The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Attention Deficit/Hyperactivity Disorder: Is There a Correlation Between Dopamine Transporter Density and Cerebral Blood Flow?
Abstract
Attention deficit/hyperactivity disorder (ADHD) is one of the most frequent behavioral problems in school-age children. Although the etiology remains unclear, the involvement of the dopaminergic system has been suggested by genetic studies that report an overexpression of the dopamine transporter (DAT) gene. In spite of these abnormalities being directly related to the decrease of dopamine (DA) in the striatum (STR), abnormalities in brain perfusion have also been observed in cortical-subcortical structures. Functional neuroimaging studies have suggested that the DA concentration may cause changes in the cerebral blood flow (CBF). The objective of our study was to evaluate the relationship between DAT density in STR and cortical-subcortical impairment in CBF. Based on the hypothesis that there is a correlation between DA availability and brain perfusion, we postulated that individuals with ADHD, with a higher DAT density in the basal ganglia, will have lower perfusion in the fronto-striatal-cerebellar networks. We used Tc-99m TRODAT-1 SPECT to measure DAT density and Tc-99m ECD SPECT to assess brain perfusion. Ten adolescents diagnosed with ADHD by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria were investigated. Analysis with Statistical Parametric Mapping 5 corrected for multiple comparisons, using small volume correction, showed a significant negative correlation between the DAT density in the STR and CBF in the cingulate gyrus, frontal lobe…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among treatment-naive adolescents with ADHD, dopamine transporter density shows a significant inverse relationship with blood flow in the cingulate cortex, frontal and temporal lobes, and cerebellum.
“Among treatment-naive adolescents with ADHD, DAT density shows a significant inverse relationship with blood flow in the cingulate cortex, the frontal and temporal lobes, and the cerebellum, brain regions which are involved in modulating attention (208).”
Citations
Cites
Dresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H. F., Hahn, K., & Tatsch, K. (2000) · European Journal of Nuclear Medicine · doi:10.1007/s002590000330 · Cited by 278
Relationship of spikes, synaptic activity, and local changes of cerebral blood flow
Lauritzen, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00001 · Cited by 253
Kim, B. N., Lee, J. S., Cho, S. C., & Lee, D. S. (2001) · Yonsei Medical Journal · doi:10.3349/ymj.2001.42.1.19 · Cited by 88
Krause, J., la Fougere, C., Krause, K.-H., Ackenheil, M., & Dresel, S. H. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0602-x · Cited by 84
la Fougère, C., Krause, J., Krause, K.-H., Josef Gildehaus, F., Hacker, M., Koch, W., Hahn, K., Tatsch, K., & Dresel, S. (2006) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000230077.48480.68 · Cited by 57
Flagged first, then by citations
Research works printed but not linked: 21
- Polanczyk, 2007, The worldwide prevalence of ADHD: a systematic review and metaregression analysis., Am J Psychiatry, 164, 942, 10.1176/ajp.2007.164.6.942 · DOI · Paper page
- Faraone, 2005, Molecular genetics of attention-deficit/hyperactivity disorder., Biol Psychiatry, 57, 1313, 10.1016/j.biopsych.2004.11.024 · DOI · Paper page
- Feron, 2005, Dopamine transporter in attention-deficit hyperactivity disorder normalizes after cessation of methylphenidate., Pediatr Neurol, 33, 179, 10.1016/j.pediatrneurol.2005.04.008 · DOI
- Cook, 1995, Association of attention-deficit disorder and the dopamine transporter gene., Am J Hum Genet, 56, 993
- Krause, 2008, SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder., Expert Rev Neurother, 8, 611, 10.1586/14737175.8.4.611 · DOI · Paper page
- Cheon, 2003, Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder., Eur J Nucl Med Mol Imaging, 30, 306, 10.1007/s00259-002-1047-3 · DOI
- Choi, 2006, Brain hemodynamic changes mediated by dopamine receptors: role of the cerebral microvasculature in dopamine-mediated neurovascular coupling., Neuroimage, 30, 700, 10.1016/j.neuroimage.2005.10.029 · DOI
- Logothetis, 2003, The underpinnings of the BOLD functional magnetic resonance imaging signal., J Neurosci, 23, 3963, 10.1523/JNEUROSCI.23-10-03963.2003 · DOI
- Jenkins, 2004, Mapping dopamine function in primates using pharmacologic magnetic resonance imaging., J Neurosci, 24, 9553, 10.1523/JNEUROSCI.1558-04.2004 · DOI
- Szobot, 2007, Is attention-deficit/hyperactivity disorder associated with illicit substance use disorders in male adolescents? A community-based case–control study?, Addiction, 102, 1122, 10.1111/j.1360-0443.2007.01850.x · DOI · Paper page
- Swanson, 2001, Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment., J Am Acad Child Adolesc Psychiatry, 40, 168, 10.1097/00004583-200102000-00011 · DOI · Paper page
- Busatto, 2000, A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single photon emission computed tomography (SPECT)., Psychiatry Res, 99, 15, 10.1016/S0925-4927(00)00050-0 · DOI
- Krause, 2000, Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography., Neurosci Lett, 285, 107, 10.1016/S0304-3940(00)01040-5 · DOI · Paper page
- Ingvar, 1983, Apomorphine-induced changes in local cerebral blood flow in normal rats and after lesions of the dopaminergic nigrostriatal bundle., Brain Res, 262, 259, 10.1016/0006-8993(83)91016-8 · DOI
- Logan, 1994, Effects of blood flow on [11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data., J Cereb Blood Flow Metab, 14, 995, 10.1038/jcbfm.1994.132 · DOI
- Erlandsson, 2003, Kinetic modelling of [123I]CNS 1261—a potential SPET tracer for the NMDA receptor., Nucl Med Biol, 30, 441, 10.1016/S0969-8051(02)00450-X · DOI
- Gustafsson, 2000, Associations between cerebral blood-flow measured by single photon emission computed tomography (SPECT), electro-encephalogram (EEG), behaviour symptoms, cognition and neurological soft signs in children with attention-deficit hyperactivity disorder (ADHD)., Acta Paediatr, 89, 830
- Kaya, 2002, Technetium-99m HMPAO brain SPECT in children with attention deficit hyperactivity disorder., Ann Nucl Med, 16, 527, 10.1007/BF02988629 · DOI
- Kim, 2002, Regional cerebral perfusion abnormalities in attention deficit/hyperactivity disorder. Statistical parametric mapping analysis., Eur Arch Psychiatry Clin Neurosci, 252, 219, 10.1007/s00406-002-0384-3 · DOI
- Szobot, 2008, Methylphenidate DAT binding in adolescents with Attention-Deficit/Hyperactivity Disorder comorbid with Substance Use Disorder—a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study., Neuroimage, 40, 1195, 10.1016/j.neuroimage.2007.12.050 · DOI
- Szobot, 2003, The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder., Eur J Nucl Med Mol Imaging, 30, 423, 10.1007/s00259-002-1082-0 · DOI
Cited by
Sorted by citations
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631
Sánchez‐Mora, C., Richarte, V., Garcia‐Martínez, I., Pagerols, M., Corrales, M., Bosch, R., Vidal, R., Viladevall, L., Casas, M., Cormand, B., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32340 · Cited by 23
Metadata
- Authors
- da Silva, N., Szobot, C. M., Anselmi, C. E., Jackowski, A. P., Chi, S. M., Hoexter, M. Q., Anselmi, O. E., Pechansky, F., Bressan, R. A., & Rohde, L. A.
- Affiliations
- Santa Casa Hospital (BR)
- Universidade Federal de São Paulo (BR)
- Corresponding author
- da Silva, Neivo
- Anselmi, Carlos E.
- Anselmi, Osvaldo E.
- Venue
- Clinical Nuclear Medicine
- Published
- 2011-08
- Volume
- 36
- Issue
- 8
- Pages
- 656-660
- ISSN
- 0363-9762 (ISSN-L)
- OpenAlex
- W2027568359
- Cited by
- 21
- References
- 5
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, dopamine transporter density, striatum, cerebral blood flow, cerebral perfusion, adolescents, attentional networks, dopamine availability
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Basal Ganglia, Cerebrovascular Circulation, Cysteine, Dopamine, Humans, Male, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Neostriatum, Dopamine Plasma Membrane Transport Proteins, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
