Postshock Intervention With High-Lipid Enteral Nutrition Reduces Inflammation and Tissue Damage
Abstract
OBJECTIVE: To investigate the effects of high-lipid enteral nutrition in a setting of developing inflammation and tissue damage. BACKGROUND: An excessive inflammatory response following severe trauma is associated with poor clinical outcome. Currently, therapies directed at attenuation of an ongoing inflammatory cascade are lacking. Administration of high-lipid enteral nutrition before hemorrhagic shock has been shown to effectively inhibit early and late proinflammatory cytokines by activation of the autonomic nervous system via cholecystokinin (CCK)-receptors. METHODS: A rat model of hemorrhagic shock was used in which animals were either fasted or treated with high-lipid or control low-lipid enteral nutrition. CCK-receptor antagonists were administered before feeding. Tissues and plasma were collected to assess inflammation and intestinal integrity. RESULTS: Administration of high-lipid enteral nutrition after shock reduced plasma interferon-gamma (IFN-gamma) significantly in comparison with those in low-lipid-treated and fasted animals (P < 0.01 and P < 0.001, respectively). Also, interleukin (IL)-10 levels in plasma were decreased in comparison with those in fasted animals (P < 0.001). Enterocyte damage, expressed as circulating ileal lipid-binding protein (ILBP), was prevented by early high-lipid nutrition in comparison with that in low-lipid-treated and fasted animals (P = 0.05 and P < 0.001, respectively). Furthermore, high-lipid feeding preserved intestinal integrity in comparison with that observed in low-lipid-treated and fasted animals, as assessed by bacterial translocation (BT) to distant organs (P < 0.05 and P < 0.001, respectively) and ileal permeability to horseradish peroxidase (HRP) (P = 0.05 and P < 0.001, respectively). The protective effects of high-lipid intervention were nullified by CCK-receptor antagonists (IFN-gamma; IL-10; BT; and HRP; P < 0.05). CONCLUSION: High-lipid enteral nutrition given postshock reduces inflammation and preserves tissue integrity via a CCK-receptor-dependent mechanism. These findings implicate that intervention with high-lipid enteral nutrition following events such as severe trauma is a potential therapy to attenuate the developing inflammatory response.
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High-lipid enteral nutrition attenuates intestinal inflammation, bacterial translocation and intestinal injury following intestinal hypoperfusion with digestive disturbances.
“In fact, high-lipid enteral nutrition has been shown to attenuate intestinal inflammation, bacterial translocation and intestinal injury following intestinal hypoperfusion with digestive disturbances [142].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [142]
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738 · see citing works
Regulation of Interferon‐γ During Innate and Adaptive Immune Responses
Schoenborn, J. R., & Wilson, C. B. (2007) · Advances in immunology · doi:10.1016/s0065-2776(07)96002-2 · Cited by 1,659 · see citing works
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170 · see citing works
Keel, M., & Trentz, O. (2005) · Injury · doi:10.1016/j.injury.2004.12.037 · Cited by 885 · see citing works
Systemic inflammation after trauma
Lenz, A. M., Franklin, G. A., & Cheadle, W. G. (2007) · Injury · doi:10.1016/j.injury.2007.10.003 · Cited by 605 · see citing works
Inflammatory cytokines and cell response in surgery
Lin, E., Calvano, S. E., & Lowry, S. F. (2000) · Surgery · doi:10.1067/msy.2000.101584 · Cited by 576 · see citing works
Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?
Biffl, W., Moore, E. E., Moore, F., & Peterson, V. M. (1996) · Annals of Surgery · doi:10.1097/00000658-199611000-00009 · Cited by 558 · see citing works
POST-INJURY MULTIPLE ORGAN FAILURE: THE ROLE OF THE GUT
Hassoun, H. T., Kone, B. C., Mercer, D., Moody, F. G., Weisbrodt, N. W., & Moore, F. A. (2001) · Shock · doi:10.1097/00024382-200115010-00001 · Cited by 540 · see citing works
Postinjury Multiple Organ Failure: A Bimodal Phenomenon
Moore, F. A., Sauaia, A., Moore, E. E., Haenel, J. B., Burch, J. M., & Lezotte, D. C. (1996) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199604000-00001 · Cited by 491 · see citing works
Fatty acid-binding proteins as plasma markers of tissue injury
Pelsers, M. M. A. L., Hermens, W. T., & Glatz, J. F. C. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.09.001 · Cited by 488 · see citing works
Clark, J. A., & Coopersmith, C. M. (2007) · Shock · doi:10.1097/shk.0b013e31805569df · Cited by 443 · see citing works
Pavlov, V. A., Ochani, M., Yang, L., Gallowitsch‐Puerta, M., Ochani, K., Lin, X., Levi, J., Parrish, W. R., Rosas‐Ballina, M., Czura, C. J., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259381.56526.96 · Cited by 353 · see citing works
Huston, J. M., Gallowitsch‐Puerta, M., Ochani, M., Ochani, K., Yuan, R., Rosas‐Ballina, M., Ashok, M., Goldstein, R. S., Chavan, S. S., Pavlov, V. A., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000288102.15975.ba · Cited by 306 · see citing works
Coopersmith, C. M. (2002) · JAMA · doi:10.1001/jama.287.13.1716 · Cited by 295 · see citing works
Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
Luyer, M. D., Greve, J. W. M., Hadfoune, M., Jacobs, J. A., Dejong, C. H., & Buurman, W. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042397 · Cited by 295 · see citing works
Self-citationPostinjury multiple organ failure
Dewar, D., Moore, F. A., Moore, E. E., & Balogh, Z. J. (2009) · Injury · doi:10.1016/j.injury.2009.05.024 · Cited by 286 · see citing works
Fink, M. P., & Delude, R. L. (2005) · Critical Care Clinics · doi:10.1016/j.ccc.2005.01.005 · Cited by 280 · see citing works
Peitzman, A. B., Harbrecht, B. G., Udekwu, A. O., Billiar, T. R., Kelly, E., & Simmons, R. L. (1995) · Current Problems in Surgery · doi:10.1016/s0011-3840(05)80008-5 · Cited by 249 · see citing works
The essential role of the intestinal microbiota in facilitating acute inflammatory responses
Souza, D. G., Vieira, A. T., Soares, A. C., Pinho, V., Nicoli, J. R., Vieira, L. Q., & Teixeira, M. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4137 · Cited by 247 · see citing works
Edwin, A. D. (2006) · Frontiers in bioscience · doi:10.2741/1816 · Cited by 242 · see citing works
Epidemiology of sepsis in patients with traumatic injury
Osborn, T. M., Tracy, J. K., Dunne, J. R., Pasquale, M. D., & Napolitano, L. M. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000145586.23276.0f · Cited by 219 · see citing works
Lieberman, J. M., Sacchettini, J. C., MARKS, C., & Marks, W. H. (1997) · Surgery · doi:10.1016/s0039-6060(97)90363-9 · Cited by 217 · see citing works
Nast-Kolb, D. C., Waydhas, C., Gippner‐Steppert, C., Schneider, I., Trupka, A., Ruchholtz, S., Zettl, R., Schweiberer, L., & Jochum, M. (1997) · doi:10.1097/00005373-199703000-00012 · Cited by 212 · see citing works
Epidemiology of Injuries: Current Trends and Future Challenges
MacKenzie, E. J. (2000) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a018006 · Cited by 204 · see citing works
Alverdy, J. C., Laughlin, R. S., & Wu, L. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000045576.55937.67 · Cited by 200 · see citing works
Training in Advanced Trauma Life Support
Collicott, P. E. (1980) · JAMA · doi:10.1001/jama.1980.03300370030022 · Cited by 147 · see citing works
EVIDENCE FOR INTESTINAL AND LIVER EPITHELIAL CELL INJURY IN THE EARLY PHASE OF SEPSIS
Derikx, J. P. M., Poeze, M., van Bijnen, A. A. J. H. M., Buurman, W. A., & Heineman, E. (2007) · Shock · doi:10.1097/shk.0b013e3180644e32 · Cited by 138 · see citing works
Self-citationLi, Q., Zhang, Q., Wang, M., Zhao, S., Ma, J., Luo, N., Li, N., Li, Y., Xu, G., & Li, J. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.017 · Cited by 126 · see citing works
Meldrum, D. R., Ayala, A., Perrin, M. M., Ertel, W., & Chaudry, I. H. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90088-4 · Cited by 93 · see citing works
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Jacobs, J. A., Konstantinov, S. R., Dejong, C. H. C., & Greve, J. W. M. (2003) · Shock · doi:10.1097/01.shk.0000101671.49265.cf · Cited by 87 · see citing works
Self-citationTschoeke, S. K., Hellmuth, M., Hostmann, A., Ertel, W., & Oberholzer, A. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e318047b7f0 · Cited by 73 · see citing works
Papa, L., Langland‐Orban, B., Kallenborn, C., Tepas, J. J., Lottenberg, L. L., Celso, B. G., Durham, R. M., & FLINT, L. M. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000221789.53864.ba · Cited by 71 · see citing works
Adaptive and Maladaptive Mechanisms of Cellular Priming
Meldrum, D. R., Cleveland, J. C., Moore, E. E., Partrick, D. A., Banerjee, A., & Harken, A. H. (1997) · Annals of Surgery · doi:10.1097/00000658-199711000-00003 · Cited by 67 · see citing works
Ertel, W., Mh, M., Ayala, A., Dean, R. E., & Ih, C. (1992) · PubMed · Cited by 61 · see citing works
Yin, K., Gribbin, E., & Wang, H. (2005) · Shock · doi:10.1097/01.shk.0000175556.03300.c6 · Cited by 59 · see citing works
Evolving trends in the care of polytrauma patients
Bose, D., & Tejwani, N. C. (2005) · Injury · doi:10.1016/j.injury.2005.06.054 · Cited by 59 · see citing works
Luyer, M. D. P., Jacobs, J. A., Vreugdenhil, A. C. E., Hadfoune, M., Dejong, C. H. C., Buurman, W. A., & Greve, J. W. M. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000108695.60059.80 · Cited by 53 · see citing works
Self-citationInterferon Gamma Modulates Trauma-Induced Muscle Wasting and Immune Dysfunction
Madihally, S. V., Toner, M., Yarmush, M. L., & Mitchell, R. N. (2002) · Annals of Surgery · doi:10.1097/00000658-200211000-00016 · Cited by 36 · see citing works
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Jacobs, J. A., Dejong, C. H. C., & Greve, J. W. M. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.04.026 · Cited by 31 · see citing works
Self-citationBarrier Defense Function of the Small Intestine: Effect of Ethanol and Acute Burn Trauma
Carter, E. A., Harmatz, P., Udall, J. N., & Walker, W. A. (1987) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5344-7_96 · Cited by 28 · see citing works
Bacterial translocation after non-lethal hemorrhage in the rat.
Bark, T. H., Katouli, M., Ljungqvist, O. H., Möllby, R., & Svenberg, T. (1993) · PubMed · Cited by 25 · see citing works
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Wolfs, T. G. A. M., Veer, C. V. ′., Jacobs, J. A., Dejong, C. H. C., & Greve, J. W. M. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000251513.59983.3b · Cited by 25 · see citing works
Self-citationAe, B., & Shires, G. T. (1996) · PubMed · Cited by 20 · see citing works
Aggressive Management of Surgical Emergencies
Bengmark, S. (2006) · Annals of The Royal College of Surgeons of England · doi:10.1308/003588406x149318 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Clark, A., & Mach, N. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0155-6 · Cited by 583 · see citing works
van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A. P., Poeze, M., van Loon, L. J. C., Dejong, C. H. C., & Buurman, W. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2012 · Cited by 285 · see citing works
Self-citationThuijls, G., Derikx, J. P. M., van Wijck, K., Zimmermann, L. J. I., Degraeuwe, P. L. J., Mulder, A., van der Zee, D. C., BROUWERS, H. A. A., Verhoeven, B. H., van Heurn, E. L. W., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181d778c4 · Cited by 222 · see citing works
Self-citationVagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease
Bonaz, B., Sinniger, V., & Pellissier, S. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12611 · Cited by 213 · see citing works
Wafaisade, A., Lefering, R. L., Bouillon, B., Sakka, S. G., Thamm, O. C., Paffrath, T., Neugebauer, E. A. M., & Maegele, M. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318206d3df · Cited by 205 · see citing works
Disturbed Intestinal Integrity in Patients With COPD
Rutten, E. P. A., Lenaerts, K., Buurman, W. A., & Wouters, E. F. �. (2013) · CHEST Journal · doi:10.1378/chest.13-0584 · Cited by 184 · see citing works
Self-citationIntestinal mast cells in gut inflammation and motility disturbances
Winter, B. Y. D., van den Wijngaard, R. M., & de Jonge, W. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.016 · Cited by 148 · see citing works
Non-invasive markers of gut wall integrity in health and disease
Derikx, J. P. M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i42.5272 · Cited by 114 · see citing works
van Dop, W. A., Heijmans, J., Büller, N. V. J. A., Snoek, S. A., Rosekrans, S. L., Wassenberg, E. A., Weerman, M. A. V. D. B., Lanske, B., Clarke, A. R., Winton, D. J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.045 · Cited by 94 · see citing works
Starvation Compromises Paneth Cells
Hodin, C. M. I. M., Lenaerts, K., Grootjans, J., de Haan, J. J., Hadfoune, M., Verheyen, F., Kiyama, H., Heineman, E., & Buurman, W. A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.030 · Cited by 93 · see citing works
Self-citationNew Insight in Loss of Gut Barrier during Major Non-Abdominal Surgery
Derikx, J. P. M., van Waardenburg, D. A., Thuijls, G., Willigers, H. M., Koenraads, M., van Bijnen, A. A. J. H. M., Heineman, E., Poeze, M., Ambergen, T., van Ooij, A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003954 · Cited by 86 · see citing works
Self-citationde Haan, J. J., Lubbers, T., Derikx, J. P. M., Relja, B., Henrich, D. M., Greve, J.-W. M., Marzi, İ., & Buurman, W. A. (2009) · Critical Care · doi:10.1186/cc7910 · Cited by 84 · see citing works
Self-citationVagal-Immune Interactions Involved in Cholinergic Anti-Inflammatory Pathway
Žila, I., Mokrá, D., Kopincová, J., Kolomaznik, M., Javorka, M., & Čalkovská, A. (2017) · Physiological Research · doi:10.33549/physiolres.933671 · Cited by 80 · see citing works
Controlling postoperative ileus by vagal activation
Lubbers, T. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i14.1683 · Cited by 78 · see citing works
Self-citationLubbers, T., de Haan, J. J., Luyer, M. D. P., Verbaeys, I., Hadfoune, M., Dejong, C. H. C., Buurman, W. A., & Greve, J. W. M. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181dae411 · Cited by 76 · see citing works
Self-citationHodin, C. M. I. M., Visschers, R. G. J., Rensen, S. S., Boonen, B., Damink, S. W. M. O., Lenaerts, K., & Buurman, W. A. (2012) · Journal of Nutrition · doi:10.3945/jn.112.162388 · Cited by 66 · see citing works
Self-citationSnoek, S. A., Verstege, M. I., Boeckxstaens, G. E., van den Wijngaard, R. M., & de Jonge, W. J. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.51 · Cited by 56 · see citing works
Enteroendocrine cells in gastrointestinal pathophysiology
Harrison, E., Lal, S., & McLaughlin, J. T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.012 · Cited by 56 · see citing works
Lubbers, T., Kox, M., de Haan, J. J., Greve, J. W. M., Pompe, J. C., Ramakers, B. P., Pickkers, P., & Buurman, W. A. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827c0a17 · Cited by 55 · see citing works
Self-citationLipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis
Lubbers, T., de Haan, J. J., Hadfoune, M., Zhang, Y., Luyer, M. D. P., Grundy, D., Buurman, W. A., & Greve, J. W. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181eb90d7 · Cited by 53 · see citing works
Self-citationNiarchou, M., Byrne, E. M., Trzaskowski, M., Sidorenko, J., Kemper, K. E., McGrath, J. J., O’Donovan, M. C., Owen, M. J., & Wray, N. R. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0688-y · Cited by 45 · see citing works
Oehlers, S. H., Flores, M. V., Hall, C. J., Wang, L., Ko, D. C., Crosier, K. E., & Crosier, P. S. (2016) · FEBS Journal · doi:10.1111/febs.13976 · Cited by 40 · see citing works
de Haan, J. J., Thuijls, G., Lubbers, T., Hadfoune, M., Reisinger, K. W., Heineman, E., Greve, J.-W. M., & Buurman, W. A. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e2cd4d · Cited by 38 · see citing works
Self-citationThe clinical importance of the anti-inflammatory vagovagal reflex.
Boeckxstaens, G. (2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53491-0.00011-0 · Cited by 29 · see citing works
Saia, R. S., Ribeiro, A. B., & Giusti, H. (2019) · Shock · doi:10.1097/shk.0000000000001355 · Cited by 33 · see citing works
van Bree, S. H. W., Cailotto, C., Giovangiulio, M. D., Jansen, E., van der Vliet, J., Costes, L. M. M., Depoortere, I., Gomez‐Pinilla, P. J., Matteoli, G., & Boeckxstaens, G. E. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12157 · Cited by 31 · see citing works
High-fat enteral nutrition reduces intestinal mucosal barrier damage after peritoneal air exposure
Tan, S., Yu, C., Yu, Z., Lin, Z., Wu, G., Yu, W., Li, J., & Li, N. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.12.010 · Cited by 23 · see citing works
Postoperative paralytic ileus remains a problem following surgery for advanced pelvic cancers
Funder, J. A., Tolstrup, R., Jepsen, B. N., & Iversen, L. H. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.05.044 · Cited by 22 · see citing works
de Haan, J. J., Pastille, E., Wirsdörfer, F., Lubbers, T., Greve, J.-W. M., Zhang, Y., Buurman, W. A., & Flohé, S. B. (2013) · Shock · doi:10.1097/shk.0000000000000062 · Cited by 18 · see citing works
Self-citationLubbers, T., de Haan, J. J., Hadfoune, M., Zabeau, L., Tavernier, J. H., Zhang, Y., Grundy, D., Greve, J. W. M., & Buurman, W. A. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.09.006 · Cited by 16 · see citing works
Self-citationLin, Z., Tan, S.-J., Cheng, M., Zhao, C., Yu, W., He, Y., Li, J., & Li, N. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.02.007 · Cited by 13 · see citing works
de Haan, J. J., Windsant, I. C. V., Lubbers, T., Hanssen, S. J., Hadfoune, M., Prinzen, F. W., Greve, J.-W. M., & Buurman, W. A. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828e9262 · Cited by 11 · see citing works
Self-citationWu, B.-G., Peng, T.-C., Tsai, P.-S., Wang, T., Jeng, M., & Huang, C. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.03.085 · Cited by 10 · see citing works
Nutritional stimulation of the autonomic nervous system
Luyer, M. D. P. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i34.3859 · Cited by 10 · see citing works
Self-citationLuyer, M. D. P., de Haan, J. J., Lubbers, T., Greve, J. W. M., & Buurman, W. A. (2013) · Shock · doi:10.1097/shk.0b013e31828def5a · Cited by 10 · see citing works
Self-citationKoelfat, K. V. K., Visschers, R. G. J., Hodin, C. M. I. M., de Waart, D. R., van Gemert, W. G., Cleutjens, J. P. M., Gijbels, M. J., Shiri‐Sverdlov, R., Mookerjee, R. P., Lenaerts, K., et al. (2017) · Journal of Clinical and Translational Research · doi:10.18053/jctres.03.201703.004 · Cited by 9 · see citing works
Gale, S. C., Shanker, B., Coyle, S. M., Macor, M., Choi, C. W., Calvano, S. E., Corbett, S., & Lowry, S. F. (2012) · Shock · doi:10.1097/shk.0b013e31826171b9 · Cited by 8 · see citing works
Thuijls, G., Derikx, J. P. M., de Kruijf, M., van Waardenburg, D. A., van Bijnen, A. A. J. H. M., Ambergen, T., van Rhijn, L. W., Willigers, H. M., & Buurman, W. A. (2011) · Shock · doi:10.1097/shk.0b013e318237d638 · Cited by 7 · see citing works
Self-citationDose–response effects of PEGylated cholecystokinin on the behavioral satiety sequence
Verbaeys, I., León-Tamaríz, F., Buyser, K. D., Buyse, J. G., Decuypere, E., Pottel, H., & Cokelaere, M. M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.05.010 · Cited by 7 · see citing works
Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?
Pijls, K. E., Jonkers, D. M. A. E., Elizalde, M., Drittij-Reijnders, M.-J., Haenen, G. R. M. M., Bast, A., Masclee, A., & Koek, G. H. (2016) · Annals of Hepatology · doi:10.5604/16652681.1198816 · Cited by 6 · see citing works
Tan, S., Yu, C., Yu, Z., Lin, Z., Wu, G., Yu, W., Li, J., & Li, N. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.11.047 · Cited by 6 · see citing works
Seesing, M. F. J., Janssen, H. J. B., Geraedts, T. C. M., Weijs, T. J., van Ark, I., Leusink-Muis, T., Folkerts, G., Garssen, J., Ruurda, J. P. H., Nieuwenhuijzen, G. A. P., et al. (2023) · Nutrients · doi:10.3390/nu15102327 · Cited by 4 · see citing works
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Worthington, J. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23720-1.00018-6 · Cited by 1 · see citing works
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Plummer, M. P., Blaser, A. R., & Deane, A. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_13 · Cited by 1 · see citing works
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Derikx, J. P. M. (2009) · doi:10.26481/dis.20090612jd · Cited by 1 · see citing works
de Haan, J. D., Lubbers, T., Luyer, M., & Buurman, W. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8503-2_103-1
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Lubbers, T. (2011) · doi:10.26481/dis.20111014tl
Self-citationArda-Pirincci, P., Turan, P., Arbak, S., & Bolkent, Ş. (2011) · DergiPark (Istanbul University)
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Verstege, M. I. (2010) · UvA-DARE (University of Amsterdam)
Slattery, E., & Seres, D. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-21831-1_9
intestinal injury during exercise: strategies for evaluation and
van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A. P., Poeze, M., van Loon, L. J. C., Dejong, C. H. C., & Buurman, W. A. (2012)
Self-citationFast Track in der Unfallchirurgie
Bail, H. J., Möbius, B., & Haas, N. P. (2009) · Der Chirurg · doi:10.1007/s00104-009-1677-0
de Haan, J. J., Lubbers, T., Luyer, M. D. P., & Buurman, W. A. (2015) · Springer eBooks · doi:10.1007/978-1-4614-7836-2_103
Self-citationАлексеевич, М. В., Андреевич, Г. М., Владимирович, К. А., & Kostrov, S. А. (2024) · Patient-Oriented Medicine and Pharmacy · doi:10.37489/2949-1924-0040
MARGINAL GAINS IN ESOPHAGECTOMY
Janssen, H. J. B. (2024) · doi:10.33540/2363
- Authors
- de Haan, J.-J., Lubbers, T., Hadfoune, M., Luyer, M. D., Dejong, C. H., Buurman, W. A., & Greve, J.-W. M.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maaslandziekenhuis (NL)
- Corresponding author
- Lubbers, Tim
- Hadfoune, M'hamed
- Dejong, Cornelis H.
- Buurman, Wim A.
- Greve, Jan-Willem M.
- Venue
- Annals of Surgery
- Published
- 2008-11
- Volume
- 248
- Issue
- 5
- Pages
- 842-848
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2091731496
- Cited by
- 59
- References
- 47
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 10 · 2012: 6
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- hemorrhagic shock, cholecystokinin receptors, IL-10, interferon-gamma, bacterial translocation, intestinal permeability, enterocyte damage, severe trauma, cytokine response
- MeSH terms
- Animals, Dietary Fats, Enteral Nutrition, Epithelial Cells, Ileum, Immunohistochemistry, Inflammation, Interferon-gamma, Male, Peroxidase, Receptors, Cholecystokinin, Shock, Hemorrhagic, Interleukin-10, Rats, Sprague-Dawley, Bacterial Translocation, Tight Junctions, Rats
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