Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease
Abstract
BACKGROUND: We examined the utility of quantification of α-synuclein (SNCA) in the cerebrospinal fluid (CSF) to differentiate patients with Alzheimer disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA). METHODS: Thirty-seven patients were divided into 4 age-matched and sex-matched clinical groups: AD (n = 9), DLB (n = 6), PD (n = 11), and MSA (n = 11). Eleven subjects served as neurological disease controls. The total of 48 subjects included 27 men and 21 women, aged 66.5 ± 11.4 years. We performed a solid-phase sandwich enzyme-linked immunosorbent assay, which enables the sensitive quantification of CSF SNCA. RESULTS: In comparison with controls, CSF SNCA levels in AD were significantly higher (P < 0.05). CSF SNCA levels in PD (P < 0.001), DLB (P < 0.01), and MSA (P < 0.05) were all significantly lower than those in AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies. CONCLUSIONS: The results of the present study suggest that quantification of CSF SNCA helps in the differentiation of synucleinopathies (PD, DLB, and MSA) from AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies.
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Patients with synucleinopathies, mainly Parkinson's disease and dementia with Lewy bodies, frequently exhibit reduced levels of cerebrospinal fluid αSyn.
“patients with synucleinopathies, mainly Parkinson’s disease (PD) and DLB, frequently exhibit reduced levels of CSF αSyn [19, 79–81]”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [80]
Numerous studies have documented unaltered or slightly increased cerebrospinal fluid αSyn levels in patients with mild cognitive impairment and Alzheimer's disease.
“numerous studies have documented unaltered or slightly increased CSF αSyn levels in patients with MCI and AD [27, 80–82, 86, 90, 91, 93, 94].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [80]
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- Authors
- Tateno, F., Sakakibara, R., Kawai, T., Kishi, M., & Murano, T.
- Affiliations
- Toho University (JP)
- Corresponding author
- Tateno, Fuyuki
- Sakakibara, Ryuji
- Kishi, Masahiko
- Venue
- Alzheimer Disease & Associated Disorders
- Published
- 2012-07
- Volume
- 26
- Issue
- 3
- Pages
- 213-216
- ISSN
- 0893-0341 (ISSN-L)
- OpenAlex
- W2322220731
- Cited by
- 121
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 10 · 2016: 8 · 2015: 14 · 2014: 13 · 2013: 17 · 2012: 6
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer Disease & Associated Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- alpha-synuclein, cerebrospinal fluid biomarkers, synucleinopathies, Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, Alzheimer's disease, differential diagnosis
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Parkinson Disease, Multiple System Atrophy, Lewy Body Disease, alpha-Synuclein
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