Sex differences in neurodevelopmental disorders
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Purpose of review: There continues to be more males than females diagnosed with neurodevelopmental disorders, which may provide clues about their cause. This review will focus on the two most common neurodevelopmental disorders – autism spectrum disorder (autism) and attention deficit hyperactivity disorder (ADHD), and explore recent research to understand recent developments in the field. Recent findings: Biological mechanisms including genetics, hormones and their interaction with other risk factors, such as stress and lead exposure, point to complex causal pathways for neurodevelopmental disorders. Over recent years, the research focus on sex differences in symptom profiles in autism has continued; however, a meta-analysis of existing studies indicated minimal sex differences in core autism symptoms. In ADHD, changes in the sex ratio from disparity in childhood to parity in adulthood may relate to the onset and trajectory of hyperactivity symptoms in females. Research into medical and psychiatric comorbidities, such as polycystic ovary syndrome and gender dysphoria, is also providing insights into the role of early androgen exposure as a potential causal factor for neurodevelopmental disorders. Summary: The factors, which contribute to an increased number of males with neurodevelopmental disorders in most cases are complex involving interactions between genetics, hormones and environmental factors.
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The results support recent findings that men are overrepresented in gender ratios and autistic traits are underdiagnosed in women.
“Our results are in support of recent findings demonstrating that men are overrepresented in gender ratios and autistic traits are underdiagnosed in women [67–69].”
Cites
1 retracted
Christensen, D. L., Braun, K. V. N., Baio, J., Bilder, D., Charles, J., Constantino, J. N., Daniels, J., Durkin, M. S., Fitzgerald, R. T., Kurzius-Spencer, M., et al. (2018) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss6513a1 · Cited by 587 · see citing works
RetractedWhat Is the Male-to-Female Ratio in Autism Spectrum Disorder? A Systematic Review and Meta-Analysis
Loomes, R., Hull, L., & Mandy, W. P. L. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.03.013 · Cited by 2,804 · see citing works
Why are autism spectrum conditions more prevalent in males?
Baron-Cohen, S., Lombardo, M. V., Auyeung, B., Ashwin, E., Chakrabarti, B., & Knickmeyer, R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001081 · Cited by 754 · see citing works
Dean, M., Harwood, R., & Kasari, C. (2017) · Autism · doi:10.1177/1362361316671845 · Cited by 566 · see citing works
Clark, T. C., Lucassen, M. F. G., Bullen, P., Denny, S. J., Fleming, T. M., Robinson, E. M., & Rossen, F. V. (2014) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.11.008 · Cited by 528 · see citing works
Autism Spectrum Disorders in Gender Dysphoric Children and Adolescents
de Vries, A. L. C., Noens, I. L. J., Cohen‐Kettenis, P. T., van Berckelaer‐Onnes, I. A., & DORELEIJERS, T. A. H. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-0935-9 · Cited by 518 · see citing works
Sex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392 · see citing works
Greenberg, D. M., Warrier, V., Allison, C. L., & Baron‐Cohen, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811032115 · Cited by 338 · see citing works
Increased Gender Variance in Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder
Strang, J. F., Kenworthy, L. E., Dominska, A., Sokoloff, J. L., Kenealy, L. E., Berl, M. M., Walsh, K. S., Menvielle, E. J., Slesaransky-Poe, G., Kim, K.-E., et al. (2014) · Archives of Sexual Behavior · doi:10.1007/s10508-014-0285-3 · Cited by 282 · see citing works
Hull, L., Mandy, W., & Petrides, K. (2017) · Autism · doi:10.1177/1362361316669087 · Cited by 254 · see citing works
Wang, T., Liu, K., Li, Z., Xu, Y., Liu, Y., Shi, W., & Chen, L. (2017) · BMC Psychiatry · doi:10.1186/s12888-016-1187-9 · Cited by 251 · see citing works
Cesta, C. E., Månsson, M., Palm, C., Lichtenstein, P., Iliadou, A. N., & Landén, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.005 · Cited by 217 · see citing works
A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder
Martin, J., Walters, R. K., Demontis, D., Mattheisen, M., Lee, S., Robinson, E., Brikell, I., Ghirardi, L., Larsson, H., Lichtenstein, P., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.026 · Cited by 190 · see citing works
Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies
Green, T., Flash, S., & Reiss, A. L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0153-2 · Cited by 167 · see citing works
Placental H3K27me3 establishes female resilience to prenatal insults
Nugent, B. M., O’Donnell, C. M., Epperson, C. N., & Bale, T. L. (2018) · Nature Communications · doi:10.1038/s41467-018-04992-1 · Cited by 150 · see citing works
ALL OUR SONS: THE DEVELOPMENTAL NEUROBIOLOGY AND NEUROENDOCRINOLOGY OF BOYS AT RISK
Schore, A. N. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21616 · Cited by 144 · see citing works
Kanfiszer, L., Davies, F., & Collins, S. (2017) · Autism · doi:10.1177/1362361316687987 · Cited by 143 · see citing works
Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory
Cherskov, A., Pohl, A. L., Allison, C. L., Zhang, H., Payne, R., & Baron‐Cohen, S. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0186-7 · Cited by 114 · see citing works
Sex differences in ADHD trajectories across childhood and adolescence
Murray, A. L., Booth, T., Eisner, M., Bonnie Auyeung, B., Murray, G. C., & Ribeaud, D. (2018) · Developmental Science · doi:10.1111/desc.12721 · Cited by 114 · see citing works
“Gender Dysphoria” and Autism Spectrum Disorder: Is the Link Real?
Turban, J. L., & van Schalkwyk, G. I. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.08.017 · Cited by 102 · see citing works
May, T., Sciberras, E., Brignell, A., & Williams, K. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015549 · Cited by 97 · see citing works
Self-citationMay, T., Pang, K. C., & Williams, K. J. (2016) · International Journal of Transgenderism · doi:10.1080/15532739.2016.1241976 · Cited by 82 · see citing works
Self-citationHegvik, T.-A., Instanes, J. T., Haavik, J., Klungsøyr, K., & Engeland, A. (2018) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1056-1 · Cited by 79 · see citing works
Taylor, M. J., Lichtenstein, P., Larsson, H., Anckarsäter, H. S., Greven, C. U., & Ronald, A. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.04.004 · Cited by 73 · see citing works
Revisiting the Link: Evidence of the Rates of Autism in Studies of Gender Diverse Individuals
Strang, J. F., Janssen, A. C., Tishelman, A. C., Leibowitz, S. F., Kenworthy, L. E., McGuire, J. K., Edwards-Leeper, L. A., Mazefsky, C. A., Rofey, D. L., Bascom, J., et al. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.04.023 · Cited by 62 · see citing works
Ji, Y.-L., Hong, X., Wang, G.-Y., Chatterjee, N., Riley, A., Lee, L.-C., Surkan, P., Bartell, T. R., Zuckerman, B., & Wang, X.-B. (2018) · Jornal de Pediatria · doi:10.1016/j.jpeds.2018.03.076 · Cited by 59 · see citing works
Gender Variance and the Autism Spectrum: An Examination of Children Ages 6–12 Years
Nabbijohn, A. N., van der Miesen, A. I. R., Santarossa, A., Peragine, D. E., de Vries, A. L. C., Popma, A., Lai, M., & VanderLaan, D. P. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3843-z · Cited by 56 · see citing works
May, T., & Williams, K. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3609-7 · Cited by 45 · see citing works
Self-citationSpann, M. N., Timonen‐Soivio, L., Suominen, A., Cheslack‐Postava, K., McKeague, I. W., Sourander, A., & Brown, A. S. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.09.444 · Cited by 34 · see citing works
Andiarena, A., Balluerka, N., Murcia, M., Ibarluzea, J. M., Glover, V. A. S., & Vegas, Ó. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.07.008 · Cited by 20 · see citing works
Flagged first, then by citations
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Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
Han, V. X., Patel, S., Jones, H. F., & Dale, R. C. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00530-8 · Cited by 683 · see citing works
Santos, S., Ferreira, H., Martins, J., Gonçalves, J., & Castelo-Branco, M. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104577 · Cited by 141 · see citing works
Christian, C. A., Reddy, D. S., Maguire, J., & Forcelli, P. A. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.017392 · Cited by 105 · see citing works
Sex Differences in the Gut-Brain Axis: Implications for Mental Health
Holingue, C., Budavari, A. C., Rodriguez, K. M., Zisman, C. R., Windheim, G., & Fallin, M. D. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-01202-y · Cited by 85 · see citing works
Shook, L. L., Kışlal, S., & Edlow, A. G. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5724 · Cited by 81 · see citing works
Bornehag, C., Engdahl, E., Hallerbäck, M. U., Wikström, S., Lindh, C. H., Rüegg, J., Tanner, E. M., & Gennings, C. (2021) · Environment International · doi:10.1016/j.envint.2021.106433 · Cited by 81 · see citing works
Tiberi, J., Cesarini, V., Stefanelli, R., Canterini, S., Fiorenza, M. T., & Rosa, P. L. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111802 · Cited by 73 · see citing works
Yang, B.-Y., Zeng, X.-W., Markevych, I., Bloom, M. S., Heinrich, J., Knibbs, L. D., Dharmage, S. C., Lin, S., Jalava, P., Guo, Y., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.17862 · Cited by 65 · see citing works
Palanza, P., Paterlini, S., Brambilla, M., Ramundo, G., Caviola, G., Gioiosa, L., Parmigiani, S., Saal, F. S. V., & Ponzi, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.015 · Cited by 59 · see citing works
Goodman, C. V., Green, R. R., DaCosta, A., Flora, D. B., Lanphear, B. P., & Till, C. (2023) · Environmental Health · doi:10.1186/s12940-023-01029-z · Cited by 52 · see citing works
Tisato, V., Silva, J. A., Longo, G., Gallo, I., Singh, A. V., Milani, D., & Gemmati, D. (2021) · Genes · doi:10.3390/genes12050782 · Cited by 43 · see citing works
In Utero Exposure to Maternal COVID-19 and Offspring Neurodevelopment Through Age 24 Months
Greenwood, E. A., Huddleston, H. G., Lindquist, K. J., Wu, A. H. B., Bishop, S. L., Kim, Y.-S., Kaing, A., Prahl, M. K., Gaw, S. L., Corley, J., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.39792 · Cited by 40 · see citing works
Francés, L., Ruiz, A., Soler, C. V., Francés, J., Caules, J., Amaia Hervas, G., Carretero, C., Cardona, B., Quezada, E. M., Fernández, A., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1260747 · Cited by 35 · see citing works
Early manifestations of genetic risk for neurodevelopmental disorders
Askeland, R. B., Hannigan, L. J., Ask, H., Ayorech, Z., Tesli, M., Corfield, E. C., Magnus, P. M., Njølstad, P. R., Andreassen, O. A., Smith, G. D., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13528 · Cited by 36 · see citing works
Deng, Y., Sun, S., Wu, S., Chen, K., Liu, Y., Wei, W., Bei, N., Qiu, C., & Li, X. (2023) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-023-02594-x · Cited by 34 · see citing works
Kooij, J. J. S., de Jong, M., Agnew‐Blais, J. C., Amoretti, S., Madsen, K. B., Barclay, I., Bölte, S., Skoglund, C. B., Broughton, T., Carucci, S., et al. (2025) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2025.1613628 · Cited by 37 · see citing works
Sex‐related differences among individuals assessed for fetal alcohol spectrum disorder in Canada
Flannigan, K., Poole, N., Cook, J. L., & Unsworth, K. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15017 · Cited by 34 · see citing works
Cosín‐Tomás, M., Luan, Y., Leclerc, D., Malysheva, O., Lauzon, N., Bahous, R. H., Christensen, K. E., Caudill, M. A., & Rozen, R. R. (2020) · Nutrients · doi:10.3390/nu12061716 · Cited by 33 · see citing works
Zhang, R., Manza, P., & Volkow, N. D. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13495 · Cited by 33 · see citing works
Sewell, R. L., Buchanan, C., Davis, S., Christakis, D., Dempsey, A. F., Furniss, A., Kazak, A. E., Kerlek, A. J., Magnusen, B., Pajor, N. M., et al. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.08.066 · Cited by 31 · see citing works
A comprehensive approach to modeling maternal immune activation in rodents
Bucknor, M. C., Gururajan, A., Dale, R. C., & Hofer, M. J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1071976 · Cited by 33 · see citing works
Polit, L. D., Eidhof, I., McNeill, R. V., Warre-Cornish, K. M., Ohki, C. M. Y., Walter, N. M., Sala, C., Verpelli, C., Radtke, F., Galderisi, S., et al. (2023) · Neuroscience Applied · doi:10.1016/j.nsa.2023.101125 · Cited by 32 · see citing works
Albertini, G., D’Andrea, I., Druart, M., Béchade, C., Nieves-Rivera, N., Etienne, F., Magueresse, C. L., Rebsam, A., Heck, N., Maroteaux, L., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02048-5 · Cited by 32 · see citing works
Li, H., Ke, X., Huang, D., Xu, X., Tian, H., Gao, J., Jiang, C., & Song, W. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1387406 · Cited by 31 · see citing works
Horwitz, E., Vos, M., de Bildt, A. A., Greaves‐Lord, K., Rommelse, N. N. J., Schoevers, R. A., & Hartman, C. A. (2023) · Autism · doi:10.1177/13623613221146477 · Cited by 33 · see citing works
The association between thyroid function biomarkers and attention deficit hyperactivity disorder
Albrecht, D., Ittermann, T., Thamm, M., Grabe, H. J., Bahls, M., & Völzke, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-75228-w · Cited by 30 · see citing works
Marchese, M. J., Zhu, T., Hawkey, A. B., Wang, K. L., Yuan, E., Wen, J., Be, S. E., Levin, E. D., & Feng, L. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170459 · Cited by 30 · see citing works
Bibliometric Analysis of Research Themes and Trends of the Co-Occurrence of Autism and ADHD
Liu, A., Lu, Y., Gong, C., Sun, J., Wang, B., & Jiang, Z. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s404801 · Cited by 30 · see citing works
Battison, E., Brown, P. C. M., Holley, A. L., & Wilson, A. C. (2023) · Children · doi:10.3390/children10010142 · Cited by 28 · see citing works
Oxidized linoleic acid metabolites regulate neuronal morphogenesis in vitro
Souza, F. D. C., Grodzki, A. C., Morgan, R. K., Zhang, Z., Taha, A. Y., & Lein, P. J. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105506 · Cited by 27 · see citing works
The impact of maternal immune activation on embryonic brain development
McEwan, F., Glazier, J. D., & Hager, R. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1146710 · Cited by 27 · see citing works
Large-scale analysis reveals racial disparities in the prevalence of ADHD and conduct disorders
Shalaby, N., Sengupta, S., & Williams, J. B. (2024) · Scientific Reports · doi:10.1038/s41598-024-75954-5 · Cited by 25 · see citing works
Ludyga, S., Pühse, U., Gerber, M., & Kamijo, K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.039 · Cited by 27 · see citing works
Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy
Zhang, Y., Hu, Y., Talarico, R., Qiu, X.-Y., Schwartz, J., Fell, D., Oskoui, M., Lavigne, É., & Messerlian, C. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.20717 · Cited by 25 · see citing works
Strain differences in behaviour and immunity in aged mice: Relevance to Autism
O’Connor, R., van de Wouw, M., Moloney, G. M., Ventura‐Silva, A. P., O’Riordan, K. J., Golubeva, A. V., Dinan, T. G., Schellekens, H., & Cryan, J. F. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113020 · Cited by 25 · see citing works
Myhre, O., Zimmer, K. E., Hudecova, A. M., Hansen, K. E. A., Khezri, A., Berntsen, H. F., Berg, V., Lyche, J. L., Mandal, S., Duale, N., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130123 · Cited by 25 · see citing works
Measures of Brain Connectivity and Cognition by Sex in US Children
Tomasi, D. G., & Volkow, N. D. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.0157 · Cited by 25 · see citing works
Zheng, S., Mansolf, M. A., McGrath, M., Churchill, M. L., Bekelman, T. A., Brennan, P. A., Margolis, A. E., Nozadi, S. S., Bastain, T. M., Elliott, A. J., et al. (2023) · JCPP Advances · doi:10.1002/jcv2.12198 · Cited by 27 · see citing works
Toward a Multidimensional Understanding of Misophonia Using Cluster-Based Phenotyping
Norris, J. E., Kimball, S. H., Nemri, D. C., & Ethridge, L. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.832516 · Cited by 25 · see citing works
Prenatal metal mixtures and sex-specific infant negative affectivity
Cowell, W., Colicino, E., Levin‐Schwartz, Y., Enlow, M. B., Amarasiriwardena, C. J., Andra, S. S., Gennings, C., Wright, R. O., & Wright, R. J. (2021) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000147 · Cited by 24 · see citing works
Xu, X., Cai, X., Meng, F., Song, T.-J., Wang, X., Wei, Y.-Z., Zhai, F.-J., Long, B., Wang, J., You, X., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.657105 · Cited by 24 · see citing works
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., Armour, G. S., Horman, B. M., Odenkirk, M. T., Aylor, D. L., Baker, E. S., & Patisaul, H. B. (2022) · Neuroendocrinology · doi:10.1159/000526959 · Cited by 24 · see citing works
Dewey, D., Martin, J. W., MacDonald, A. M., Kinniburgh, D. W., Letourneau, N. L., Giesbrecht, G. F., Field, C. J., Bell, R. C., & England-Mason, G. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.07.005 · Cited by 24 · see citing works
The Phenotypic and Genotypic Spectrum of CSF1R ‐Related Disorder in China
Wu, J., Cheng, X., Ji, D., Niu, H., Yao, S., Lv, X., Wang, J., Li, Z., Zheng, H., Cao, Y., et al. (2024) · Movement Disorders · doi:10.1002/mds.29764 · Cited by 24 · see citing works
ADHD and Neurodegenerative Disease Risk: A Critical Examination of the Evidence
Becker, S., Sharma, M. J., & Callahan, B. L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.826213 · Cited by 24 · see citing works
Qin, Q., Fan, L., Zeng, X., Zheng, D., Wang, H., Li, M., Jiang, Y., Wang, H., Liu, H., Liang, S., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03250-z · Cited by 24 · see citing works
Watanabe, T., & Akechi, T. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04811-y · Cited by 21 · see citing works
Bishop, S. A., Okagbue, H. I., & Odukoya, J. A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03377 · Cited by 21 · see citing works
Yada, Y., Ohkuchi, A., Otsuki, K., Goishi, K., Takahashi, M., Yonemoto, N., Saito, S., Kusuda, S., The Survey Group Studying the Effects of Tocolytic Agents on Neonatal Adverse Events in Japan Society of Perinatal and Neonatal Medicine, Ota, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64687-w · Cited by 21 · see citing works
Sex-biased gene expression during neural differentiation of human embryonic stem cells
Pottmeier, P., Nikolantonaki, D., Lanner, F., Peuckert, C., & JAZIN, E. E. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1341373 · Cited by 20 · see citing works
The epidemiology of cognitive development
Guez, A., Peyre, H., Williams, C. M., Labouret, G., & Ramus, F. (2020) · Cognition · doi:10.1016/j.cognition.2021.104690 · Cited by 23 · see citing works
How does genetic variation modify ND-CNV phenotypes?
Dinneen, T. J., Ghrálaigh, F. N., Walsh, R., Lopez, L. M., & Gallagher, L. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.07.006 · Cited by 21 · see citing works
The role of neuroactive steroids in tic disorders
Branca, C., & Bortolato, M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105637 · Cited by 20 · see citing works
Xie, X., Lei, X., Xiao, C.-Y., Li, Y., & Lei, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.982696 · Cited by 18 · see citing works
Shook, L. L., Castro, V. M., Ibanez-Pintor, L. C., Perlis, R. H., & Edlow, A. G. (2025) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000006112 · Cited by 18 · see citing works
Arnold, M. L., & Saijo, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.717411 · Cited by 18 · see citing works
Ning, J., Ding, C., Xu, H., Liu, Z., Guan, Q., Xia, Y., & Xu, Q. (2024) · Environment International · doi:10.1016/j.envint.2024.109003 · Cited by 18 · see citing works
Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study
Dipnall, L. M., Yang, J., Chen, J., Fuelscher, I., Craig, J. M., & Silk, T. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02718-8 · Cited by 13 · see citing works
Cha, J. H., Ahn, J., Kim, Y. J., Lee, B. G., Kim, J. I., Park, H., Kim, B.-N., & Lee, H. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092476 · Cited by 18 · see citing works
Luan, Y., Leclerc, D., Cosín‐Tomás, M., Malysheva, O., Wasek, B. L., Bottiglieri, T., Caudill, M. A., & Rozen, R. R. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100197 · Cited by 17 · see citing works
Review of neurodevelopmental disorders in patients with HNF1B gene variations
Nittel, C. M., Dobelke, F., König, J. C., Konrad, M., Becker, K., Kamp‐Becker, I., & Weber, S. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1149875 · Cited by 16 · see citing works
Becker, S., Chowdhury, M., Tavilsup, P., Seitz, D. P., & Callahan, B. L. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1158546 · Cited by 16 · see citing works
Placental Changes and Neuropsychological Development in Children—A Systematic Review
Lodefalk, M., Chelslín, F., Karlsson, J. P., & Hansson, S. R. (2023) · Cells · doi:10.3390/cells12030435 · Cited by 15 · see citing works
Nayan, N. M., Husin, A., & Siran, R. (2024) · Early Human Development · doi:10.1016/j.earlhumdev.2024.106120 · Cited by 15 · see citing works
Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
Nguyen, L. D., Nolte, L., Tan, W. J. T., Giuvelis, D., Santos‐Sacchi, J., Bilsky, E. J., & Ehrlich, B. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-81650-5 · Cited by 14 · see citing works
Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development
Marinello, W. P., & Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.04.003 · Cited by 16 · see citing works
Kelly, R. S., Lee‐Sarwar, K. A., Chen, Y., Laranjo, N., Fichorova, R. N., Chu, S. H., Prince, N., Lasky-Su, J. A., Weiss, S. T., & Litonjua, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315249 · Cited by 14 · see citing works
Neurodevelopment of children who are HIV‐exposed and uninfected in Kenya
Bulterys, M. A., Njuguna, I. N., King’e, M., Chebet, D. J., Moraa, H., Gómez, L., Onyango, A., Malavi, K., Nzia, G., Chege, M. W., et al. (2023) · Journal of the International AIDS Society · doi:10.1002/jia2.26149 · Cited by 15 · see citing works
Yao, L., Fu, H., Bai, L., Deng, W., Xie, F., Li, Y., Zhang, R., Xu, X., Wang, T., Lai, S., et al. (2021) · Redox Report · doi:10.1080/13510002.2021.1959133 · Cited by 14 · see citing works
Yang, J., Zhang, Q., Li, J., Guan, S., Wang, K., Xu, H., & Liu, Z. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.113 · Cited by 14 · see citing works
Sex effects on gene expression across the human cerebral cortex at cell type resolution
DeCasien, A. R., Auluck, P. K., Liu, S., Feng, N., Elkahloun, A. G., Xu, Q., Marenco, S., Cookson, M., & Raznahan, A. (2026) · Science · doi:10.1126/science.aea9063 · Cited by 21 · see citing works
Che, X., Gross, S. M., Wang, G., Hong, X., Pearson, C., Bartell, T. R., & Wang, X. (2023) · PubMed Central · doi:10.1097/pn9.0000000000000047 · Cited by 13 · see citing works
Maciver, D., Singh-Roy, A., Johnston, L., Boilson, M., Curnow, E., Johnstone-Cooke, V., & Rutherford, M. (2025) · Autism · doi:10.1177/13623613251383343 · Cited by 14 · see citing works
Coley, E. J. L., Lum, G. R., Pronovost, G. N., Yu, L. W., Özcan, E., Yu, K. B., McDermott, J., Chakhoyan, A., Goldman, E., Vuong, H. E., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02022-7 · Cited by 13 · see citing works
Evolutionary divergence between homologous X–Y chromosome genes shapes sex-biased biology
DeCasien, A. R., Tsai, K., Liu, S., Thomas, A. G., & Raznahan, A. (2025) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02627-x · Cited by 12 · see citing works
Zhu, J., He, T., Huang, Z., Yu, W., Lu, J.-N., Zhang, S., Zhang, X., Dong, H., Xu, Y., Wang, X., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02002-2 · Cited by 11 · see citing works
Davies, W. (2021) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2021.104169 · Cited by 11 · see citing works
Zhang, Y., Lu, D., Guo, V. Y., Wang, Y., Qiu, S., Zhang, J., Zhang, Y., Chen, W., Wang, B., & Yang, W. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1032315 · Cited by 12 · see citing works
Risk factors for perinatal stroke in term infants: A case–control study in Australia
Roy, B., Webb, A., Walker, K., Morgan, C., Badawi, N. A., & Novak, I. (2023) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.16372 · Cited by 11 · see citing works
Gilmore, J. C., Serghides, L., & Bendayan, R. (2020) · AIDS · doi:10.1097/qad.0000000000002707 · Cited by 11 · see citing works
Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors
Lee, S. Y., Kweon, H., Kang, H., & Kim, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1022306 · Cited by 10 · see citing works
Wolf, D. C., Sanon, N. T., Cunha, A. O. S., Chen, J., Shaker, T., Elhassan, A.-R., do Nascimento, A. S. F., Cristo, G. D., & Weil, A. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-06769-5 · Cited by 10 · see citing works
Wang, Q., Luo, Y., Mao, C., Xiang, X., & Chen, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1645137 · Cited by 9 · see citing works
Microglia alter sex-specific cerebellar myelination following placental hormone loss
Salzbank, J., Lacaille, H., Gaby, J., O’Reilly, J. J., Kissner, M. D., Vacher, C., & Penn, A. A. (2025) · Nature Communications · doi:10.1038/s41467-025-64814-z · Cited by 9 · see citing works
Kiris, E. (2021) · Advances in experimental medicine and biology · doi:10.1007/5584_2021_683 · Cited by 9 · see citing works
Gallo, M. T., Brivio, P., Dolci, B., Fumagalli, F., & Calabrese, F. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.016 · Cited by 9 · see citing works
Fernandez, A., Pasquet-Levy, M., Laure, G., Thümmler, S., & Askenazy-Gittard, F. (2021) · The Canadian Journal of Psychiatry · doi:10.1177/0706743721990822 · Cited by 9 · see citing works
Hsu, C., Wang, L., Lin, P., Hung, C., Yang, Y., Chen, Y.-M., & Kao, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153294 · Cited by 9 · see citing works
Sex differences in gene regulatory networks during mid-gestational brain development
de Toledo, V. H. C., Feltrin, A. S., Barbosa, A. D. L., Tahira, A. C., & Brentani, H. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.955607 · Cited by 10 · see citing works
Notario-Barandiarán, L., Coto, S. D., Jimenez-Redondo, N., Guxens, M., Vrijheid, M., Andiarena, A., Irizar, A., Galán, I. R., Fernández‐Somoano, A., Llop, S., et al. (2023) · Exposure and Health · doi:10.1007/s12403-023-00610-8 · Cited by 8 · see citing works
Understanding and harnessing differences in women with ADHD: A qualitative study
Bradley, S., Parzych, I., Platts, J., & Powell, L. (2025) · Neurodiversity · doi:10.1177/27546330251317199 · Cited by 8 · see citing works
Herrero, F., Heeb, C., Meier, M. G., Lin, H.-Y., Mueller, F. S., Schalbetter, S. M., Gruchot, J., Weber‐Stadlbauer, U., Notter, T., Perron, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02955-9 · Cited by 9 · see citing works
Hall, M., Ashley‐Martin, J., Till, C., Hu, J. M. Y., Lanphear, B. P., Curl, C. L., Arbuckle, T. E., Boivin, M., Booij, L., Muckle, G., et al. (2025) · Environment International · doi:10.1016/j.envint.2025.109480 · Cited by 8 · see citing works
Alenezi, S., Alkhiri, A., Hassanin, W., AlHarbi, A., Assaf, M. A., Alzunaydi, N., Alsharif, S., Alhaidar, M., Alnujide, A., Alkathiri, F., et al. (2022) · Behavioral Sciences · doi:10.3390/bs12120509 · Cited by 9 · see citing works
Rice, L. C., Rochowiak, R., Plotkin, M. R., Rosch, K. S., Mostofsky, S. H., & Crocetti, D. (2023) · The Cerebellum · doi:10.1007/s12311-023-01569-7 · Cited by 8 · see citing works
Layo-Carris, D. E., Lubin, E. E., Sangree, A. K., Clark, K. J., Durham, E. L., Gonzalez, E. M., Smith, S. M., Angireddy, R., Wang, X. M., Weiss, E., et al. (2024) · European Journal of Human Genetics · doi:10.1038/s41431-024-01610-1 · Cited by 8 · see citing works
Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
Shen, F.-S., Liu, C., Sun, H.-Z., Chen, X., Xue, Y., & Chen, L. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae098 · Cited by 8 · see citing works
Hollingdale, J., Woodhouse, E., Tibber, M. S., Simonoff, E. A., Hollocks, M. J., & Charman, T. (2024) · Journal of Intellectual Disability Research · doi:10.1111/jir.13170 · Cited by 8 · see citing works
Canitano, R., & Bozzi, Y. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00125 · Cited by 8 · see citing works
Davis, L. K., Ince, L. M., Gullapalli, S., & Fonken, L. K. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.005 · Cited by 7 · see citing works
- Authors
- May, T., Adesina, I., McGillivray, J., & Rinehart, N. J.
- Affiliations
- Deakin University (AU)
- Corresponding author
- May, Tamara
- Venue
- Current Opinion in Neurology
- Published
- 2019-08
- Volume
- 32
- Issue
- 4
- Pages
- 622-626
- ISSN
- 1350-7540 (ISSN-L)
- 1473-6551
- OpenAlex
- W2945989667
- Cited by
- 235
- References
- 30
- Citations by year
- 2026: 29 · 2025: 46 · 2024: 40 · 2023: 45 · 2022: 30 · 2021: 27 · 2020: 16 · 2019: 1 · 2017: 1
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- sex differences, neurodevelopmental disorders, autism spectrum disorder, attention deficit hyperactivity disorder, sex ratio, androgen exposure, polycystic ovary syndrome, gender dysphoria, comorbidities, stress, lead exposure, genetic risk factors, hormonal risk factors
- MeSH terms
- Autism Spectrum Disorder, Attention Deficit Disorder with Hyperactivity, Female, Humans, Male, Sex Characteristics, Neurodevelopmental Disorders
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