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HIV reservoirs: pathogenesis and obstacles to viral eradication and cure

Chun, Tae-Wook, Fauci, Anthony S.·2012·AIDS

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Abstract

Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved. However, ART alone cannot eradicate HIV in infected individuals and this impediment is likely in part due to the persistence of viral reservoirs in the peripheral blood and lymphoid tissues of infected individuals despite the suppression of plasma viremia. In recent years, major research efforts have been dedicated to a better understanding of the pathogenesis of persistent HIV infection and to the development of therapeutic strategies aimed at eradicating virus in infected individuals receiving ART. In this review, we discuss the pathophysiology of CD4 T-cell HIV reservoirs, including recent advances in our understanding of the mechanisms of persistent viral infection and perspectives for eradication of HIV in infected individuals.

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Authors: Chun, T.-W., & Fauci, A. S.
Affiliations: National Institutes of Health (US)
Corresponding author: Chun, Tae-Wook
ORCID: Chun, Tae-Wook
Fauci, Anthony S.
Venue: AIDS
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-06-19
Volume: 26
Issue: 10
Pages: 1261-1268
ISSN: 0269-9370 (ISSN-L)
DOI: 10.1097/qad.0b013e328353f3f1
OpenAlex: W2044293862
Cited by: 175
References: 99
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 21 · 2015: 18 · 2014: 13 · 2013: 34 · 2012: 8
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Locations: AIDS (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Keywords: HIV reservoir, persistent HIV infection, antiretroviral therapy, viral eradication, lymphoid tissue, HIV pathogenesis
MeSH terms: Disease Reservoirs, Humans, Viremia, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Anti-Retroviral Agents

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HIV reservoirs: pathogenesis and obstacles to viral eradication and cure

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