Cited by 121Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

Tateno, Fuyuki, Sakakibara, Ryuji, Kawai, Takayuki, Kishi, Masahiko, Murano, Takeyoshi·2012·Alzheimer Disease & Associated Disorders

Abstract

BACKGROUND: We examined the utility of quantification of α-synuclein (SNCA) in the cerebrospinal fluid (CSF) to differentiate patients with Alzheimer disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA). METHODS: Thirty-seven patients were divided into 4 age-matched and sex-matched clinical groups: AD (n = 9), DLB (n = 6), PD (n = 11), and MSA (n = 11). Eleven subjects served as neurological disease controls. The total of 48 subjects included 27 men and 21 women, aged 66.5 ± 11.4 years. We performed a solid-phase sandwich enzyme-linked immunosorbent assay, which enables the sensitive quantification of CSF SNCA. RESULTS: In comparison with controls, CSF SNCA levels in AD were significantly higher (P < 0.05). CSF SNCA levels in PD (P < 0.001), DLB (P < 0.01), and MSA (P < 0.05) were all significantly lower than those in AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies. CONCLUSIONS: The results of the present study suggest that quantification of CSF SNCA helps in the differentiation of synucleinopathies (PD, DLB, and MSA) from AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies.

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Crossref · 10.1097/wad.0b013e31823899cc

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  • Patients with synucleinopathies, mainly Parkinson's disease and dementia with Lewy bodies, frequently exhibit reduced levels of cerebrospinal fluid αSyn.

    “patients with synucleinopathies, mainly Parkinson’s disease (PD) and DLB, frequently exhibit reduced levels of CSF αSyn [19, 79–81]”

    From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [80]

  • Numerous studies have documented unaltered or slightly increased cerebrospinal fluid αSyn levels in patients with mild cognitive impairment and Alzheimer's disease.

    “numerous studies have documented unaltered or slightly increased CSF αSyn levels in patients with MCI and AD [27, 80–82, 86, 90, 91, 93, 94].”

    From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [80]

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Authors
Tateno, F., Sakakibara, R., Kawai, T., Kishi, M., & Murano, T.
Affiliations
Toho University (JP)
Corresponding author
  • Tateno, Fuyuki
  • Sakakibara, Ryuji
  • Kishi, Masahiko
Venue
Alzheimer Disease & Associated Disorders
Published
2012-07
Volume
26
Issue
3
Pages
213-216
ISSN
0893-0341 (ISSN-L)
OpenAlex
W2322220731
Cited by
121
References
28
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 10 · 2016: 8 · 2015: 14 · 2014: 13 · 2013: 17 · 2012: 6
FWCI
7.30
Type
journal article
Language
en
Open access
closed
Locations
  • Alzheimer Disease & Associated Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
alpha-synuclein, cerebrospinal fluid biomarkers, synucleinopathies, Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, Alzheimer's disease, differential diagnosis
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Parkinson Disease, Multiple System Atrophy, Lewy Body Disease, alpha-Synuclein

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