Cited by 235Autism Spectrum Disorder ResearchSexual Differentiation and DisordersAttention Deficit Hyperactivity Disorder

Sex differences in neurodevelopmental disorders

Open access
May, Tamara, Adesina, Ife, McGillivray, Jane, Rinehart, Nicole J.·2019·Current Opinion in Neurology

Abstract

Purpose of review: There continues to be more males than females diagnosed with neurodevelopmental disorders, which may provide clues about their cause. This review will focus on the two most common neurodevelopmental disorders – autism spectrum disorder (autism) and attention deficit hyperactivity disorder (ADHD), and explore recent research to understand recent developments in the field. Recent findings: Biological mechanisms including genetics, hormones and their interaction with other risk factors, such as stress and lead exposure, point to complex causal pathways for neurodevelopmental disorders. Over recent years, the research focus on sex differences in symptom profiles in autism has continued; however, a meta-analysis of existing studies indicated minimal sex differences in core autism symptoms. In ADHD, changes in the sex ratio from disparity in childhood to parity in adulthood may relate to the onset and trajectory of hyperactivity symptoms in females. Research into medical and psychiatric comorbidities, such as polycystic ovary syndrome and gender dysphoria, is also providing insights into the role of early androgen exposure as a potential causal factor for neurodevelopmental disorders. Summary: The factors, which contribute to an increased number of males with neurodevelopmental disorders in most cases are complex involving interactions between genetics, hormones and environmental factors.

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Crossref · 10.1097/wco.0000000000000714

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Authors
May, T., Adesina, I., McGillivray, J., & Rinehart, N. J.
Affiliations
Deakin University (AU)
Corresponding author
May, Tamara
Venue
Current Opinion in Neurology
Published
2019-08
Volume
32
Issue
4
Pages
622-626
ISSN
  • 1350-7540 (ISSN-L)
  • 1473-6551
OpenAlex
W2945989667
Cited by
235
References
30
Citations by year
2026: 29 · 2025: 46 · 2024: 40 · 2023: 45 · 2022: 30 · 2021: 27 · 2020: 16 · 2019: 1 · 2017: 1
FWCI
2.34
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Current Opinion in Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
sex differences, neurodevelopmental disorders, autism spectrum disorder, attention deficit hyperactivity disorder, sex ratio, androgen exposure, polycystic ovary syndrome, gender dysphoria, comorbidities, stress, lead exposure, genetic risk factors, hormonal risk factors
MeSH terms
Autism Spectrum Disorder, Attention Deficit Disorder with Hyperactivity, Female, Humans, Male, Sex Characteristics, Neurodevelopmental Disorders

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