Differential longitudinal decline on the mini-mental state examination in frontotemporal lobar degeneration and Alzheimer disease
Open accessAbstract
OBJECTIVE: To examine how phenotype affects longitudinal decline on the Mini-Mental State Examination (MMSE) in patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD). BACKGROUND: The MMSE is the most commonly administered assessment for dementia severity; however, the effects of phenotype on longitudinal MMSE performance in FTLD and AD have not been extensively studied. METHODS: Data from 185 patients diagnosed with AD (n=106) and 3 FTLD (n=79) phenotypes [behavioral variant frontotemporal dementia (bvFTD), nonfluent agrammatic variant of primary progressive aphasia (nfaPPA), and semantic variant PPA (svPPA)] were collected for up to 52 months since initial evaluation. RESULTS: Differential rates of decline were noted in that MMSE scores declined more precipitously for AD and svPPA compared with bvFTD and nfaPPA patients (P=0.001). The absolute 4-year MMSE decline given median baseline MMSE for bvFTD [14.67; 95% confidence interval (CI), 14.63-14.71] and nfaPPA (11.02; 95% CI, 10.98-11.06) were lower than svPPA (22.32; 95% CI, 22.29-22.34) or AD (22.24; 95% CI, 22.22-22.26). CONCLUSIONS: These data suggest that within-group AD and FTLD phenotypes present distinct patterns of longitudinal decline on the MMSE. MMSE may not be adequately sensitive to track disease progression in some phenotypes of FTLD.
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For MMSE, rates of decline are lacking or modest, and unrelated to frontotemporal changes on multiple neuroimaging modalities.
“For MMSE in specific, rates of decline are known to be lacking or modest, and unrelated to frontotemporal changes on multiple neuroimaging modalities (Borroni et al., 2010; Tan et al., 2013; Premi et al., 2016; Leroy et al., 2021).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Tan et al., 2013
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- Authors
- Tan, K. S., Libon, D. J., Rascovsky, K., Grossman, M., & Xie, S. X.
- Affiliations
- Drexel University (US)
- University of Pennsylvania (US)
- Corresponding author
- Tan, Kay See
- Xie, Sharon X.
- Venue
- Alzheimer Disease & Associated Disorders
- Published
- 2013-10
- Volume
- 27
- Issue
- 4
- Pages
- 310-315
- ISSN
- 0893-0341 (ISSN-L)
- PMC
- PMC3648632
- OpenAlex
- W2021789724
- Cited by
- 36
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer Disease & Associated Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG15116, AG-32953, P30AG010124, R01AG015116, P01AG017586, AG17586, AG-10124, P01AG032953)
- National Institute of Neurological Disorders and Stroke (NS53488, NS-44266, P50NS053488, R01NS044266)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- frontotemporal lobar degeneration, Alzheimer's disease, Mini-Mental State Examination, cognitive decline, behavioral variant frontotemporal dementia, semantic dementia, dementia severity assessment, disease progression, test sensitivity
- MeSH terms
- Aged, Alzheimer Disease, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Brief Psychiatric Rating Scale, Cohort Studies, Single-Blind Method, Disease Progression, Frontotemporal Lobar Degeneration
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