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HIV reservoirs: pathogenesis and obstacles to viral eradication and cure
Abstract
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved. However, ART alone cannot eradicate HIV in infected individuals and this impediment is likely in part due to the persistence of viral reservoirs in the peripheral blood and lymphoid tissues of infected individuals despite the suppression of plasma viremia. In recent years, major research efforts have been dedicated to a better understanding of the pathogenesis of persistent HIV infection and to the development of therapeutic strategies aimed at eradicating virus in infected individuals receiving ART. In this review, we discuss the pathophysiology of CD4 T-cell HIV reservoirs, including recent advances in our understanding of the mechanisms of persistent viral infection and perspectives for eradication of HIV in infected individuals.
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“HIV-1 persists in ∼10 6 cells per patient during HAART, and is linked to comorbidities including heart and renal diseases, osteopenia, and neurological disorders”
From RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection (2014) · cites this paper as [5]
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Metadata
- Authors
- Chun, T.-W., & Fauci, A. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chun, Tae-Wook
- Venue
- AIDS
- Published
- 2012-06-19
- Volume
- 26
- Issue
- 10
- Pages
- 1261-1268
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2044293862
- Cited by
- 175
- References
- 99
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 21 · 2015: 18 · 2014: 13 · 2013: 34 · 2012: 8
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- HIV reservoir, persistent HIV infection, antiretroviral therapy, viral eradication, lymphoid tissue, HIV pathogenesis
- MeSH terms
- Disease Reservoirs, Humans, Viremia, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Anti-Retroviral Agents
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