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Cited by 9Child Abuse and TraumaCardiovascular Health and Disease PreventionGenetic Associations and Epidemiology

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Monoamine Oxidase A Genotype, Childhood Trauma, and Subclinical Atherosclerosis: A Twin Study

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Zhao, Jinying, Bremner, James D., Goldberg, Jack, Quyyumi, Arshed A., Vaccarino, Viola·2013·Psychosomatic Medicine
DOI 10.1097/psy.0b013e318292922aPMC PMC3739689
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Abstract

OBJECTIVE: A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated in neuropsychiatric disorders and also moderates the association between early-life stress and mental disorders, which often co-occur with cardiovascular disease. No study has examined the relationship between MAOA genotype, childhood trauma, and subclinical atherosclerosis. The objective of this investigation was to examine whether childhood trauma moderates the association between MAOA genotype and subclinical atherosclerosis. METHODS: A sample including 289 middle-aged male twin pairs was studied. Subclinical atherosclerosis was assessed by brachial flow-mediated dilation (FMD) using ultrasound. Childhood trauma, before age 18 years, was measured with the Early Trauma Inventory and included physical, emotional, and sexual abuse as well as general trauma. Generalized estimating equation models were used to test the main and interactive effects of the MAOA genotype and each domain of childhood trauma on FMD, adjusting for known risk factors. RESULTS: General trauma was the most prevalent childhood trauma (28.4%), followed by physical abuse (25.0%), emotional abuse (19.4%), and sexual abuse (11.6%). MAOA genotype was not associated with any domain of childhood trauma. There was no significant evidence for a main effect for the MAOA genotype (β = .02, p = .82) or childhood trauma (.005 < β < .10, p > .54) FMD. However, a significant interaction was observed between MAOA genotype and physical (β interaction = .37, p = .026) or emotional abuse (β interaction = .43, p = .025) on subclinical atherosclerosis. CONCLUSIONS: Childhood trauma modulates the impact of MAOA variant on subclinical atherosclerosis, independent of traditional cardiovascular risk factors.

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  • ELA effects are modified by genetics, child sex and/or gender, exposure features (e.g., timing, nature, and intensity), and the presence of other risks or protective factors.

    “Some observed modifiers of ELA effects include genetics [25, 87–89], child sex and/or gender [19, 90, 91], exposure features (e.g., timing, nature, and intensity) [21, 25], and the presence of other risks or protective factors [36].”

    From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [89]

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Metadata

Authors
Zhao, J., Bremner, J. D., Goldberg, J., Quyyumi, A. A., & Vaccarino, V.
Affiliations
Tulane University (US)
Corresponding author
Zhao, Jinying
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-06
Volume
75
Issue
5
Pages
471-477
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e318292922a
PMC
PMC3739689
OpenAlex
W2035534975
Cited by
9
References
10
Citations by year
2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1
FWCI
0.74
Type
journal article
Language
en
Open access
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (K01AG034259, R01AG026255)
  • National Heart, Lung, and Blood Institute (R01HL068630, R21HL092363, K24HL077506, R01HL088726, R01 HL68630)
  • National Institute of Mental Health (R01MH056120, K24MH076955)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091369)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
monoamine oxidase A, childhood trauma, subclinical atherosclerosis, flow-mediated dilation, physical abuse, emotional abuse, sexual abuse, gene-environment interaction, cardiovascular risk, twin pairs, middle-aged men
MeSH terms
Adolescent, Adult, Child, Child Abuse, Genotype, Humans, Life Change Events, Male, Middle Aged, Monoamine Oxidase, Polymorphism, Genetic, Promoter Regions, Genetic, Risk Factors, Stress, Psychological, Twins, Ultrasonography, Models, Statistical, Minisatellite Repeats, Genetic Predisposition to Disease, Atherosclerosis, Gene-Environment Interaction

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