Early life experience alters response of adult neurogenesis to stress
Abstract
Maternal deprivation produces persistent abnormalities in behavioral and neuroendocrine functions associated with the hippocampus, a brain region that shows considerable structural change in response to experience throughout life. Here we show that adverse experience early in life affects the regulation of adult neurogenesis in the hippocampus. More specifically, a decrease in cell proliferation and immature neuron production are observed in the dentate gyrus of adult rats that are maternally separated as pups. Although maternally separated rats show normal basal levels of corticosterone, the suppression of cell proliferation in these rats can be reversed by lowering corticosterone below the control value. In addition, normal stress-induced suppression of cell proliferation and neurogenesis, despite normal activation of the hypothalamic pituitary adrenal (HPA) axis, is not observed in maternally separated rats. Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood.
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Early life adversity reduces the production of new neurons in the dentate gyrus.
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From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [37]
Maternal separation stress reduced adult neurogenesis in the rat hippocampus in previous work.
“Previous work showed maternal separation stress reduced adult neurogenesis in the rat hippocampus (37; 62–64), although other studies failed to show this (65).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [37]
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- Authors
- Mirescu, C., Peters, J. D., & Gould, E.
- Affiliations
- Princeton University (US)
- Corresponding author
- Gould, Elizabeth
- Venue
- Nature Neuroscience
- Published
- 2004-07-25
- Volume
- 7
- Issue
- 8
- Pages
- 841-846
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1964173716
- Cited by
- 625
- References
- 45
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 23 · 2023: 18 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 31 · 2018: 18 · 2017: 22 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 34 · 2012: 24
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH059740, P50MH058922, MH58922, MH-59740)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- childhood adversity, maternal separation, adult neurogenesis, hippocampus, dentate gyrus, cell proliferation, corticosterone, glucocorticoid sensitivity, stress response, hypothalamic-pituitary-adrenal axis, structural plasticity
- MeSH terms
- Animals, Cell Division, Corticosterone, Female, Hippocampus, Hypothalamo-Hypophyseal System, Immunohistochemistry, Maternal Deprivation, Neuronal Plasticity, Pituitary-Adrenal System, Stress, Psychological, Rats
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