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Stress, Inflammation, and Yoga Practice
Open accessAbstract
Objective: To address the mechanisms underlying hatha yoga’s potential stress-reduction benefits, we compared inflammatory and endocrine responses of novice and expert yoga practitioners before, during, and after a restorative hatha yoga session, as well as in two control conditions. Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual’s physiological recovery. Methods: A total of 50 healthy women (mean age, 41.32 years; range, 30–65 years), 25 novices and 25 experts, were exposed to each of the conditions (yoga, movement control, and passive-video control) during three separate visits. Results: The yoga session boosted participants’ positive affect compared with the control conditions, but no overall differences in inflammatory or endocrine responses were unique to the yoga session. Importantly, even though novices and experts did not differ on key dimensions, including age, abdominal adiposity, and cardiorespiratory fitness, novices’ serum interleukin (IL)-6 levels were 41% higher than those of experts across sessions, and the odds of a novice having detectable C-reactive protein (CRP) were 4.75 times as high as that of an expert. Differences in stress responses between experts and novices provided one plausible mechanism for their divergent serum IL-6 data; experts produced less lipopolysaccharide-stimulated IL-6 in response to the stressor than novices, and IL-6 promotes CRP production. Conclusion: The ability to minimize inflammatory responses to stressful encounters influences the burden that stressors place on an individual. If yoga dampens or limits stress-related changes, then regular practice could have substantial health benefits. CRC = Clinical Research Center; CRP = C-reactive protein; HR = heart rate; hsCRP = high-sensitivity C-reactive protein; IL = interleukin; LPS = lipopolysaccharide; MASQ = Mood and Anxiety Symptom Questionnaire; PANAS = Positive and Negative Affect Scale; PBLs = peripheral blood leukocytes; sIL-6r = soluble IL-6 receptor; TEWL = transepidermal water loss; TNF = tumor necrosis factor; JOURNAL/psme/04.03/00006842-201002000-00002/OV0312/v/2021-02-12T104333Z/r/image-pngo2 max = maximum oxygen consumption.
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“Although the yoga intervention did not impact inflammatory activity, novices' IL-6 levels were 41% higher than those of experts across the sessions”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Kiecolt-Glaser, Christian, et al., 2010
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Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Small sample inference for fixed effects from restricted maximum likelihood
Kenward, M. G., & Roger, J. H. (1997) · Biometrics · doi:10.2307/2533558 · Cited by 4,552
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Self-citationInflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Watson, D., Weber, K., Assenheimer, J. S., Clark, L. A., Strauss, M. E., & McCormick, R. A. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.3 · Cited by 1,423
Inflammation and cancer: how hot is the link?
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267 · cited 2×
“Serum levels of TNF- , IL-6, and sIL-6r were assayed, using Quantikine High Sensitivity Immunoassay kits (R&D, Minneapolis, Minnesota), per kit instructions (16,40).”
BackgroundMethodSelf-citationEmotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176
Self-citationThe Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers
Kasapis, C., & Thompson, P. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.077 · Cited by 1,149
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050
Measurement Characteristics of the Women’s Health Initiative Food Frequency Questionnaire
Patterson, R. E., Kristal, A. R., Tinker, L. F., Carter, R. A., Bolton, M. P., & Agurs‐Collins, T. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00055-6 · Cited by 1,021
Interleukin-6 in acute exercise and training: what is the biological relevance?
Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817
Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.011 · Cited by 748
Subliminal processing of emotional information in anxiety and depression.
Mogg, K., Bradley, B. P., Williams, R. M., & Mathews, A. (1993) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.102.2.304 · Cited by 498
Subliminal processing of emotional information in anxiety and depression.
Mogg, K., Bradley, B. P., Williams, R., & Mathews, A. (1993) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.102.2.304 · Cited by 497
Yoga for depression: the research evidence
Pilkington, K., Kirkwood, G., Rampes, H., & Richardson, J. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.08.013 · Cited by 495
Effect of rosary prayer and yoga mantras on autonomic cardiovascular rhythms: comparative study
Bernardi, L., Sleight, P., Bandinelli, G., Cencetti, S., Fattorini, L., Wdowczyc-Szulc, J., & Lagi, A. (2001) · BMJ · doi:10.1136/bmj.323.7327.1446 · Cited by 486 · cited 1×
“Mechanistic explanations for yoga’s potential mental and physical health benefits have highlighted reductions in sympathetic nervous system tone (21,22), and increases in vagal activity (22), both of which could have favorable endocrine and immune consequences, including lower inflammation.”
Background(2004) · PubMed · Cited by 381
Stress-Induced Changes in Skin Barrier Function in Healthy Women
Altemus, M. M., Rao, B. K., Dhabhar, F. S., Ding, W., & Granstein, R. D. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01373.x · Cited by 347
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · cited 1×
“Additionally, psychological stressors can directly provoke transient increases in proinflammatory cytokines (14,15), and chronic stressors have been linked to sustained overproduction of IL-6 (16,17).”
BackgroundGenomic counter-stress changes induced by the relaxation response
Dusek, J. A., Otu, H. H., Wohlhueter, A. L., Bhasin, M., Zerbini, L. F., Joseph, M. G., Benson, H., & Libermann, T. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002576 · Cited by 248
Regulatory concerns and appraisal efficiency: The general impact of promotion and prevention.
Shah, J., & Higgins, E. T. (2001) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.80.5.693 · Cited by 245
Glaser, R., Robles, T. F., Sheridan, J. F., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1009 · Cited by 242
Self-citationEffects of yoga on inflammation and exercise capacity in patients with chronic heart failure.
Pullen, P., Nagamia, S. H., Mehta, P., Thompson, W., Benardot, D., Hammoud, R. A., Parrott, J. M., Sola, S., & Khan, B. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.12.007 · Cited by 228
Yoga for Cancer Patients and Survivors
Bower, J. E., Woolery, A., Sternlieb, B., & Garet, D. (2005) · Cancer Control · doi:10.1177/107327480501200304 · Cited by 224
Clasey, J. L., Bouchard, C., Teates, C. D., Riblett, J. E., Thorner, M. O., Hartman, M. L., & WELTMAN, A. L. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00404.x · Cited by 223
Olfactory influences on mood and autonomic, endocrine, and immune function
Kiecolt‐Glaser, J. K., Graham‐Engeland, J. E., Malarkey, W. B., Porter, K. M., Lemeshow, S. A., & Glaser, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.015 · Cited by 194
Self-citationLEMMINK, K. A. P. M., Kemper, H. C. G., Greef, M. H. G. D., Rispens, P., & Stevens, M. J. (2003) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2003.10609099 · Cited by 176
Stress alters cutaneous permeability barrier homeostasis
Denda, M., Tsuchiya, T., Elias, P. M., & Feingold, K. R. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.2.r367 · Cited by 166
Sivasankaran, S., Pollard-Quintner, S., Sachdeva, R., Pugeda, J., Hoq, S. M., & ZARICH, S. W. (2006) · Clinical Cardiology · doi:10.1002/clc.4960290905 · Cited by 148
The relative influences of fitness and fatness on inflammatory factors
Hamer, M. (2006) · Preventive Medicine · doi:10.1016/j.ypmed.2006.09.005 · Cited by 132
Tai Chi Chih acutely decreases sympathetic nervous system activity in older adults.
Motivala, S. J., Sollers, J., Thayer, J., & Irwin, M. R. (2006) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/61.11.1177 · Cited by 128
Markers of inflammation are inversely associated with V̇ o 2 max in asymptomatic men
Kullo, I. J., Khaleghi, M., & Hensrud, D. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01028.2006 · Cited by 128
C-Reactive protein is inversely related to physical fitness in middle-aged subjects
Aronson, D., Sheikh‐Ahmad, M., Avizohar, O., Kerner, A., Sella, R., Bartha, P., Markiewicz, W., Levy, Y., & Brook, G. J. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.04.025 · Cited by 115
Hatha yoga and the treatment of illness.
Riley, D. (2004) · PubMed · Cited by 104
A SIMULATION STUDY TO EVALUATE PROC MIXED ANALYSIS OF REPEATED MEASURES DATA
Guerin, L., & Stroup, W. W. (2000) · Conference on Applied Statistics in Agriculture · doi:10.4148/2475-7772.1249 · Cited by 71
Hirsch, M. S., & Liebert, R. M. (1998) · Pain · doi:10.1016/s0304-3959(98)00080-3 · Cited by 69
How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitis
Kiecolt‐Glaser, J. K., Heffner, K. L., Glaser, R., Malarkey, W. B., Porter, K. M., Atkinson, C., Laskowski, B. F., Lemeshow, S. A., & Marshall, G. D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.11.010 · Cited by 68
Self-citationvon Känel, R., Hong, S. J., Pung, M. A., & MILLS, P. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.01.005 · Cited by 16
Research works printed but not linked: 1
- Ruth, 2001, Differentiating depression and anxiety: psychometric implications of the tripartite model of affect., J Pers Clin Stud, 17, 9
Cited by
Sorted by citations
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844
“In addition, some evidence suggests that meditation and yoga may reduce inflammatory responsiveness (181, 183, 184).”
BackgroundSelf-citationYoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis.
Pascoe, M. C., Thompson, D. R., & Ski, C. F. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.08.008 · Cited by 570
“Yoga asanas were found to mitigate changes in IL-6 and CRP following a stressful laboratory test, compared to a movement control condition and a video control condition (Kiecolt-Glaser et al., 2010).”
Effective and viable mind-body stress reduction in the workplace: A randomized controlled trial.
Wolever, R. Q., Bobinet, K. J., McCabe, K., Mackenzie, E. R., Fekete, E., Kusnick, C. A., & Baime, M. (2012) · Journal of Occupational Health Psychology · doi:10.1037/a0027278 · Cited by 539
Bower, J. E., & Lamkin, D. M. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.06.011 · Cited by 383
Metadata
- Authors
- Kiecolt-Glaser, J. K., Christian, L., Preston, H., Houts, C. R., Malarkey, W. B., Emery, C. F., & Glaser, R.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Psychosomatic Medicine
- Published
- 2010-02
- Volume
- 72
- Issue
- 2
- Pages
- 113-121
- ISSN
- 0033-3174 (ISSN-L)
- PMC
- PMC2820143
- OpenAlex
- W2165834433
- Cited by
- 327
- References
- 47
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 19 · 2023: 19 · 2022: 28 · 2021: 41 · 2020: 19 · 2019: 22 · 2018: 10 · 2017: 17 · 2016: 16 · 2015: 23 · 2014: 25 · 2013: 21 · 2012: 19
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA016058)
- National Institute of Allergy and Infectious Diseases (T32AI055411)
- National Center for Research Resources (UL1RR025755, M01RR000034)
- National Center for Complementary and Integrative Health (R21AT002971)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- hatha yoga, stress reduction, inflammation, interleukin-6, C-reactive protein, physiological recovery, endocrine response, positive affect, soluble IL-6 receptor, women, restorative yoga, stress response mechanisms, mood and anxiety symptoms, transepidermal water loss
- MeSH terms
- Adaptation, Physiological, Adult, Aged, Complementary Therapies, C-Reactive Protein, Catecholamines, Cold Temperature, Female, Humans, Hydrocortisone, Inflammation, Middle Aged, Motor Activity, Physical Fitness, Psychoneuroimmunology, Stress, Psychological, Water Loss, Insensible, Yoga, Interleukin-6, Meditation
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