Assessment and Management of Delirium in Older Adults in the Emergency Department: Literature Review to Inform Development of a Novel Clinical Protocol
Open accessAbstract
Delirium occurs frequently in older patients in the emergency department (ED), is underrecognized, and has potentially serious consequences. Despite its seriousness, delirium is frequently missed by emergency providers, and patients with unrecognized delirium are often discharged from the ED. Even when it is appropriately recognized, managing delirium in older adults poses a significant challenge for ED providers. Geriatric delirium is typically caused by the interaction of multiple factors, including several that are commonly missed: pain, urinary retention, constipation, dehydration, and polypharmacy. Appropriate management includes nonpharmacological management with medication intervention reserved for emergencies. We have developed a new, comprehensive, evidence-based protocol for diagnosis/recognition, management, and disposition of geriatric delirium patients in the ED with a focus on identifying and treating commonly missed contributing causes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Clarifying Confusion: The Confusion Assessment Method: A New Method for Detection of Delirium
Inouye, S. K., van Dyck, C. H., Alessi, C. A., Balkin, S., Siegal, A. P., & Horwitz, R. I. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-941 · Cited by 5,250 · see citing works
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye, S. K., Bogardus, S. T., Charpentier, P. A., Leo-Summers, L. S., Acampora, D., Holford, T. R., & Cooney, L. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400901 · Cited by 2,904 · see citing works
The American Geriatrics Society 2012 Beers Criteria Update Expert Panel (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.03923.x · Cited by 2,578 · see citing works
Inouye, S. K. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052321 · Cited by 2,091 · see citing works
Precipitating Factors for Delirium in Hospitalized Elderly Persons
Inouye, S. K. (1996) · JAMA · doi:10.1001/jama.1996.03530350034031 · Cited by 1,430 · see citing works
Pandharipande, P. P., Shintani, A., Peterson, J. F., Pun, B. T., Wilkinson, G. R., Dittus, R. S., Bernard, G. R., & Ely, E. W. (2005) · Anesthesiology · doi:10.1097/00000542-200601000-00005 · Cited by 1,231 · see citing works
The Confusion Assessment Method: A Systematic Review of Current Usage
Wei, L. A., Fearing, M. A., Sternberg, E. J., & Inouye, S. K. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01674.x · Cited by 796 · see citing works
Older Patients in the Emergency Department: A Review
Samaras, N., Chevalley, T., Samaras, D., & Gold, G. (2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.04.015 · Cited by 656 · see citing works
Devlin, J. W., Roberts, R. J., Fong, J. J., Skrobik, Y. K., Riker, R. R., Hill, N. S., Robbins, T., & Garpestad, E. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b9e302 · Cited by 532 · see citing works
Quetiapine in Patients With Schizophrenia
Small, J. G. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830180067009 · Cited by 482 · see citing works
Hohl, C. M., Dankoff, J., Colacone, A., & Afilalo, M. (2001) · Annals of Emergency Medicine · doi:10.1067/mem.2001.119456 · Cited by 477 · see citing works
Delirium in Older Emergency Department Patients: Recognition, Risk Factors, and Psychomotor Subtypes
Han, J. H., Zimmerman, E. E., Cutler, N. S., Schnelle, J. F., Morandi, A., Dittus, R. S., Storrow, A. B., & Ely, E. W. (2009) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2008.00339.x · Cited by 435 · see citing works
Dorman, T. (2011) · Yearbook of Critical Care Medicine · doi:10.1016/s0734-3299(10)79437-5 · Cited by 385 · see citing works
Science is Revolutionizing Our View of Addiction—and What to Do About It
Leshner, A. I. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.1 · Cited by 370 · see citing works
Delirium in Older Emergency Department Patients Discharged Home: Effect on Survival
Kakuma, R., du Fort, G. G., Arsenault, L., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51151.x · Cited by 336 · see citing works
Han, J. H., Wilson, A., Vasilevskis, E. E., Shintani, A., Schnelle, J. F., Dittus, R. S., Graves, A. J., Storrow, A. B., Shuster, J. L., & Ely, E. W. (2013) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2013.05.003 · Cited by 329 · see citing works
Using antipsychotic agents in older patients.
Alexopoulos, G. S., Streim, J. E., Carpenter, D., & Docherty, J. P. (2004) · PubMed · Cited by 327 · see citing works
Diagnosis, prevention, and management of delirium: summary of NICE guidance
Young, J. B., Murthy, L., Westby, M. J., Akunne, A. F., O’Mahony, R., & on behalf of the Guideline Development Group (2010) · BMJ · doi:10.1136/bmj.c3704 · Cited by 303 · see citing works
Introduction: Methods, Commentary, and Summary
Allen, M. H., Currier, G. W., Carpenter, D. P., ROSS, R. W., & Docherty, J. P. (2005) · Journal of Psychiatric Practice · doi:10.1097/00131746-200511001-00002 · Cited by 265 · see citing works
Delirium in the Emergency Department: An Independent Predictor of Death Within 6 Months
Han, J. H., Shintani, A., Eden, S., et al. (2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.03.003 · Cited by 254 · see citing works
Risk Factors for Delirium at Discharge
Inouye, S. K., Zhang, Y., Jones, R. N., Kiely, D. K., Yang, F. M., & Marcantonio, E. R. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.13.1406 · Cited by 237 · see citing works
Practice Guideline for the Treatment of Patients With Delirium
(2007) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890423363.42494 · Cited by 235 · see citing works
Bhana, N., Foster, R. H., Olney, R., & Plosker, G. L. (2001) · Drugs · doi:10.2165/00003495-200161010-00011 · Cited by 217 · see citing works
Impaired cognitive function and mental performance in mild dehydration
Wilson, M.-M. G., & Morley, J. E. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601898 · Cited by 198 · see citing works
Appropriateness of Medication Selection for Older Persons in an Urban Academic Emergency Department
Chin, M. H., Wang, L. C., Jin, L., Mulliken, R., Walter, J. J., Hayley, D. C., Karrison, T. G., Nerney, M. P., Miller, A., & Friedmann, P. D. (1999) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.1999.tb00139.x · Cited by 193 · see citing works
Pitkälä, K. H., Laurila, J., Strandberg, T. E., & Tilvis, R. S. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.2.176 · Cited by 151 · see citing works
Review Article: Serum Biomarkers for Delirium
Marcantonio, E. R., Rudolph, J. L., Culley, D., Crosby, G., Alsop, D. C., & Inouye, S. K. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.12.1281 · Cited by 140 · see citing works
Practice guideline for the treatment of patients with delirium. American Psychiatric Association.
(1999) · PubMed · Cited by 139 · see citing works
A Multifactorial Intervention to Reduce Prevalence of Delirium and Shorten Hospital Length of Stay
Naughton, B. J., Saltzman, S., Ramadan, F. H., Chadha, N., Priore, R. L., & Mylotte, J. M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53005.x · Cited by 133 · see citing works
Delirium in the Older Emergency Department Patient: A Quiet Epidemic
Han, J. H., Wilson, A., & Ely, E. W. (2010) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2010.03.005 · Cited by 124 · see citing works
Han, J. H., Eden, S., Shintani, A., Morandi, A., Schnelle, J. F., Dittus, R. S., Storrow, A. B., & Ely, E. W. (2011) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2011.01065.x · Cited by 119 · see citing works
Leonard, R., Tinetti, M. E., Allore, H. G., & Drickamer, M. A. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.12.1295 · Cited by 108 · see citing works
Traumatic Brain Injuries Sustained in the Afghanistan and Iraq Wars
Martin, E. M., Lu, W., Helmick, K. M., French, L. M., & Warden, D. L. (2008) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000315260.92070.3f · Cited by 105 · see citing works
Dahlke, S., & Phinney, A. (2008) · Journal of Gerontological Nursing · doi:10.3928/00989134-20080601-03 · Cited by 105 · see citing works
Effect of Establishing Guidelines on Appropriate Urinary Catheter Placement
Fakih, M. G., Pena, M. E., Shemes, S. P., et al. (2010) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2009.00677.x · Cited by 101 · see citing works
Han, J. H., Wilson, A., Graves, A. J., Shintani, A., Schnelle, J. F., Dittus, R. S., Powers, J. S., Vernon, J., Storrow, A. B., & Ely, E. W. (2014) · Academic Emergency Medicine · doi:10.1111/acem.12309 · Cited by 100 · see citing works
Carpenter, C. R., Shah, M. N., Hustey, F. M., Heard, K. J., Gerson, L. W., & Miller, D. K. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr040 · Cited by 98 · see citing works
Validity of the Confusion Assessment Method in Detecting Postoperative Delirium in the Elderly
Rolfson, D. B., McElhaney, J. E., Jhangri, G. S., et al. (1999) · International Psychogeriatrics · doi:10.1017/s1041610299006043 · Cited by 96 · see citing works
Han, J. H., Bryce, S., Ely, E. W., Kripalani, S. B., Morandi, A., Shintani, A., Jackson, J. C., Storrow, A. B., Dittus, R. S., & Schnelle, J. F. (2011) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.12.002 · Cited by 92 · see citing works
Constipation in Long-Term Care
Tariq, S. H. (2007) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.02.009 · Cited by 88 · see citing works
Atypical Antipsychotics for the Treatment of Delirious Elders
Ozbolt, L. B., Paniagua, M. A., & Kaiser, R. M. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.08.007 · Cited by 86 · see citing works
Amisulpride versus quetiapine for the treatment of delirium: a randomized, open prospective study
Lee, K., Won, W.-Y., Lee, H., et al. (2005) · International Clinical Psychopharmacology · doi:10.1097/00004850-200511000-00005 · Cited by 86 · see citing works
Clinical practice guidelines for the management of delirium in older people in Australia
Tropea, J., Slee, J., Brand, C. A., Gray, L., & Snell, T. (2008) · Australian Journal on Ageing · doi:10.1111/j.1741-6612.2008.00301.x · Cited by 82 · see citing works
Antipsychotics in the Treatment of Delirium in Older Hospitalized Adults: A Systematic Review
Flaherty, J. H., Gonzales, J. P., & Dong, B. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03675.x · Cited by 77 · see citing works
Use of Propofol and Other Nonbenzodiazepine Sedatives in the Intensive Care Unit
Angelini, G., Ketzler, J. T., & Coursin, D. B. (2001) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70184-6 · Cited by 72 · see citing works
Clinical review: Agitation and delirium in the critically ill – significance and management
Chevrolet, J.-C., & Jolliet, P. (2007) · Critical Care · doi:10.1186/cc5787 · Cited by 70 · see citing works
Preskorn, S., Silkey, B., SHAH, R., et al. (2005) · Journal of Psychiatric Practice · doi:10.1097/00131746-200501000-00002 · Cited by 67 · see citing works
Attard, A., Ranjith, G., & Taylor, D. M. (2008) · CNS Drugs · doi:10.2165/00023210-200822080-00002 · Cited by 67 · see citing works
Physicians Vary in Approaches to the Clinical Management of Delirium
Carnes, M. L., Howell, T., Rosenberg, M. A., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51063.x · Cited by 65 · see citing works
Emergency Department Management of Delirium in the Elderly
Gower, L. E. J., Gatewood, M., & Kang, C. (2012) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2011.10.6654 · Cited by 64 · see citing works
Chung, A. K., & Chua, S.-E. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110376685 · Cited by 63 · see citing works
BORRIE, M. J., Campbell, K., Arcese, Z. A., Bray, J., Hart, P., Labate, T., & Hesch, P. (2001) · Rehabilitation Nursing · doi:10.1002/j.2048-7940.2001.tb01950.x · Cited by 61 · see citing works
Altered Mental Status in Older Emergency Department Patients
Wilber, S. T. (2006) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2006.01.011 · Cited by 59 · see citing works
Avoiding Restraints in Patients with Dementia
Evans, L. K., & Cotter, V. T. (2008) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000311827.75816.8b · Cited by 57 · see citing works
Wu, J., & Baguley, I. J. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.01.012 · Cited by 56 · see citing works
Antipsychotics and dopamine transporter gene polymorphisms in delirium patients
KIM, J., Jung, I., HAN, C., et al. (2005) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2005.01355.x · Cited by 51 · see citing works
Delirium in the Hospitalized Elder and Recommendations for Practice
Rigney, T. (2006) · Geriatric Nursing · doi:10.1016/j.gerinurse.2006.03.014 · Cited by 47 · see citing works
Ross, D. D., & Alexander, C. S. (2001) · PubMed · Cited by 43 · see citing works
Devlin, J. W., & Skrobik, Y. K. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.565247 · Cited by 41 · see citing works
Constipation and Irritable Bowel Syndrome in the Elderly
Morley, J. E. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2007.06.008 · Cited by 41 · see citing works
Nursing Care, Delirium, and Pain Management for the Hospitalized Older Adult
Schreier, A. M. (2010) · Pain Management Nursing · doi:10.1016/j.pmn.2009.07.002 · Cited by 40 · see citing works
The evaluation and management of the acutely agitated elderly patient.
Nassisi, D., Korc, B., Hahn, S. A., Bruns, J. J., & Jagoda, A. S. (2006) · PubMed · Cited by 39 · see citing works
Tropea, J., Slee, J., Holmes, A. C. N., et al. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208008028 · Cited by 35 · see citing works
Acute Urinary Retention in Elderly Men
Thorne, M. B., & Geraci, S. A. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.05.009 · Cited by 27 · see citing works
Dehydration and Delirium--Not a Simple Relationship
George, J., & Rockwood, K. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.8.m811 · Cited by 25 · see citing works
Waardenburg, I. E. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02035.x · Cited by 23 · see citing works
Treating delirium in a general hospital: a descriptive study of prescribing patterns and outcomes
Briskman, I., Dubinski, R., & Barak, Y. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209990986 · Cited by 22 · see citing works
Nurse staffing and patient safety.
MacPhee, M., Ellis, J., & Mccutcheon, A. (2006) · PubMed · Cited by 21 · see citing works
Tardive dyskinesia in a patient treated with quetiapine
Rizos, E. N., Douzenis, A., Gournellis, R., et al. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701362550 · Cited by 19 · see citing works
Conley, D. M. (2011) · Urologic Nursing · doi:10.7257/1053-816x.2011.31.6.337 · Cited by 18 · see citing works
Tobias, D. E. (2003) · Hospital Pharmacy · doi:10.1177/001857870303800707 · Cited by 18 · see citing works
Probable Quetiapine-Mediated Prolongation of the QT Interval
Aghaienia, N., Brahm, N. C., Lussier, K. M., et al. (2011) · Journal of Pharmacy Practice · doi:10.1177/0897190011415683 · Cited by 17 · see citing works
Biomarkers of delirium: Well evidenced or not?
Chu, C., Liang, C., Lin, Y.-T., Chow, P. C., Pan, C., Chou, M.-Y., & Lu, T. (2011) · Journal of Clinical Gerontology and Geriatrics · doi:10.1016/j.jcgg.2011.11.005 · Cited by 17 · see citing works
Delirium and Hospitalized Older Adults: A Review of Nonpharmacologic Treatment
Aguirre, E. A. (2010) · The Journal of Continuing Education in Nursing · doi:10.3928/00220124-20100326-09 · Cited by 16 · see citing works
Escobar, R., San, L., Pérez, V., et al. (2008) · PubMed · Cited by 14 · see citing works
Cystocerebral syndrome: a possible explanation
Ph, L. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.9.1884a · Cited by 11 · see citing works
Hwang, U. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.262 · Cited by 8 · see citing works
Cystocerebral Syndrome: A Possible Explanation
Liem, P. H. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400090150034 · Cited by 8 · see citing works
Early‐onset tardive dyskinesia in a neuroleptic‐naive patient exposed to low‐dose quetiapine
Walsh, R. A., & Lang, A. E. (2011) · Movement Disorders · doi:10.1002/mds.23831 · Cited by 7 · see citing works
Gillis, A. J., & MacDonald, B. L. (2006) · PubMed · Cited by 7 · see citing works
Sudden Confusion and Agitation: Causes to Investigate! Delirium, Dementia, Depression
Somes, J., Donatelli, N. S., & Barrett, J. H. (2010) · Journal of Emergency Nursing · doi:10.1016/j.jen.2010.06.010 · Cited by 6 · see citing works
Isoniazid Prophylaxis for Young Adults
Rose, D. N. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400090150033 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Allen MH Currier GW Carpenter D Ross RW Docherty JP 2005 The expert consensus guideline series. Treatment of behavioral emergencies 2005 Journal of Psychiatric Practice 11 5 108 16319571
- Campanelli CM 2012 American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults: The American Geriatrics Society 2012 Beers Criteria Update Expert Panel Journal of the American Geriatrics Society 60 4 616 22376048 PMC3571677
- Hogan DB Gage L Bruto V Burne D Chan P Wiens C 2006 National Guidelines for Seniors’ Mental Health—The assessment and treatment of Delirium Canadian Journal of Geriatrics 9 Suppl 2 542 551
Cited by
Sorted by citations
Gilmore-Bykovskyi, A. L., Block, L. M., Walljasper, L., Hill, N., Gleason, C., & Shah, M. N. (2018) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocy070 · Cited by 21 · see citing works
Thompson, C., Brienza, V. J. M., Sandre, A., Caine, S., Borgundvaag, B., & McLeod, S. (2018) · CJEM · doi:10.1017/cem.2018.427 · Cited by 21 · see citing works
- Authors
- Rosen, T., Connors, S., Clark, S., Halpern, A., Stern, M. E., DeWald, J., Lachs, M. S., & Flomenbaum, N.
- Affiliations
- Cornell University (US)
- Venue
- Advanced Emergency Nursing Journal
- Published
- 2015-07
- Volume
- 37
- Issue
- 3
- Pages
- 183-196
- ISSN
- 1931-4485 (ISSN-L)
- PMC
- PMC4633298
- OpenAlex
- W984596996
- Cited by
- 49
- References
- 82
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 2
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Emergency Nursing Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000457)
- National Institute on Aging (K24AG022399)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- delirium, older adults, geriatric delirium, emergency department, delirium management, delirium diagnosis, non-pharmacological treatment, polypharmacy, pain, urinary retention, constipation, dehydration, discharge disposition, clinical protocols
- MeSH terms
- Aged, Clinical Protocols, Delirium, Education, Continuing, Emergency Service, Hospital, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review