity and (2) to compare the responsiveness of ambulatory activity parameters to clinical measures of gait and disease severity. METHODS: Thirty-three persons with PD participated (Hoehn and Yahr range of 1-3). Participants wore a step activity monitor for up to 7 days at baseline and again at 1-year follow-up. Mean daily values were calculated for parameters indicative of amount, intensity, frequency, and duration of ambulatory activity. Clinical measures included the Unified Parkinson Disease Rating Scale, the 6-Minute Walk, and Maximal Gait Speed. Parametric tests for paired samples were used to investigate changes in ambulatory activity parameters and clinical measures. RESULTS: Participants had significant declines in the amount and intensity of daily ambulatory activity but not in its frequency and duration (P < 0.007). Declines occurred in the absence of changes in clinical measures of gait or disease severity. The greatest 1-year decline occurred in the number of daily minutes participants spent engaging in at least moderate-intensity ambulatory activity. CONCLUSION: Continuous monitoring of ambulatory activity beyond mere step counts may serve as a distinct and important means of quantifying declining ambulatory behavior associated with disease progression or improved ambulatory behavior resulting from rehabilitation and medical and/or surgical interventions in persons with PD.
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Over a 1-year period, a decline in physical activity levels was detected using accelerometers in individuals with Parkinson's disease.
“Over a 1-year period, a decline in physical activity levels was detected using accelerometers in individuals with PD [37].”
From Wearable sensors for clinical applications in epilepsy, Parkinson’s disease, and stroke: A mixed-methods systematic review (2018) · cites this paper as [37]
Clinical scales may adequately reflect the patients' symptoms or disabilities, but they are often limited by the predefined ordinal scoring levels and lack sensitivity to more detailed and subtle changes in the clinical status.
“Although the clinical scales may adequately reflect the patients’ symptoms or disabilities, they are often limited by the predefined ordinal scoring levels and lack sensitivity to more detailed and subtle changes in the clinical status [22, 37, 70, 71].”
From Wearable sensors for clinical applications in epilepsy, Parkinson’s disease, and stroke: A mixed-methods systematic review (2018) · cites this paper as [37]
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- Authors
- Cavanaugh, J. T., Ellis, T. D., Earhart, G. M., Ford, M. P., Foreman, K. B., & Dibble, L. E.
- Affiliations
- University of New England (US)
- Boston University (US)
- Corresponding author
- Cavanaugh, James T.
- Venue
- Journal of Neurologic Physical Therapy
- Published
- 2012-06
- Volume
- 36
- Issue
- 2
- Pages
- 51-57
- ISSN
- 1085-049X (ISSN-L)
- 1557-0576
- PMC
- PMC3934648
- OpenAlex
- W2013491566
- Cited by
- 141
- References
- 43
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 15 · 2019: 4 · 2018: 13 · 2017: 14 · 2016: 16 · 2015: 9 · 2014: 6 · 2013: 8
- FWCI
- 18.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurology Report (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k12hd043444-10)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD043444)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Parkinson's disease, ambulatory activity, physical activity decline, gait, disease severity, disease progression, physical activity intensity, rehabilitation outcomes, wearable sensors
- MeSH terms
- Activities of Daily Living, Aged, Female, Follow-Up Studies, Gait, Humans, Male, Middle Aged, Parkinson Disease, Prospective Studies, Psychiatric Status Rating Scales, Severity of Illness Index, Walking, Monitoring, Ambulatory
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